The finite volume method was applied to numerically simulate the bottom pressure field induced by regular waves,vehicles in calm water and vehicles in regular waves.The solution of Navier-Stokes(N-S)equations in the v...The finite volume method was applied to numerically simulate the bottom pressure field induced by regular waves,vehicles in calm water and vehicles in regular waves.The solution of Navier-Stokes(N-S)equations in the vicinity of numerical wave tank's boundary was forced towards the wave theoretical solution by incorporating momentum source terms,thereby reducing adverse effects such as wave reflection.Simulations utilizing laminar flow,turbulent flow,and ideal fluid models were all found capable of effectively capturing the waveform and bottom pressure of regular waves,agreeing well with experimental data.In predicting the bottom pressure field of the submerged vehicle,turbulent simulations considering fluid viscosity and boundary layer development provided more accurate predictions for the stern region than inviscid simulations.Due to sphere's diffractive effect,the sphere's bottom pressure field in waves is not a linear superposition of the wave's and the sphere's bottom pressure field.However,a slender submerged vehicle exhibits a weaker diffractive effect on waves,thus the submerged vehicle's bottom pressure field in waves can be approximated as a linear superposition of the wave's and the submerged vehicle's bottom pressure field,which simplifies computation and analysis.展开更多
On a compact Riemann surface with finite punctures P_(1),…P_(k),we define toric curves as multivalued,totallyunramified holomorphic maps to P^(n)with monodromy in a maximal torus of PSU(n+1).Toric solutions to SU(n+1...On a compact Riemann surface with finite punctures P_(1),…P_(k),we define toric curves as multivalued,totallyunramified holomorphic maps to P^(n)with monodromy in a maximal torus of PSU(n+1).Toric solutions to SU(n+1)Todasystems on X\{P_(1);…;P_(k)}are recognized by the associated toric curves in.We introduce character n-ensembles as-tuples of meromorphic one-forms with simple poles and purely imaginary periods,generating toric curves on minus finitelymany points.On X,we establish a correspondence between character-ensembles and toric solutions to the SU(n+1)system with finitely many cone singularities.Our approach not only broadens seminal solutions with two conesingularities on the Riemann sphere,as classified by Jost-Wang(Int.Math.Res.Not.,2002,(6):277-290)andLin-Wei-Ye(Invent.Math.,2012,190(1):169-207),but also advances beyond the limits of Lin-Yang-Zhong’s existencetheorems(J.Differential Geom.,2020,114(2):337-391)by introducing a new solution class.展开更多
Modern warfare demands weapons capable of penetrating substantial structures,which presents sig-nificant challenges to the reliability of the electronic devices that are crucial to the weapon's perfor-mance.Due to...Modern warfare demands weapons capable of penetrating substantial structures,which presents sig-nificant challenges to the reliability of the electronic devices that are crucial to the weapon's perfor-mance.Due to miniaturization of electronic components,it is challenging to directly measure or numerically predict the mechanical response of small-sized critical interconnections in board-level packaging structures to ensure the mechanical reliability of electronic devices in projectiles under harsh working conditions.To address this issue,an indirect measurement method using the Bayesian regularization-based load identification was proposed in this study based on finite element(FE)pre-dictions to estimate the load applied on critical interconnections of board-level packaging structures during the process of projectile penetration.For predicting the high-strain-rate penetration process,an FE model was established with elasto-plastic constitutive models of the representative packaging ma-terials(that is,solder material and epoxy molding compound)in which material constitutive parameters were calibrated against the experimental results by using the split-Hopkinson pressure bar.As the impact-induced dynamic bending of the printed circuit board resulted in an alternating tensile-compressive loading on the solder joints during penetration,the corner solder joints in the edge re-gions experience the highest S11 and strain,making them more prone to failure.Based on FE predictions at different structural scales,an improved Bayesian method based on augmented Tikhonov regulariza-tion was theoretically proposed to address the issues of ill-posed matrix inversion and noise sensitivity in the load identification at the critical solder joints.By incorporating a wavelet thresholding technique,the method resolves the problem of poor load identification accuracy at high noise levels.The proposed method achieves satisfactorily small relative errors and high correlation coefficients in identifying the mechanical response of local interconnections in board-level packaging structures,while significantly balancing the smoothness of response curves with the accuracy of peak identification.At medium and low noise levels,the relative error is less than 6%,while it is less than 10%at high noise levels.The proposed method provides an effective indirect approach for the boundary conditions of localized solder joints during the projectile penetration process,and its philosophy can be readily extended to other scenarios of multiscale analysis for highly nonlinear materials and structures under extreme loading conditions.展开更多
The advancement of Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR)gene editing technology has revolutionized the comprehension of human genome,propelling molecular and cellular biology research into ...The advancement of Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR)gene editing technology has revolutionized the comprehension of human genome,propelling molecular and cellular biology research into unexplored realms and accelerating progress in life sciences and medicine.CRISPR-based gene screening,recognized for its efficiency and practicality,is widely utilized across diverse biological fields.Aging is a multifaceted process governed by a myriad of genetic and epigenetic factors.Unraveling the genes regulating aging holds promise for understanding this intricate phenomenon and devising strategies for its assessment and intervention.This review provides a comprehensive overview of the progress in CRISPR screening and its applications in aging research,while also offering insights into future directions.CRISPR-based genetic-manipulation tools are positioned as indispensable instruments for mitigating aging and managing age-related diseases.展开更多
A small problem about soil particle regularization and contacts but essential to geotechnical engineering was studied.The soils sourced from Guangzhou and Xiamen were sieved into five different particle scale ranges(d...A small problem about soil particle regularization and contacts but essential to geotechnical engineering was studied.The soils sourced from Guangzhou and Xiamen were sieved into five different particle scale ranges(d<0.075 mm,0.075 mm≤d<0.1 mm,0.1 mm≤d<0.2 mm,0.2 mm≤d<0.5 mm and 0.5 mm≤d<1.0 mm)to study the structures and particle contacts of granite residual soil.The X-ray micro computed tomography method was used to reconstruct the microstructure of granite residual soil.The particle was identified and regularized using principal component analysis(PCA).The particle contacts and geometrical characteristics in 3D space were analyzed and summarized using statistical analyses.The results demonstrate that the main types of contact among the particles are face-face,face-angle,face-edge,edge-edge,edge-angle and angle-angle contacts for particle sizes less than 0.2 mm.When the particle sizes are greater than 0.2 mm,the contacts are effectively summarized as face-face,face-angle,face-edge,edge-edge,edge-angle,angle-angle,sphere-sphere,sphere-face,sphere-edge and sphere-angle contacts.The differences in porosity among the original sample,reconstructed sample and regularized sample are closely related to the water-swelling and water-disintegrable characteristics of granite residual soil.展开更多
Measuring the internal stress of Al alloy forgings accurately is critical for controlling the deformation during the subsequent machine process.In this work,the crack compliance method was used to calculate the intern...Measuring the internal stress of Al alloy forgings accurately is critical for controlling the deformation during the subsequent machine process.In this work,the crack compliance method was used to calculate the internal residual stress of Al-Cu high strength alloys,and the effect of various model parameters of crack compliance method on the calculated precision was studied by combining the numerical simulation and experimental method.The results show that the precision first increased and then decreased with increasing the crack range.The decreased precision when using a high crack range was due to the strain fluctuation during the machining process,and the optimized crack range was 71%of the thickness of forgings.Low orders of Legendre polynomial can result in residual stress curve more smooth,while high orders led to the occurrence of distortion.The Tikhonov regularization method effectively suppressed the distortion of residual stress caused by the fluctuation of strain data,which significantly improved the precision.In addition,The crack compliance method with optimized parameters was used to measure the residual stress of Al-Cu alloy with different quenching methods.The calculated results demonstrated that the distribution of residual stress was obtained accurately.展开更多
A new normalized least mean square(NLMS) adaptive filter is first derived from a cost function, which incorporates the conventional one of the NLMS with a minimum-disturbance(MD)constraint. A variable regularization f...A new normalized least mean square(NLMS) adaptive filter is first derived from a cost function, which incorporates the conventional one of the NLMS with a minimum-disturbance(MD)constraint. A variable regularization factor(RF) is then employed to control the contribution made by the MD constraint in the cost function. Analysis results show that the RF can be taken as a combination of the step size and regularization parameter in the conventional NLMS. This implies that these parameters can be jointly controlled by simply tuning the RF as the proposed algorithm does. It also demonstrates that the RF can accelerate the convergence rate of the proposed algorithm and its optimal value can be obtained by minimizing the squared noise-free posteriori error. A method for automatically determining the value of the RF is also presented, which is free of any prior knowledge of the noise. While simulation results verify the analytical ones, it is also illustrated that the performance of the proposed algorithm is superior to the state-of-art ones in both the steady-state misalignment and the convergence rate. A novel algorithm is proposed to solve some problems. Simulation results show the effectiveness of the proposed algorithm.展开更多
A method for fast 1-fold cross validation is proposed for the regularized extreme learning machine （RELM）. The computational time of fast l-fold cross validation increases as the fold number decreases, which is oppo...A method for fast 1-fold cross validation is proposed for the regularized extreme learning machine （RELM）. The computational time of fast l-fold cross validation increases as the fold number decreases, which is opposite to that of naive 1-fold cross validation. As opposed to naive l-fold cross validation, fast l-fold cross validation takes the advantage in terms of computational time, especially for the large fold number such as l 〉 20. To corroborate the efficacy and feasibility of fast l-fold cross validation, experiments on five benchmark regression data sets are evaluated.展开更多
In recent years, with the increase of the depth of open-pit mining, the pollution level has been on the rise due to harmful gases and dust occurring in the process of mining. In order to accelerate the diffusion of th...In recent years, with the increase of the depth of open-pit mining, the pollution level has been on the rise due to harmful gases and dust occurring in the process of mining. In order to accelerate the diffusion of these air pollutants, the distributed regularity of the rock face temperature which is directly related to the air ventilation in deep open-pit mines should be studied. Here, we establish the key factors influencing the rock face temperature in a deep open-pit mine. We also present an empirical model of the rock face temperature variation in the deep open-pit mine, of which the performance is interestingly high compared with that of the field test. This study lays a foundation to study the ventilation thermodynamic theory in the deep open-pit mine, which is of great importance for theoretical studies and engineering applications of solving air pollution problem in deep open-pit mines.展开更多
文摘The finite volume method was applied to numerically simulate the bottom pressure field induced by regular waves,vehicles in calm water and vehicles in regular waves.The solution of Navier-Stokes(N-S)equations in the vicinity of numerical wave tank's boundary was forced towards the wave theoretical solution by incorporating momentum source terms,thereby reducing adverse effects such as wave reflection.Simulations utilizing laminar flow,turbulent flow,and ideal fluid models were all found capable of effectively capturing the waveform and bottom pressure of regular waves,agreeing well with experimental data.In predicting the bottom pressure field of the submerged vehicle,turbulent simulations considering fluid viscosity and boundary layer development provided more accurate predictions for the stern region than inviscid simulations.Due to sphere's diffractive effect,the sphere's bottom pressure field in waves is not a linear superposition of the wave's and the sphere's bottom pressure field.However,a slender submerged vehicle exhibits a weaker diffractive effect on waves,thus the submerged vehicle's bottom pressure field in waves can be approximated as a linear superposition of the wave's and the submerged vehicle's bottom pressure field,which simplifies computation and analysis.
基金supported by the National Natural Science Foundation of China(11931009,12271495,11971450,and 12071449)Anhui Initiative in Quantum Information Technologies(AHY150200)the Project of Stable Support for Youth Team in Basic Research Field,Chinese Academy of Sciences(YSBR-001).
文摘On a compact Riemann surface with finite punctures P_(1),…P_(k),we define toric curves as multivalued,totallyunramified holomorphic maps to P^(n)with monodromy in a maximal torus of PSU(n+1).Toric solutions to SU(n+1)Todasystems on X\{P_(1);…;P_(k)}are recognized by the associated toric curves in.We introduce character n-ensembles as-tuples of meromorphic one-forms with simple poles and purely imaginary periods,generating toric curves on minus finitelymany points.On X,we establish a correspondence between character-ensembles and toric solutions to the SU(n+1)system with finitely many cone singularities.Our approach not only broadens seminal solutions with two conesingularities on the Riemann sphere,as classified by Jost-Wang(Int.Math.Res.Not.,2002,(6):277-290)andLin-Wei-Ye(Invent.Math.,2012,190(1):169-207),but also advances beyond the limits of Lin-Yang-Zhong’s existencetheorems(J.Differential Geom.,2020,114(2):337-391)by introducing a new solution class.
基金supported by the National Natural Science Foundation of China(Grant Nos.52475166,52175148)the Regional Collaboration Project of Shanxi Province(Grant No.202204041101044).
文摘Modern warfare demands weapons capable of penetrating substantial structures,which presents sig-nificant challenges to the reliability of the electronic devices that are crucial to the weapon's perfor-mance.Due to miniaturization of electronic components,it is challenging to directly measure or numerically predict the mechanical response of small-sized critical interconnections in board-level packaging structures to ensure the mechanical reliability of electronic devices in projectiles under harsh working conditions.To address this issue,an indirect measurement method using the Bayesian regularization-based load identification was proposed in this study based on finite element(FE)pre-dictions to estimate the load applied on critical interconnections of board-level packaging structures during the process of projectile penetration.For predicting the high-strain-rate penetration process,an FE model was established with elasto-plastic constitutive models of the representative packaging ma-terials(that is,solder material and epoxy molding compound)in which material constitutive parameters were calibrated against the experimental results by using the split-Hopkinson pressure bar.As the impact-induced dynamic bending of the printed circuit board resulted in an alternating tensile-compressive loading on the solder joints during penetration,the corner solder joints in the edge re-gions experience the highest S11 and strain,making them more prone to failure.Based on FE predictions at different structural scales,an improved Bayesian method based on augmented Tikhonov regulariza-tion was theoretically proposed to address the issues of ill-posed matrix inversion and noise sensitivity in the load identification at the critical solder joints.By incorporating a wavelet thresholding technique,the method resolves the problem of poor load identification accuracy at high noise levels.The proposed method achieves satisfactorily small relative errors and high correlation coefficients in identifying the mechanical response of local interconnections in board-level packaging structures,while significantly balancing the smoothness of response curves with the accuracy of peak identification.At medium and low noise levels,the relative error is less than 6%,while it is less than 10%at high noise levels.The proposed method provides an effective indirect approach for the boundary conditions of localized solder joints during the projectile penetration process,and its philosophy can be readily extended to other scenarios of multiscale analysis for highly nonlinear materials and structures under extreme loading conditions.
文摘The advancement of Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR)gene editing technology has revolutionized the comprehension of human genome,propelling molecular and cellular biology research into unexplored realms and accelerating progress in life sciences and medicine.CRISPR-based gene screening,recognized for its efficiency and practicality,is widely utilized across diverse biological fields.Aging is a multifaceted process governed by a myriad of genetic and epigenetic factors.Unraveling the genes regulating aging holds promise for understanding this intricate phenomenon and devising strategies for its assessment and intervention.This review provides a comprehensive overview of the progress in CRISPR screening and its applications in aging research,while also offering insights into future directions.CRISPR-based genetic-manipulation tools are positioned as indispensable instruments for mitigating aging and managing age-related diseases.
基金Projects(41572277,41877229)supported by the National Natural Science Foundation of ChinaProject(2015A030313118)supported by the Natural Science Foundation of Guangdong Province,ChinaProject(201607010023)supported by the Science and Technology Program of Guangzhou,China
文摘A small problem about soil particle regularization and contacts but essential to geotechnical engineering was studied.The soils sourced from Guangzhou and Xiamen were sieved into five different particle scale ranges(d<0.075 mm,0.075 mm≤d<0.1 mm,0.1 mm≤d<0.2 mm,0.2 mm≤d<0.5 mm and 0.5 mm≤d<1.0 mm)to study the structures and particle contacts of granite residual soil.The X-ray micro computed tomography method was used to reconstruct the microstructure of granite residual soil.The particle was identified and regularized using principal component analysis(PCA).The particle contacts and geometrical characteristics in 3D space were analyzed and summarized using statistical analyses.The results demonstrate that the main types of contact among the particles are face-face,face-angle,face-edge,edge-edge,edge-angle and angle-angle contacts for particle sizes less than 0.2 mm.When the particle sizes are greater than 0.2 mm,the contacts are effectively summarized as face-face,face-angle,face-edge,edge-edge,edge-angle,angle-angle,sphere-sphere,sphere-face,sphere-edge and sphere-angle contacts.The differences in porosity among the original sample,reconstructed sample and regularized sample are closely related to the water-swelling and water-disintegrable characteristics of granite residual soil.
基金Project(51875583)supported by the National Natural Science Foundation of ChinaProject(zzyjkt2018-03)supported by the State Key Laboratory of High Performance Complex Manufacturing,China。
文摘Measuring the internal stress of Al alloy forgings accurately is critical for controlling the deformation during the subsequent machine process.In this work,the crack compliance method was used to calculate the internal residual stress of Al-Cu high strength alloys,and the effect of various model parameters of crack compliance method on the calculated precision was studied by combining the numerical simulation and experimental method.The results show that the precision first increased and then decreased with increasing the crack range.The decreased precision when using a high crack range was due to the strain fluctuation during the machining process,and the optimized crack range was 71%of the thickness of forgings.Low orders of Legendre polynomial can result in residual stress curve more smooth,while high orders led to the occurrence of distortion.The Tikhonov regularization method effectively suppressed the distortion of residual stress caused by the fluctuation of strain data,which significantly improved the precision.In addition,The crack compliance method with optimized parameters was used to measure the residual stress of Al-Cu alloy with different quenching methods.The calculated results demonstrated that the distribution of residual stress was obtained accurately.
基金supported by the National Natural Science Foundation of China(61571131 11604055)
文摘A new normalized least mean square(NLMS) adaptive filter is first derived from a cost function, which incorporates the conventional one of the NLMS with a minimum-disturbance(MD)constraint. A variable regularization factor(RF) is then employed to control the contribution made by the MD constraint in the cost function. Analysis results show that the RF can be taken as a combination of the step size and regularization parameter in the conventional NLMS. This implies that these parameters can be jointly controlled by simply tuning the RF as the proposed algorithm does. It also demonstrates that the RF can accelerate the convergence rate of the proposed algorithm and its optimal value can be obtained by minimizing the squared noise-free posteriori error. A method for automatically determining the value of the RF is also presented, which is free of any prior knowledge of the noise. While simulation results verify the analytical ones, it is also illustrated that the performance of the proposed algorithm is superior to the state-of-art ones in both the steady-state misalignment and the convergence rate. A novel algorithm is proposed to solve some problems. Simulation results show the effectiveness of the proposed algorithm.
基金supported by the National Natural Science Foundation of China(51006052)the NUST Outstanding Scholar Supporting Program
文摘A method for fast 1-fold cross validation is proposed for the regularized extreme learning machine （RELM）. The computational time of fast l-fold cross validation increases as the fold number decreases, which is opposite to that of naive 1-fold cross validation. As opposed to naive l-fold cross validation, fast l-fold cross validation takes the advantage in terms of computational time, especially for the large fold number such as l 〉 20. To corroborate the efficacy and feasibility of fast l-fold cross validation, experiments on five benchmark regression data sets are evaluated.
基金Project(51274023) supported by the National Natural Science Foundation of ChinaProject(FRF-BD-17-007A) supported by Fundamental Research Funds for the Central Universities,China
文摘In recent years, with the increase of the depth of open-pit mining, the pollution level has been on the rise due to harmful gases and dust occurring in the process of mining. In order to accelerate the diffusion of these air pollutants, the distributed regularity of the rock face temperature which is directly related to the air ventilation in deep open-pit mines should be studied. Here, we establish the key factors influencing the rock face temperature in a deep open-pit mine. We also present an empirical model of the rock face temperature variation in the deep open-pit mine, of which the performance is interestingly high compared with that of the field test. This study lays a foundation to study the ventilation thermodynamic theory in the deep open-pit mine, which is of great importance for theoretical studies and engineering applications of solving air pollution problem in deep open-pit mines.
