期刊文献+
共找到2,325篇文章
< 1 2 117 >
每页显示 20 50 100
A virtual experiment showing single particle motion on a linearly vibrating screen-deck 被引量:11
1
作者 ZHAO, Lala LIU, Chusheng YAN, Junxia 《Mining Science and Technology》 EI CAS 2010年第2期276-280,共5页
A virtual sieving experimental simulation system was built using physical simulation principles.The effects of vibration frequency and amplitude,the inclination angle of the screen-deck and the vibration direction ang... A virtual sieving experimental simulation system was built using physical simulation principles.The effects of vibration frequency and amplitude,the inclination angle of the screen-deck and the vibration direction angle of screen on single particle kinematics were predicted.Properties such as the average velocity and the average throw height were studied.The results show that the amplitude and the angle of vibration have a great effect on particle average velocity and average height.The vibration frequency and the screen-deck inclination angle appear to have little influence on these responses.For materials that are difficult to screen the vibration frequency and amplitude,the screen-deck inclination angle and the vibration angle should be set to 14 Hz,6.6 mm,6° and 40°,respectively,to obtain optimal particle kinematics.A screening process can be simulated reliably by means of a virtual experiment and these results provide references for both screening theory research and sieving practice. 展开更多
关键词 linear vibrating screen kinematics parameters single particle throwing motion virtual experiment
在线阅读 下载PDF
Model experiment of rock blasting with single borehole and double free-surface 被引量:5
2
作者 TIAN Jian-sheng QU Fan-fei 《Mining Science and Technology》 EI CAS 2009年第3期395-398,404,共5页
In order to improve the quality of laneways and tunnel excavation by drilling and blasting and by making effective use of explosive energy, a model experiment of rock blasting with a single borehole and a double free-... In order to improve the quality of laneways and tunnel excavation by drilling and blasting and by making effective use of explosive energy, a model experiment of rock blasting with a single borehole and a double free-surface was performed with the objective of studying the effect of parameters such as charge structure, free-surface and rock compressive strength on rock blasting.The model experiments indicate that:1) the smaller the rock compressive strength and density, the more distinctive the cavity expanding action by blasting;2) the powder factor in an air-decoupling charge structure is larger than that in a coupling charge structure, i.e., the explosive energy in an air-decoupling charge structure transferred to the rocks is less than that in a coupling charge structure;3) a free-surface improves the utilizations of explosive energy;4) an air-decoupling charge structure helps to maintain the integrity and stability of wall rock in controlled perimeter blasting, such as in roadways and tunnel excavation by drilling and blasting. 展开更多
关键词 model experiment single borehole cylindrical charge air-decoupling charge structure free surface
在线阅读 下载PDF
Single-event response of the SiGe HBT in TCAD simulations and laser microbeam experiment 被引量:2
3
作者 李培 郭红霞 +7 位作者 郭旗 张晋新 肖尧 魏莹 崔江维 文林 刘默寒 王信 《Chinese Physics B》 SCIE EI CAS CSCD 2015年第8期609-612,共4页
In this paper the single-event responses of the silicon germanium heterojunction bipolar transistors(SiGe HBTs) are investigated by TCAD simulations and laser microbeam experiment. A three-dimensional(3D) simulation m... In this paper the single-event responses of the silicon germanium heterojunction bipolar transistors(SiGe HBTs) are investigated by TCAD simulations and laser microbeam experiment. A three-dimensional(3D) simulation model is established, the single event effect(SEE) simulation is further carried out on the basis of Si Ge HBT devices, and then, together with the laser microbeam test, the charge collection behaviors are analyzed, including the single event transient(SET) induced transient terminal currents, and the sensitive area of SEE charge collection. The simulations and experimental results are discussed in detail and it is demonstrated that the nature of the current transient is controlled by the behaviors of the collector–substrate(C/S) junction and charge collection by sensitive electrodes, thereby giving out the sensitive area and electrode of SiGe HBT in SEE. 展开更多
关键词 Si Ge heterojunction bipolar transistor single event effect three-dimensional numerical simulation laser microbeam experiment
在线阅读 下载PDF
Experimental study on heavy ion single-event effects in flash-based FPGAs 被引量:2
4
作者 Zhen-Lei Yang Xiao-Hui Wang +6 位作者 Hong Su Jie Liu Tian-Qi Liu Kai Xi Bin Wang Song Gu Qian-Shun She 《Nuclear Science and Techniques》 SCIE CAS CSCD 2016年第1期98-105,共8页
With extensive use of flash-based field-programmable gate arrays(FPGAs) in military and aerospace applications, single-event effects(SEEs) of FPGAs induced by radiations have been a major concern. In this paper, we pr... With extensive use of flash-based field-programmable gate arrays(FPGAs) in military and aerospace applications, single-event effects(SEEs) of FPGAs induced by radiations have been a major concern. In this paper, we present SEE experimental study of a flash-based FPGA from Microsemi Pro ASIC3 product family. The relation between the cross section and different linear energy transfer(LET) values for the logic tiles and embedded RAM blocks is obtained. The results show that the sequential logic cross section depends not too much on operating frequency of the device. And the relationship between 0 →1 upsets(zeros) and 1 →0 upsets(ones) is different for different kinds of D-flip-flops. The devices are not sensitive to SEL up to a LET of 99.0 Me V cm2/mg.Post-beam tests show that the programming module is damaged due to the high-LET ions. 展开更多
关键词 Flash 单粒子效应 FPGA 重离子 实验 现场可编程门阵列 设备选择 航天应用
在线阅读 下载PDF
Experimental verification of the parasitic bipolar amplification effect in PMOS single event transients
5
作者 何益百 陈书明 《Chinese Physics B》 SCIE EI CAS CSCD 2014年第7期775-779,共5页
The contribution of parasitic bipolar amplification to SETs is experimentally verified using two P-hit target chains in the normal layout and in the special layout. For PMOSs in the normal layout, the single-event cha... The contribution of parasitic bipolar amplification to SETs is experimentally verified using two P-hit target chains in the normal layout and in the special layout. For PMOSs in the normal layout, the single-event charge collection is composed of diffusion, drift, and the parasitic bipolar effect, while for PMOSs in the special layout, the parasitic bipolar junction transistor cannot turn on. Heavy ion experimental results show that PMOSs without parasitic bipolar amplification have a 21.4% decrease in the average SET pulse width and roughly a 40.2% reduction in the SET cross-section. 展开更多
关键词 single event effect single event transient parasitic bipolar amplification heavy ion experiments
在线阅读 下载PDF
Single Molecule Fluorescence Resonance Energy Transfer and Ensemble Biophysical Characterization of a G-quadruplex Formed in the Promoter of Human Myocyte Enhancer Factor 2D
6
作者 ZHOU Wen-Hua YING Li-Ming 《物理化学学报》 SCIE CAS CSCD 北大核心 2010年第4期1099-1106,共8页
关键词 荧光分光计 能量共振转移 杂种栽培 种植
在线阅读 下载PDF
Centrifuge experiment on the penetration test for evaluating undrained strength of deep-sea surface soils 被引量:6
7
作者 Xingsen Guo Tingkai Nian +4 位作者 Wei Zhao Zhongde Gu Chunpeng Liu Xiaolei Liu Yonggang Jia 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2022年第2期363-373,共11页
Rapid advances in deep-sea mining engineering have created an urgent need for the accurate evaluation of the undrained strength of marine soils,especially surface soils.Significant achievements have been made using fu... Rapid advances in deep-sea mining engineering have created an urgent need for the accurate evaluation of the undrained strength of marine soils,especially surface soils.Significant achievements have been made using full-flow penetration penetrometers to evaluate marine soil strength in the deep penetration;however,a method considering the effect of ambient water on the surface penetration needs to be established urgently.In this study,penetrometers with multiple probes were developed and used to conduct centrifuge experiments on South China Sea soil and kaolin clay.First,the forces on the probes throughout the penetration process were systematically analyzed and quantified.Second,the spatial influence zone was determined by capturing the resistance changes and sample crack development,and the penetration depth for a sample to reach a stable failure mode was given.Third,the vane shear strength was used to invert the penetration resistance factor of the ball and determine the range of the penetration resistance factor values.Furthermore,a methodology to determine the penetration resistance factors for surface marine soils was established.Finally,the effect of the water cavity above various probes in the surface penetration was used to formulate an internal mechanism for variations in the penetration resistance factor. 展开更多
关键词 Static penetrometer Centrifuge experiment Deep-sea surface soil Undrained shear strength Penetration resistance factor Water cavity
在线阅读 下载PDF
The exciton-longitudinal-optical-phonon coupling in InGaN/GaN single quantum wells with various cap layer thicknesses 被引量:1
8
作者 胡晓龙 张江勇 +2 位作者 尚景智 刘文杰 张保平 《Chinese Physics B》 SCIE EI CAS CSCD 2010年第11期653-657,共5页
This paper studies the exciton-longitudinal-optical-phonon coupling in InGaN/GaN single quantum wells with various cap layer thicknesses by low temperature photoluminescence (PL) measurements. With increasing cap la... This paper studies the exciton-longitudinal-optical-phonon coupling in InGaN/GaN single quantum wells with various cap layer thicknesses by low temperature photoluminescence (PL) measurements. With increasing cap layer thickness, the PL peak energy shifts to lower energy and the coupling strength between the exciton and longitudinal- optical (LO) phonon, described by Huang-Rhys factor, increases remarkably due to an enhancement of the internal electric field. With increasing excitation intensity, the zero-phonon peak shows a blueshift and the Huang-Rhys factor decreases. These results reveal that there is a large built-in electric field in the well layer and the exciton-LO-phonon coupling is strongly affected by the thickness of the cap layer. 展开更多
关键词 exciton longitudinal-optical-phonon InGaN/GaN single quantum well GaN cap layer Huang-Rhys factor
在线阅读 下载PDF
Experimental investigation on stable displacement mechanism and oil recovery enhancement of oxygen-reduced air assisted gravity drainage 被引量:2
9
作者 CHEN Xiaolong LI Yiqiang +4 位作者 LIAO Guangzhi ZHANG Chengming XU Shanzhi QI Huan TANG Xiang 《Petroleum Exploration and Development》 2020年第4期836-845,共10页
The effects of gravity,capillary force,and viscous force on the migration characteristics of oil and gas interface in oxygen-reduced air-assisted gravity drainage(OAGD)were studied through a two-dimensional visualizat... The effects of gravity,capillary force,and viscous force on the migration characteristics of oil and gas interface in oxygen-reduced air-assisted gravity drainage(OAGD)were studied through a two-dimensional visualization model.The effects of bond number,capillary number and low-temperature oxidation on OAGD recovery were studied by long core displacement experiments.On this basis,the low-temperature oxidation number was introduced and its relationship with the OAGD recovery was established.The results show that the shape and changing law of oil and gas front are mainly influenced by gravity,capillary force and viscous force.When the bond number is constant(4.52×10-4),the shape of oil-gas front is controlled by capillary number.When the capillary number is less than 1.68×10-3,the oil and gas interface is stable.When the capillary number is greater than 2.69×10-2,the oil and gas interface shows viscous fingering.When the capillary number is between 1.68×10-3 and 2.69×10-2,the oil and gas interface becomes capillary fingering.The core flooding experiments results show that for OAGD stable flooding,before the gas breakthrough,higher recovery is obtained in higher gravity number and lower capillary number.In this stage,gravity is predominant in controlling OAGD recovery and the oil recovery could be improved by reducing injection velocity.After gas breakthrough,higher recovery was obtained in lower gravity and higher capillary numbers,which means that the viscous force had a significant influence on the recovery.Increasing gas injection velocity in this stage is an effective measure to improve oil recovery.The low-temperature oxidation number has a good correlation with the recovery and can be used to predict the OAGD recovery. 展开更多
关键词 oxygen-reduced air drainage gravity drainage experiment oil displacement mechanism recovery influence factor
在线阅读 下载PDF
Analysis on influencing factors of patients experience in community health centers of Shenzhen,China
10
作者 CHANG Feifei CHEN Xianhui +1 位作者 HUANG Hong WANG Qiang 《中西医结合护理(中英文)》 2019年第1期224-230,共7页
Objective To investigate the patients experience in community health centers( CHCs) and explore its associated factors. Methods A cross-sectional study was conducted among 330 patients who visited CHCs in Shenzhen,Chi... Objective To investigate the patients experience in community health centers( CHCs) and explore its associated factors. Methods A cross-sectional study was conducted among 330 patients who visited CHCs in Shenzhen,China from January to March 2018. Dependent variable was patient experience. Key descriptive variables were age,gender,marital status,working status groups,visits frequency for the past 6 months,whether patients had signed a family doctor,whether trusted in family doctor,whether had chronic diseases. Results Questionnaires for 300 patients were assessed. In the univariate analysis,patients experience total score was significantly associated with marital status( P < 0. 1),working status groups( P < 0. 1),frequency of visit for the past 6 months( P < 0. 05),whether had signed a family doctor( P < 0. 05),whether trusted in family doctor( P < 0. 05),whether had chronic diseases( P < 0. 05). The multivariate analysis showed that unmarried patients( P = 0. 011,OR = 2. 96,95% CI: 1. 24-5. 43) and had signed a family doctor( P = 0. 023,OR = 0. 44,95% CI: 0. 22-0. 85) were more likely to get a higher score. Conclusions Findings of this study showed a medium-level score of patients experience in the community. Patients had a quite good experience and more interventions should be focused upon the influence factors to improve patients experience. 展开更多
关键词 PATIENTS experiENCE influencing factors community health CENTERS family DOCTOR CHRONIC disease
在线阅读 下载PDF
A Novel Single-Switch Single-Stage Electronic Ballast
11
作者 Lu-Hua Zhu Xing-Bi Chen Hong-Sheng Zhong 《Journal of Electronic Science and Technology of China》 2009年第2期156-159,共4页
A single-stage single-switch high- frequency electronic ballast topology is presented. The circuit topology is the integration of a buck power- factor-correction (PFC) converter and a class E resonant inverter with ... A single-stage single-switch high- frequency electronic ballast topology is presented. The circuit topology is the integration of a buck power- factor-correction (PFC) converter and a class E resonant inverter with only one active power switch. The buck converter is operated in discontinuous conduction mode and at a fixed switching frequency, and constant duty cycle to achieve high power factor and it can be controlled easily. Detailed analysis of the operation and characteristics of the circuit is provided. Simulation results satisfy present standard requirements. 展开更多
关键词 Electronic ballast single-switch single-stage power factor correction(PFC).
在线阅读 下载PDF
凝固型玉米桂花风味酸奶发酵工艺条件研究
12
作者 段飞 《现代食品》 2025年第3期90-92,97,共4页
本文以玉米、桂花、牛奶为主要原料,感官评分为评价指标,通过单因素和正交试验确定凝固型玉米桂花风味酸奶的最佳发酵工艺条件。结果表明,在玉米浆添加量为12%,桂花汁添加量为11%,接种量为6%的条件下,在42℃发酵6 h后,制得的凝固型玉米... 本文以玉米、桂花、牛奶为主要原料,感官评分为评价指标,通过单因素和正交试验确定凝固型玉米桂花风味酸奶的最佳发酵工艺条件。结果表明,在玉米浆添加量为12%,桂花汁添加量为11%,接种量为6%的条件下,在42℃发酵6 h后,制得的凝固型玉米桂花风味酸奶呈浅黄色,口感酸甜可口、质地光滑细腻,具有浓郁的玉米香甜和桂花清香气。 展开更多
关键词 玉米 桂花 单因素试验 正交试验
在线阅读 下载PDF
一种简便的临床决策模型——注射用血栓通不良反应危险因素分析
13
作者 肖正国 刘效栓 +6 位作者 李喜香 刘军刚 张民 王炯 李莉 豆金彦 季文莹 《西部中医药》 2025年第3期36-41,共6页
目的:利用在兰州地区收集的数据,探讨引起注射用血栓通(Xueshuantong injection,XSTI)不良反应的潜在危险因素,并开发一种简单的工具以预测和控制其人为因素,为临床合理用药提供依据。方法:在兰州地区收集1229例使用注射用血栓通的住院... 目的:利用在兰州地区收集的数据,探讨引起注射用血栓通(Xueshuantong injection,XSTI)不良反应的潜在危险因素,并开发一种简单的工具以预测和控制其人为因素,为临床合理用药提供依据。方法:在兰州地区收集1229例使用注射用血栓通的住院病例,其中23例发生了不良反应。运用倾向性匹配(propensity score matching,PSM)对性别、年龄、民族、身高、体质量等混杂因素按照(1∶4)匹配后,得到共115个病例,用决策树(decision tree,DT)分析建模,用随机森林模型(random forest,RF)计算出各自变量的重要性。结果:重要性排名前四的变量为合并用药种类(number of combined drugs,NOCD)、单位体表面积单次给药量(single dose per body surface area,DPBSA)、静滴速度(IV drip rate,IV rate)、溶媒种类(solution type,S type),其平均Gini指数减少量>3.7,是最重要的危险因素。最终临床预测模型中输出的变量只有NOCD、DPBSA,是密切相关因素。结论:Decision Tree模型是一种简单的不良反应风险预测工具;合并用药种类、单位体表面积给药剂量与注射用血栓通不良反应发生率密切相关;注射用血栓通给药剂量应按体表面积法计算,单位体表面积给药剂量应<289.2 mg/m2。 展开更多
关键词 注射用血栓通 倾向性匹配 决策树 随机森林 单位体表面积给药剂量 不良反应 危险因素
在线阅读 下载PDF
PRE-CORROSION FATIGUE NOTCH FACTOR 被引量:1
14
作者 张川 姚卫星 余建航 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2011年第4期331-336,共6页
The notched and smooth specimens of aluminum alloy LC4CS soaked in EXCO solution for different time are tested under the constant amplitude cyclic loading to obtain S-N curves and fatigue notch factors with different ... The notched and smooth specimens of aluminum alloy LC4CS soaked in EXCO solution for different time are tested under the constant amplitude cyclic loading to obtain S-N curves and fatigue notch factors with different pre-corrosion time. By analyzing the corrosion process of LC4CS specimens in EXCO solution, the influ- ence mechanism of corrosion on fatigue notch factor is expounded. Then, a two-parameter model used to describe the change of corrosion fatigue notch factor with time is established and verified by experiment. The results show that the pre-corrosion fatigue notch factor of LC4CS material decreases at first and then increases with the increasing pre-corrosion time. The inflection point appears at the beginning of denudation stage. 展开更多
关键词 PRE-CORROSION EXCO solution fatigue notch factor LC4CS fatigue experiments
在线阅读 下载PDF
防痛风复合型果蔬汁饮料研制
15
作者 王思睿 钟添宇 汪建明 《饮料工业》 2025年第1期48-53,共6页
为了探究桑葚-玉米苞叶和玉米须复合饮料的制作工艺及其抗黄嘌呤氧化酶特性和抗氧化性,以桑葚、玉米苞叶和玉米须为原料,通过单因素和正交试验,优化复合饮料的制作工艺。结果表明,复合饮料的最佳工艺为桑葚添加量15%,玉米须添加量为45%... 为了探究桑葚-玉米苞叶和玉米须复合饮料的制作工艺及其抗黄嘌呤氧化酶特性和抗氧化性,以桑葚、玉米苞叶和玉米须为原料,通过单因素和正交试验,优化复合饮料的制作工艺。结果表明,复合饮料的最佳工艺为桑葚添加量15%,玉米须添加量为45%,玉米苞叶添加量为35%,得到的饮料酸甜适中、风味独特。在此工艺条件下,通过单因素确定最佳抑制黄嘌呤氧化酶条件为酶解温度45℃,酶解时间30min;适宜抗氧化特性条件为:酶解温度45℃~65℃,酶解时间30min。评价复合饮料抗氧化能力和抑制黄嘌呤氧化酶的能力,得到DPPH自由基清除率最高可为80.15%,黄嘌呤氧化酶抑制率最高可为64.57%。 展开更多
关键词 桑葚 玉米须 玉米苞叶 正交试验 单因素实验 抗氧化 黄嘌呤氧化酶
在线阅读 下载PDF
响应面法优化铁观音新式茶饮配方的研究
16
作者 盛思杰 吴媛媛 +6 位作者 叶海波 徐铃琳 朱天乐 吴学进 温欣黎 郝连奇 屠幼英 《中国茶叶》 2025年第2期40-45,共6页
近年来,时尚和快捷的新式茶饮受到年轻消费者的追捧,并且随着消费者健康意识的提高,越来越多的新式茶饮品牌开始关注茶饮产品的养生功能。研究通过单因素试验对铁观音、罗汉果、桑叶提取液配比进行优化,以感官评价为关键指标,确定初步... 近年来,时尚和快捷的新式茶饮受到年轻消费者的追捧,并且随着消费者健康意识的提高,越来越多的新式茶饮品牌开始关注茶饮产品的养生功能。研究通过单因素试验对铁观音、罗汉果、桑叶提取液配比进行优化,以感官评价为关键指标,确定初步配方。采用响应面法得出铁观音新式茶饮感官评价的多元回归方程,确定铁观音∶罗汉果∶桑叶提取液最佳比例为4.6∶3.2∶0.9,3种原材料对茶饮的感官品质影响从大到小依次为:铁观音>桑叶>罗汉果。对响应面法所得最佳配方制得的茶饮样品进行审评,得分为92.33分,高于单因素筛选配方的90.02分。最终得到的铁观音新式茶饮香气丰富、口感顺滑,满足现代消费者对口味与健康的双重追求。 展开更多
关键词 铁观音新式茶饮 配方 单因素法 响应面优化 感官评价
在线阅读 下载PDF
一种麻辣型火锅底料的配方优化研究
17
作者 乔雪 马明 刘海英 《食品安全导刊》 2025年第5期124-126,172,共4页
为了优化一种麻辣型火锅底料的工艺配方,以感官评分为标准,分别进行了单因素和正交试验。结果表明,麻辣型火锅底料最佳工艺配方为牛油200 g、盐65 g、大葱5 g、大蒜3 g、鲜姜2.5 g、豆豉5 g、牛肉粉3 g、辣椒30 g、花椒3.5 g、豆瓣酱40 ... 为了优化一种麻辣型火锅底料的工艺配方,以感官评分为标准,分别进行了单因素和正交试验。结果表明,麻辣型火锅底料最佳工艺配方为牛油200 g、盐65 g、大葱5 g、大蒜3 g、鲜姜2.5 g、豆豉5 g、牛肉粉3 g、辣椒30 g、花椒3.5 g、豆瓣酱40 g和复合香辛料3.5 g。在此条件下,麻辣型火锅底料的感官评分为9.6分。 展开更多
关键词 麻辣型火锅底料 单因素试验 正交试验
在线阅读 下载PDF
西安市高陵区土壤重金属污染现状分析
18
作者 殷宗敏 殷宗奇 何文熹 《安徽农业科学》 2025年第4期47-52,共6页
通过分析高陵区土壤中汞(Hg)、砷(As)、镉(Cd)、铬(Cr)、铅(Pb)含量,采用单因子污染指数法进行污染等级划分,并进行不同元素间相关分析。结果表明:高陵区Hg、As、Cd、Pb含量正态分布呈现左偏,Cr含量呈现右偏。各元素含量排序为Cr>Pb&... 通过分析高陵区土壤中汞(Hg)、砷(As)、镉(Cd)、铬(Cr)、铅(Pb)含量,采用单因子污染指数法进行污染等级划分,并进行不同元素间相关分析。结果表明:高陵区Hg、As、Cd、Pb含量正态分布呈现左偏,Cr含量呈现右偏。各元素含量排序为Cr>Pb>As>Cd>Hg。Hg元素存在分布中心,含量由中心向周边递减;As和Cr元素不存在分布中心。Hg分布存在安全和轻污染级,As分布存在安全和轻污染级,Cd分布存在安全、轻污染和中污染级,Cr分布存在安全和轻污染级,Pb分布存在安全、轻污染和中污染级,其中Hg、Cd、Pb的分布特征较相似,在药惠乡部分区域均存在较重污染。Hg与As存在中度负相关,与Cd、Cr存在中度正相关,与Pb存在弱正相关性;As与Cd、Cr均存在弱负相关性;Cd与Cr存在弱正相关,与Pb均存在强正相关性;Cr与Pb存在中度正相关。综上,高陵区土壤存在重金属污染,应加强治理。 展开更多
关键词 土壤重金属 单因子污染指数法 安全分级 空间分析 相关性 高陵区
在线阅读 下载PDF
单细胞联合转录组测序分析原发性开角型青光眼小梁网组织细胞通信变化
19
作者 赵雅婷 赵春峰 +2 位作者 王文晶 蒋晓迪 姜雅琴 《眼科新进展》 CAS 北大核心 2025年第1期39-45,共7页
目的探究原发性开角型青光眼(POAG)房角细胞类型和细胞通信模式变化。方法从基因表达综合(GEO)数据库中下载单细胞数据集GSE231749(包含POAG的食蟹猴房角组织样本3例和健康食蟹猴房角组织样本3例,数据更新时间为2023年),分别设为POAG组... 目的探究原发性开角型青光眼(POAG)房角细胞类型和细胞通信模式变化。方法从基因表达综合(GEO)数据库中下载单细胞数据集GSE231749(包含POAG的食蟹猴房角组织样本3例和健康食蟹猴房角组织样本3例,数据更新时间为2023年),分别设为POAG组与健康对照组。采用R包“Seurat”对数据进行降维、聚类、分群和可视化,并通过R包“CellChat”进行了细胞通信分析,确认POAG组和健康对照组细胞通信模式的差异。同时,联合GEO数据库中转录组测序(RNA-seq)数据集GSE27276(包含POAG的人类房角组织样本17例和健康人房角组织样本19例,数据更新时间为2023年)的差异基因分析,确定具体的细胞通信信号变化。结果健康对照组与POAG组细胞类型无明显差异,均可分为小梁网细胞、巨噬细胞、黑素细胞、周细胞、施莱姆氏管细胞、有髓施万细胞、无髓施万细胞、平滑肌细胞和血管内皮细胞。POAG组与健康对照组细胞间通信强度具有显著差异,其中,POAG组巨噬细胞移动抑制因子(MIF)-CD74、CX3C趋化因子配体1(CX3CL1)-CX3C趋化因子受体1(CX3CR1)、HBB等通信概率显著上调,分泌型磷蛋白1(SPP1)-(ITGA8+ITGB1)、SPP1-(ITGA4+ITGB1)、IGF2-IGF2R、CCL8-CCR1、CCL8/26/24/2-ACKR2等信号明显下调;RNA-seq分析证实,POAG组HBB、HBD、HBA、CD74等基因表达水平均高于健康对照组。结论小梁网组织中通过MIF/CD74信号上调、SPP1-(ITGA8+ITGB1)、SPP1-(ITGA4+ITGB1)信号下调共同参与纤维化过程,这可能是POAG潜在的致病机制。 展开更多
关键词 开角型青光眼 RNA测序 单细胞分析 细胞间通信 巨噬细胞移动抑制因子 分泌型磷蛋白1
在线阅读 下载PDF
小型单关节机器鱼设计与游动稳定性分析
20
作者 谢智钧 赵灿明 +3 位作者 柯鑫 肖扬 武静 宋加雷 《集成技术》 2025年第1期39-49,共11页
该文基于鲹科鱼的推进模式和鱼鳍模块化设计了一款结构紧凑、成本低廉、高效游动的小型单关节仿生机器鱼,其胸鳍、腹鳍和尾鳍拆装方便。此外,该文对仿生机器鱼的直线推进、静止转弯、鱼头稳定性进行了水下实验,研究了胸鳍和腹鳍对游动... 该文基于鲹科鱼的推进模式和鱼鳍模块化设计了一款结构紧凑、成本低廉、高效游动的小型单关节仿生机器鱼,其胸鳍、腹鳍和尾鳍拆装方便。此外,该文对仿生机器鱼的直线推进、静止转弯、鱼头稳定性进行了水下实验,研究了胸鳍和腹鳍对游动性能的影响。在样机游动测试中,该文利用一台高速相机和一面平面镜构建了一个记录机器鱼运动的“双目视觉系统”,可对鱼头最前端和质点上方两处标记点进行追踪,并可记录三维位置信息,这为机器鱼的游动性能、姿态变化和头部稳定性的定量分析提供参考。结果表明:机器鱼的直线推进和转弯性能较好;在稳定性实验中,配备胸鳍和腹鳍的机器鱼在低频游动时,头部稳定性更优,而在高频游动时,未显示出优势,这与自然界中鱼类在高频游动时除尾鳍外的各种鳍紧贴身体的现象一致。 展开更多
关键词 小型机器鱼 单关节 水下实验 头部稳定性
在线阅读 下载PDF
上一页 1 2 117 下一页 到第
使用帮助 返回顶部