The complex of[N,N,N ’ ,N ’- tetrakis(2 - benzimida zolyl methyl) - 1,4 - diethylene amino] - glycol ether(EGTB)with zinc (Ⅱ) ,[Zn 2 (EGTB)Cl 2 ](ClO 4 ) 2 · CH 3 OH · 3H 2 O was synthesized and character...The complex of[N,N,N ’ ,N ’- tetrakis(2 - benzimida zolyl methyl) - 1,4 - diethylene amino] - glycol ether(EGTB)with zinc (Ⅱ) ,[Zn 2 (EGTB)Cl 2 ](ClO 4 ) 2 · CH 3 OH · 3H 2 O was synthesized and characterized with element analysis,UV and IR spectroscopy,and X - ray diffraction method.The crystal belongs to monoclinic with space group of P2 1 /c.The cell parameters are a=1.4376(2)nm,b=2.52650(4)nm,c=1.43531(2)nm,β =101.7037(8) ° ,Z=4,F(000)=2376,D c =1.503g · cm -3 ,The final R=0.0804,wR 2 =0.2236.Biological activities of the complexe was traced by UV - Vis spectrum.The result demonstrates that the complexe has good catalytic abliliy.CCDC:180994.展开更多
The title complex {[%n%|Bu-2SnO-2CCH(CS-2NEt-2)-2]-2O}-2 was synthesized and characterized by elemental analysis, IR, NMR and X|ray single crystal diffraction. The results show that the complex belongs to a monoclinic...The title complex {[%n%|Bu-2SnO-2CCH(CS-2NEt-2)-2]-2O}-2 was synthesized and characterized by elemental analysis, IR, NMR and X|ray single crystal diffraction. The results show that the complex belongs to a monoclinic system with space group %C2/c%, and unit cell dimensions: %a%=2.848(5) nm, {%b%=1.381(2) nm}, %c%=3.239(6) nm, %β%=111.11(2)°, %Z=4, V%=11.884(35) nm+3, %D%-c=1.329 g/cm+3, {%F%(000)}=4 912, %S=0.991, R-1=0.053 5, wR-2=0.116 6.% The complex has a centrosymmetric dimer structure mode with a four|membered central %endo%|cyclic Sn-2O-2 unit. The %endo%|cyclic tin atoms are six|coordination and have coordition geometry of distorted octahedron. The %exo%|cyclic tin atoms are five|coordination and have coordination geometry of distorted trigonal bipyramid. This complex was tested %in vitro% against human tumour cell lines, MCF-7 and WiDr, and displayed the higher activity.展开更多
用二对氯苄基二氯化锡分别与对甲基苯甲酰肼缩苯甲酰甲酸及苯甲酰肼缩苯甲酰甲酸反应,合成了2个对氯苄基锡配合物(C1、C2),通过元素分析、IR、1 H NMR、13C NMR、119Sn NMR、HRMS以及X射线单晶衍射等表征了配合物结构。测试了配合物C1...用二对氯苄基二氯化锡分别与对甲基苯甲酰肼缩苯甲酰甲酸及苯甲酰肼缩苯甲酰甲酸反应,合成了2个对氯苄基锡配合物(C1、C2),通过元素分析、IR、1 H NMR、13C NMR、119Sn NMR、HRMS以及X射线单晶衍射等表征了配合物结构。测试了配合物C1、C2的热稳定性以及配合物对癌细胞NCI‑H460、HepG2、MCF7的体外抑制活性,发现配合物C2对癌细胞NCI‑H460、HepG2、MCF7等均表现出良好的抑制作用。利用紫外吸收光谱、荧光猝灭光谱以及粘度法研究了配合物C2与ct‑DNA之间的相互作用,结果表明配合物C2以插入模式与DNA结合。展开更多
文摘The complex of[N,N,N ’ ,N ’- tetrakis(2 - benzimida zolyl methyl) - 1,4 - diethylene amino] - glycol ether(EGTB)with zinc (Ⅱ) ,[Zn 2 (EGTB)Cl 2 ](ClO 4 ) 2 · CH 3 OH · 3H 2 O was synthesized and characterized with element analysis,UV and IR spectroscopy,and X - ray diffraction method.The crystal belongs to monoclinic with space group of P2 1 /c.The cell parameters are a=1.4376(2)nm,b=2.52650(4)nm,c=1.43531(2)nm,β =101.7037(8) ° ,Z=4,F(000)=2376,D c =1.503g · cm -3 ,The final R=0.0804,wR 2 =0.2236.Biological activities of the complexe was traced by UV - Vis spectrum.The result demonstrates that the complexe has good catalytic abliliy.CCDC:180994.
文摘The title complex {[%n%|Bu-2SnO-2CCH(CS-2NEt-2)-2]-2O}-2 was synthesized and characterized by elemental analysis, IR, NMR and X|ray single crystal diffraction. The results show that the complex belongs to a monoclinic system with space group %C2/c%, and unit cell dimensions: %a%=2.848(5) nm, {%b%=1.381(2) nm}, %c%=3.239(6) nm, %β%=111.11(2)°, %Z=4, V%=11.884(35) nm+3, %D%-c=1.329 g/cm+3, {%F%(000)}=4 912, %S=0.991, R-1=0.053 5, wR-2=0.116 6.% The complex has a centrosymmetric dimer structure mode with a four|membered central %endo%|cyclic Sn-2O-2 unit. The %endo%|cyclic tin atoms are six|coordination and have coordition geometry of distorted octahedron. The %exo%|cyclic tin atoms are five|coordination and have coordination geometry of distorted trigonal bipyramid. This complex was tested %in vitro% against human tumour cell lines, MCF-7 and WiDr, and displayed the higher activity.
文摘用二对氯苄基二氯化锡分别与对甲基苯甲酰肼缩苯甲酰甲酸及苯甲酰肼缩苯甲酰甲酸反应,合成了2个对氯苄基锡配合物(C1、C2),通过元素分析、IR、1 H NMR、13C NMR、119Sn NMR、HRMS以及X射线单晶衍射等表征了配合物结构。测试了配合物C1、C2的热稳定性以及配合物对癌细胞NCI‑H460、HepG2、MCF7的体外抑制活性,发现配合物C2对癌细胞NCI‑H460、HepG2、MCF7等均表现出良好的抑制作用。利用紫外吸收光谱、荧光猝灭光谱以及粘度法研究了配合物C2与ct‑DNA之间的相互作用,结果表明配合物C2以插入模式与DNA结合。
