原发性睾丸核蛋白中线癌(NUT中线癌)是伴有睾丸核蛋白(nuclear protein in testis,NUT)基因重排的一种极其罕见并具有高度侵袭性的恶性上皮细胞肿瘤,该肿瘤可发生于全身多个部位,以头颈部中线结构及纵隔多见,组织起源不明,缺乏特异性临...原发性睾丸核蛋白中线癌(NUT中线癌)是伴有睾丸核蛋白(nuclear protein in testis,NUT)基因重排的一种极其罕见并具有高度侵袭性的恶性上皮细胞肿瘤,该肿瘤可发生于全身多个部位,以头颈部中线结构及纵隔多见,组织起源不明,缺乏特异性临床表现,侵袭性强,恶性程度高,确诊时大多已属晚期,且缺乏有效治疗手段,预后极差。展开更多
目的 探讨睾丸核蛋白(nuclear protein in testis,NUT)癌的临床病理学特征、诊断及鉴别诊断。方法 收集10例NUT癌临床病理资料,采用免疫组化和FISH法对NUT癌进行检测,并复习相关文献。结果 10例NUT癌均发生于头颈部或肺脏,平均年龄35.7...目的 探讨睾丸核蛋白(nuclear protein in testis,NUT)癌的临床病理学特征、诊断及鉴别诊断。方法 收集10例NUT癌临床病理资料,采用免疫组化和FISH法对NUT癌进行检测,并复习相关文献。结果 10例NUT癌均发生于头颈部或肺脏,平均年龄35.7岁。组织学特点:8例为形态单一的圆形或卵圆形未分化肿瘤细胞,有少量或中等量淡粉染或透明胞质,典型者呈“煎蛋样”。肿瘤细胞呈巢团状或片状分布,浸润性生长。2例为未分化圆形肿瘤细胞伴突然的鳞状细胞分化。免疫表型:10例肿瘤细胞核NUT弥漫表达,9例表达p63和p40,部分病例亦表达CK5/6、CK7、CK8/18、MOC31、EMA、S-100和p16,8例p53为野生型,4例弥漫表达干细胞转录因子SOX-2。FISH检测4例有NUT基因重排。结论 NUT癌是一种罕见的高侵袭性恶性肿瘤,有独特的形态学特点、免疫表型及分子遗传学改变,应避免误诊。展开更多
A nonlinear finite element model of the nut post reinforced concrete （RC） structure of the safety mechanism in the Three Gorges Project （TGP） ship lift was built by ANSYS software. Some irregular structures such a...A nonlinear finite element model of the nut post reinforced concrete （RC） structure of the safety mechanism in the Three Gorges Project （TGP） ship lift was built by ANSYS software. Some irregular structures such as the nut post and the rotary rod were divided by curved surface into a series of regular parts, and the structures were all meshed to hexahedron. Constraint equations were defined between two interfaces with different element sizes and mesh patterns. PRETS179 elements were used to simulate the preload in the tendons and the pre-stressed screws, and the loss of prestressing force was calculated. Five extreme load cases were analyzed. The stress of each part in the structure was obtained. The results indicate that the maximum compressive stress of concrete C35 is 24.13 MPa, so the concrete may be partially crushed; the maximum tensile stress of the grouting motar is 6.73 MPa, so the grouting motar may partially fracture; the maximum yon Mises stress of the rotary rod is 648.70 MPa, therefore the rotary rod may partially yield.展开更多
文摘原发性睾丸核蛋白中线癌(NUT中线癌)是伴有睾丸核蛋白(nuclear protein in testis,NUT)基因重排的一种极其罕见并具有高度侵袭性的恶性上皮细胞肿瘤,该肿瘤可发生于全身多个部位,以头颈部中线结构及纵隔多见,组织起源不明,缺乏特异性临床表现,侵袭性强,恶性程度高,确诊时大多已属晚期,且缺乏有效治疗手段,预后极差。
文摘目的 探讨睾丸核蛋白(nuclear protein in testis,NUT)癌的临床病理学特征、诊断及鉴别诊断。方法 收集10例NUT癌临床病理资料,采用免疫组化和FISH法对NUT癌进行检测,并复习相关文献。结果 10例NUT癌均发生于头颈部或肺脏,平均年龄35.7岁。组织学特点:8例为形态单一的圆形或卵圆形未分化肿瘤细胞,有少量或中等量淡粉染或透明胞质,典型者呈“煎蛋样”。肿瘤细胞呈巢团状或片状分布,浸润性生长。2例为未分化圆形肿瘤细胞伴突然的鳞状细胞分化。免疫表型:10例肿瘤细胞核NUT弥漫表达,9例表达p63和p40,部分病例亦表达CK5/6、CK7、CK8/18、MOC31、EMA、S-100和p16,8例p53为野生型,4例弥漫表达干细胞转录因子SOX-2。FISH检测4例有NUT基因重排。结论 NUT癌是一种罕见的高侵袭性恶性肿瘤,有独特的形态学特点、免疫表型及分子遗传学改变,应避免误诊。
基金Project (SPKJ 016-06) supported by the Key Research Project of State Power CorporationProject (2004AC101D31) supported the Key Scientific Research Project of Hubei Province, China
文摘A nonlinear finite element model of the nut post reinforced concrete （RC） structure of the safety mechanism in the Three Gorges Project （TGP） ship lift was built by ANSYS software. Some irregular structures such as the nut post and the rotary rod were divided by curved surface into a series of regular parts, and the structures were all meshed to hexahedron. Constraint equations were defined between two interfaces with different element sizes and mesh patterns. PRETS179 elements were used to simulate the preload in the tendons and the pre-stressed screws, and the loss of prestressing force was calculated. Five extreme load cases were analyzed. The stress of each part in the structure was obtained. The results indicate that the maximum compressive stress of concrete C35 is 24.13 MPa, so the concrete may be partially crushed; the maximum tensile stress of the grouting motar is 6.73 MPa, so the grouting motar may partially fracture; the maximum yon Mises stress of the rotary rod is 648.70 MPa, therefore the rotary rod may partially yield.
