Background Increased levels of inflammatory markers have been documented in various settings of coronary artery disease. The vulnerability of coronary lesions in acute myocardial infarction(AMI) at the time of onset m...Background Increased levels of inflammatory markers have been documented in various settings of coronary artery disease. The vulnerability of coronary lesions in acute myocardial infarction(AMI) at the time of onset may be related to serum levels of C reactive protein(CRP) on admission, before CRP levels are affected by myocardial damage.Objective This study assessed the predictive value of CRP levels within six hours after the onset of acute anterior myocardial infarction with primary percutaneous coronary intervention(PCI).Methods The plasma CRP of 76 patients with first acute anterior myocardial infarction was measured within 6 hours after onset. They were divided into 2 groups: group 1( n =20) with elevated CRP( ≥0.3mg/dl ) on admission within 6 hours after onset and group 2( n =56) with normal CRP( <0.3mg/dl ) within 6 hours after onset. All patients were treated by primary PCI. The primary combined end points, including death due to cardiac causes, re MI related to the infarction artery(RIA) and repeat intervention of the RIA, and the restenosis rate were assessed in relation to CRP levels within 6 hours after onset. Left ventricular end diastolic volume index(EDVI),end systolic volume index(ESVI),and ejection fraction(EF) on admission and 6 month after the onset were assessed by left ventriculography. Changes in EDVI(ΔEDVI),ESVI(ΔESVI), and EF(ΔEF) were obtained by subtracting respective on admission values from corresponding 6 month follow up values. Results There were no significant differences in baseline characteristics between the two groups. The primary combined end points were significantly more frequent in group 1(20%) than those in group 2( 1.79% , P <0.01 ).In addition, restenosis rates were significantly higher in group 1 than in group 2(41.18% vs 16.07%, P<0.05). Group 1 showed greater increases in left ventricular volume and less improvement in EF compared with group 2(ΔEDVI 6.31 ±2.17 vs 3.29 ±9.46ml/m 2 , ΔESVI 5.92 ±2.31 vs 3.86 ±1.08ml/m 2 , ΔEF 1.92 ±0.47 vs 4.79 ±1.73% , P <0.05 , respectively).Conclusions CRP levels within 6 hours after the onset of AMI might predict adverse outcome after primary PCI and progressive ventricular remodeling within 6 month of AMI.展开更多
Corona discharge is being detected by UV imaging detection technology at home and abroad in recent years.This technology is used in the corona tests of conductor bundles in this paper.In order to further research the ...Corona discharge is being detected by UV imaging detection technology at home and abroad in recent years.This technology is used in the corona tests of conductor bundles in this paper.In order to further research the corona characteristic,optimize geometry parameters and diameter of sub-conductor,and increase corona onset voltage of transmission lines,corona tests of three model conductors which are placed inside the outdoor corona cage are conducted.Corona cage could be used to simulate the corona activities on transmission lines under a low voltage and different conditions in an effective and economical way.Photon which was created by UV light as a result of corona discharge on conductors is detected by the UV detection apparatus.The photon number within unit interval,namely photon counting rate is adopted as the parameter of quantifying the intensity of corona discharge.According to the apparent change of photon number,corona onset voltage can be judged.All tests are conducted under almost same atmosphere condition.Using the method,corona onset voltage is acquired.The results indicate that the tests have a good repeatability,in other words,repeating same test twice same result can be aquired.The corona onset voltage can be acquired exactly from the curve of applied voltage vs.photon counting rate.Therefore UV detection apparatus can not only used to find discharge point exactly,but also applied on corona discharge research and live detection for power equipments.The method using in this paper is proved that is a new available method.展开更多
报告以脑积水起病的晚发型戊二酸血症1型(glutaric acidemia type 1,GA1)1例。患者女性,21岁,以急性脑积水为主要临床表现,头颅MRI示脑内大范围脑白质、双侧基底节区及小脑半球蚓部异常信号,双侧脑室扩张,双侧颞极蛛网膜囊肿。血尿有机...报告以脑积水起病的晚发型戊二酸血症1型(glutaric acidemia type 1,GA1)1例。患者女性,21岁,以急性脑积水为主要临床表现,头颅MRI示脑内大范围脑白质、双侧基底节区及小脑半球蚓部异常信号,双侧脑室扩张,双侧颞极蛛网膜囊肿。血尿有机酸分析检出大量戊二酸和3-羟基戊二酸,GCDH基因检测发现为复合杂合性突变(S119L和R355H),确诊为戊二酸血症1型,给予相关治疗后,症状缓解。可见临床上如遇上难以解释的脑积水,头部MRI示典型对称性病灶,包括小脑损害,应进行血尿有机酸筛查以除外代谢性疾病。展开更多
世界卫生组织(World Health Organization, WHO)强调通过健康促进、疾病预防和早诊早治以提升健康水平。由于疾病种类繁多、观点错杂,病机往往呈现为“多元化”的势态,尤其重大慢病、疑难重症、复合共病更是与复合体质状态密切关联,故...世界卫生组织(World Health Organization, WHO)强调通过健康促进、疾病预防和早诊早治以提升健康水平。由于疾病种类繁多、观点错杂,病机往往呈现为“多元化”的势态,尤其重大慢病、疑难重症、复合共病更是与复合体质状态密切关联,故而从“体病相关”切入探讨是突破疾病预测、预防以及治疗瓶颈的关键。基于多年的研究提出“五行十态体质”创新观点;遵循“天人相应”规律,将传统六十甲子周期理论运用于体质状态研究,综合考虑五运六气交互承制、天干地支本属系统、正化对化、天地二甲子、运气的平气状态等关键因素对人体五脏六腑功能的影响,运用传统“医算法”,依据“生克制化”“胜复郁发”“淫胜郁复”之气机升降特点,详细分析了基础体质与后天体质状态的关联;重视始生之时、疾病始发时、传变时、欲解时以及就诊时等不同节点的运气格局对人体的影响,以揭示体质特异性与相应系统疾病的易感性以及脏腑复合病机主、次标本的关系,预判健康状态与疾病不同阶段的病机、病势演变,为临床疾病的预测、预防、个体化干预以及群体化防治提供指导思路。展开更多
目的分析1990—2021年中国与全球早发女性乳腺癌的疾病负担、变化趋势及归因风险因素。方法从全球疾病负担(Global Burden of Disease,GBD)2021数据库提取1990—2021年中国与全球早发女性乳腺癌(诊断年龄<50岁)的发病、死亡和伤残调...目的分析1990—2021年中国与全球早发女性乳腺癌的疾病负担、变化趋势及归因风险因素。方法从全球疾病负担(Global Burden of Disease,GBD)2021数据库提取1990—2021年中国与全球早发女性乳腺癌(诊断年龄<50岁)的发病、死亡和伤残调整生命年(disability adjusted life years,DALYs)的绝对值和粗率,提取5种风险因素(吸烟、饮酒、低体力活动、高红肉饮食、高空腹血糖)和全部风险因素的DALYs归因占比数据。采用Joinpoint回归模型,以年度变化百分比(annual percentage change,APC)和平均年度变化百分比(average annual percentage change,AAPC)分析标化率的变化趋势。结果1990—2021年,中国和全球早发女性乳腺癌标化发病率均呈整体上升趋势(中国:AAPC=2.25%;全球:AAPC=0.64%;成对比较,P<0.001),标化死亡率(中国:AAPC=-0.82%;全球:AAPC=-0.26%;成对比较,P<0.001)和标化DALYs率(中国:AAPC=-0.63%;全球:AAPC=-0.18%;成对比较,P=0.004)均呈整体下降趋势。2021年中国和全球标化发病率分别为13.49/10万和13.61/10万,标化死亡率分别为1.99/10万和3.14/10万。中国标化死亡率(APC=0.78%)和标化DALYs率(APC=1.38%)分别在2014年和2015年呈逐渐上升趋势。2021年,中国(13.55%)与全球(11.20%)早发女性乳腺癌DALYs归因于高红肉饮食的比例均相对最高。结论中国早发女性乳腺癌标化发病率增长迅速,正向全球整体水平靠近,标化死亡率和标化DALYs率在近十余年均呈上升趋势,防治形势依然严峻。未来应进一步扩大乳腺癌筛查项目的推广范围,优化乳腺癌筛查方案,提高居民癌症防治知识水平,以减轻中国日益增长的早发女性乳腺癌疾病负担。展开更多
目的评估全球和中国早发性肺癌(诊断肺癌时患者年龄为15~49岁)疾病负担流行现状和主要风险因素。方法基于GLOBOCAN 2022数据集和全球疾病负担(Global Burden of Disease,GBD)2021数据集,按年龄、性别、地理位置和人类发展指数(human dev...目的评估全球和中国早发性肺癌(诊断肺癌时患者年龄为15~49岁)疾病负担流行现状和主要风险因素。方法基于GLOBOCAN 2022数据集和全球疾病负担(Global Burden of Disease,GBD)2021数据集,按年龄、性别、地理位置和人类发展指数(human development index,HDI)评估全球和中国早发性肺癌疾病负担和相关风险因素,主要观察指标为年龄标化发病率(age-standardized incidence rate,ASIR)、年龄标化死亡率(age-standardized mortality rate,ASMR)及伤残调整生命年(disability adjusted life years,DALYs)损失贡献率。结果2022年全球早发性肺癌新增病例137705例,死亡病例72646例,ASIR和ASMR分别为3.43/10万人和1.82/10万人,男性早发性肺癌疾病负担高于女性(ASIR:3.72/10万人比3.14/10万人,ASMR:2.31/10万人比1.33/10万人)。高HDI地区早发性肺癌的ASIR(5.51/10万人)和ASMR(2.57/10万人)高于其他水平HDI地区;健康不平等性分析发现,早发性肺癌疾病负担主要集中于高HDI地区。中国是全球早发性肺癌疾病负担最为严重的国家,2022年中国早发性肺癌新增和死亡病例分别占全球总数的48.69%和35.77%,ASIR和ASMR分别为8.21/10万人和3.17/10万人,男性早发性肺癌发病负担低于女性(ASIR:7.67/10万人比8.78/10万人),但死亡负担高于女性(ASMR:4.01/10万人比2.29/10万人)。吸烟和室外颗粒物污染是早发性肺癌最主要的风险因素,其DALYs损失贡献率在全球范围内分别为42.01%和15.62%,在中国分别为46.78%和20.84%。全球范围内,早发性肺癌的第三大风险因素为室内空气污染,在中国则为二手烟,室内空气污染降至第五位。不同年龄组中,早发性肺癌的风险因素构成存在明显差异,其中在15~24岁年龄组中,可控风险因素所致的疾病负担相对较低。结论早发性肺癌疾病负担在不同性别、区域和HDI水平之间呈现明显差异,中国的早发性肺癌负担较为严重。政策制订者应根据疾病负担差异,考虑公平分配卫生资源,并采取针对性干预措施,特别是在烟草控制和空气污染方面,应进一步采取措施控制吸烟率和降低空气污染,以提升癌症防治整体成效。展开更多
文摘Background Increased levels of inflammatory markers have been documented in various settings of coronary artery disease. The vulnerability of coronary lesions in acute myocardial infarction(AMI) at the time of onset may be related to serum levels of C reactive protein(CRP) on admission, before CRP levels are affected by myocardial damage.Objective This study assessed the predictive value of CRP levels within six hours after the onset of acute anterior myocardial infarction with primary percutaneous coronary intervention(PCI).Methods The plasma CRP of 76 patients with first acute anterior myocardial infarction was measured within 6 hours after onset. They were divided into 2 groups: group 1( n =20) with elevated CRP( ≥0.3mg/dl ) on admission within 6 hours after onset and group 2( n =56) with normal CRP( <0.3mg/dl ) within 6 hours after onset. All patients were treated by primary PCI. The primary combined end points, including death due to cardiac causes, re MI related to the infarction artery(RIA) and repeat intervention of the RIA, and the restenosis rate were assessed in relation to CRP levels within 6 hours after onset. Left ventricular end diastolic volume index(EDVI),end systolic volume index(ESVI),and ejection fraction(EF) on admission and 6 month after the onset were assessed by left ventriculography. Changes in EDVI(ΔEDVI),ESVI(ΔESVI), and EF(ΔEF) were obtained by subtracting respective on admission values from corresponding 6 month follow up values. Results There were no significant differences in baseline characteristics between the two groups. The primary combined end points were significantly more frequent in group 1(20%) than those in group 2( 1.79% , P <0.01 ).In addition, restenosis rates were significantly higher in group 1 than in group 2(41.18% vs 16.07%, P<0.05). Group 1 showed greater increases in left ventricular volume and less improvement in EF compared with group 2(ΔEDVI 6.31 ±2.17 vs 3.29 ±9.46ml/m 2 , ΔESVI 5.92 ±2.31 vs 3.86 ±1.08ml/m 2 , ΔEF 1.92 ±0.47 vs 4.79 ±1.73% , P <0.05 , respectively).Conclusions CRP levels within 6 hours after the onset of AMI might predict adverse outcome after primary PCI and progressive ventricular remodeling within 6 month of AMI.
基金Project Supported by UHV Transmission and Transformation System Development and Demonstration Program of National Key Tech-nology R&D Program(2006BAA02A04)
文摘Corona discharge is being detected by UV imaging detection technology at home and abroad in recent years.This technology is used in the corona tests of conductor bundles in this paper.In order to further research the corona characteristic,optimize geometry parameters and diameter of sub-conductor,and increase corona onset voltage of transmission lines,corona tests of three model conductors which are placed inside the outdoor corona cage are conducted.Corona cage could be used to simulate the corona activities on transmission lines under a low voltage and different conditions in an effective and economical way.Photon which was created by UV light as a result of corona discharge on conductors is detected by the UV detection apparatus.The photon number within unit interval,namely photon counting rate is adopted as the parameter of quantifying the intensity of corona discharge.According to the apparent change of photon number,corona onset voltage can be judged.All tests are conducted under almost same atmosphere condition.Using the method,corona onset voltage is acquired.The results indicate that the tests have a good repeatability,in other words,repeating same test twice same result can be aquired.The corona onset voltage can be acquired exactly from the curve of applied voltage vs.photon counting rate.Therefore UV detection apparatus can not only used to find discharge point exactly,but also applied on corona discharge research and live detection for power equipments.The method using in this paper is proved that is a new available method.
文摘报告以脑积水起病的晚发型戊二酸血症1型(glutaric acidemia type 1,GA1)1例。患者女性,21岁,以急性脑积水为主要临床表现,头颅MRI示脑内大范围脑白质、双侧基底节区及小脑半球蚓部异常信号,双侧脑室扩张,双侧颞极蛛网膜囊肿。血尿有机酸分析检出大量戊二酸和3-羟基戊二酸,GCDH基因检测发现为复合杂合性突变(S119L和R355H),确诊为戊二酸血症1型,给予相关治疗后,症状缓解。可见临床上如遇上难以解释的脑积水,头部MRI示典型对称性病灶,包括小脑损害,应进行血尿有机酸筛查以除外代谢性疾病。
文摘世界卫生组织(World Health Organization, WHO)强调通过健康促进、疾病预防和早诊早治以提升健康水平。由于疾病种类繁多、观点错杂,病机往往呈现为“多元化”的势态,尤其重大慢病、疑难重症、复合共病更是与复合体质状态密切关联,故而从“体病相关”切入探讨是突破疾病预测、预防以及治疗瓶颈的关键。基于多年的研究提出“五行十态体质”创新观点;遵循“天人相应”规律,将传统六十甲子周期理论运用于体质状态研究,综合考虑五运六气交互承制、天干地支本属系统、正化对化、天地二甲子、运气的平气状态等关键因素对人体五脏六腑功能的影响,运用传统“医算法”,依据“生克制化”“胜复郁发”“淫胜郁复”之气机升降特点,详细分析了基础体质与后天体质状态的关联;重视始生之时、疾病始发时、传变时、欲解时以及就诊时等不同节点的运气格局对人体的影响,以揭示体质特异性与相应系统疾病的易感性以及脏腑复合病机主、次标本的关系,预判健康状态与疾病不同阶段的病机、病势演变,为临床疾病的预测、预防、个体化干预以及群体化防治提供指导思路。
文摘目的评估全球和中国早发性肺癌(诊断肺癌时患者年龄为15~49岁)疾病负担流行现状和主要风险因素。方法基于GLOBOCAN 2022数据集和全球疾病负担(Global Burden of Disease,GBD)2021数据集,按年龄、性别、地理位置和人类发展指数(human development index,HDI)评估全球和中国早发性肺癌疾病负担和相关风险因素,主要观察指标为年龄标化发病率(age-standardized incidence rate,ASIR)、年龄标化死亡率(age-standardized mortality rate,ASMR)及伤残调整生命年(disability adjusted life years,DALYs)损失贡献率。结果2022年全球早发性肺癌新增病例137705例,死亡病例72646例,ASIR和ASMR分别为3.43/10万人和1.82/10万人,男性早发性肺癌疾病负担高于女性(ASIR:3.72/10万人比3.14/10万人,ASMR:2.31/10万人比1.33/10万人)。高HDI地区早发性肺癌的ASIR(5.51/10万人)和ASMR(2.57/10万人)高于其他水平HDI地区;健康不平等性分析发现,早发性肺癌疾病负担主要集中于高HDI地区。中国是全球早发性肺癌疾病负担最为严重的国家,2022年中国早发性肺癌新增和死亡病例分别占全球总数的48.69%和35.77%,ASIR和ASMR分别为8.21/10万人和3.17/10万人,男性早发性肺癌发病负担低于女性(ASIR:7.67/10万人比8.78/10万人),但死亡负担高于女性(ASMR:4.01/10万人比2.29/10万人)。吸烟和室外颗粒物污染是早发性肺癌最主要的风险因素,其DALYs损失贡献率在全球范围内分别为42.01%和15.62%,在中国分别为46.78%和20.84%。全球范围内,早发性肺癌的第三大风险因素为室内空气污染,在中国则为二手烟,室内空气污染降至第五位。不同年龄组中,早发性肺癌的风险因素构成存在明显差异,其中在15~24岁年龄组中,可控风险因素所致的疾病负担相对较低。结论早发性肺癌疾病负担在不同性别、区域和HDI水平之间呈现明显差异,中国的早发性肺癌负担较为严重。政策制订者应根据疾病负担差异,考虑公平分配卫生资源,并采取针对性干预措施,特别是在烟草控制和空气污染方面,应进一步采取措施控制吸烟率和降低空气污染,以提升癌症防治整体成效。
