Objective To evaluate the effect of propofol,sevoflurane,and dexmedetomidine on respiratory complications inchildren undergoing fiberoptic bronchoscopy(FOB).Methods This double-blind randomized clinical trial was cond...Objective To evaluate the effect of propofol,sevoflurane,and dexmedetomidine on respiratory complications inchildren undergoing fiberoptic bronchoscopy(FOB).Methods This double-blind randomized clinical trial was conductedamong 120 children aged 1 month to 3 years undergoing FOB.The patients were randomized into 3 groups(n=40)foranesthesia induction with sevoflurane inhalation,1 mg/kg propofol,or 1μg/kg dexmedetomidine before bronchoscopy,andthe changes in hemodynamic parameters,sedation level,and respiratory complications during and after the procedure wereassessed.Results The patients'heart rate during bronchoscopy was significantly lower and the mean arterial blood pressuresignificantly higher in dexmedetomidine group than in sevoflurane and propofol groups(P<0.05).Cough duringbronchoscopy did not occur in any of the cases in propofol group,while the highest frequency of cough was recorded indexmedetomidine group.The incidence of laryngospasm in the propofol group(12.5%)was significantly lower than those insevoflurane and dexmedetomidine groups(30%and 32.5%,respectively)(P<0.05).Conclusion Sevoflurane and propofol aresafe and suitable for anesthesia induction in children below 3 years of age undergoing diagnostic FOB and can achieve bettersedative effect and lower the incidences of cough and respiratory complications as compared with dexmedetomidine.展开更多
Objective To investigate the effects of sevoflurane preconditioning and postconditioning on electrophysiological characteristics of transient outward potassium channel(Ito)in rat ventricular myocytes.Methods Isolated ...Objective To investigate the effects of sevoflurane preconditioning and postconditioning on electrophysiological characteristics of transient outward potassium channel(Ito)in rat ventricular myocytes.Methods Isolated rat hearts were harvested and balanced with Langendorff perfusion system,then they were randomly assigned to one of the following 4 groups(n=10):(1)Time Control group(perfused with KH solution for 75 min);(2)Ischemia/reperfusion(I/R)group(perfused with KH solution for 20 min and then subjected to 25 min of global ischemia followed by 30 min of reperfusion with KH solution).展开更多
Fluoromethyl pentafluoroprop-1-en-2-yl ether(compound A),which is a degradation product of sevoflurane,a novel anaesthetic,is harmful to renal function.A GC and GC-MS method for the determination of compound A has bee...Fluoromethyl pentafluoroprop-1-en-2-yl ether(compound A),which is a degradation product of sevoflurane,a novel anaesthetic,is harmful to renal function.A GC and GC-MS method for the determination of compound A has been established and more than 160 real samples were analyzed.The result indicated that the highest concentration of the compound A was 40.1 mg/kg,and the detection limit of the method was 0.1 mg/kg.展开更多
文摘Objective To evaluate the effect of propofol,sevoflurane,and dexmedetomidine on respiratory complications inchildren undergoing fiberoptic bronchoscopy(FOB).Methods This double-blind randomized clinical trial was conductedamong 120 children aged 1 month to 3 years undergoing FOB.The patients were randomized into 3 groups(n=40)foranesthesia induction with sevoflurane inhalation,1 mg/kg propofol,or 1μg/kg dexmedetomidine before bronchoscopy,andthe changes in hemodynamic parameters,sedation level,and respiratory complications during and after the procedure wereassessed.Results The patients'heart rate during bronchoscopy was significantly lower and the mean arterial blood pressuresignificantly higher in dexmedetomidine group than in sevoflurane and propofol groups(P<0.05).Cough duringbronchoscopy did not occur in any of the cases in propofol group,while the highest frequency of cough was recorded indexmedetomidine group.The incidence of laryngospasm in the propofol group(12.5%)was significantly lower than those insevoflurane and dexmedetomidine groups(30%and 32.5%,respectively)(P<0.05).Conclusion Sevoflurane and propofol aresafe and suitable for anesthesia induction in children below 3 years of age undergoing diagnostic FOB and can achieve bettersedative effect and lower the incidences of cough and respiratory complications as compared with dexmedetomidine.
文摘Objective To investigate the effects of sevoflurane preconditioning and postconditioning on electrophysiological characteristics of transient outward potassium channel(Ito)in rat ventricular myocytes.Methods Isolated rat hearts were harvested and balanced with Langendorff perfusion system,then they were randomly assigned to one of the following 4 groups(n=10):(1)Time Control group(perfused with KH solution for 75 min);(2)Ischemia/reperfusion(I/R)group(perfused with KH solution for 20 min and then subjected to 25 min of global ischemia followed by 30 min of reperfusion with KH solution).
文摘Fluoromethyl pentafluoroprop-1-en-2-yl ether(compound A),which is a degradation product of sevoflurane,a novel anaesthetic,is harmful to renal function.A GC and GC-MS method for the determination of compound A has been established and more than 160 real samples were analyzed.The result indicated that the highest concentration of the compound A was 40.1 mg/kg,and the detection limit of the method was 0.1 mg/kg.
