An improved method for showing Gc band by sulfosalicylic acidafter IEF is reported. This method provides us an effective mean to identify theGc subtypes and its variants within 4 h without using anti-serum for immunof...An improved method for showing Gc band by sulfosalicylic acidafter IEF is reported. This method provides us an effective mean to identify theGc subtypes and its variants within 4 h without using anti-serum for immunofix-ation. And new variants Gc<sup>1c3</sup> and Gc<sup>2c7</sup> are discovered in Chinese people, andtheir frequencies are 0. 0008 and 0. 0004 respectively.展开更多
OBJECTIVE The specificity of drug therapy in individuals and races has promoted the development and improvement of pharmacogenomics and precision medicine.While there is a few cognition on the minorities in China,espe...OBJECTIVE The specificity of drug therapy in individuals and races has promoted the development and improvement of pharmacogenomics and precision medicine.While there is a few cognition on the minorities in China,especially in Lisu nationality from the Yunnan province.Therefore,we performed the research to improve the role of pharmacogenomics in the Lisu population from the Yunnan province of China.METHODS 54 variants of very important pharmacogenes selected from the PharmGKB database were genotyped in 199 unrelated and healthy Lisu adults from the Yunnan province of China,and then,genotyping data wtih χ^(2) test were analyzed.RESULTS We compared our data with those of other 26 populations from the 1000 Genomes Project,and acquired that the Lisu ethnicity is similar with the CDX(Chinese Dai in Xishuangbanna,China)and CHS(Southern Han Chinese,China).Furthermore,rs776746(CYP3A5),rs1805123(KCNH2),rs4291(ACE),rs1051298(SLC19A1)and rs1065852(CYP2D6)were deemed as the most varying loci.The MAF of“G”at rs1805123(KCNH2)in the Lisu population was the largest with the value of 51.0%.CONCLUSION There are significant differences in single nucleotide polymorphism loci,supplementing the pharmacogenomic information of the Lisu population in Yunnan province,China,and can provide a theoretical basis for individualized medication in the future.展开更多
On naming two theories can be found in the philosophy of language research field,descriptive theory and historical casual theory.For the former,characteristics of social entities are fundamentally fore-grounded in the...On naming two theories can be found in the philosophy of language research field,descriptive theory and historical casual theory.For the former,characteristics of social entities are fundamentally fore-grounded in the process of naming,for the latter social context changes taken into account.Social contexts exert the same influence on the initial naming and the renaming of social entities over time with the same mechanism,conforming to certain social conventions and filtering the unwanted and presenting the value-added judgments.Both the naming and renaming of objects involve the judgments given to the entities in society.Hereby it is safe to say that under no case shall language use be value-free and that name variants mirror social contexts developments.展开更多
间变型弥漫大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)是一种罕见的非特指型DLBCL,组织形态学常为窦性或者弥漫生长。该文报道1例,其左侧腋窝淋巴结具有大量多形性的中心母细胞样伴间变特征的细胞和HRS样细胞呈结节状或滤泡...间变型弥漫大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)是一种罕见的非特指型DLBCL,组织形态学常为窦性或者弥漫生长。该文报道1例,其左侧腋窝淋巴结具有大量多形性的中心母细胞样伴间变特征的细胞和HRS样细胞呈结节状或滤泡生发中心样生长,符合DLBCL,非特殊类型,间变型。结合相关文献探讨其临床病理学及分子遗传学特征,以提高临床和病理医师对该肿瘤的认识。展开更多
目的观察咳喘镇定汤在小儿咳嗽变异性哮喘治疗中的作用及对患儿嗜酸性粒细胞计数(eosinophil count,EOS)、白介素-23(interleukin-23,IL-23)/辅助性T细胞17(helper T cells17,Th17)轴的影响。方法选取2020年8月—2023年2月收治的小儿咳...目的观察咳喘镇定汤在小儿咳嗽变异性哮喘治疗中的作用及对患儿嗜酸性粒细胞计数(eosinophil count,EOS)、白介素-23(interleukin-23,IL-23)/辅助性T细胞17(helper T cells17,Th17)轴的影响。方法选取2020年8月—2023年2月收治的小儿咳嗽变异性哮喘患儿104例,将患儿采用简单随机法分为两组。常规组给予止咳化痰、抗炎、平喘等常规治疗,咳喘镇定汤组在常规组基础上采用咳喘镇定汤辅助治疗。检测组间及组内T淋巴亚群、EOS、巨噬细胞炎症蛋白-1α(macrophage inflammatory protein-1α,MIP-1α)、Clara细胞分泌蛋白16(clara cell secreted protein 16,CC-16)、嗜酸细胞活化趋化因子(Eotaxin)、IL-23/Th17轴、小气道功能水平。评估组间及组内咳嗽症状评分、中医证候评分差异。统计组间疗效和不良反应。结果治疗前T淋巴亚群、CC-16、Eotaxin等差异无统计学意义(P>0.05)。两组治疗后CD_(8)^(+)、EOS、MIP-1α、Eotaxin降低,CC-16、CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)升高,咳喘镇定汤组治疗后CD_(8)^(+)、EOS、MIP-1α、Eotaxin低于常规组,CC-16、CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)高于常规组(P<0.05)。治疗前比较IL-23/Th17轴差异无统计学意义(P>0.05)。两组治疗后IL-23、Th17、白介素-17(interleukin-17,IL-17)降低,咳喘镇定汤组治疗后IL-23/Th17轴低于常规组(P<0.05)。治疗前相关评分无差异(P>0.05)。两组治疗后咳嗽症状评分、中医证候评分降低,咳喘镇定汤组治疗后咳嗽症状评分、中医症候评分低于常规组(P<0.05)。治疗前小气道功能无差异(P>0.05)。两组治疗后小气道功能升高,咳喘镇定汤组治疗后小气道功能高于常规组(P<0.05)。咳喘镇定汤组治愈13例,显效和有效共35例,总有效率92.31%高于常规组,差异有统计学意义(P<0.05)。结论咳喘镇定汤可通过调控小儿咳嗽变异性哮喘患儿IL-23/Th17轴,改善T淋巴亚群和小气道功能,减轻咳嗽症状,提高疗效。展开更多
文摘An improved method for showing Gc band by sulfosalicylic acidafter IEF is reported. This method provides us an effective mean to identify theGc subtypes and its variants within 4 h without using anti-serum for immunofix-ation. And new variants Gc<sup>1c3</sup> and Gc<sup>2c7</sup> are discovered in Chinese people, andtheir frequencies are 0. 0008 and 0. 0004 respectively.
文摘OBJECTIVE The specificity of drug therapy in individuals and races has promoted the development and improvement of pharmacogenomics and precision medicine.While there is a few cognition on the minorities in China,especially in Lisu nationality from the Yunnan province.Therefore,we performed the research to improve the role of pharmacogenomics in the Lisu population from the Yunnan province of China.METHODS 54 variants of very important pharmacogenes selected from the PharmGKB database were genotyped in 199 unrelated and healthy Lisu adults from the Yunnan province of China,and then,genotyping data wtih χ^(2) test were analyzed.RESULTS We compared our data with those of other 26 populations from the 1000 Genomes Project,and acquired that the Lisu ethnicity is similar with the CDX(Chinese Dai in Xishuangbanna,China)and CHS(Southern Han Chinese,China).Furthermore,rs776746(CYP3A5),rs1805123(KCNH2),rs4291(ACE),rs1051298(SLC19A1)and rs1065852(CYP2D6)were deemed as the most varying loci.The MAF of“G”at rs1805123(KCNH2)in the Lisu population was the largest with the value of 51.0%.CONCLUSION There are significant differences in single nucleotide polymorphism loci,supplementing the pharmacogenomic information of the Lisu population in Yunnan province,China,and can provide a theoretical basis for individualized medication in the future.
基金Science and Technology Innovation Fund of Nanjing Forestry University(X09-102-1)2011 Annual University Guidance Program of Philosophy and Social Science from Jiangsu Provincial Education Department(2011SJD740019)
文摘On naming two theories can be found in the philosophy of language research field,descriptive theory and historical casual theory.For the former,characteristics of social entities are fundamentally fore-grounded in the process of naming,for the latter social context changes taken into account.Social contexts exert the same influence on the initial naming and the renaming of social entities over time with the same mechanism,conforming to certain social conventions and filtering the unwanted and presenting the value-added judgments.Both the naming and renaming of objects involve the judgments given to the entities in society.Hereby it is safe to say that under no case shall language use be value-free and that name variants mirror social contexts developments.
文摘间变型弥漫大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)是一种罕见的非特指型DLBCL,组织形态学常为窦性或者弥漫生长。该文报道1例,其左侧腋窝淋巴结具有大量多形性的中心母细胞样伴间变特征的细胞和HRS样细胞呈结节状或滤泡生发中心样生长,符合DLBCL,非特殊类型,间变型。结合相关文献探讨其临床病理学及分子遗传学特征,以提高临床和病理医师对该肿瘤的认识。
文摘目的观察咳喘镇定汤在小儿咳嗽变异性哮喘治疗中的作用及对患儿嗜酸性粒细胞计数(eosinophil count,EOS)、白介素-23(interleukin-23,IL-23)/辅助性T细胞17(helper T cells17,Th17)轴的影响。方法选取2020年8月—2023年2月收治的小儿咳嗽变异性哮喘患儿104例,将患儿采用简单随机法分为两组。常规组给予止咳化痰、抗炎、平喘等常规治疗,咳喘镇定汤组在常规组基础上采用咳喘镇定汤辅助治疗。检测组间及组内T淋巴亚群、EOS、巨噬细胞炎症蛋白-1α(macrophage inflammatory protein-1α,MIP-1α)、Clara细胞分泌蛋白16(clara cell secreted protein 16,CC-16)、嗜酸细胞活化趋化因子(Eotaxin)、IL-23/Th17轴、小气道功能水平。评估组间及组内咳嗽症状评分、中医证候评分差异。统计组间疗效和不良反应。结果治疗前T淋巴亚群、CC-16、Eotaxin等差异无统计学意义(P>0.05)。两组治疗后CD_(8)^(+)、EOS、MIP-1α、Eotaxin降低,CC-16、CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)升高,咳喘镇定汤组治疗后CD_(8)^(+)、EOS、MIP-1α、Eotaxin低于常规组,CC-16、CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)高于常规组(P<0.05)。治疗前比较IL-23/Th17轴差异无统计学意义(P>0.05)。两组治疗后IL-23、Th17、白介素-17(interleukin-17,IL-17)降低,咳喘镇定汤组治疗后IL-23/Th17轴低于常规组(P<0.05)。治疗前相关评分无差异(P>0.05)。两组治疗后咳嗽症状评分、中医证候评分降低,咳喘镇定汤组治疗后咳嗽症状评分、中医症候评分低于常规组(P<0.05)。治疗前小气道功能无差异(P>0.05)。两组治疗后小气道功能升高,咳喘镇定汤组治疗后小气道功能高于常规组(P<0.05)。咳喘镇定汤组治愈13例,显效和有效共35例,总有效率92.31%高于常规组,差异有统计学意义(P<0.05)。结论咳喘镇定汤可通过调控小儿咳嗽变异性哮喘患儿IL-23/Th17轴,改善T淋巴亚群和小气道功能,减轻咳嗽症状,提高疗效。
