Objective:Practice related to the traditional postpartum confinement custom“Zuo Yuezi”vary among individuals,and its relationship with postpartum depression(PPD)remains unclear.This study aims to explore the current...Objective:Practice related to the traditional postpartum confinement custom“Zuo Yuezi”vary among individuals,and its relationship with postpartum depression(PPD)remains unclear.This study aims to explore the current practice and heterogeneity of“Zuo Yuezi”among Chinese women and to analyze its association with PPD.Methods:A cross-sectional study was conducted among 542 women from 3 hospitals between January and February 2016.Data were collected on whether participants practiced“Zuo Yuezi”,their willingness and attitudes toward“Zuo Yuezi”,demographic characteristics,adherence to specific“Zuo Yuezi”practices,emotional experiences during the“Zuo Yuezi”period,and PPD symptoms.Latent profile analysis(LPA)was used to identify heterogeneity in“Zuo Yuezi”practices,and multivariate logistic regression was used to analyze the association between practice patterns and PPD.Results:A total of 542 postpartum women completed the survey.About 98%(531/542)of participants reported practicing“Zuo Yuezi”,among whom 41.2%followed traditional customs and 29.5%followed parental advice.Approximately 95%of women practiced“Zuo Yuezi”for≥30 days,and nearly half strictly followed a 30-day“Zuo Yuezi”period.Significant heterogeneity was observed in practice components and adherence levels,with the greatest heterogeneity in dietary practices and the lowest in hygiene practices.Latent profile analysis identified 4 levels of adherence to“Zuo Yuezi”practices:low,mediumlow,medium,and high.Higher adherence was associated with belief in disease prevention,home-based“Zuo Yuezi”practices,and longer“Zuo Yuezi”duration.Lower adherence was associated with an increased risk of PPD(χ^(2)=16.103,P<0.05).Conclusion:The practice of“Zuo Yuezi”is widespread but heterogeneous.Lower adherence to“Zuo Yuezi”practices may increase the risk of postpartum depression,highlighting the need for culturally sensitive and individualized perinatal care.展开更多
Objective:Pelvic floor dysfunction is common among pregnant and postpartum women and significantly impacts quality of life.This study aims to translate the German Pelvic Floor Questionnaire for Pregnant and Postpartum...Objective:Pelvic floor dysfunction is common among pregnant and postpartum women and significantly impacts quality of life.This study aims to translate the German Pelvic Floor Questionnaire for Pregnant and Postpartum Women into Chinese and to evaluate its reliability and validity in the Chinese population.Methods:The questionnaire was translated using the Brislin model.A cross-sectional study was conducted among pregnant and postpartum women to assess the content validity,construct validity,Cronbach’sαcoefficient,test-retest reliability,and split-half reliability of the Chinese version.Results:A total of 72 women were included,with 6.9% being pregnant and 93.1% postpartum;the age was(32.3±3.6)years.The Chinese version of the questionnaire contains 4 dimensions and 45 items.The content validity index of individual items ranged from 0.833 to 1.000,with a scale-level content validity index of 0.977 and intraclass correlation coefficients(ICCs)exceeding 0.90.The overall Cronbach’s α coefficient was 0.891,with subscale coefficients ranging from 0.732 to 0.884(all ICCs>0.70).The testretest reliability of the total scale was 0.833,and for the 4 dimensions,bladder,bowel,prolapse,and sexual function,the values were 0.776,0.579,0.732,and 0.645,respectively.The split-half reliability was 0.74.Conclusion:The Chinese version of the questionnaire demonstrated good reliability and validity,indicating its applicability in assessing pelvic floor dysfunction and associated risk factors during pregnancy and postpartum.展开更多
Objective:Postpartum depression(PPD)is a common and serious mental disorder after childbirth,imposing a heavy burden on mothers,infants,and families.Abnormalities in the tryptophan-kynurenine(TRP-KYN)metabolic pathway...Objective:Postpartum depression(PPD)is a common and serious mental disorder after childbirth,imposing a heavy burden on mothers,infants,and families.Abnormalities in the tryptophan-kynurenine(TRP-KYN)metabolic pathway are considered to be involved in its pathogenesis,but the role of quinolinic acid phosphoribosyltransferase(QPRT),a key downstream enzyme in this pathway,remains unclear.This study aims to explore the association between PPD in women undergoing cesarean section and QPRT gene polymorphisms,as well as other risk factors for PPD.Methods:A candidate gene association study design was adopted.From January 2024 to June 2025,full-term singleton pregnant women scheduled to undergo elective cesarean section under spinal anesthesia were recruited at the Third Xiangya Hospital of Central South University and Hunan Provincial Maternal and Child Health Hospital.At 42 days postpartum,postpartum depression was assessed using the Edinburgh Postnatal Depression Scale(EPDS).Peripheral blood samples were collected and genomic DNA was extracted.Four QPRT single nucleotide polymorphism loci(rs1134700,rs2303255,rs9922666,and rs9933310)were selected for genotyping to analyze the association between these loci and PPD.Bioinformatics analysis and dual-luciferase reporter gene assays were performed to investigate the possible mechanism by which significant loci influence disease occurrence.Results:A total of 362 women were ultimately included in the analysis,among whom 29 were diagnosed with PPD,with an incidence of 8.01%.Analysis of general data showed that comorbid hypertension or thyroid disease,inconsistency between neonatal sex and expectation,prenatal depression,prenatal self-harm ideation,domestic violence,poor marital and mother-in-law/daughter-in-law relationships,stressful life events,dissatisfaction with current life status,poor mood during pregnancy,and high stress during pregnancy were all risk factors for PPD in women undergoing cesarean section(all P<0.05).Genetic association analysis revealed that the QPRT rs9933310 A>G polymorphism was associated with PPD.Women carrying the rs9933310 GG or AG genotype had a 2.92-fold higher risk of PPD compared with women with the AA genotype(OR=2.92,95%CI 1.18 to 6.99).Expression quantitative trait loci(eQTL)analysis suggested that the G allele at this locus was associated with downregulation of QPRT expression(AA>AG>GG).Multi-database queries indicated that the rs9933310 locus may have promoter and/or enhancer activity.In addition,JASPAR database prediction and experimental validation showed that the mutant(G)allele at the QPRT rs9933310 locus was more likely than the wild-type(A)allele to weaken promoter-enhancer activity at this locus,and resulted in loss of transcription factors Gata1,GATA2,GATA3,Gata4,Sox17,Sox2,Sox3,Sox6,and SRY,thereby regulating QPRT expression.Conclusion:Comorbid hypertension or thyroid disease,inconsistency between neonatal sex and expectation,prenatal depression,prenatal self-harm ideation,domestic violence,poor marital and mother-in-law/daughter-in-law relationships,stressful life events,dissatisfaction with current life status,poor mood during pregnancy,high stress during pregnancy,and mutation at the QPRT rs9933310 locus are all risk factors for PPD.The QPRT rs9933310 G allele is an independent risk factor for PPD in women undergoing cesarean section,and its pathogenic mechanism may involve downregulation of QPRT expression and disruption of TRP-KYN pathway homeostasis.QPRT has a potential role in the pathogenesis of PPD and may become a novel antidepressant target acting on the TRPKYN pathway.展开更多
Sequential ultrasonograms of the ccrvix and uterus were taken in both cross and longitudinal sections at different periods of involution in eleven postparturn Jersey cows, and in the meantime the concentrations of ...Sequential ultrasonograms of the ccrvix and uterus were taken in both cross and longitudinal sections at different periods of involution in eleven postparturn Jersey cows, and in the meantime the concentrations of ocstndiol-17β and progesterone in peripheral circulation of the cows were measured by radioimmunoassay(RIA). Cervical involution was showed in detail by using ultrasound scanner during its whole involuting phase, and the oestrus could be indicated by the differences of the ultrasonograms of the genital tract at the time. It took 46.7+3.9 days for the cervix to complete involution after calving, and its involuting rate was delayed by the occurence of the periparturient fatty liver and injury of the cervix during parturtion.展开更多
Two postpartum cows were used to study the ultrastructural changes of uterine endometrium by using scanning electron microscope.The results showed that the process of repair of uterine endometrium after calving was de...Two postpartum cows were used to study the ultrastructural changes of uterine endometrium by using scanning electron microscope.The results showed that the process of repair of uterine endometrium after calving was demonstrated by scanning electron microscope through a series of endometrium biopsy.Some part of the endometrium was damaged after calving and its adjacent endometrium cells became necrosis and exfoliated during the first 7 days post-partum;the cilium and microvillus of the epithelial cell in the undamaged area of the endometrium disappeared.By 26 days postpartum the damaged area reduced and the cilium and microvillus increased in their numbers.The damaged tissues were all repaired by day 60 postpartum.展开更多
Ovarian activitly in 10 postpartum Chinese-Holstein cows was monitored by ultrasonography every other day, stared from day 3 postpartum and finished by the end of a normal ovarian cycle. Meanwhile, the concentrations ...Ovarian activitly in 10 postpartum Chinese-Holstein cows was monitored by ultrasonography every other day, stared from day 3 postpartum and finished by the end of a normal ovarian cycle. Meanwhile, the concentrations of progesterone and 17β-oestradiol in peripheral plasma of the cows were measured by radioimmunoassay (RIA). The resutis showed that the first postpartum ovulation was found in 67% of the cows on the ovary opposed to the gravid horn. The first dominant foillicles ovulated for the six of ten cows. The time intervals from calving to the first ovulation were significantly associated with the number of follicular waves (r=0.83, P<0.01). No difference between the diameters of the first and the second ovulated follicles was found in the study, however, the growth rates of the first and the second ovulated follicles were significantly different (P<0.05), and the concentrations of 17β-oestradiol prior to the first ovulation were significantly lower than that before the second ovulation.展开更多
目的评估亚麻醉剂量艾司氯胺酮对剖宫产术后产妇睡眠质量及产后恢复质量的影响。方法选择2024年1—6月择期行剖宫产的产妇,年龄18~35岁,BMI 20.0~30.0 kg/m 2,ASAⅡ级。采用随机数字表法将产妇分为两组:对照组(C组)和艾司氯胺酮组(E组)...目的评估亚麻醉剂量艾司氯胺酮对剖宫产术后产妇睡眠质量及产后恢复质量的影响。方法选择2024年1—6月择期行剖宫产的产妇,年龄18~35岁,BMI 20.0~30.0 kg/m 2,ASAⅡ级。采用随机数字表法将产妇分为两组:对照组(C组)和艾司氯胺酮组(E组)。在胎儿娩出并断脐后,E组立即静脉注射艾司氯胺酮0.25 mg/kg,C组给予等体积生理盐水。采用匹兹堡睡眠质量评分(PSQI)和理查兹-坎贝尔睡眠量表(RCSQ)评估产妇睡眠情况并使用Fibit智能手环记录产妇的睡眠时间以及觉醒次数。主要指标为术后1 d RCSQ评分。次要指标包括术前1 d、术后2 d RCSQ评分,术前1 d、术后1、2 d PSQI评分、总睡眠时间、深睡眠时间、觉醒次数,前1 d、术后1、2、42 d EPDS评分,术后12、24 h NRS疼痛评分,术后3 d QoR-40评分、首次下床活动时间、住院时间以及不良反应发生情况。结果最终纳入产妇104例,其中C组53例,E组51例。与C组比较,E组术后1、2 d PSQI评分明显降低,RCSQ评分明显升高,总睡眠时间明显延长,深睡眠比例明显升高,觉醒次数明显减少,术后1 d EPDS评分、术后12、24 h的NRS疼痛评分明显降低,舒芬太尼用量及补救镇痛次数明显减少,QoR-40评分明显升高,首次下床时间明显缩短(P<0.05)。两组不良反应发生率差异无统计学意义。结论剖宫产术中单次应用亚麻醉剂量艾司氯胺酮可延长睡眠时间,改善睡眠质量,促进产后恢复,且不增加不良反应。展开更多
基金supported by the National Natural Science Foundation(82273643 and 81973059)the Hunan Provincial Natural Science Foundation(2023JJ30712)+1 种基金the Youth Science Foundation of Hunan Provincial Natural Science Foundation Committee Class A Project(2025JJ20095)the Nutrition and Care of Maternal&Child Research Fund Project of Biostime Institute of Nutrition&Care(2018BINCMCF31),China.
文摘Objective:Practice related to the traditional postpartum confinement custom“Zuo Yuezi”vary among individuals,and its relationship with postpartum depression(PPD)remains unclear.This study aims to explore the current practice and heterogeneity of“Zuo Yuezi”among Chinese women and to analyze its association with PPD.Methods:A cross-sectional study was conducted among 542 women from 3 hospitals between January and February 2016.Data were collected on whether participants practiced“Zuo Yuezi”,their willingness and attitudes toward“Zuo Yuezi”,demographic characteristics,adherence to specific“Zuo Yuezi”practices,emotional experiences during the“Zuo Yuezi”period,and PPD symptoms.Latent profile analysis(LPA)was used to identify heterogeneity in“Zuo Yuezi”practices,and multivariate logistic regression was used to analyze the association between practice patterns and PPD.Results:A total of 542 postpartum women completed the survey.About 98%(531/542)of participants reported practicing“Zuo Yuezi”,among whom 41.2%followed traditional customs and 29.5%followed parental advice.Approximately 95%of women practiced“Zuo Yuezi”for≥30 days,and nearly half strictly followed a 30-day“Zuo Yuezi”period.Significant heterogeneity was observed in practice components and adherence levels,with the greatest heterogeneity in dietary practices and the lowest in hygiene practices.Latent profile analysis identified 4 levels of adherence to“Zuo Yuezi”practices:low,mediumlow,medium,and high.Higher adherence was associated with belief in disease prevention,home-based“Zuo Yuezi”practices,and longer“Zuo Yuezi”duration.Lower adherence was associated with an increased risk of PPD(χ^(2)=16.103,P<0.05).Conclusion:The practice of“Zuo Yuezi”is widespread but heterogeneous.Lower adherence to“Zuo Yuezi”practices may increase the risk of postpartum depression,highlighting the need for culturally sensitive and individualized perinatal care.
基金supported by the Natural Science Foundation of Hunan Province(2024JJ6626)the Hunan Provincial Key Laboratory of Regional Hereditary Birth Defects Prevention and Control(HPKL202320),China.
文摘Objective:Pelvic floor dysfunction is common among pregnant and postpartum women and significantly impacts quality of life.This study aims to translate the German Pelvic Floor Questionnaire for Pregnant and Postpartum Women into Chinese and to evaluate its reliability and validity in the Chinese population.Methods:The questionnaire was translated using the Brislin model.A cross-sectional study was conducted among pregnant and postpartum women to assess the content validity,construct validity,Cronbach’sαcoefficient,test-retest reliability,and split-half reliability of the Chinese version.Results:A total of 72 women were included,with 6.9% being pregnant and 93.1% postpartum;the age was(32.3±3.6)years.The Chinese version of the questionnaire contains 4 dimensions and 45 items.The content validity index of individual items ranged from 0.833 to 1.000,with a scale-level content validity index of 0.977 and intraclass correlation coefficients(ICCs)exceeding 0.90.The overall Cronbach’s α coefficient was 0.891,with subscale coefficients ranging from 0.732 to 0.884(all ICCs>0.70).The testretest reliability of the total scale was 0.833,and for the 4 dimensions,bladder,bowel,prolapse,and sexual function,the values were 0.776,0.579,0.732,and 0.645,respectively.The split-half reliability was 0.74.Conclusion:The Chinese version of the questionnaire demonstrated good reliability and validity,indicating its applicability in assessing pelvic floor dysfunction and associated risk factors during pregnancy and postpartum.
基金supported by the Natural Science Foundation of Hunan Province,China(2018JJ2598).
文摘Objective:Postpartum depression(PPD)is a common and serious mental disorder after childbirth,imposing a heavy burden on mothers,infants,and families.Abnormalities in the tryptophan-kynurenine(TRP-KYN)metabolic pathway are considered to be involved in its pathogenesis,but the role of quinolinic acid phosphoribosyltransferase(QPRT),a key downstream enzyme in this pathway,remains unclear.This study aims to explore the association between PPD in women undergoing cesarean section and QPRT gene polymorphisms,as well as other risk factors for PPD.Methods:A candidate gene association study design was adopted.From January 2024 to June 2025,full-term singleton pregnant women scheduled to undergo elective cesarean section under spinal anesthesia were recruited at the Third Xiangya Hospital of Central South University and Hunan Provincial Maternal and Child Health Hospital.At 42 days postpartum,postpartum depression was assessed using the Edinburgh Postnatal Depression Scale(EPDS).Peripheral blood samples were collected and genomic DNA was extracted.Four QPRT single nucleotide polymorphism loci(rs1134700,rs2303255,rs9922666,and rs9933310)were selected for genotyping to analyze the association between these loci and PPD.Bioinformatics analysis and dual-luciferase reporter gene assays were performed to investigate the possible mechanism by which significant loci influence disease occurrence.Results:A total of 362 women were ultimately included in the analysis,among whom 29 were diagnosed with PPD,with an incidence of 8.01%.Analysis of general data showed that comorbid hypertension or thyroid disease,inconsistency between neonatal sex and expectation,prenatal depression,prenatal self-harm ideation,domestic violence,poor marital and mother-in-law/daughter-in-law relationships,stressful life events,dissatisfaction with current life status,poor mood during pregnancy,and high stress during pregnancy were all risk factors for PPD in women undergoing cesarean section(all P<0.05).Genetic association analysis revealed that the QPRT rs9933310 A>G polymorphism was associated with PPD.Women carrying the rs9933310 GG or AG genotype had a 2.92-fold higher risk of PPD compared with women with the AA genotype(OR=2.92,95%CI 1.18 to 6.99).Expression quantitative trait loci(eQTL)analysis suggested that the G allele at this locus was associated with downregulation of QPRT expression(AA>AG>GG).Multi-database queries indicated that the rs9933310 locus may have promoter and/or enhancer activity.In addition,JASPAR database prediction and experimental validation showed that the mutant(G)allele at the QPRT rs9933310 locus was more likely than the wild-type(A)allele to weaken promoter-enhancer activity at this locus,and resulted in loss of transcription factors Gata1,GATA2,GATA3,Gata4,Sox17,Sox2,Sox3,Sox6,and SRY,thereby regulating QPRT expression.Conclusion:Comorbid hypertension or thyroid disease,inconsistency between neonatal sex and expectation,prenatal depression,prenatal self-harm ideation,domestic violence,poor marital and mother-in-law/daughter-in-law relationships,stressful life events,dissatisfaction with current life status,poor mood during pregnancy,high stress during pregnancy,and mutation at the QPRT rs9933310 locus are all risk factors for PPD.The QPRT rs9933310 G allele is an independent risk factor for PPD in women undergoing cesarean section,and its pathogenic mechanism may involve downregulation of QPRT expression and disruption of TRP-KYN pathway homeostasis.QPRT has a potential role in the pathogenesis of PPD and may become a novel antidepressant target acting on the TRPKYN pathway.
文摘Sequential ultrasonograms of the ccrvix and uterus were taken in both cross and longitudinal sections at different periods of involution in eleven postparturn Jersey cows, and in the meantime the concentrations of ocstndiol-17β and progesterone in peripheral circulation of the cows were measured by radioimmunoassay(RIA). Cervical involution was showed in detail by using ultrasound scanner during its whole involuting phase, and the oestrus could be indicated by the differences of the ultrasonograms of the genital tract at the time. It took 46.7+3.9 days for the cervix to complete involution after calving, and its involuting rate was delayed by the occurence of the periparturient fatty liver and injury of the cervix during parturtion.
基金The projectis supported financially by Heilongjiang( C- 970 2 ) and Chinese national( 39870 572 ) natural and scientificfunds.
文摘Two postpartum cows were used to study the ultrastructural changes of uterine endometrium by using scanning electron microscope.The results showed that the process of repair of uterine endometrium after calving was demonstrated by scanning electron microscope through a series of endometrium biopsy.Some part of the endometrium was damaged after calving and its adjacent endometrium cells became necrosis and exfoliated during the first 7 days post-partum;the cilium and microvillus of the epithelial cell in the undamaged area of the endometrium disappeared.By 26 days postpartum the damaged area reduced and the cilium and microvillus increased in their numbers.The damaged tissues were all repaired by day 60 postpartum.
文摘Ovarian activitly in 10 postpartum Chinese-Holstein cows was monitored by ultrasonography every other day, stared from day 3 postpartum and finished by the end of a normal ovarian cycle. Meanwhile, the concentrations of progesterone and 17β-oestradiol in peripheral plasma of the cows were measured by radioimmunoassay (RIA). The resutis showed that the first postpartum ovulation was found in 67% of the cows on the ovary opposed to the gravid horn. The first dominant foillicles ovulated for the six of ten cows. The time intervals from calving to the first ovulation were significantly associated with the number of follicular waves (r=0.83, P<0.01). No difference between the diameters of the first and the second ovulated follicles was found in the study, however, the growth rates of the first and the second ovulated follicles were significantly different (P<0.05), and the concentrations of 17β-oestradiol prior to the first ovulation were significantly lower than that before the second ovulation.
文摘目的评估亚麻醉剂量艾司氯胺酮对剖宫产术后产妇睡眠质量及产后恢复质量的影响。方法选择2024年1—6月择期行剖宫产的产妇,年龄18~35岁,BMI 20.0~30.0 kg/m 2,ASAⅡ级。采用随机数字表法将产妇分为两组:对照组(C组)和艾司氯胺酮组(E组)。在胎儿娩出并断脐后,E组立即静脉注射艾司氯胺酮0.25 mg/kg,C组给予等体积生理盐水。采用匹兹堡睡眠质量评分(PSQI)和理查兹-坎贝尔睡眠量表(RCSQ)评估产妇睡眠情况并使用Fibit智能手环记录产妇的睡眠时间以及觉醒次数。主要指标为术后1 d RCSQ评分。次要指标包括术前1 d、术后2 d RCSQ评分,术前1 d、术后1、2 d PSQI评分、总睡眠时间、深睡眠时间、觉醒次数,前1 d、术后1、2、42 d EPDS评分,术后12、24 h NRS疼痛评分,术后3 d QoR-40评分、首次下床活动时间、住院时间以及不良反应发生情况。结果最终纳入产妇104例,其中C组53例,E组51例。与C组比较,E组术后1、2 d PSQI评分明显降低,RCSQ评分明显升高,总睡眠时间明显延长,深睡眠比例明显升高,觉醒次数明显减少,术后1 d EPDS评分、术后12、24 h的NRS疼痛评分明显降低,舒芬太尼用量及补救镇痛次数明显减少,QoR-40评分明显升高,首次下床时间明显缩短(P<0.05)。两组不良反应发生率差异无统计学意义。结论剖宫产术中单次应用亚麻醉剂量艾司氯胺酮可延长睡眠时间,改善睡眠质量,促进产后恢复,且不增加不良反应。
