Bisphosphonate Liposomes for Cobalt and Strontium Decorporation?Géraldine Landon1,Guillaume Phan1,François Fay2,David Suhard1,David Broggio1,Raphaël Bô1,Céline Bouvier-Capely1,Elias Fattal2(1....Bisphosphonate Liposomes for Cobalt and Strontium Decorporation?Géraldine Landon1,Guillaume Phan1,François Fay2,David Suhard1,David Broggio1,Raphaël Bô1,Céline Bouvier-Capely1,Elias Fattal2(1.Health Division,Institute for Radiological Protection and Nuclear Safety(IRSN),Fontenay-aux-Roses,France;2.UniversitéParis-Saclay,CNRS,Institut Galien Paris-Saclay,91400 Orsay,France)Abstract:During a nuclear/radiological incident or an accident involving internal intakes with radioactive cobalt or strontium,the recommended treatments,consisting of the administration of diethylenetriaminepentaacetic acid for^(60)Co and calcium gluconate for^(90)Sr,are of low specificity,and their effectiveness can be enhanced.In this manuscript,a liposomal formulation was developed to deliver potential chelating agents to the main retention organs of both radionuclides.A bisphosphonate,etidronate,has been selected as a possible candidate due to its satisfying decorporation activity for uranium,bone tropism,and potential affinity with cobalt.Pre-clinical studies have been carried out on rats using radionuclide contamination and treatment administration by the intravenous route.展开更多
In this paper we investigate the complexity of several problems concerning 2CNF formulas. At first, we show that the minimal unsatisfiability problem for 2CNF formulas can be solved in linear time. Then we prove that ...In this paper we investigate the complexity of several problems concerning 2CNF formulas. At first, we show that the minimal unsatisfiability problem for 2CNF formulas can be solved in linear time. Then we prove that the problem determining if a 2CNF formula can be transformed to a minimal unsatisfiable formula is also solvable in linear time. Thirdly, we show the polynomial solvability of the satisfiability problem for symmetric monotone formulas in which all clauses has length 2 or ? n - k ( n is the ...展开更多
Oleosomes,which are pre-emulsified oil bodies found naturally in plants,have excellent stability,therefore making their use more popular in the food industries.However,the mechanism of EGCG in regulat-ing the physicoc...Oleosomes,which are pre-emulsified oil bodies found naturally in plants,have excellent stability,therefore making their use more popular in the food industries.However,the mechanism of EGCG in regulat-ing the physicochemical and oxidative stability,and digestion of oleosome emulsions is not yet clear.In this study,the effect of EGCG on the properties of soybean oleosome emulsions(SOE)was examined at different p H values(5.0,7.0,and9.0).EGCG was significantly more effective in maintaining the stability of SOE at p H 5.0 and 7.0 over the 14 days of storage,but less effective at p H 9.0.Furthermore,lipid oxidation of SOE at p H 7.0 was successfully retarded by incorporating EGCG,but not at p H 5.0 and 9.0.The in vitro gastrointestinal results suggested that EGCG retarded the digestion rate of SOE based on a 20%reduction in free fatty acid release.The results of this study will help food technologists to design slow-digestive oleosome-based products that will satisfy health-conscious consumers’demand for healthier food choices.展开更多
A hierarchical satisfying optimal algorithm incorporating different importance and preemptive priorities is formulated. With the priority structure given by the decision-maker in the constrained multi-objective multi-...A hierarchical satisfying optimal algorithm incorporating different importance and preemptive priorities is formulated. With the priority structure given by the decision-maker in the constrained multi-objective multi-degree-of-freedom optimization (CMMO) problem, the commonly used quadratic programming model is converted into a two-level optimization problem solved by the tolerant lexicographic method and the varying-domain optimization method. In contrast to previous works, the proposed approach allows the decision-maker to determine a desirable achievement degree for each goal to reflect explicitly the relative importance of these goals. The resulting solutions satisfy both the preemptive priority structure and have the maximum achievement degrees in sum. The power of the proposed approach is demonstrated with an example.展开更多
In this paper, solution to the LQ inverse problem has been pre-sented. With the control weight in an LQ optimal control system fixed,the state weighting matrix is parametrized in terms of a set of freevariables and th...In this paper, solution to the LQ inverse problem has been pre-sented. With the control weight in an LQ optimal control system fixed,the state weighting matrix is parametrized in terms of a set of freevariables and the closed-loop eigenvalues of the control system. Basedon this parametrization, an algorithmic procedure is proposed to deter-mine the state weighting matrix and the free variables by matrixtransformation. Meanwhile, by using the solved free variables, theoptimal feedback gain matrix K can also be obtained without solving thealgebraic Riccati equation.展开更多
文摘Bisphosphonate Liposomes for Cobalt and Strontium Decorporation?Géraldine Landon1,Guillaume Phan1,François Fay2,David Suhard1,David Broggio1,Raphaël Bô1,Céline Bouvier-Capely1,Elias Fattal2(1.Health Division,Institute for Radiological Protection and Nuclear Safety(IRSN),Fontenay-aux-Roses,France;2.UniversitéParis-Saclay,CNRS,Institut Galien Paris-Saclay,91400 Orsay,France)Abstract:During a nuclear/radiological incident or an accident involving internal intakes with radioactive cobalt or strontium,the recommended treatments,consisting of the administration of diethylenetriaminepentaacetic acid for^(60)Co and calcium gluconate for^(90)Sr,are of low specificity,and their effectiveness can be enhanced.In this manuscript,a liposomal formulation was developed to deliver potential chelating agents to the main retention organs of both radionuclides.A bisphosphonate,etidronate,has been selected as a possible candidate due to its satisfying decorporation activity for uranium,bone tropism,and potential affinity with cobalt.Pre-clinical studies have been carried out on rats using radionuclide contamination and treatment administration by the intravenous route.
文摘In this paper we investigate the complexity of several problems concerning 2CNF formulas. At first, we show that the minimal unsatisfiability problem for 2CNF formulas can be solved in linear time. Then we prove that the problem determining if a 2CNF formula can be transformed to a minimal unsatisfiable formula is also solvable in linear time. Thirdly, we show the polynomial solvability of the satisfiability problem for symmetric monotone formulas in which all clauses has length 2 or ? n - k ( n is the ...
基金the financial support received from the National Natural Science Foundation of China(No.31871809,31601475,and 31671807)the financial support from the China Postdoctoral Science Foundation funded project(No.2018T110265,2017M610200)+1 种基金the Heilongjiang National Nature Science Foundation(LC2017009)the Heilongjiang Postdoctoral Foundation(No.LBHZ17011)
文摘Oleosomes,which are pre-emulsified oil bodies found naturally in plants,have excellent stability,therefore making their use more popular in the food industries.However,the mechanism of EGCG in regulat-ing the physicochemical and oxidative stability,and digestion of oleosome emulsions is not yet clear.In this study,the effect of EGCG on the properties of soybean oleosome emulsions(SOE)was examined at different p H values(5.0,7.0,and9.0).EGCG was significantly more effective in maintaining the stability of SOE at p H 5.0 and 7.0 over the 14 days of storage,but less effective at p H 9.0.Furthermore,lipid oxidation of SOE at p H 7.0 was successfully retarded by incorporating EGCG,but not at p H 5.0 and 9.0.The in vitro gastrointestinal results suggested that EGCG retarded the digestion rate of SOE based on a 20%reduction in free fatty acid release.The results of this study will help food technologists to design slow-digestive oleosome-based products that will satisfy health-conscious consumers’demand for healthier food choices.
文摘A hierarchical satisfying optimal algorithm incorporating different importance and preemptive priorities is formulated. With the priority structure given by the decision-maker in the constrained multi-objective multi-degree-of-freedom optimization (CMMO) problem, the commonly used quadratic programming model is converted into a two-level optimization problem solved by the tolerant lexicographic method and the varying-domain optimization method. In contrast to previous works, the proposed approach allows the decision-maker to determine a desirable achievement degree for each goal to reflect explicitly the relative importance of these goals. The resulting solutions satisfy both the preemptive priority structure and have the maximum achievement degrees in sum. The power of the proposed approach is demonstrated with an example.
文摘In this paper, solution to the LQ inverse problem has been pre-sented. With the control weight in an LQ optimal control system fixed,the state weighting matrix is parametrized in terms of a set of freevariables and the closed-loop eigenvalues of the control system. Basedon this parametrization, an algorithmic procedure is proposed to deter-mine the state weighting matrix and the free variables by matrixtransformation. Meanwhile, by using the solved free variables, theoptimal feedback gain matrix K can also be obtained without solving thealgebraic Riccati equation.
