Early human embryonic development remains mysterious due to drastic species divergences between humans and othermammalian models and limited accessibility to human embryo samples. Recent studies from my laboratory and...Early human embryonic development remains mysterious due to drastic species divergences between humans and othermammalian models and limited accessibility to human embryo samples. Recent studies from my laboratory and others haveshown that under suitable culture conditions human pluripotent stem cells ( hPSCs) can undergo intricate morphogenetic eventsand self-organize to form patterned human embryo-like structures in vitro. These synthetic human embryonic tissueshold great promises for advancing human embryology and reproductive medicine. In this talk,I will describe a hPSC-based,synthetic 3D model of human post-implantation development that recapitulates key developmental landmarks successively,including pro-amniotic cavity formation,amniotic ectoderm-epiblast patterning,primordial germ cell specification,and developmentof the primitive streak with controlled anteroposterior polarity ( Fig.1) . We further show that the amniotic ectoderm,as the first lineage that segregates from the epiblast upon implantation of the human embryo,functions as a signaling centerto trigger primitive streak development in the epiblast. Together,our research has developed a powerful synthetic embryologicalmodel and provided new understandings of previously inaccessible but critical embryogenic events in human development.展开更多
Osteocytes in vivo are embedded in the mineralized extracellular bone matrix,where their cell bodies reside in the lacunae and are interconnected to neighboring osteocytes through numerous intercellular processes.The ...Osteocytes in vivo are embedded in the mineralized extracellular bone matrix,where their cell bodies reside in the lacunae and are interconnected to neighboring osteocytes through numerous intercellular processes.The 3-dimensional（3D）osteocyte network positioning and ability to communicate with other bone cells make osteocytes ideal mechanosensors of bone.Thus the role of osteocyte network and intercellular communication between osteocytes in response to mechanical stimulation may clarify the mechanisms behind normal bone adaptation to mechanical loading.We have been using intracellular calcium([Ca<sup>2+</sup>]<sub>i</sub>)as a ubiquitous real-time signaling indicator for studying mechanotransduction in osteocytic network展开更多
This paper examines the impacts of information technology (IT) on LDCs' competitive conditions, especially the impacts on intra-organization's linkage and technology capability formation via innovation, as the...This paper examines the impacts of information technology (IT) on LDCs' competitive conditions, especially the impacts on intra-organization's linkage and technology capability formation via innovation, as the rising of the new paradigms of system integration. And some strategic implications are made.展开更多
Contemporary Chinese political research usually adopts three basic methods of field investigation,theoretical creation and practical participation,which respectively correspond to the life logic,theoretical logic and ...Contemporary Chinese political research usually adopts three basic methods of field investigation,theoretical creation and practical participation,which respectively correspond to the life logic,theoretical logic and practical logic in political functioning.Field investigation has become an important approach to"understanding Chinese politics"and promoting the localization of contemporary Chinese political research.Meanwhile,the new perspective of theoretical field besides empirical field marks the self-awareness and transition of the methodology in Chinese political research.To study Chinese experience itself,we should not only consciously focus upon China,but also continuously promote experience based on field research,as well as perfect and improve the research through the interaction between experience,theory and practice.The popular paradigms at home and abroad,including"authoritarianism"and"a developmental country",fail to explain Chinese experience and Chinese political development,so we still need a theoretical paradigm more appropriate to Chinese experience and practice.展开更多
Intellectual narration has long been the emotional proposition of the traditional Chinese literature,and it is also the basis of the western rational narration.With the tendency of the artistic media,the absence of id...Intellectual narration has long been the emotional proposition of the traditional Chinese literature,and it is also the basis of the western rational narration.With the tendency of the artistic media,the absence of identity of the intellectual has already become a new problem for the restoration of the narratology research.This paper attempts to interpret the restoration routes such as subject,aesthetics,transmission,society and so on,and discuss the modern Chinese emotional history and the ancient Chinese emotional history,the historical value and popularization function of the artistic media style,based on which it puts forward the intellectual narrative art criticism.展开更多
Western postmodern philosophy of religion is the third significant shift following the ancient ontology paradigm and the modern subject paradigm.Postmodern religious philosophers,taking the focus on language as their ...Western postmodern philosophy of religion is the third significant shift following the ancient ontology paradigm and the modern subject paradigm.Postmodern religious philosophers,taking the focus on language as their theoretical basis,criticize the paradigm of the traditional philosophy of religion.At the same time,as a kind of complex thought trend,the postmodern philosophy of relligion also presents different ideological trends--one is radical and the other is conservative.展开更多
立足科技情报知识服务视角,梳理AI for Science (AI4S)推动的“平台科研”范式内涵与框架。根据库恩范式理论论述了AI4S推动科研范式革新的必然性,采用培根归纳法总结的科学研究流程作为框架线索,阐明创新知识服务与“平台科研”范式的...立足科技情报知识服务视角,梳理AI for Science (AI4S)推动的“平台科研”范式内涵与框架。根据库恩范式理论论述了AI4S推动科研范式革新的必然性,采用培根归纳法总结的科学研究流程作为框架线索,阐明创新知识服务与“平台科研”范式的互促共进关系并作为理论指导。创新知识服务视角下的“平台科研”范式以服务科研创新活动为宗旨,主要内容包括知识表示视角下的科学数据管理、知识融合视角下的通用知识库构建、知识推理视角下的科学假设预测、知识发现视角下的科学实验执行和知识应用视角下的工业赋能。本文提出了一种创新知识服务视角下的“平台科研”范式框架,旨在从创新知识服务角度理解“平台科研”范式,厘清各主要环节创新知识服务的核心研究内容,以期成为科技情报研究领域的新兴知识生长点,为我国抢抓AI4S科研范式革新机遇提供参考思路。展开更多
基金supported by the National Science Foundation ( CMMI 1129611 and CBET 1149401)the National Institutes of Health ( R21 HL114011 and R21 EB017078)+3 种基金the American Heart Association ( 12SDG12180025)the Department of Mechanical Engineering at the University of Michigan,Ann ArborThe Lurie Nanofabrication Facility at the University of Michigan,a member of the National Nanotechnology Infrastructure Network ( NNIN)funded by the National Science Foundation,is acknowledged for support in microfabrication
文摘Early human embryonic development remains mysterious due to drastic species divergences between humans and othermammalian models and limited accessibility to human embryo samples. Recent studies from my laboratory and others haveshown that under suitable culture conditions human pluripotent stem cells ( hPSCs) can undergo intricate morphogenetic eventsand self-organize to form patterned human embryo-like structures in vitro. These synthetic human embryonic tissueshold great promises for advancing human embryology and reproductive medicine. In this talk,I will describe a hPSC-based,synthetic 3D model of human post-implantation development that recapitulates key developmental landmarks successively,including pro-amniotic cavity formation,amniotic ectoderm-epiblast patterning,primordial germ cell specification,and developmentof the primitive streak with controlled anteroposterior polarity ( Fig.1) . We further show that the amniotic ectoderm,as the first lineage that segregates from the epiblast upon implantation of the human embryo,functions as a signaling centerto trigger primitive streak development in the epiblast. Together,our research has developed a powerful synthetic embryologicalmodel and provided new understandings of previously inaccessible but critical embryogenic events in human development.
基金supported by the US National Institutes of Health grants R21 AR052417,R01 AR052461,RC1 AR058453(XEG),and R01 AR054385(LW)
文摘Osteocytes in vivo are embedded in the mineralized extracellular bone matrix,where their cell bodies reside in the lacunae and are interconnected to neighboring osteocytes through numerous intercellular processes.The 3-dimensional（3D）osteocyte network positioning and ability to communicate with other bone cells make osteocytes ideal mechanosensors of bone.Thus the role of osteocyte network and intercellular communication between osteocytes in response to mechanical stimulation may clarify the mechanisms behind normal bone adaptation to mechanical loading.We have been using intracellular calcium([Ca<sup>2+</sup>]<sub>i</sub>)as a ubiquitous real-time signaling indicator for studying mechanotransduction in osteocytic network
文摘This paper examines the impacts of information technology (IT) on LDCs' competitive conditions, especially the impacts on intra-organization's linkage and technology capability formation via innovation, as the rising of the new paradigms of system integration. And some strategic implications are made.
文摘Contemporary Chinese political research usually adopts three basic methods of field investigation,theoretical creation and practical participation,which respectively correspond to the life logic,theoretical logic and practical logic in political functioning.Field investigation has become an important approach to"understanding Chinese politics"and promoting the localization of contemporary Chinese political research.Meanwhile,the new perspective of theoretical field besides empirical field marks the self-awareness and transition of the methodology in Chinese political research.To study Chinese experience itself,we should not only consciously focus upon China,but also continuously promote experience based on field research,as well as perfect and improve the research through the interaction between experience,theory and practice.The popular paradigms at home and abroad,including"authoritarianism"and"a developmental country",fail to explain Chinese experience and Chinese political development,so we still need a theoretical paradigm more appropriate to Chinese experience and practice.
基金the staged achievement of the fund project of the humanistic and social sciences of the Ministry of Education-on Intellectual Narration of the Literary Works of Natsume Soseki(No.:12YJA752004)the fund project of the humanistic and social sciences of colleges and universities in Shandong Province-from Social Criticism to Self Closure:Intellectual Narration in the Works of Natsume Soseki(No.:J11WD02)
文摘Intellectual narration has long been the emotional proposition of the traditional Chinese literature,and it is also the basis of the western rational narration.With the tendency of the artistic media,the absence of identity of the intellectual has already become a new problem for the restoration of the narratology research.This paper attempts to interpret the restoration routes such as subject,aesthetics,transmission,society and so on,and discuss the modern Chinese emotional history and the ancient Chinese emotional history,the historical value and popularization function of the artistic media style,based on which it puts forward the intellectual narrative art criticism.
文摘Western postmodern philosophy of religion is the third significant shift following the ancient ontology paradigm and the modern subject paradigm.Postmodern religious philosophers,taking the focus on language as their theoretical basis,criticize the paradigm of the traditional philosophy of religion.At the same time,as a kind of complex thought trend,the postmodern philosophy of relligion also presents different ideological trends--one is radical and the other is conservative.
文摘立足科技情报知识服务视角,梳理AI for Science (AI4S)推动的“平台科研”范式内涵与框架。根据库恩范式理论论述了AI4S推动科研范式革新的必然性,采用培根归纳法总结的科学研究流程作为框架线索,阐明创新知识服务与“平台科研”范式的互促共进关系并作为理论指导。创新知识服务视角下的“平台科研”范式以服务科研创新活动为宗旨,主要内容包括知识表示视角下的科学数据管理、知识融合视角下的通用知识库构建、知识推理视角下的科学假设预测、知识发现视角下的科学实验执行和知识应用视角下的工业赋能。本文提出了一种创新知识服务视角下的“平台科研”范式框架,旨在从创新知识服务角度理解“平台科研”范式,厘清各主要环节创新知识服务的核心研究内容,以期成为科技情报研究领域的新兴知识生长点,为我国抢抓AI4S科研范式革新机遇提供参考思路。
