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一个彝族家系视网膜色素变性RHO基因突变的基因型与表型相关性分析
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作者 张亚娟 杨红 +5 位作者 赵洪超 马丹 师美玉 郑唯一 王翔 刘建平 《国际眼科杂志》 2025年第3期499-505,共7页
目的:明确一个彝族大家系视网膜色素变性(RP)的基因突变位点,分析RHO基因突变位点与临床表型的相关性。方法:收集一诊断为RP的先证者及其家系成员临床资料并进行详细的眼科检查。采集家系成员外周血,提取基因组DNA,用全外显子组测序(WES... 目的:明确一个彝族大家系视网膜色素变性(RP)的基因突变位点,分析RHO基因突变位点与临床表型的相关性。方法:收集一诊断为RP的先证者及其家系成员临床资料并进行详细的眼科检查。采集家系成员外周血,提取基因组DNA,用全外显子组测序(WES)筛选出先证者的潜在致病基因突变位点,用Sanger测序法对变异位点进行验证,随后用遗传学数据库和相关文献等资料对突变位点进行分析,最终确认致病突变位点,并对突变基因型与表型关系进行分析。结果:该RP家系共5代,共42名成员,其中男19人,女23人;确诊RP共13例,其中男4例,女9例,符合常染色体显性遗传模式。该家系的临床特点为发病早,病情发展迅速,病情较严重。患者6岁左右即被发现有夜盲,这是目前报道的RP家系中夜盲发生最早的病例;视网膜表现为进行性的眼底骨细胞样色素沉着,视野缩小,ERG显示a,b波幅明显下降甚至熄灭;WES和Sanger测序结果共同显示先证者存在RHO基因杂合错义变异c.1040C>T:p.P347L,该变异为cDNA第1040碱基C被T替换,导致第347位密码子由编码脯氨酸变为编码亮氨酸。通过查阅数据库、文献等资料,发现该突变未在中国人群中报道过。结论:本研究证实了一彝族家系RP的突变基因是RHO(c.1040C>T)。该突变导致第347位密码子由编码脯氨酸变为编码亮氨酸,导致家系成员出现严重的临床表型,该研究为RHO的遗传咨询及基因诊断提供一定的分子临床及遗传基础。 展开更多
关键词 彝族 视网膜色素变性 rho基因
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Rho相关激酶抑制剂治疗Fuchs角膜内皮营养不良新进展
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作者 孙浩源 王姝丹 张弘 《国际眼科杂志》 2025年第5期739-742,共4页
Fuchs角膜内皮营养不良(FECD)是以角膜内皮进行性损害,逐渐发展为角膜内皮失代偿为特征的一种营养不良性疾病,目前的标准疗法即角膜移植手术存在种种限制。最近的研究发现,Rho相关激酶抑制剂可通过调节细胞周期蛋白D和p27信号传导通路... Fuchs角膜内皮营养不良(FECD)是以角膜内皮进行性损害,逐渐发展为角膜内皮失代偿为特征的一种营养不良性疾病,目前的标准疗法即角膜移植手术存在种种限制。最近的研究发现,Rho相关激酶抑制剂可通过调节细胞周期蛋白D和p27信号传导通路促进细胞增殖,激活Rac1蛋白驱动肌动蛋白相关蛋白复合物(ARPC2)增加细胞黏附,调节膜出泡、核崩解和凋亡小体的形成抑制角膜内皮细胞的凋亡,有望治疗FECD。文章主要对Rho相关激酶抑制剂治疗FECD的药理作用、基础研究、临床试验以及不良反应等相关进展进行综述,希望能尽早开发出疗效稳定且副作用少的化合物,为治疗FECD提供新方案。 展开更多
关键词 Fuchs角膜内皮营养不良 rho相关激酶抑制剂 治疗进展
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Electrode/Electrolyte Optimization‑Induced Double‑Layered Architecture for High‑Performance Aqueous Zinc‑(Dual)Halogen Batteries
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作者 Chengwang Zhou Zhezheng Ding +7 位作者 Shengzhe Ying Hao Jiang Yan Wang Timing Fang You Zhang Bing Sun Xiao Tang Xiaomin Liu 《Nano-Micro Letters》 SCIE EI CAS 2025年第3期121-137,共17页
Aqueous zinc-halogen batteries are promising candidates for large-scale energy storage due to their abundant resources,intrinsic safety,and high theoretical capacity.Nevertheless,the uncontrollable zinc dendrite growt... Aqueous zinc-halogen batteries are promising candidates for large-scale energy storage due to their abundant resources,intrinsic safety,and high theoretical capacity.Nevertheless,the uncontrollable zinc dendrite growth and spontaneous shuttle effect of active species have prohibited their practical implementation.Herein,a double-layered protective film based on zinc-ethylenediamine tetramethylene phosphonic acid(ZEA)artificial film and ZnF2-rich solid electrolyte interphase(SEI)layer has been successfully fabricated on the zinc metal anode via electrode/electrolyte synergistic optimization.The ZEA-based artificial film shows strong affinity for the ZnF2-rich SEI layer,therefore effectively suppressing the SEI breakage and facilitating the construction of double-layered protective film on the zinc metal anode.Such double-layered architecture not only modulates Zn2+flux and suppresses the zinc dendrite growth,but also blocks the direct contact between the metal anode and electrolyte,thus mitigating the corrosion from the active species.When employing optimized metal anodes and electrolytes,the as-developed zinc-(dual)halogen batteries present high areal capacity and satisfactory cycling stability.This work provides a new avenue for developing aqueous zinc-(dual)halogen batteries. 展开更多
关键词 Zn metal anodes Double-layered protective film Electrode/electrolyte optimization Aqueous zinc-(dual)halogen batteries
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Optimization of Nesting Systems in Shipbuilding:A Review
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作者 Sari Wanda Rulita Gunawan Muzhoffar Dimas Angga Fakhri 《哈尔滨工程大学学报(英文版)》 2025年第1期152-175,共24页
This review article provides a comprehensive analysis of nesting optimization algorithms in the shipbuilding industry,emphasizing their role in improving material utilization,minimizing waste,and enhancing production ... This review article provides a comprehensive analysis of nesting optimization algorithms in the shipbuilding industry,emphasizing their role in improving material utilization,minimizing waste,and enhancing production efficiency.The shipbuilding process involves the complex cutting and arrangement of steel plates,making the optimization of these operations vital for cost-effectiveness and sustainability.Nesting algorithms are broadly classified into four categories:exact,heuristic,metaheuristic,and hybrid.Exact algorithms ensure optimal solutions but are computationally demanding.In contrast,heuristic algorithms deliver quicker results using practical rules,although they may not consistently achieve optimal outcomes.Metaheuristic algorithms combine multiple heuristics to effectively explore solution spaces,striking a balance between solution quality and computational efficiency.Hybrid algorithms integrate the strengths of different approaches to further enhance performance.This review systematically assesses these algorithms using criteria such as material dimensions,part geometry,component layout,and computational efficiency.The findings highlight the significant potential of advanced nesting techniques to improve material utilization,reduce production costs,and promote sustainable practices in shipbuilding.By adopting suitable nesting solutions,shipbuilders can achieve greater efficiency,optimized resource management,and superior overall performance.Future research directions should focus on integrating machine learning and real-time adaptability to further enhance nesting algorithms,paving the way for smarter,more sustainable manufacturing practices in the shipbuilding industry. 展开更多
关键词 Cutting plate Nesting algorithms Nesting optimization Shipbuilding efficiency Algorithmic optimization
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Parameters Optimization of Decoy-State Phase-Matching Quantum Key Distribution Based on the Nature-Inspired Algorithms
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作者 Chang Liu Yue Li +4 位作者 Haoyang Wang Kaiyi Shi Duo Ma Yujia Zhang Haiqiang Ma 《Chinese Physics Letters》 2025年第1期23-27,共5页
Phase-matching quantum-key distribution(PM-QKD)has achieved significant results in various practical applications.However,real-time communication requires dynamic adjustment and optimization of key parameters during c... Phase-matching quantum-key distribution(PM-QKD)has achieved significant results in various practical applications.However,real-time communication requires dynamic adjustment and optimization of key parameters during communication.In this letter,we predict the PM-QKD parameters using nature-inspired algorithms(NIAs).The results are obtained from an exhaustive traversal algorithm(ETA),which serves as a benchmark.We mainly study the parameter optimization effects of the two NIAs:ant colony optimization(ACO)and the genetic algorithm(GA).The configuration of the inherent parameters of these algorithms in the decoy-state PM-QKD is also discussed.The simulation results indicate that the parameters obtained by the ACO exhibit superior convergence and stability,whereas the GA results are relatively scattered.Nevertheless,more than 97%of the key rates predicted by both algorithms are highly consistent with the optimal key rate.Moreover,the relative error of the key rates remained below 10%.Furthermore,NIAs maintain power consumption below 8 W and require three orders of magnitude less computing time than ETA. 展开更多
关键词 optimization SCATTERED LETTER
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Neural Network-Based Frequency Optimization for Superconducting Quantum Chips
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作者 Bin-Han Lu Qing-Song Li +3 位作者 Peng Wang Zhao-Yun Chen Yu-Chun Wu Guo-Ping Guo 《Chinese Physics Letters》 2025年第3期16-22,共7页
Optimizing frequency configurations for qubits and gates in superconducting quantum chips presents a complex NP-complete challenge,critical for mitigating decoherence and crosstalk.This paper introduces a neural netwo... Optimizing frequency configurations for qubits and gates in superconducting quantum chips presents a complex NP-complete challenge,critical for mitigating decoherence and crosstalk.This paper introduces a neural network-based approach,leveraging the network as a surrogate model to predict frequency errors.The method employs a closed-loop Bayesian optimization framework to iteratively refine configurations,guided by the network’s knowledge of nonlinear error mechanisms.By focusing on localized chip windows,the optimization identifies optimal frequency settings that minimize errors.The approach is validated through randomized and cross-entropy benchmarking,showing improved energy calculations when optimizing frequency configurations for a crosstalkaware hardware-efficient ansatz in variational quantum eigensolvers on superconducting quantum chips. 展开更多
关键词 QUANTUM optimization VARIATIONAL
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Optimization Strategies of Na_(3)V_(2)(PO_(4))_(3) Cathode Materials for Sodium‑Ion Batteries
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作者 Jiawen Hu Xinwei Li +4 位作者 Qianqian Liang Li Xu Changsheng Ding Yu Liu Yanfeng Gao 《Nano-Micro Letters》 SCIE EI CAS 2025年第2期204-251,共48页
Na_(3)V_(2)(PO_(4))_(3)(NVP)has garnered great attentions as a prospective cathode material for sodium-ion batteries(SIBs)by virtue of its decent theoretical capacity,superior ion conductivity and high structural stab... Na_(3)V_(2)(PO_(4))_(3)(NVP)has garnered great attentions as a prospective cathode material for sodium-ion batteries(SIBs)by virtue of its decent theoretical capacity,superior ion conductivity and high structural stability.However,the inherently poor electronic conductivity and sluggish sodium-ion diffusion kinetics of NVP material give rise to inferior rate performance and unsatisfactory energy density,which strictly confine its further application in SIBs.Thus,it is of significance to boost the sodium storage performance of NVP cathode material.Up to now,many methods have been developed to optimize the electrochemical performance of NVP cathode material.In this review,the latest advances in optimization strategies for improving the electrochemical performance of NVP cathode material are well summarized and discussed,including carbon coating or modification,foreign-ion doping or substitution and nanostructure and morphology design.The foreign-ion doping or substitution is highlighted,involving Na,V,and PO_(4)^(3−)sites,which include single-site doping,multiple-site doping,single-ion doping,multiple-ion doping and so on.Furthermore,the challenges and prospects of high-performance NVP cathode material are also put forward.It is believed that this review can provide a useful reference for designing and developing high-performance NVP cathode material toward the large-scale application in SIBs. 展开更多
关键词 Sodium-ion batteries Na_(3)V_(2)(PO_(4))_(3) Cathode materials Electrochemical performance optimization strategies
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Energy Efficient Clustering and Sink Mobility Protocol Using Hybrid Golden Jackal and Improved Whale Optimization Algorithm for Improving Network Longevity in WSNs
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作者 S B Lenin R Sugumar +2 位作者 J S Adeline Johnsana N Tamilarasan R Nathiya 《China Communications》 2025年第3期16-35,共20页
Reliable Cluster Head(CH)selectionbased routing protocols are necessary for increasing the packet transmission efficiency with optimal path discovery that never introduces degradation over the transmission reliability... Reliable Cluster Head(CH)selectionbased routing protocols are necessary for increasing the packet transmission efficiency with optimal path discovery that never introduces degradation over the transmission reliability.In this paper,Hybrid Golden Jackal,and Improved Whale Optimization Algorithm(HGJIWOA)is proposed as an effective and optimal routing protocol that guarantees efficient routing of data packets in the established between the CHs and the movable sink.This HGJIWOA included the phases of Dynamic Lens-Imaging Learning Strategy and Novel Update Rules for determining the reliable route essential for data packets broadcasting attained through fitness measure estimation-based CH selection.The process of CH selection achieved using Golden Jackal Optimization Algorithm(GJOA)completely depends on the factors of maintainability,consistency,trust,delay,and energy.The adopted GJOA algorithm play a dominant role in determining the optimal path of routing depending on the parameter of reduced delay and minimal distance.It further utilized Improved Whale Optimisation Algorithm(IWOA)for forwarding the data from chosen CHs to the BS via optimized route depending on the parameters of energy and distance.It also included a reliable route maintenance process that aids in deciding the selected route through which data need to be transmitted or re-routed.The simulation outcomes of the proposed HGJIWOA mechanism with different sensor nodes confirmed an improved mean throughput of 18.21%,sustained residual energy of 19.64%with minimized end-to-end delay of 21.82%,better than the competitive CH selection approaches. 展开更多
关键词 Cluster Heads(CHs) Golden Jackal optimization Algorithm(GJOA) Improved Whale optimization Algorithm(IWOA) unequal clustering
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Optimization strategies for operational parameters of Rydberg atom-based amplitude modulation receiver
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作者 Yuhao Wu Dongping Xiao +1 位作者 Huaiqing Zhang Sheng Yan 《Chinese Physics B》 2025年第1期280-287,共8页
The Rydberg atom-based receiver, as a novel type of antenna, demonstrates broad application prospects in the field of microwave communications. However, since Rydberg atomic receivers are nonlinear systems, mismatches... The Rydberg atom-based receiver, as a novel type of antenna, demonstrates broad application prospects in the field of microwave communications. However, since Rydberg atomic receivers are nonlinear systems, mismatches between the parameters of the received amplitude modulation(AM) signals and the system's linear workspace and demodulation operating points can cause severe distortion in the demodulated signals. To address this, the article proposes a method for determining the operational parameters based on the mean square error(MSE) and total harmonic distortion(THD) assessments and presents strategies for optimizing the system's operational parameters focusing on linear response characteristics(LRC) and linear dynamic range(LDR). Specifically, we employ a method that minimizes the MSE to define the system's linear workspace, thereby ensuring the system has a good LRC while maximizing the LDR. To ensure that the signal always operates within the linear workspace, an appropriate carrier amplitude is set as the demodulation operating point. By calculating the THD at different operating points, the LRC performance within different regions of the linear workspace is evaluated, and corresponding optimization strategies based on the range of signal strengths are proposed. Moreover, to more accurately restore the baseband signal, we establish a mapping relationship between the carrier Rabi frequency and the transmitted power of the probe light, and optimize the slope of the linear demodulation function to reduce the MSE to less than 0.8×10^(-4). Finally, based on these methods for determining the operational parameters, we explore the effects of different laser Rabi frequencies on the system performance, and provide optimization recommendations. This research provides robust support for the design of high-performance Rydberg atom-based AM receivers. 展开更多
关键词 Rydberg atom-based receiver amplitude modulation(AM) operating parameters optimization
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Review of Vibration Analysis and Structural Optimization Research for Rotating Blades
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作者 Saifeng Zhong Guoyong Jin +2 位作者 Yukun Chen Tiangui Ye Tuo Zhou 《哈尔滨工程大学学报(英文版)》 2025年第1期120-136,共17页
Blades are important parts of rotating machinery such as marine gas turbines and wind turbines,which are exposed to harsh environments during mechanical operations,including centrifugal loads,aerodynamic forces,or hig... Blades are important parts of rotating machinery such as marine gas turbines and wind turbines,which are exposed to harsh environments during mechanical operations,including centrifugal loads,aerodynamic forces,or high temperatures.These demanding working conditions considerably influence the dynamic performance of blades.Therefore,because of the challenges posed by blades in complex working environments,in-depth research and optimization are necessary to ensure that blades can operate safely and efficiently,thus guaranteeing the reliability and performance of mechanical systems.Focusing on the vibration analysis of blades in rotating machinery,this paper conducts a comprehensive literature review on the research advancements in vibration modeling and structural optimization of blades under complex operational conditions.First,the paper outlines the development of several modeling theories for rotating blades,including one-dimensional beam theory,two-dimensional plate-shell theory,and three-dimensional solid theory.Second,the research progress in the vibrational analysis of blades under aerodynamic loads,thermal environments,and crack factors is separately discussed.Finally,the developments in rotating blade structural optimization are presented from material optimization and shape optimization perspectives.The methodology and theory of analyzing and optimizing blade vibration characteristics under multifactorial operating conditions are comprehensively outlined,aiming to assist future researchers in proposing more effective and practical approaches for the vibration analysis and optimization of blades. 展开更多
关键词 Rotating blade Vibration characteristics Structural optimization Harsh operating conditions REVIEW
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Optimization of electron beams for ion bombardment secondary emission electron gun
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作者 Zebin WANG Junbiao LIU +3 位作者 Aiguo CHEN Dazheng WANG Pengfei WANG Li HAN 《Plasma Science and Technology》 2025年第3期63-71,共9页
Electron beam fluorescence technology is an advanced non-contact measurement in rarefied flow fields,and the fluorescence signal intensity is positively correlated with the electron beam current.The ion bombardment se... Electron beam fluorescence technology is an advanced non-contact measurement in rarefied flow fields,and the fluorescence signal intensity is positively correlated with the electron beam current.The ion bombardment secondary emission electron gun is suitable for the technology.To enhance the beam current,COMSOL simulations and analyses were conducted to examine plasma density distribution in the discharge chamber under the effects of various conditions and the electric field distribution between the cathode and the spacer gap.The anode shape and discharge pressure conditions were optimized to increase plasma density.Additionally,an improved spacer structure was designed with the dual purpose of enhancing the electric field distribution between the cathode-spacer gaps and improving vacuum differential effects.This design modification aims to increase the pass rate of secondary electrons.Both simulation and experimental results demonstrated that the performance of the optimized electron gun was effectively enhanced.When the electrode voltage remains constant and the discharge gas pressure is adjusted to around 8 Pa,the maximum beam current was increased from 0.9 mA to 1.6 mA. 展开更多
关键词 air plasma secondary emission electron gun electron beam performance optimization
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Geostatistics-block-based characterization of the relationship between rock mass quality and powder factor and its application on open-pit limit optimization
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作者 Jinduo Li Tianhong Yang +6 位作者 Feiyue Liu Shigui Du Wenxue Deng Yong Zhao Honglei Liu Leilei Niu Zhiqiang Xu 《International Journal of Mining Science and Technology》 2025年第1期135-147,共13页
Accurately predicting the powder factor during blasting is essential for sustainable production planning in low-grade mines.This research presents a method for predicting powder factor based on the heterogeneity of ro... Accurately predicting the powder factor during blasting is essential for sustainable production planning in low-grade mines.This research presents a method for predicting powder factor based on the heterogeneity of rock mass rating(RMR).Considering a low-grade metal mine as an example,this study exploited geostatistical methods to obtain independent RMR for each block unit.A three-dimensional spatial distribution model for the powder factor was developed on the basis of the relationships between the RMR and the powder factor.Subsequently,models for blasting cost and mining value were built and employed to optimize the open-pit limit.The multi-variable model based on the RMR performed well in predicting the powder factor,achieving a correlation coefficient of 0.88(root mean square error of 4.3)and considerably outperforming the uniaxial compressive strength model.After model optimization,the mean size and standard deviation of the fragments in the blast pile decreased by 8.5%and 35.1%,respectively,whereas the boulder yield and its standard deviation decreased by 33.3%and 58.8%,respectively.Additionally,optimizing the open-pit limit using this method reduced the amount of rock,increased the amount of ore,and lowered blasting costs,thereby enhancing the economic efficiency of the mine.This study provides valuable insights for blasting design and mining decisions,demonstrating the advantages and potential applications of powder factor prediction based on the heterogeneity of rock mass quality. 展开更多
关键词 Geostatistics method Powder factor Open-pit limit optimization Blasting cost Rock mass quality
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Optimal power extraction of PV-TEG hybrid system via fitness-distance-balance-based beluga whale optimization
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作者 Bo Yang Boxiao Liang +4 位作者 Shaocong Wu Hongbiao Li Dengke Gao Lin Jiang Jingbo Wang 《Global Energy Interconnection》 2025年第1期43-61,共19页
This study integrates the individual photovoltaic(PV)and thermoelectric generator(TEG)systems into a PV-TEG hybrid system to improve its overall power output by reutilizing the waste heat generated during PV power pro... This study integrates the individual photovoltaic(PV)and thermoelectric generator(TEG)systems into a PV-TEG hybrid system to improve its overall power output by reutilizing the waste heat generated during PV power production to enhance its operational relia-bility.However,stochastic environmental conditions often result in partial shading conditions and nonuniform thermal distribution across the PV-TEG modules,which negatively affect the output characteristics of the system,thus presenting a significant challenge to maintaining their optimal performance.To address these challenges,a novel fitness-distance-balance-based beluga whale optimization(FDBBWO)strategy has been devised for maximizing the power output of the PV-TEG hybrid system under dynamic operation scenar-ios.A broader spectrum of complex and authentic operational contexts has been considered in case studies to examine the effectiveness and feasibility of FDBBWO.For this,real-world datasets collected from different seasons in Hong Kong have been used to validate the practical viability of the proposed strategy.Simulation results reveal that the FDBBWO based maximum power point tracking technique outperforms its competing methods by achieving the highest energy output,with a remarkable increase of up to 134.25%with minimal power fluctuations.For instance,the energy obtained by FDBBWO is 47.45%and 58.34%higher than BWO and perturb and observe methods,respectively,in the winter season. 展开更多
关键词 Photovoltaic-thermoelectric-generator Hybrid system Maximum power point tracking Partial shading conditions Fitness-distance-balance-based beluga whale optimization SimuNPS
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Multi-Objective optimization for stable and efficient cargo transportation of partial space elevator
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作者 Gefei Shi Zheng H.Zhu 《Defence Technology(防务技术)》 2025年第2期17-29,共13页
This paper proposed a new libration decoupling analytical speed function(LD-ASF)in lieu of the classic analytical speed function to control the climber's speed along a partial space elevator to improve libration s... This paper proposed a new libration decoupling analytical speed function(LD-ASF)in lieu of the classic analytical speed function to control the climber's speed along a partial space elevator to improve libration stability in cargo transportation.The LD-ASF is further optimized for payload transportation efficiency by a novel coordinate game theory to balance competing control objectives among payload transport speed,stable end body's libration,and overall control input via model predictive control.The transfer period is divided into several sections to reduce computational burden.The validity and efficacy of the proposed LD-ASF and coordinate game-based model predictive control are demonstrated by computer simulation.Numerical results reveal that the optimized LD-ASF results in higher transportation speed,stable end body's libration,lower thrust fuel consumption,and more flexible optimization space than the classic analytical speed function. 展开更多
关键词 Partial space elevator Stable transportation Libration decoupling analytical speed function Coordinate game Model predictive control Pareto optimization
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对香豆酸通过抑制RhoA/ROCK信号通路减轻糖尿病肾病病变
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作者 王晶 朱燕亭 +2 位作者 吴冰 金刚 王琼 《山西医科大学学报》 CAS 2024年第8期976-984,共9页
目的探讨对香豆酸(p-CA)对糖尿病肾病(DN)大鼠的治疗作用及对Ras同源基因家族成员A(RhoA)/Rho相关卷曲螺旋蛋白激酶(ROCK)信号通路的影响。方法将大鼠分为6组:对照组(n=10)、DN组(n=10)、低剂量对香豆酸组(L-p-CA)(n=10)、中剂量对香豆... 目的探讨对香豆酸(p-CA)对糖尿病肾病(DN)大鼠的治疗作用及对Ras同源基因家族成员A(RhoA)/Rho相关卷曲螺旋蛋白激酶(ROCK)信号通路的影响。方法将大鼠分为6组:对照组(n=10)、DN组(n=10)、低剂量对香豆酸组(L-p-CA)(n=10)、中剂量对香豆酸组(M-p-CA)(n=10)、高剂量对香豆酸组(H-p-CA)(n=10)和RhoA激动剂U-46619组(U-46619)(n=12)。对照组大鼠为健康SD大鼠,其他组大鼠均为高脂饮食联合链脲佐菌素诱导的DN模型大鼠。造模后,对照组和DN组大鼠灌胃2 mL 0.5%羧甲基纤维素溶液,L-p-CA组、M-p-CA组和H-p-CA组大鼠分别灌胃2 mL剂量为50,100,200 mg/(kg·d)的对香豆酸溶液,U-46619组大鼠同时灌胃1 mL对香豆酸溶液(剂量为200 mg/(kg·d))以及1 mL剂量为30μg/(kg·d)的RhoA激动剂U-46619。各组大鼠均干预12周。治疗后检测各组大鼠生化指标水平:空腹血糖(FPG)、空腹胰岛素(FINS)、糖化血红蛋白(HbA1c)、尿素氮(BUN)、血肌酐(Cr)和24 h尿蛋白;以及血清氧化应激指标水平:超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GSH-PX)和丙二醛(MDA)。通过苏木精-伊红(HE)和Masson三色染色评价大鼠肾脏损伤和纤维化。通过qRT-PCR检测肾脏肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)和单核细胞趋化蛋白-1(MCP-1)转录活性。通过Western blot检测肾脏TNF-α、IL-1β、MCP-1、RhoA和ROCK1蛋白表达水平。结果与对照组比较,DN组大鼠的FPG、FINS、24 h尿蛋白、HbA1c、BUN和Cr水平升高(P<0.05);肾组织发生明显病变,肾组织纤维化面积升高(P<0.05);血清SOD、CAT和GSH-PX水平均降低(P<0.05),MDA水平升高(P<0.05);肾组织TNF-α、IL-1β和MCP-1的mRNA和蛋白水平均升高(P<0.05);肾组织RhoA和ROCK1蛋白表达水平升高(P<0.05)。与DN组比较,L-p-CA组、M-p-CA组和H-p-CA组大鼠的FPG、FINS、24 h尿蛋白、HbA1c、BUN和Cr水平降低(P<0.05);肾组织病变减轻,肾组织纤维化面积降低(P<0.05);血清SOD、CAT和GSH-PX水平均升高(P<0.05),MDA水平降低(P<0.05);肾组织TNF-α、IL-1β和MCP-1的mRNA和蛋白水平均降低(P<0.05);肾组织RhoA和ROCK1蛋白表达水平降低(P<0.05)。与L-p-CA组和M-p-CA组比较,H-p-CA组大鼠的FPG、FINS、24 h尿蛋白、HbA1c、BUN和Cr水平降低(P<0.05);肾组织病变减轻,肾组织纤维化面积降低(P<0.05);血清SOD、CAT和GSH-PX水平均升高(P<0.05),MDA水平降低(P<0.05);肾组织TNF-α、IL-1β和MCP-1的mRNA和蛋白水平均降低(P<0.05);肾组织RhoA和ROCK1蛋白表达水平降低(P<0.05)。与H-p-CA组比较,U-46619组大鼠的FPG、FINS、24 h尿蛋白、HbA1c、BUN和Cr水平均升高(P<0.05);肾组织病变加重,肾组织纤维化面积升高(P<0.05);血清SOD、CAT和GSH-PX水平均降低(P<0.05),MDA水平升高(P<0.05);肾组织TNF-α、IL-1β和MCP-1的mRNA和蛋白水平均升高(P<0.05);肾组织RhoA和ROCK1蛋白表达水平升高(P<0.05)。结论对香豆酸通过抑制RhoA/ROCK信号通路减轻糖尿病肾病病变。 展开更多
关键词 对香豆酸 糖尿病肾病 Ras同源基因家族成员A rho相关卷曲螺旋蛋白激酶 氧化应激 炎症 纤维化
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槐耳多糖调节Rho/ROCK信号通路对结肠癌SW620细胞恶性生物学行为的影响 被引量:1
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作者 温秀英 陈战 +3 位作者 黄军利 陈洪标 林茜 温志坚 《解剖学杂志》 CAS 2024年第5期410-414,429,共6页
目的:探讨槐耳多糖调节Rho/Rho相关卷曲螺旋蛋白激酶(ROCK)信号通路影响结肠癌SW620细胞恶性生物学行为。方法:人结肠癌细胞株SW620分为对照组、槐耳多糖组、水仙环素(Rho/ROCK途径激活剂)组、槐耳多糖+水仙环素组。分析各组细胞增殖、... 目的:探讨槐耳多糖调节Rho/Rho相关卷曲螺旋蛋白激酶(ROCK)信号通路影响结肠癌SW620细胞恶性生物学行为。方法:人结肠癌细胞株SW620分为对照组、槐耳多糖组、水仙环素(Rho/ROCK途径激活剂)组、槐耳多糖+水仙环素组。分析各组细胞增殖、迁移、侵袭、凋亡和集落形成能力。免疫印迹检测RhoA、ROCK1、增殖细胞周期相关核抗原(Ki67)、基质金属蛋白酶2(MMP2)、caspase-3蛋白表达水平。建立裸鼠结肠癌移植瘤模型验证槐耳多糖对裸鼠体内移植瘤生长的影响。结果:槐耳多糖抑制SW620细胞增殖、迁移、侵袭、克隆集落数,并增加细胞凋亡以及RhoA、ROCK1、Ki67、MMP2蛋白表达水平。水仙环素逆转了槐耳多糖对SW620细胞恶性生物学行为的抑制作用。结论:槐耳多糖通过抑制Rho/ROCK信号通路抑制SW620细胞恶性生物学行为。 展开更多
关键词 槐耳多糖 rho/ROCK信号通路 结肠癌细胞
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Cooperative User-Scheduling and Resource Allocation Optimization for Intelligent Reflecting Surface Enhanced LEO Satellite Communication 被引量:2
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作者 Meng Meng Bo Hu +1 位作者 Shanzhi Chen Jianyin Zhang 《China Communications》 SCIE CSCD 2024年第2期227-244,共18页
Lower Earth Orbit(LEO) satellite becomes an important part of complementing terrestrial communication due to its lower orbital altitude and smaller propagation delay than Geostationary satellite. However, the LEO sate... Lower Earth Orbit(LEO) satellite becomes an important part of complementing terrestrial communication due to its lower orbital altitude and smaller propagation delay than Geostationary satellite. However, the LEO satellite communication system cannot meet the requirements of users when the satellite-terrestrial link is blocked by obstacles. To solve this problem, we introduce Intelligent reflect surface(IRS) for improving the achievable rate of terrestrial users in LEO satellite communication. We investigated joint IRS scheduling, user scheduling, power and bandwidth allocation(JIRPB) optimization algorithm for improving LEO satellite system throughput.The optimization problem of joint user scheduling and resource allocation is formulated as a non-convex optimization problem. To cope with this problem, the nonconvex optimization problem is divided into resource allocation optimization sub-problem and scheduling optimization sub-problem firstly. Second, we optimize the resource allocation sub-problem via alternating direction multiplier method(ADMM) and scheduling sub-problem via Lagrangian dual method repeatedly.Third, we prove that the proposed resource allocation algorithm based ADMM approaches sublinear convergence theoretically. Finally, we demonstrate that the proposed JIRPB optimization algorithm improves the LEO satellite communication system throughput. 展开更多
关键词 convex optimization intelligent reflecting surface LEO satellite communication OFDM
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Wellbore-heat-transfer-model-based optimization and control for cooling downhole drilling fluid 被引量:1
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作者 Chao Wang He Liu +3 位作者 Guo-Wei Yu Chen Yu Xian-Ming Liu Peng Huang 《Petroleum Science》 SCIE EI CAS CSCD 2024年第3期1955-1968,共14页
To address the two critical issues of evaluating the necessity of implementing cooling techniques and achieving real-time temperature control of drilling fluids underground in the current drilling fluid cooling techno... To address the two critical issues of evaluating the necessity of implementing cooling techniques and achieving real-time temperature control of drilling fluids underground in the current drilling fluid cooling technology,we first established a temperature and pressure coupled downhole heat transfer model,which can be used in both water-based and oil-based drilling fluid.Then,fourteen factors,which could affect wellbore temperature,were analyzed.Based on the standard deviation of the downhole temperature corresponding to each influencing factor,the influence of each factor was quantified.The influencing factors that can be used to guide the drilling fluid's cooling technology were drilling fluid thermal conductivity,drilling fluid heat capacity,drilling fluid density,drill strings rotation speed,pump rate,viscosity,ROP,and injection temperature.The nondominated sorting genetic algorithm was used to optimize these six parameters,but the optimization process took 182 min.Combining these eight parameters'influence rules with the nondominated sorting genetic algorithm can reduce the optimization time to 108 s.Theoretically,the downhole temperature has been demonstrated to increase with the inlet temperature increasing linearly under quasi-steady states.Combining this law and PID,the downhole temperature can be controlled,which can reduce the energy for cooling the surface drilling fluid and can ensure the downhole temperature reaches the set value as soon as possible. 展开更多
关键词 DRILLING COOLING Influencing factors Analysis optimization Control
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Towards the performance limit of catenary meta-optics via field-driven optimization 被引量:1
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作者 Siran Chen Yingli Ha +8 位作者 Fei Zhang Mingbo Pu Hanlin Bao Mingfeng Xu Yinghui Guo Yue Shen Xiaoliang Ma Xiong Li Xiangang Luo 《Opto-Electronic Advances》 SCIE EI CAS CSCD 2024年第5期33-42,共10页
Catenary optics enables metasurfaces with higher efficiency and wider bandwidth,and is highly anticipated in the imaging system,super-resolution lithography,and broadband absorbers.However,the periodic boundary approx... Catenary optics enables metasurfaces with higher efficiency and wider bandwidth,and is highly anticipated in the imaging system,super-resolution lithography,and broadband absorbers.However,the periodic boundary approximation without considering aperiodic electromagnetic crosstalk poses challenges for catenary optical devices to reach their performance limits.Here,perfect control of both local geometric and propagation phases is realized through field-driven optimization,in which the field distribution is calculated under real boundary conditions.Different from other optimization methods requiring a mass of iterations,the proposed design method requires less than ten iterations to get the efficiency close to the optimal value.Based on the library of shape-optimized catenary structures,centimeter-scale devices can be designed in ten seconds,with the performance improved by ~15%.Furthermore,this method has the ability to extend catenary-like continuous structures to arbitrary polarization,including both linear and elliptical polarizations,which is difficult to achieve with traditional design methods.It provides a way for the development of catenary optics and serves as a potent tool for constructing high-performance optical devices. 展开更多
关键词 catenary optics catenary structures field-driven optimization
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A FLEXIBLE OBJECTIVE-CONSTRAINT APPROACH AND A NEW ALGORITHM FOR CONSTRUCTING THE PARETO FRONT OF MULTIOBJECTIVE OPTIMIZATION PROBLEMS 被引量:1
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作者 N.HOSEINPOOR M.GHAZNAVI 《Acta Mathematica Scientia》 SCIE CSCD 2024年第2期702-720,共19页
In this article, a novel scalarization technique, called the improved objective-constraint approach, is introduced to find efficient solutions of a given multiobjective programming problem. The presented scalarized pr... In this article, a novel scalarization technique, called the improved objective-constraint approach, is introduced to find efficient solutions of a given multiobjective programming problem. The presented scalarized problem extends the objective-constraint problem. It is demonstrated that how adding variables to the scalarized problem, can lead to find conditions for (weakly, properly) Pareto optimal solutions. Applying the obtained necessary and sufficient conditions, two algorithms for generating the Pareto front approximation of bi-objective and three-objective programming problems are designed. These algorithms are easy to implement and can achieve an even approximation of (weakly, properly) Pareto optimal solutions. These algorithms can be generalized for optimization problems with more than three criterion functions, too. The effectiveness and capability of the algorithms are demonstrated in test problems. 展开更多
关键词 multiobjective optimization Pareto front SCALARIZATION objective-constraint approach proper efficient solution
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