Objective N6-methyladenosine(m6A),the most prevalent epigenetic modification in eukaryotic RNA,plays a pivotal role in regulating cellular differentiation and developmental processes,with its dysregulation implicated ...Objective N6-methyladenosine(m6A),the most prevalent epigenetic modification in eukaryotic RNA,plays a pivotal role in regulating cellular differentiation and developmental processes,with its dysregulation implicated in diverse pathological conditions.Accurate prediction of m6A sites is critical for elucidating their regulatory mechanisms and informing drug development.However,traditional experimental methods are time-consuming and costly.Although various computational approaches have been proposed,challenges remain in feature learning,predictive accuracy,and generalization.Here,we present m6A-PSRA,a dual-branch residual-network-based predictor that fully exploits RNA sequence information to enhance prediction performance and model generalization.Methods m6A-PSRA adopts a parallel dual-branch network architecture to comprehensively extract RNA sequence features via two independent pathways.The first branch applies one-hot encoding to transform the RNA sequence into a numerical matrix while strictly preserving positional information and sequence continuity.This ensures that the biological context conveyed by nucleotide order is retained.A bidirectional long short-term memory network(BiLSTM)then processes the encoded matrix,capturing both forward and backward dependencies between bases to resolve contextual correlations.The second branch employs a k-mer tokenization strategy(k=3),decomposing the sequence into overlapping 3-mer subsequences to capture local sequence patterns.A pre-trained Doc2vec model maps these subsequences into fixeddimensional vectors,reducing feature dimensionality while extracting latent global semantic information via context learning.Both branches integrate residual networks(ResNet)and a self-attention mechanism:ResNet mitigates vanishing gradients through skip connections,preserving feature integrity,while self-attention adaptively assigns weights to focus on sequence regions most relevant to methylation prediction.This synergy enhances both feature learning and generalization capability.Results Across 11 tissues from humans,mice,and rats,m6A-PSRA consistently outperformed existing methods in accuracy(ACC)and area under the curve(AUC),achieving>90%ACC and>95%AUC in every tissue tested,indicating strong cross-species and cross-tissue adaptability.Validation on independent datasets—including three human cell lines(MOLM1,HEK293,A549)and a long-sequence dataset(m6A_IND,1001 nt)—confirmed stable performance across varied biological contexts and sequence lengths.Ablation studies demonstrated that the dual-branch architecture,residual network,and self-attention mechanism each contribute critically to performance,with their combination reducing interference between pathways.Motif analysis revealed an enrichment of m6A sites in guanine(G)and cytosine(C),consistent with known regulatory patterns,supporting the model’s biological plausibility.Conclusion m6A-PSRA effectively captures RNA sequence features,achieving high prediction accuracy and robust generalization across tissues and species,providing an efficient computational tool for m6A methylation site prediction.展开更多
In the field of image processing,the analysis of Synthetic Aperture Radar(SAR)images is crucial due to its broad range of applications.However,SAR images are often affected by coherent speckle noise,which significantl...In the field of image processing,the analysis of Synthetic Aperture Radar(SAR)images is crucial due to its broad range of applications.However,SAR images are often affected by coherent speckle noise,which significantly degrades image quality.Traditional denoising methods,typically based on filter techniques,often face challenges related to inefficiency and limited adaptability.To address these limitations,this study proposes a novel SAR image denoising algorithm based on an enhanced residual network architecture,with the objective of enhancing the utility of SAR imagery in complex electromagnetic environments.The proposed algorithm integrates residual network modules,which directly process the noisy input images to generate denoised outputs.This approach not only reduces computational complexity but also mitigates the difficulties associated with model training.By combining the Transformer module with the residual block,the algorithm enhances the network's ability to extract global features,offering superior feature extraction capabilities compared to CNN-based residual modules.Additionally,the algorithm employs the adaptive activation function Meta-ACON,which dynamically adjusts the activation patterns of neurons,thereby improving the network's feature extraction efficiency.The effectiveness of the proposed denoising method is empirically validated using real SAR images from the RSOD dataset.The proposed algorithm exhibits remarkable performance in terms of EPI,SSIM,and ENL,while achieving a substantial enhancement in PSNR when compared to traditional and deep learning-based algorithms.The PSNR performance is enhanced by over twofold.Moreover,the evaluation of the MSTAR SAR dataset substantiates the algorithm's robustness and applicability in SAR denoising tasks,with a PSNR of 25.2021 being attained.These findings underscore the efficacy of the proposed algorithm in mitigating speckle noise while preserving critical features in SAR imagery,thereby enhancing its quality and usability in practical scenarios.展开更多
In low signal-to-noise ratio(SNR)environments,the traditional radar emitter recognition(RER)method struggles to recognize multiple radar emitter signals in parallel.This paper proposes a multi-label classification and...In low signal-to-noise ratio(SNR)environments,the traditional radar emitter recognition(RER)method struggles to recognize multiple radar emitter signals in parallel.This paper proposes a multi-label classification and recognition method for multiple radar-emitter modulation types based on a residual network.This method can quickly perform parallel classification and recognition of multi-modulation radar time-domain aliasing signals under low SNRs.First,we perform time-frequency analysis on the received signal to extract the normalized time-frequency image through the short-time Fourier transform(STFT).The time-frequency distribution image is then denoised using a deep normalized convolutional neural network(DNCNN).Secondly,the multi-label classification and recognition model for multi-modulation radar emitter time-domain aliasing signals is established,and learning the characteristics of radar signal time-frequency distribution image dataset to achieve the purpose of training model.Finally,time-frequency image is recognized and classified through the model,thus completing the automatic classification and recognition of the time-domain aliasing signal.Simulation results show that the proposed method can classify and recognize radar emitter signals of different modulation types in parallel under low SNRs.展开更多
Higher-order statistics based approaches and signal sparseness based approaches have emerged in recent decades to resolve the underdetermined direction-of-arrival(DOA)estimation problem.These model-based methods face ...Higher-order statistics based approaches and signal sparseness based approaches have emerged in recent decades to resolve the underdetermined direction-of-arrival(DOA)estimation problem.These model-based methods face great challenges in practical applications due to high computational complexity and dependence on ideal assumptions.This paper presents an effective DOA estimation approach based on a deep residual network(DRN)for the underdetermined case.We first extract an input feature from a new matrix calculated by stacking several covariance matrices corresponding to different time delays.We then provide the input feature to the trained DRN to construct the super resolution spectrum.The DRN learns the mapping relationship between the input feature and the spatial spectrum by training.The proposed approach is superior to existing model-based estimation methods in terms of calculation efficiency,independence of source sparseness and adaptive capacity to non-ideal conditions(e.g.,low signal to noise ratio,short bit sequence).Simulations demonstrate the validity and strong performance of the proposed algorithm on both overdetermined and underdetermined cases.展开更多
The fifth-generation (5G) communication requires a highly accurate estimation of the channel state information (CSI)to take advantage of the massive multiple-input multiple-output(MIMO) system. However, traditional ch...The fifth-generation (5G) communication requires a highly accurate estimation of the channel state information (CSI)to take advantage of the massive multiple-input multiple-output(MIMO) system. However, traditional channel estimation methods do not always yield reliable estimates. The methodology of this paper consists of deep residual shrinkage network (DRSN)neural network-based method that is used to solve this problem.Thus, the channel estimation approach, based on DRSN with its learning ability of noise-containing data, is first introduced. Then,the DRSN is used to train the noise reduction process based on the results of the least square (LS) channel estimation while applying the pilot frequency subcarriers, where the initially estimated subcarrier channel matrix is considered as a three-dimensional tensor of the DRSN input. Afterward, a mixed signal to noise ratio (SNR) training data strategy is proposed based on the learning ability of DRSN under different SNRs. Moreover, a joint mixed scenario training strategy is carried out to test the multi scenarios robustness of DRSN. As for the findings, the numerical results indicate that the DRSN method outperforms the spatial-frequency-temporal convolutional neural networks (SF-CNN)with similar computational complexity and achieves better advantages in the full SNR range than the minimum mean squared error (MMSE) estimator with a limited dataset. Moreover, the DRSN approach shows robustness in different propagation environments.展开更多
Automatic modulation recognition(AMR)of radiation source signals is a research focus in the field of cognitive radio.However,the AMR of radiation source signals at low SNRs still faces a great challenge.Therefore,the ...Automatic modulation recognition(AMR)of radiation source signals is a research focus in the field of cognitive radio.However,the AMR of radiation source signals at low SNRs still faces a great challenge.Therefore,the AMR method of radiation source signals based on two-dimensional data matrix and improved residual neural network is proposed in this paper.First,the time series of the radiation source signals are reconstructed into two-dimensional data matrix,which greatly simplifies the signal preprocessing process.Second,the depthwise convolution and large-size convolutional kernels based residual neural network(DLRNet)is proposed to improve the feature extraction capability of the AMR model.Finally,the model performs feature extraction and classification on the two-dimensional data matrix to obtain the recognition vector that represents the signal modulation type.Theoretical analysis and simulation results show that the AMR method based on two-dimensional data matrix and improved residual network can significantly improve the accuracy of the AMR method.The recognition accuracy of the proposed method maintains a high level greater than 90% even at -14 dB SNR.展开更多
Taking the real part and the imaginary part of complex sound pressure of the sound field as features,a transfer learning model is constructed.Based on the pre-training of a large amount of underwater acoustic data in ...Taking the real part and the imaginary part of complex sound pressure of the sound field as features,a transfer learning model is constructed.Based on the pre-training of a large amount of underwater acoustic data in the preselected sea area using the convolutional neural network(CNN),the few-shot underwater acoustic data in the test sea area are retrained to study the underwater sound source ranging problem.The S5 voyage data of SWellEX-96 experiment is used to verify the proposed method,realize the range estimation for the shallow source in the experiment,and compare the range estimation performance of the underwater target sound source of four methods:matched field processing(MFP),generalized regression neural network(GRNN),traditional CNN,and transfer learning.Experimental data processing results show that the transfer learning model based on residual CNN can effectively realize range estimation in few-shot scenes,and the estimation performance is remarkably better than that of other methods.展开更多
基金supported by grants from The National Natural Science Foundation of China(12361104)Yunnan Fundamental Research Projects(202301AT070016,202401AT070036)+2 种基金the Youth Talent Program of Xingdian Talent Support Plan(XDYC-QNRC-2022-0514)the Yunnan Province International Joint Laboratory for Intelligent Integration and Application of Ethnic Multilingualism(202403AP140014)the Open Research Fund of Yunnan Key Laboratory of Statistical Modeling and Data Analysis,Yunnan University(SMDAYB2023004)。
文摘Objective N6-methyladenosine(m6A),the most prevalent epigenetic modification in eukaryotic RNA,plays a pivotal role in regulating cellular differentiation and developmental processes,with its dysregulation implicated in diverse pathological conditions.Accurate prediction of m6A sites is critical for elucidating their regulatory mechanisms and informing drug development.However,traditional experimental methods are time-consuming and costly.Although various computational approaches have been proposed,challenges remain in feature learning,predictive accuracy,and generalization.Here,we present m6A-PSRA,a dual-branch residual-network-based predictor that fully exploits RNA sequence information to enhance prediction performance and model generalization.Methods m6A-PSRA adopts a parallel dual-branch network architecture to comprehensively extract RNA sequence features via two independent pathways.The first branch applies one-hot encoding to transform the RNA sequence into a numerical matrix while strictly preserving positional information and sequence continuity.This ensures that the biological context conveyed by nucleotide order is retained.A bidirectional long short-term memory network(BiLSTM)then processes the encoded matrix,capturing both forward and backward dependencies between bases to resolve contextual correlations.The second branch employs a k-mer tokenization strategy(k=3),decomposing the sequence into overlapping 3-mer subsequences to capture local sequence patterns.A pre-trained Doc2vec model maps these subsequences into fixeddimensional vectors,reducing feature dimensionality while extracting latent global semantic information via context learning.Both branches integrate residual networks(ResNet)and a self-attention mechanism:ResNet mitigates vanishing gradients through skip connections,preserving feature integrity,while self-attention adaptively assigns weights to focus on sequence regions most relevant to methylation prediction.This synergy enhances both feature learning and generalization capability.Results Across 11 tissues from humans,mice,and rats,m6A-PSRA consistently outperformed existing methods in accuracy(ACC)and area under the curve(AUC),achieving>90%ACC and>95%AUC in every tissue tested,indicating strong cross-species and cross-tissue adaptability.Validation on independent datasets—including three human cell lines(MOLM1,HEK293,A549)and a long-sequence dataset(m6A_IND,1001 nt)—confirmed stable performance across varied biological contexts and sequence lengths.Ablation studies demonstrated that the dual-branch architecture,residual network,and self-attention mechanism each contribute critically to performance,with their combination reducing interference between pathways.Motif analysis revealed an enrichment of m6A sites in guanine(G)and cytosine(C),consistent with known regulatory patterns,supporting the model’s biological plausibility.Conclusion m6A-PSRA effectively captures RNA sequence features,achieving high prediction accuracy and robust generalization across tissues and species,providing an efficient computational tool for m6A methylation site prediction.
文摘In the field of image processing,the analysis of Synthetic Aperture Radar(SAR)images is crucial due to its broad range of applications.However,SAR images are often affected by coherent speckle noise,which significantly degrades image quality.Traditional denoising methods,typically based on filter techniques,often face challenges related to inefficiency and limited adaptability.To address these limitations,this study proposes a novel SAR image denoising algorithm based on an enhanced residual network architecture,with the objective of enhancing the utility of SAR imagery in complex electromagnetic environments.The proposed algorithm integrates residual network modules,which directly process the noisy input images to generate denoised outputs.This approach not only reduces computational complexity but also mitigates the difficulties associated with model training.By combining the Transformer module with the residual block,the algorithm enhances the network's ability to extract global features,offering superior feature extraction capabilities compared to CNN-based residual modules.Additionally,the algorithm employs the adaptive activation function Meta-ACON,which dynamically adjusts the activation patterns of neurons,thereby improving the network's feature extraction efficiency.The effectiveness of the proposed denoising method is empirically validated using real SAR images from the RSOD dataset.The proposed algorithm exhibits remarkable performance in terms of EPI,SSIM,and ENL,while achieving a substantial enhancement in PSNR when compared to traditional and deep learning-based algorithms.The PSNR performance is enhanced by over twofold.Moreover,the evaluation of the MSTAR SAR dataset substantiates the algorithm's robustness and applicability in SAR denoising tasks,with a PSNR of 25.2021 being attained.These findings underscore the efficacy of the proposed algorithm in mitigating speckle noise while preserving critical features in SAR imagery,thereby enhancing its quality and usability in practical scenarios.
基金The authors would like to acknowledge National Natural Science Foundation of China under Grant 61973037 and Grant 61673066 to provide fund for conducting experiments.
文摘In low signal-to-noise ratio(SNR)environments,the traditional radar emitter recognition(RER)method struggles to recognize multiple radar emitter signals in parallel.This paper proposes a multi-label classification and recognition method for multiple radar-emitter modulation types based on a residual network.This method can quickly perform parallel classification and recognition of multi-modulation radar time-domain aliasing signals under low SNRs.First,we perform time-frequency analysis on the received signal to extract the normalized time-frequency image through the short-time Fourier transform(STFT).The time-frequency distribution image is then denoised using a deep normalized convolutional neural network(DNCNN).Secondly,the multi-label classification and recognition model for multi-modulation radar emitter time-domain aliasing signals is established,and learning the characteristics of radar signal time-frequency distribution image dataset to achieve the purpose of training model.Finally,time-frequency image is recognized and classified through the model,thus completing the automatic classification and recognition of the time-domain aliasing signal.Simulation results show that the proposed method can classify and recognize radar emitter signals of different modulation types in parallel under low SNRs.
基金supported by the Program for Innovative Research Groups of the Hunan Provincial Natural Science Foundation of China(2019JJ10004)。
文摘Higher-order statistics based approaches and signal sparseness based approaches have emerged in recent decades to resolve the underdetermined direction-of-arrival(DOA)estimation problem.These model-based methods face great challenges in practical applications due to high computational complexity and dependence on ideal assumptions.This paper presents an effective DOA estimation approach based on a deep residual network(DRN)for the underdetermined case.We first extract an input feature from a new matrix calculated by stacking several covariance matrices corresponding to different time delays.We then provide the input feature to the trained DRN to construct the super resolution spectrum.The DRN learns the mapping relationship between the input feature and the spatial spectrum by training.The proposed approach is superior to existing model-based estimation methods in terms of calculation efficiency,independence of source sparseness and adaptive capacity to non-ideal conditions(e.g.,low signal to noise ratio,short bit sequence).Simulations demonstrate the validity and strong performance of the proposed algorithm on both overdetermined and underdetermined cases.
基金supported by the National Key Scientific Instrument and Equipment Development Project(61827801).
文摘The fifth-generation (5G) communication requires a highly accurate estimation of the channel state information (CSI)to take advantage of the massive multiple-input multiple-output(MIMO) system. However, traditional channel estimation methods do not always yield reliable estimates. The methodology of this paper consists of deep residual shrinkage network (DRSN)neural network-based method that is used to solve this problem.Thus, the channel estimation approach, based on DRSN with its learning ability of noise-containing data, is first introduced. Then,the DRSN is used to train the noise reduction process based on the results of the least square (LS) channel estimation while applying the pilot frequency subcarriers, where the initially estimated subcarrier channel matrix is considered as a three-dimensional tensor of the DRSN input. Afterward, a mixed signal to noise ratio (SNR) training data strategy is proposed based on the learning ability of DRSN under different SNRs. Moreover, a joint mixed scenario training strategy is carried out to test the multi scenarios robustness of DRSN. As for the findings, the numerical results indicate that the DRSN method outperforms the spatial-frequency-temporal convolutional neural networks (SF-CNN)with similar computational complexity and achieves better advantages in the full SNR range than the minimum mean squared error (MMSE) estimator with a limited dataset. Moreover, the DRSN approach shows robustness in different propagation environments.
基金National Natural Science Foundation of China under Grant No.61973037China Postdoctoral Science Foundation under Grant No.2022M720419。
文摘Automatic modulation recognition(AMR)of radiation source signals is a research focus in the field of cognitive radio.However,the AMR of radiation source signals at low SNRs still faces a great challenge.Therefore,the AMR method of radiation source signals based on two-dimensional data matrix and improved residual neural network is proposed in this paper.First,the time series of the radiation source signals are reconstructed into two-dimensional data matrix,which greatly simplifies the signal preprocessing process.Second,the depthwise convolution and large-size convolutional kernels based residual neural network(DLRNet)is proposed to improve the feature extraction capability of the AMR model.Finally,the model performs feature extraction and classification on the two-dimensional data matrix to obtain the recognition vector that represents the signal modulation type.Theoretical analysis and simulation results show that the AMR method based on two-dimensional data matrix and improved residual network can significantly improve the accuracy of the AMR method.The recognition accuracy of the proposed method maintains a high level greater than 90% even at -14 dB SNR.
基金supported by the National Natural Science Foundation of China(1197428611904274)+1 种基金the Shaanxi Young Science and Technology Star Program(2021KJXX-07)the fundamental research funding for characteristic disciplines(G2022WD0235)。
文摘Taking the real part and the imaginary part of complex sound pressure of the sound field as features,a transfer learning model is constructed.Based on the pre-training of a large amount of underwater acoustic data in the preselected sea area using the convolutional neural network(CNN),the few-shot underwater acoustic data in the test sea area are retrained to study the underwater sound source ranging problem.The S5 voyage data of SWellEX-96 experiment is used to verify the proposed method,realize the range estimation for the shallow source in the experiment,and compare the range estimation performance of the underwater target sound source of four methods:matched field processing(MFP),generalized regression neural network(GRNN),traditional CNN,and transfer learning.Experimental data processing results show that the transfer learning model based on residual CNN can effectively realize range estimation in few-shot scenes,and the estimation performance is remarkably better than that of other methods.
