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MATHEMATICAL MODELING AND BIFURCATION ANALYSIS FOR A BIOLOGICAL MECHANISM OF CANCER DRUG RESISTANCE
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作者 包康博 梁桂珍 +1 位作者 田天海 张兴安 《Acta Mathematica Scientia》 SCIE CSCD 2024年第3期1165-1188,共24页
Drug resistance is one of the most intractable issues in targeted therapy for cancer diseases.It has also been demonstrated to be related to cancer heterogeneity,which promotes the emergence of treatment-refractory ca... Drug resistance is one of the most intractable issues in targeted therapy for cancer diseases.It has also been demonstrated to be related to cancer heterogeneity,which promotes the emergence of treatment-refractory cancer cell populations.Focusing on how cancer cells develop resistance during the encounter with targeted drugs and the immune system,we propose a mathematical model for studying the dynamics of drug resistance in a conjoint heterogeneous tumor-immune setting.We analyze the local geometric properties of the equilibria of the model.Numerical simulations show that the selectively targeted removal of sensitive cancer cells may cause the initially heterogeneous population to become a more resistant population.Moreover,the decline of immune recruitment is a stronger determinant of cancer escape from immune surveillance or targeted therapy than the decay in immune predation strength.Sensitivity analysis of model parameters provides insight into the roles of the immune system combined with targeted therapy in determining treatment outcomes. 展开更多
关键词 mathematical model drug resistance cancer heterogeneity immune system targeted therapy
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MATHEMATICAL MODEL OF ~4He QUANTUM INTERFEROMETER GYROSCOPE 被引量:5
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作者 郑睿 赵伟 +2 位作者 刘建业 谢征 冯铭瑜 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2012年第4期360-366,共7页
The mathematical model of 4He quantum interferometer gyroscope is presented. The model includes the driven equation, the current equation and the position equation. Therefore, it can sufficiently describe the gyro- sc... The mathematical model of 4He quantum interferometer gyroscope is presented. The model includes the driven equation, the current equation and the position equation. Therefore, it can sufficiently describe the gyro- scope system. The driven equation shows the thermally driven gyroscope can work for a long time but the pres- sure driven one cannot. From the current equation, the superfluid currents passing through the weak link contain the AC currents which show the rotation flux, and other currents caused by drive. As shown in the position equa- tion, the displacement of diaphragm is the only detectable parameter in the gyroscope system. The model is tested by the simulations based on experimental parameters, and can be used to research performance of the gyroscope and analyse the gyroscope error. 展开更多
关键词 4He quantum interferometer gyroscope mathematical model pressure drive thermal drive
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MATHEMATICAL MODEL OF SELF-REPAIRING FLIGHT CONTROL 被引量:2
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作者 王永 詹训慧 +1 位作者 吴刚 胡寿松 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2003年第2期178-183,共6页
The most prospective method for certain structural failures and damages that cannot employ redundancy is self-repairing techniques, to ensure especially the maximum flight safety. Based on the characters of self-repai... The most prospective method for certain structural failures and damages that cannot employ redundancy is self-repairing techniques, to ensure especially the maximum flight safety. Based on the characters of self-repairing aircraft, this paper states some basic assumptions of the self-repairing aircraft, and puts forward some special new conceptions concerning the self-repairing aircraft: control input, operating input, command input, repair input and operating and control factor as well as their relationships. Thus it provides a simple and reliable mathematical model structure for the research on the self-repairing control of the aircraft. 展开更多
关键词 SELF-REPAIRING flight control mathematical model operating and control factor
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Mathematical Models of Tire-Longitudinal Road Adhesion and Their Use in the Study of Road Vehicle Dynamics 被引量:7
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作者 刘昭度 《Journal of Beijing Institute of Technology》 EI CAS 1996年第2期204+193-204,共13页
Mathematical models of tire-longitudinal road adhesion for use in the study of road vehicle dynamics are set up so as to express the relations of longitudinal adhesion coefficients with the slip ratio. They perfect th... Mathematical models of tire-longitudinal road adhesion for use in the study of road vehicle dynamics are set up so as to express the relations of longitudinal adhesion coefficients with the slip ratio. They perfect the Pacejka's models in practical use by taking into account the influences of all essential parameters such as road surface condition. vehicle velocity. slip angle. vertical load and slip ratio on the longitudinal adhesion coefficients. The new models are more comprehensive more concise. simpler and more convenient in application in all kinds of simulations of car dynamics in various sorts of braking modes. 展开更多
关键词 mathematical model tire-longitudinal ROAD ADHESION coefficient: ROAD vehicle DYNAMICS
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Mathematical Models of Tire-Lateral Road Adhesion for Use in Road Vehicle Dynamics Studies 被引量:1
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作者 刘昭度 《Journal of Beijing Institute of Technology》 EI CAS 1997年第1期92-99,共8页
Mathematical models of tire-lateral mad adhesion for use in mad vehicle dynamics studies are set up to express the relations of adhesion coefficients with slip ratio in lateral direction.The models of tire-lateral mad... Mathematical models of tire-lateral mad adhesion for use in mad vehicle dynamics studies are set up to express the relations of adhesion coefficients with slip ratio in lateral direction.The models of tire-lateral mad adhesion revolutionize the Pacejka's model in concept and therefore make it possible for applications in vehicle dynamics studies by the expression of lateral adhesion coefficient as a function of wheel slip ratio,instead of the wheel slip angle,taking into account in the mean time the influences of mad surface condition, vehicle velocity,vertical load,tire slip angle,and wheel camber angle. 展开更多
关键词 mathematical model tire-lateral road adhesion coefficient vehicle dynamics
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STREAMLINE-BASED MATHEMATICAL MODEL FOR CO_2 MISCIBLE FLOODING 被引量:9
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作者 侯健 《应用数学和力学》 EI CSCD 北大核心 2004年第6期635-642,共8页
According to the research theory of improved black oil simulator, a practical mathematical model for CO2 miscible flooding was presented. In the model, the miscible process simulation was realized by adjusting oil/gas... According to the research theory of improved black oil simulator, a practical mathematical model for CO2 miscible flooding was presented. In the model, the miscible process simulation was realized by adjusting oil/gas relative permeability and effective viscosity under the condition of miscible flow. In order to predict the production performance(fast,) streamline method is employed to solve this model as an alternative to traditional finite(difference) (methods.) Based on streamline distribution of steady-state flow through porous media with complex boundary confirmed with the boundary element method (BEM), an explicit total variation diminishing (TVD) method is used to solve the one-dimensional flow problem. At the same time, influences of development scheme, solvent slug size, and injection periods on CO2 drive recovery are discussed. The model has the advantages of less(information) need, fast calculation, and adaptation to calculate CO2 drive performance of all kinds of patterns in a random shaped porous media with assembly boundary. It can be an(effective) tool for early stage screening and reservoir dynamic management of the CO2(miscible) oil field. 展开更多
关键词 混相驱 流线 数学模型 边界元法 提高采收率
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Mathematical models for foam-diverted acidizing and their applications 被引量:3
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作者 Li Songyan Li Zhaomin Lin Riyi 《Petroleum Science》 SCIE CAS CSCD 2008年第2期145-152,共8页
Foam diversion can effectively solve the problem of uneven distribution of acid in layers of different permeabilities during matrix acidizing. Based on gas trapping theory and the mass conservation equation, mathemati... Foam diversion can effectively solve the problem of uneven distribution of acid in layers of different permeabilities during matrix acidizing. Based on gas trapping theory and the mass conservation equation, mathematical models were developed for foam-diverted acidizing, which can be achieved by a foam slug followed by acid injection or by continuous injection of foamed acid. The design method for foam-diverted acidizing was also given. The mathematical models were solved by a computer program. Computed results show that the total formation skin factor, wellhead pressure and bottomhole pressure increase with foam injection, but decrease with acid injection. Volume flow rate in a highpermeability layer decreases, while that in a low-permeability layer increases, thus diverting acid to the low-permeability layer from the high-permeability layer. Under the same formation conditions, for foamed acid treatment the operation was longer, and wellhead and bottomhole pressures are higher. Field application shows that foam slug can effectively block high permeability layers, and improve intake profile noticeably. 展开更多
关键词 Foam slug foamed acid DIVERSION ACIDIZING nonhomogenous mathematical model
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Mathematical Model of Seam-Cavity Growth of Underground Coal Gasification at High Temperature 被引量:2
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作者 陈启辉 郭秋英 余力 《International Journal of Mining Science and Technology》 SCIE EI 1998年第2期131-135,共5页
A mathematical model to describe the seam-cavity growth during underground coal gasification(UCG) is developed. The effect of coal gasification or coal combustion on lateral growth of coal wall is mainly considered in... A mathematical model to describe the seam-cavity growth during underground coal gasification(UCG) is developed. The effect of coal gasification or coal combustion on lateral growth of coal wall is mainly considered in this model. It is based on some basic assumptions and balances of heat and mass transfer in gasification zone of cavity,and considers the effect of dry distillation of seams. The gasifing zone of coal wall is assumpted to be a thin,highly permeable char layer and an ash layer seperating inert ash rubble of the main cavity from coal wall. The model can explain lateral growth mechanism of coal wall in entire gasification process,and determine the growth velocity v (x,t) of coal wall. 展开更多
关键词 seam-cavity growth governing EQUATION mathematical model UCG
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A continuous and high-efficiency process to separate coal bed methane with porous ZIF-8 slurry:Experimental study and mathematical modelling 被引量:7
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作者 Wan Chen Xiaonan Guo +10 位作者 Enbao Zou Mengling Luo Mengzijing Chen Mingke Yang Hai Li Chongzhi Jia Chun Deng Changyu Sun Bei Liu Lanying Yang Guangjin Chen 《Green Energy & Environment》 SCIE CSCD 2020年第3期347-363,共17页
Coal bed methane has been considered as an important energy resource.One major difficulty of purifying coal bed methane comes from the similar physical properties of CH_4 and N_2.The ZIF-8/water-glycol slurry was used... Coal bed methane has been considered as an important energy resource.One major difficulty of purifying coal bed methane comes from the similar physical properties of CH_4 and N_2.The ZIF-8/water-glycol slurry was used as a medium to separate coal bed methane by fluidifying the solid adsorbent material.The sorption equilibrium experiment of binary mixture(CH_4/N_2)and slurry was conducted.The selectivity of CH_4 to N_2 is within the range of 2-6,which proved the feasibility of the slurry separation method.The modified Langmuir equation was used to describe the gas-slurry phase equilibrium behavior,and the calculated results were in good agreement with the experimental data.A continuous absorption-adsorption and desorption process on the separation of CH_4/N_2 in slurry is proposed and its mathematical model is also developed.Sensitivity analysis is conducted to determine the operation conditions and the energy performance of the proposed process was also evaluated.Feed gas contains 30 mol%of methane and the methane concentration in product gas is 95.46 mol%with the methane recovery ratio of 90.74%.The total energy consumption for per unit volume of product gas is determined as 1.846 kWh Nm^(-3).Experimental results and process simulation provide basic data for the design and operation of pilot and industrial plant. 展开更多
关键词 Coal bed methane Gas separation Phase equilibrium experiment mathematical model Process simulation
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A mathematical model of the temperature in a coalfield fire area 被引量:5
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作者 LU Guo-dong ZHOU Xin-quan JIANG Jie 《Journal of China University of Mining and Technology》 EI 2008年第3期358-361,共4页
The regular pattern of temperature change in a coalfield fire area while the fire is being extinguished was studied. To determine the extinguishing effect, a series of linear, logarithmic, polynomial or exponential ma... The regular pattern of temperature change in a coalfield fire area while the fire is being extinguished was studied. To determine the extinguishing effect, a series of linear, logarithmic, polynomial or exponential mathematical regression models were constructed using the observed temperature data from the Xinjiang coalfield fire extinguishing project. The quadratic polynomial mathematical model had the best fit. A large coal fire oven was also used to simulate the coal fire extinguishing process. The same mathematical regression experiments were carried out on that observed data. The results verified that the quadratic polynomial mathematical model had the best fit. Therefore, a quadratic polynomial mathematical model is proposed to accurately model the temperature-time relationship in a coalfield fire area. An application to coalfield fire suppression shows that the deduced mathe-matical model can be used to predict the temperature conditions and to determine the effect of fire extinguishing, thereby helping to speed up the fire suppression process in the coalfield fire area. 展开更多
关键词 coalfield fire area TEMPERATURE mathematical model
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Evaluation of a mathematical model using experimental data and artificial neural network for prediction of gas separation 被引量:1
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作者 M.Peer M.Mahdyarfar T.Mohammadi 《Journal of Natural Gas Chemistry》 EI CAS CSCD 2008年第2期135-141,共7页
In recent times, membranes have found wide applications in gas separation processes. As most of the industrial membrane separation units use hollow fiber modules, having a proper model for simulating this type of memb... In recent times, membranes have found wide applications in gas separation processes. As most of the industrial membrane separation units use hollow fiber modules, having a proper model for simulating this type of membrane module is very useful in achieving guidelines for design and characterization of membrane separation units. In this study, a model based on Coker, Freeman, and Fleming's study was used for estimating the required membrane area. This model could simulate a multicomponent gas mixture separation by solving the governing differential mass balance equations with numerical methods. Results of the model were validated using some binary and multicomponent experimental data from the literature. Also, the artificial neural network (ANN) technique was applied to predict membrane gas separation behavior and the results of the ANN simulation were compared with the simulation results of the model and the experimental data. Good consistency between these results shows that ANN method can be successfully used for prediction of the separation behavior after suitable training of the network 展开更多
关键词 hollow fiber membrane gas separation mathematical modeling artificial neural network
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Analysis of mathematical model for micromechanical vibratory wheel gyroscope 被引量:2
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作者 LUOYue-sheng FANChong-jin TANZhen-fan 《Journal of Marine Science and Application》 2003年第1期53-59,65,共8页
By the sketch of structure of MVWG,the working laws of this kind of gyroscope we re explained.To the aid of Euler′s Dynamics Equation,a mathematical model of the gyroscope was constructed,and then by the basic workin... By the sketch of structure of MVWG,the working laws of this kind of gyroscope we re explained.To the aid of Euler′s Dynamics Equation,a mathematical model of the gyroscope was constructed,and then by the basic working laws of MVWG the model was simplified.Under the conditions of the three axial direction rotations and general rotation,the mathematical model was resolved.And finally by the solutions, the working laws of the gyroscope, the working disparity among all sorts of gyrations and the influences from the gyrations in the axial directions were analysed. 展开更多
关键词 micromechanical silicon gyroscopes mathematical model Euler′s dynamics equati on
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Impact of pertinent parameters on foam behavior in the entrance region of porous media:mathematical modeling 被引量:1
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作者 Fereshteh Samimi Zahra Sakhaei Masoud Riazi 《Petroleum Science》 SCIE CAS CSCD 2020年第6期1669-1682,共14页
Foam injection is a promising solution for control of mobility in oil and gas field exploration and development,including enhanced oil recovery,matrix-acidization treatments,contaminated-aquifer remediation and gas le... Foam injection is a promising solution for control of mobility in oil and gas field exploration and development,including enhanced oil recovery,matrix-acidization treatments,contaminated-aquifer remediation and gas leakage prevention.This study presents a numerical investigation of foam behavior in a porous medium.Fractional flow method is applied to describe steady-state foam displacement in the entrance region.In this model,foam flow for the cases of excluding and including capillary pressure and for two types of gas,nitrogen(N2)and carbon dioxide(CO2)are investigated.Effects of pertinent parameters are also verified.Results indicate that the foam texture strongly governs foam flow in porous media.Required entrance region may be quite different for foam texture to accede local equilibrium,depending on the case and physical properties that are used.According to the fact that the aim of foaming of injected gas is to reduce gas mobility,results show that CO2 is a more proper injecting gas than N2.There are also some ideas presented here on improvement in foam displacement process.This study will provide an insight into future laboratory research and development of full-field foam flow in a porous medium. 展开更多
关键词 Foam displacement Entrance region Fractional flow method Foam texture Water saturation mathematical modeling
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Tight gas charging and accumulation mechanisms and mathematical model 被引量:1
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作者 ZHOU Nengwu LU Shuangfang +11 位作者 ZHANG Pengfei LIN Zizhi XIAO Dianshi LU Jiamin ZHU Yingkang LIU Yancheng LIN Liming WANG Min JIANG Xinyu LIU Yang WANG Ziyi LI Wenbiao 《Petroleum Exploration and Development》 SCIE 2023年第6期1411-1425,共15页
The gas-water distribution and production heterogeneity of tight gas reservoirs have been summarized from experimental and geological observations, but the charging and accumulation mechanisms have not been examined q... The gas-water distribution and production heterogeneity of tight gas reservoirs have been summarized from experimental and geological observations, but the charging and accumulation mechanisms have not been examined quantitatively by mathematical model. The tight gas charging and accumulation mechanisms were revealed from a combination of physical simulation of nuclear magnetic resonance coupling displacement, numerical simulation considering material and mechanical equilibria, as well as actual geological observation. The results show that gas migrates into tight rocks to preferentially form a gas saturation stabilization zone near the source-reservoir interface. When the gas source is insufficient, gas saturation reduction zone and uncharged zone are formed in sequence from the source-reservoir interface. The better the source rock conditions with more gas expulsion volume and higher overpressure, the thicker the gas saturation stabilization and reduction zones, and the higher the overall gas saturation. When the source rock conditions are limited, the better the tight reservoir conditions with higher porosity and permeability as well as larger pore throat, the thinner the gas saturation stabilization and reduction zones, but the gas saturation is high. The sweet spot of tight gas is developed in the high-quality reservoir near the source rock, which often corresponds to the gas saturation stabilization zone. The numerical simulation results by mathematical model agree well with the physical simulation results by nuclear magnetic resonance coupling displacement, and reasonably explain the gas-water distribution and production pattern of deep reservoirs in the Xujiaweizi fault depression of the Songliao Basin and tight gas reservoirs in the Linxing-Huangfu area of the Ordos Basin. 展开更多
关键词 tight gas charging and accumulation mechanism mathematical model Xujiaweizi fault depression Songliao Basin Linxing-Huangfu area Ordos Basin
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Mathematical Constraints in Multiscale Subgrid-Scale Modeling of Nonlinear Systems 被引量:1
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作者 方乐 葛铭纬 《Chinese Physics Letters》 SCIE CAS CSCD 2017年第3期17-20,共4页
To shed light on the subgrid-seale (SGS) modeling methodology of nonlinear systems such as the Navier-Stokes turbulence, we define the concepts of assumption and restriction in the modeling procedure, which are show... To shed light on the subgrid-seale (SGS) modeling methodology of nonlinear systems such as the Navier-Stokes turbulence, we define the concepts of assumption and restriction in the modeling procedure, which are shown by generalized derivation of three general mathematical constraints for different combinations of restrictions. These constraints are verified numerically in a one-dimensional nonlinear advection equation. This study is expected to inspire future research on the SGS modeling methodology of nonlinear systems. 展开更多
关键词 SGS mathematical Constraints in Multiscale Subgrid-Scale modeling of Nonlinear Systems
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Study on Mathematical Model of Jig Stratifying Process
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作者 王振翀 高湛 《International Journal of Mining Science and Technology》 SCIE EI 1999年第1期25-28,共4页
Through analyzing the movement characteristics of particles and particle group in jig bed, the mathematical model of jig stratifying process is established with Markov chain theory and it has been examined by stratify... Through analyzing the movement characteristics of particles and particle group in jig bed, the mathematical model of jig stratifying process is established with Markov chain theory and it has been examined by stratifying test with laboratory U-type jig. The experiment shows that the mathematical model can describe jig stratifying process well. 展开更多
关键词 MINERAL PROCESSING mathematical model COMPUTER
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Mathematical modeling of the bellows dispersion system of submunitions
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作者 师娇 唐胜景 高峰 《Journal of Beijing Institute of Technology》 EI CAS 2012年第1期23-30,共8页
A mathematical model of the bellows dispersion system is developed by combining the interior ballistic theory with structural dynamics theory to describe the deformation course of bellows. By analyzing the physical mo... A mathematical model of the bellows dispersion system is developed by combining the interior ballistic theory with structural dynamics theory to describe the deformation course of bellows. By analyzing the physical model of the bellows dispersion system, the dispersion course is divided into three stages. For each stage, mathematical model is built and its terminal conditions are given. The numerical simulation is based on the Runge-Kutta method and differential quadrature method. Simulation results of the model agree with those of the model built by only interior ballistics theory. However, this model is congruous with the actual dispersion course and can more easily determine the dispersion time and submunition displacement. 展开更多
关键词 mathematical model differential quadrature method DEFORMATION DISPERSION submu- nitions
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Dynamic Factor Method of Computing Dynamic Mathematical Model for System Simulation
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作者 老大中 吴娟 +1 位作者 杨策 蒋滋康 《Journal of Beijing Institute of Technology》 EI CAS 2003年第2期143-148,共6页
The computational methods of a typical dynamic mathematical model that can describe the differential element and the inertial element for the system simulation are researched. The stability of numerical solutions of t... The computational methods of a typical dynamic mathematical model that can describe the differential element and the inertial element for the system simulation are researched. The stability of numerical solutions of the dynamic mathematical model is researched. By means of theoretical analysis, the error formulas, the error sign criteria and the error relationship criterion of the implicit Euler method and the trapezoidal method are given, the dynamic factor affecting the computational accuracy has been found, the formula and the methods of computing the dynamic factor are given. The computational accuracy of the dynamic mathematical model like this can be improved by use of the dynamic factor. 展开更多
关键词 system simulation dynamic mathematical model computational method dynamic factor ERROR
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Mathematical Model and Simulation of Cutting Layer Geometry in Orthogonal Turn⁃Milling with Zero Eccentricity
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作者 SUN Tao QIN Lufang +1 位作者 FU Yucan HOU Junming 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI CSCD 2020年第6期839-847,共9页
Orthogonal turn-milling is a high-efficiency and precision machining method.Its cutting layer directly affects chip formation,cutting forces,and chatter,and further affects tool life,machining quality,etc.We studied T... Orthogonal turn-milling is a high-efficiency and precision machining method.Its cutting layer directly affects chip formation,cutting forces,and chatter,and further affects tool life,machining quality,etc.We studied The cutting layer geometry(CLG)in orthogonal turn-milling with zero eccentricity(OTMZE)is studied to explore orthogonal turn-milling cutting layer formation process.OTMZE principles of motion and formation processes are analyzed statically without considering kinetic influences.Mathematical models of the entrance and exit angles,cutting thickness,and cutting depth are established.In addition,these models are validated experimentally and some influences of cutting parameters on the tool cutting layer are analyzed.The results show that OTMZE cutting layer formation can be divided into two stages,chip shapes are nearly consistent with the simulated CLGs,and the most influencial parameter in affecting the cutting layer is found to be the tool feed per revolation of workpiece fa,followed by the ratio of the tool and workpiece speedsλand the cutting depth ap.These models and results can provide theoretical guidance to clarify formation processes and quantitatively analyze changes in cutting layer geometry during OTMZE.In addition,they offer theoretical guidelines for cutting forces and chatter. 展开更多
关键词 orthogonal turn-milling zero eccentricity cutting layer geometry mathematical model forming process
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Mathematical Model for Takeoff Simulation of a Wing in Proximity to the Ground
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作者 Omer Kemal Kinaci 《Journal of Marine Science and Application》 CSCD 2016年第2期136-143,共8页
Aircraft flying close to the ground benefit from enhanced efficiency owing to decreased induced drag and increased lift. In this study, a mathematical model is developed to simulate the takeoff of a wing near the grou... Aircraft flying close to the ground benefit from enhanced efficiency owing to decreased induced drag and increased lift. In this study, a mathematical model is developed to simulate the takeoff of a wing near the ground using an Iterative Boundary Element Method (IBEM) and the finite difference scheme. Two stand-alone sub-codes and a mother code, which enables communication between the sub-codes, are developed to solve for the self-excitation of the Wing-In-Ground (WIG) effect. The aerodynamic force exerted on the wing is calculated by the first sub-code using the IBEM, and the vertical displacement of the wing is calculated by the second sub-code using the finite difference scheme. The mother code commands the two sub-codes and can solve for the aerodynamics of the wing and operating height within seconds. The developed code system is used to solve for the force, velocity, and displacement of an NACA6409 wing at a 4° Angle of Attack (AoA) which has various numerical and experimental studies in the literature. The effects of thickness and AoA are then investigated and conclusions were drawn with respect to generated results. The proposed model provides a practical method for understanding the flight dynamics and it is specifically beneficial at the pre-design stages of a WIG effect craft. 展开更多
关键词 wing-in-ground effect ground proximity flightdynamics iterative boundary element method mathematical model takeoff simulation
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