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Mitigation strategies for blasting-induced cracks and vibrations in twin-arch tunnel structures
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作者 Xianshun Zhou Jin Chen +4 位作者 Xuemin Zhang Kai Zhu Yanyong Zhang Jianbo Fei Muhammad Irslan Khalid 《Defence Technology(防务技术)》 2025年第7期242-259,共18页
Due to space constraints in mountainous areas,twin tunnels are sometimes constructed very close to each other or even overlap.This proximity challenges the structural stability of tunnels built with the drill-and-blas... Due to space constraints in mountainous areas,twin tunnels are sometimes constructed very close to each other or even overlap.This proximity challenges the structural stability of tunnels built with the drill-and-blast method,as the short propagation distance amplifies blasting vibrations.A case of blasting damage is reported in this paper,where concrete cracks crossed construction joints in the twin-arch lining.To identify the causes of these cracks and develop effective vibration mitigation measures,field monitoring and numerical analysis were conducted.Specifically,a restart method was used to simulate the second peak particle velocity(PPV)of MS3 delays occurring 50 ms after the MS1 delays.The study found that the dynamic tensile stress in the tunnel induced by the blast wave has a linear relationship with the of the product of the concrete wave impedance and the PPV.A blast vibration velocity exceeding 23.3 cm/s resulted in tensile stress in the lining surpassing the ultimate tensile strength of C30 concrete,leading to tensile cracking on the blast-facing arch of the constructed tunnel.To control excessive vi-bration velocity,a mitigation trench was implemented to reduce blast wave impact.The trench,approximately 15 m in length,50 cm in width,and 450 cm in height,effectively lowered vibration ve-locities,achieving an average reduction rate of 52%according to numerical analysis.A key innovation of this study is the on-site implementation and validation of the trench's effectiveness in mitigating vi-brations.A feasible trench construction configuration was proposed to overcome the limitations of a single trench in fully controlling vibrations.To further enhance protection,zoned blasting and an auxiliary rock pillar,80 cm in width,were incorporated to reinforce the mid-wall.This study introduces novel strategies for vibration protection in tunnel blasting,offering innovative solutions to address blasting-induced vibrations and effectively minimize their impact,thereby enhancing safety and struc-tural stability. 展开更多
关键词 Twin-arch tunnel Drill-and-blast Blasting vibration mitigation LS-DYNA Restart method
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Experimental investigation on weak shock wave mitigation characteristics of flexible polyurethane foam and polyurea 被引量:2
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作者 Shiyu Jia Cheng Wang +2 位作者 Wenlong Xu Dong Ma Fangfang Qi 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第1期179-191,共13页
In recent years,explosion shock wave has been considered as a signature injury of the current military conflicts.Although strong shock wave is lethal to the human body,weak shock wave can cause many more lasting conse... In recent years,explosion shock wave has been considered as a signature injury of the current military conflicts.Although strong shock wave is lethal to the human body,weak shock wave can cause many more lasting consequences.To investigate the protection ability and characteristics of flexible materials and structures under weak shock wave loading,the blast wave produced by TNT explosive is loaded on the polyurethane foam with the density of 200.0 kg/m3(F-200)and 400.0 kg/m3(F-400),polyurea with the density of 1100.0 kg/m^(3)(P-1100)and structures composed of the two materials,which are intended for individual protection.Experimental results indicate that the shock wave is attenuated to weak pressure disturbance after interacting with the flexible materials which are not damaged.The shock wave protective capability of single-layer materials is dependent on their thickness,density and microscopic characteristics.The overpressure,maximum pressure rise rate and impulse of transmitted wave decrease exponentially with increase in sample thickness.For the same thickness,F-400 provides better protective capability than F-200 while P-1100 shows the best protective capability among the three materials.In this study,as the materials are not destroyed,F-200 with a thickness more than10.0 mm,F-400 with a thickness more than 4.0 mm,and P-1100 with a thickness more than 1.0 mm can attenuate the overpressure amplitude more than 90.0%.Further,multi-layer flexible composites are designed.Different layer layouts of designed structures and layer thickness of the single-layer materials can affect the protective performance.Within the research range,the structure in which polyurea is placed on the impact side shows the optimal shock wave protective performance,and the thicknesses of polyurea and polyurethane foam are 1.0 mm and 4.0 mm respectively.The overpressure attenuation rate reached maximum value of 93.3%and impulse attenuation capacity of this structure are better than those of single-layer polyurea and polyurethane foam with higher areal density. 展开更多
关键词 Free-field explosion Weak shock wave mitigation POLYUREA Polyurethane foam Multi-layered composites
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An experimental study on shock wave mitigation capability of polyurea and shear thickening fluid based suspension pads 被引量:8
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作者 Andi Haris Heow Pueh Lee Vincent Beng Chye Tan 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2018年第1期12-18,共7页
The present experimental study investigates shock wave mitigation capability of potentially new personal protective equipment(PPE) suspension pads made from polyurea and shear thickening fluid(STF).The shock tube test... The present experimental study investigates shock wave mitigation capability of potentially new personal protective equipment(PPE) suspension pads made from polyurea and shear thickening fluid(STF).The shock tube test results show that when placed behind Twaron fabric systems with thickness ranging from 2 mm to 18 mm, the replacement of conventional flexible foam pad with STF and STF-infused foam pads with the same thickness of 20 mm greatly reduces the normalized peak pressure(by about 72% for each pad). However, this benefit is partially offset by a large increase in the normalized impulse(by about78% for the STF pad and 131% for the STF-infused foam pad) which may cause the shock wave mitigation performance of these two pads to become less effective. Interestingly, the use of 4 mm thick polyurea pad can greatly reduce the normalized peak pressure and impulse as well(by about 74% and 49%, respectively). These results reveal that among the potentially new suspension pads tested, the polyurea pad displays the best shock wave mitigation performance. Therefore, polyurea has potential for use as a suspension pad in personal protective equipment requiring shock wave mitigation capability such as fabric ballistic vests, bomb suits and combat helmets. 展开更多
关键词 Shock wave mitigation POLYUREA Shear THICKENING FLUID SUSPENSION pad Ballistic fabric Primary blast injuries
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GPS short-delay multipath estimation and mitigation based on least square method 被引量:6
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作者 Zhang Shengkang~(1,2),Wang Hongbo~(1,2),Yang Jun~(1,2) & He Leiming~(1,2) 1.Beijing Inst.of Radio Metrology and Measurement,Beijing 100854,P.R.China 2.National Key Laboratory of Metrology and Calibration Technology,Beijing 100854,P.R.China 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2009年第5期954-961,共8页
The GPS multipath signal model is presented, which indicates that the coherent DLL outputs in multipath environment are the convolution between the ideal DLL outputs and the channel responses. So the channel responses... The GPS multipath signal model is presented, which indicates that the coherent DLL outputs in multipath environment are the convolution between the ideal DLL outputs and the channel responses. So the channel responses can be estimated by a least square method using the observed curve of the DLL discriminator. In terms of the estimated multipath channels, two multipath mitigation methods are discussed, which are equalization filtering and multipath subtracting, respectively. It is shown, by computer simulation, that the least square method has a good performance in channels estimation and the multipath errors can be mitigated almost completely by either of the methods. However, the multipath subtracting method has relative small remnant errors than equalization filtering. 展开更多
关键词 global positioning system short-delay least square method multipath mitigation.
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Antenna planes based wall-clutter mitigation in through-wall-imaging applications 被引量:4
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作者 孙鑫 陆必应 +1 位作者 金添 周智敏 《Journal of Central South University》 SCIE EI CAS CSCD 2016年第10期2638-2646,共9页
In ultra-wideband through-wall-imaging applications, wall clutters are always much stronger than the target reflections, and they tend to persist over a long period of time. As a result, targets are obscured and not v... In ultra-wideband through-wall-imaging applications, wall clutters are always much stronger than the target reflections, and they tend to persist over a long period of time. As a result, targets are obscured and not visible in the image. In this work, an antenna planes-based wall clutter mitigation method was proposed. By using two imaging procedures in different scanning planes, this method can mitigate the wall clutter in both SAR and MIMO modes. The proposed method was tested using EM numerical data via the FDTD method. The processing results show that the imaging quality is improved significantly. 展开更多
关键词 through-the-wall wall-clutter mitigation SAR mode MIMO mode
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Application of IPv6 and NGN to the information network of earthquake preparedness and disaster mitigation 被引量:1
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作者 连尉平 刘举 +3 位作者 侯燕燕 刘小雨 邹锐 杨大克 《地震学报》 CSCD 北大核心 2008年第6期658-662,673,共5页
下一代网络(next generation network,缩写为NGN)是以高性能、可扩展、可运营、可管理、更安全的下一代电信网络为基础,实现高质量流媒体应用、无线和移动应用、多样化终端设备、按需的传输质量控制和更高安全保障的新型网络,IPv6... 下一代网络(next generation network,缩写为NGN)是以高性能、可扩展、可运营、可管理、更安全的下一代电信网络为基础,实现高质量流媒体应用、无线和移动应用、多样化终端设备、按需的传输质量控制和更高安全保障的新型网络,IPv6是下一代网络的关键支撑技术.IPv6网是下一代IP网,不等同于下一代网络,IPv6网只有在满足下一代网络的必要特征后才可成为下一代网络. 展开更多
关键词 防震减灾 下一代网络 IPV6
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Relative performance of novel blast wave mitigation system to conventional system based on mitigation percent criteria 被引量:3
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作者 Moustafa Esa Mostafa S.Amin Ahmed Hassan 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2021年第3期912-922,共11页
Recent researches focused on developing robust blast load mitigation systems due to the threats of terrorist attacks.One of the main embraced strategies is the structural systems that use mitigation techniques.They ar... Recent researches focused on developing robust blast load mitigation systems due to the threats of terrorist attacks.One of the main embraced strategies is the structural systems that use mitigation techniques.They are developed from a combination of structural elements and described herein as conventional systems.Among the promising techniques is that redirect the waves propagation through hollow tubes.The blast wave propagation through tubes provides an efficient system since it combines many blast wave phenomena,such as reflection,diffraction,and interaction.In this research,a novel blast load mitigation system,employed as a protection fence,is developed using a technique similar to the technique of the bent tube in manipulating the shock-wave.The relative performance of the novel system to the conventional system is evaluated based on mitigation percent criteria.Performances of both systems are calculated through numerical simulation.The proposed novel system proved to satisfy high performance in mitigating the generated blast waves from charges weight up to 500 kg TNT at relatively small standoff distances(5 m and 8 m).It mitigates at least 94%of the blast waves,which means that only 6%of that blast impulse is considered as the applied load on the targeted structure. 展开更多
关键词 Blast mitigation Blast barriers Protection system mitigation percent Protection evaluation
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Mitigation effects on the reflected overpressure of blast shock with water surrounding an explosive in a confined space 被引量:7
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作者 Hai-bin Xu Long-kui Chen +4 位作者 De-zhi Zhang Fang-ping Zhang Zhao-wu Shen Wen-xiang Liu Sheng-hong Huang 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2021年第3期1071-1080,共10页
The mitigation of blast shock with water has broad application prospects. Understanding the mitigation effects on the reflected overpressure of the explosion shock with water surrounding an explosive in a confined spa... The mitigation of blast shock with water has broad application prospects. Understanding the mitigation effects on the reflected overpressure of the explosion shock with water surrounding an explosive in a confined space is of great significance for military explosives safety applications. To estimate the effects of the parameters on the reflected overpressure of blasted shock wave, a series of experiments were carried out in confined containers with spherical explosives immersed in a certain thickness of water,and numerical simulations were conducted to explore the corresponding mechanisms. The results reveal that the reflected overpressure is abnormally aggravated at a small scaled distance. This aggravation is due to the high impulse of the bulk accelerated water shell converted from the explosion. With increasing scaled distance, the energy will be gradually dissipated. The mitigation effects will appear with the dispersed water phase front impacting at a larger scaled distance, except in the case of a dense water phase state. A critical scaled distance range of 0.7-0.8 m/kg^(1/3) for effective mitigation was found. It is suggested that the scaled distance of space walls should be larger than the critical value for a certain water-to-explosive weight ratio range(5-20). 展开更多
关键词 Shock Water mitigation Scaled distance Water-to-explosive weight ratio Confined container
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Core discing characteristics and mitigation approach by a novel developed drill bit in deep rocks 被引量:7
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作者 ZHENG Min-zong LI Shao-jun +3 位作者 YAO Zou ZHANG Ao-dong XU Ding-ping ZHOU Ji-fang 《Journal of Central South University》 SCIE EI CAS CSCD 2020年第10期2822-2833,共12页
Core discing often occurs in deep rocks under high-stress conditions and has been identified as an important characteristic for deep rock engineering.This paper presents the formation mechanism of core discing firstly... Core discing often occurs in deep rocks under high-stress conditions and has been identified as an important characteristic for deep rock engineering.This paper presents the formation mechanism of core discing firstly.Then,the interaction between diamond drill bits and rock was analyzed based on numerical modeling.A novel drill bit with an inner conical crown for the mitigation of core discing was designed and verified by simulation experiments.The mitigation method was applied in the cavern B1 of CJPL-Ⅱand satisfactory results had been achieved.The percentage of core discing had been obviously decreased from 67.8%when drilling with a rectangular crown drill bit,to 26.5%when an inner conical crown drill bit had been adopted.This paper gives full insight into core discing characteristics and provides a new method for core discing mitigation;it will potentially contribute to stress measurement in deep rock engineering. 展开更多
关键词 core discing mitigation drill bit crown deep rocks in-situ stress measurements
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Mitigation of blast loadings on structures by an anti-blast plastic water wall 被引量:5
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作者 张力 陈力 +1 位作者 方秦 张亚栋 《Journal of Central South University》 SCIE EI CAS CSCD 2016年第2期461-469,共9页
Seven in-situ tests were carried out in far field to study the blast mitigation effect of a kind of water filled plastic wall. Test results show that the mitigation effect of water filled plastic wall is remarkable. T... Seven in-situ tests were carried out in far field to study the blast mitigation effect of a kind of water filled plastic wall. Test results show that the mitigation effect of water filled plastic wall is remarkable. The maximum reduction of peak reflected overpressure reaches up to 94.53%, as well as 36.3% of the minimum peak reflected overpressure reduction in the scaled distance ranging from 1.71 m/kg1/3 to 3.42 m/kg1/3. Parametric studies were also carried out. The effects of the scaled gauge height, water/charge scaled distance(the distance between the explosive charge and the water wall), water wall scaled height and water/structure scaled distance(the distance between the water wall and the structure) were systematically investigated and compared with the usual rigid anti-blast wall. It is concluded that these parameters affect the mitigation effects of plastic water wall on blast loadings significantly, which is basically consistent to the trend of usual rigid anti-blast wall. Some formulae are also derived based on the numerical and test results, providing a simple but reliable prediction model to evaluate the peak overpressure of mitigated blast loadings on the structures. 展开更多
关键词 water wall blast mitigating effect protective technique prediction model
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Pre-processing filter design at transmitters for IBI mitigation in an OFDM system 被引量:1
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作者 Xia Wang Lei Wang 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2013年第5期722-728,共7页
In order to meet the demands for high transmission rates and high service quality in broadband wireless communication systems, orthogonal frequency division multiplexing (OFDM) has been adopted in some standards. Ho... In order to meet the demands for high transmission rates and high service quality in broadband wireless communication systems, orthogonal frequency division multiplexing (OFDM) has been adopted in some standards. However, the inter-block interference (IBI) and inter-carrier interference (ICI) in an OFDM system affect the performance. To mitigate IBI and ICI, some pre-processing approaches have been proposed based on full channel state information (CSI), which improved the system performance. A pre-processing filter based on partial CSI at the transmitter is designed and investigated. The filter coefficient is given by the optimization processing, the symbol error rate (SER) is tested, and the computation complexity of the proposed scheme is analyzed. Computer simulation results show that the proposed pre-processing filter can effectively mitigate IBI and ICI and the performance can be improved. Compared with pre-processing approaches at the transmitter based on full CSI, the proposed scheme has high spectral efficiency, limited CSI feedback and low computation complexity. 展开更多
关键词 pre-processing filter inter-block interference (IBI) mitigation limited feedback orthogonal frequency division multiplexing (OFDM).
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Shock wave mitigation using zig-zag structures and cylindrical obstructions 被引量:3
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作者 Arun Kumar R Vaibhav Pathak 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2021年第6期1840-1851,共12页
The present study focuses on the mitigation of shock wave using novel geometric passages in the flow field.The strategy is to produce multiple shock reflections and diffractions in the passage with minimum flow obstru... The present study focuses on the mitigation of shock wave using novel geometric passages in the flow field.The strategy is to produce multiple shock reflections and diffractions in the passage with minimum flow obstruction,which in turn is expected to reduce the shock wave strength at the target location.In the present study the interaction of a plane shock front(generated from a shock tube)with various geometric designs such as,1)zig-zag geometric passage,2)staggered cylindrical obstructions and 3)zigzag passage with cylindrical obstructions have been investigated using computational technique.It is seen from the numerical simulation that,among the various designs,the maximum shock attenuation is produced by the zig-zag passage with cylindrical obstructions which is then followed by zig-zag passage and staggered cylindrical obstructions.A comprehensive investigation on the shock wave reflection and diffraction phenomena happening in the proposed complex passages have also been carried out.In the new zig-zag design,the initial shock wave undergoes shock wave reflection and diffraction process which swaps alternatively as the shock front moves from one turn to the other turn.This cyclic shock reflection and diffraction process helps in diffusing the shock wave energy with practically no obstruction to the flow field.It is found that by combining the shock attenuation ability of zig-zag passage(using shock reflection and diffraction)with the shock attenuation ability of cylindrical blocks(by flow obstruction),a drastic attenuation in shock strength can be achieved with moderate level of flow blocking. 展开更多
关键词 Blast wave mitigation Blockage ratio Geometric obstructions Shock wave reflection and diffraction Zig-zag structure
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Multi-layer protective armour for underwater shock wave mitigation 被引量:2
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作者 Ahmed HAWASS Hosam MOSTAFA Ahmed ELBEIH 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2015年第4期338-343,共6页
The effect of underwater shock wave on different target plates has been studied.An underwater shock wave generator(shock tube) was used to study the interactions between water and different constructed targets which a... The effect of underwater shock wave on different target plates has been studied.An underwater shock wave generator(shock tube) was used to study the interactions between water and different constructed targets which act as shock wave mitigation.Target plates,composed of sandwich of two aluminum sheets with rubber and foam in between,were prepared and studied.For comparison,the target plates composed of triple aluminum sheets were tested.The study includes the testing of the selected plates in water under the effect of different peak pressures and the analysis of the results.The strain gauge data and displacement sensors results showed that the multi-layer plates have higher level of underwater shock wave mitigation than the triple aluminum plates with strain and deflection of nearly 50%. 展开更多
关键词 冲击波 水下 防护装甲 位移传感器 波发生器 相互作用 压力作用 目标板
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The properties of Sn-Zn-Al-La fusible alloy for mitigation devices of solid propellant rocket motors 被引量:2
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作者 Zi-ting Wei Nan Li +5 位作者 Jian-xin Nie Jia-hao Liang Xue-yong Guo Shi Yan Tao Zhang Qing-jie Jiao 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2022年第9期1688-1696,共9页
The Al and La elements are added to the Sn9Zn alloy to obtain the fusible alloy for the mitigation devices of solid propellant rocket motors. Differential scanning calorimetry(DSC), metallographic analysis,scanning el... The Al and La elements are added to the Sn9Zn alloy to obtain the fusible alloy for the mitigation devices of solid propellant rocket motors. Differential scanning calorimetry(DSC), metallographic analysis,scanning electron microscopy(SEM), energy dispersive spectroscopy(EDS), tensile testing and fracture analysis were used to study the effect of Al and La elements on the microstructure, melting characteristics, and mechanical properties of the Sn9Zn alloy. Whether the fusible diaphragm can effectively relieve pressure was investigated by the hydrostatic pressure at high-temperature test. Experimental results show that the melting point of the Sn9Zn-0.8Al0·2La and Sn9Zn-3Al0·2La fusible alloys can meet the predetermined working temperature of ventilation. The mechanical properties of those are more than 35% higher than that of the Sn9Zn alloy at-50°C-70°C, and the mechanical strength is reduced by 80% at 175°C. It is proven by the hydrostatic pressure at high-temperature test that the fusible diaphragm can relieve pressure effectively and can be used for the design of the mitigation devices of solid propellant rocket motors. 展开更多
关键词 mitigation devices Solid propellant rocket motors Sn9Zn Al element La element Hydrostatic pressure at high-temperature test
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Climate Change Mitigation and Adaptation in Agriculture
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作者 CHEN Zhuochun 《Journal of Northeast Agricultural University(English Edition)》 CAS 2009年第4期70-77,共8页
Mitigation and adaptation are two principle strategies for managing human-induced climate change. Agriculture plays a duet role in climate change. It has been a major source of greenhouse gases to the atmosphere. It i... Mitigation and adaptation are two principle strategies for managing human-induced climate change. Agriculture plays a duet role in climate change. It has been a major source of greenhouse gases to the atmosphere. It is also one of the sectors most vulnerable to the risks and impacts of global climate change. This paper first indentified the mitigative and adaptative options and potential in agriculture, then addressed the integrated analysis of mitigation and adaptation and its benefits for agriculture. Finally, it discussed the implications to Chinese agriculture in dealing with the global climate change. 展开更多
关键词 climate change mitigation and adaptation AGRICULTURE INTEGRATION
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Preliminary Study in Spatial Data Warehouse of Flood Control and Disaster Mitigation in Yangtze River Basin
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作者 ZHAN Xiao guoSenior engineer, Yangtze River Scientific Research Institute, Changjiang Water Resources Commission, Wuhan 430010, China 《人民长江》 北大核心 2002年第S1期90-92,共3页
Since 1990s,the spatial data warehouse technology has rapidly been developing, but due to the complexity of multi-dimensional analysis, extensive application of the spatial data warehouse technology is affected. In th... Since 1990s,the spatial data warehouse technology has rapidly been developing, but due to the complexity of multi-dimensional analysis, extensive application of the spatial data warehouse technology is affected. In the light of the characteristics of the flood control and disaster mitigation in the Yangtze river basin, it is proposed to design a scheme about the subjects and data distribution of the spatial data warehouse of the flood control and disaster mitigation in Yangtze river basin, i.e., to adopt a distributed scheme. The creation and development of the spatial data warehouse of the flood control and disaster mitigation in Yangtze river basin is presented .The necessity and urgency of establishing the spatial data warehouse is expounded from the viewpoint of the present situation being short of available information for the flood control and disaster mitigation in Yangtze river basin. 展开更多
关键词 spatial data WAREHOUSE distributional scheme FLOOD control and DISASTER mitigation YANGTZE RIVER
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IDMA based MAI mitigation scheme with low complexity and low latency
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作者 Zuoliang Yin Xingpeng Mao +1 位作者 Jun Cai Naitong Zhang 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2012年第6期791-801,共11页
High complexity and high latency are key problems for multiuser detection (MUD) to be applied to a mobile station in cellular networks. To tackle these problems, an interleave division multiple access (IDMA) based... High complexity and high latency are key problems for multiuser detection (MUD) to be applied to a mobile station in cellular networks. To tackle these problems, an interleave division multiple access (IDMA) based multiple access scheme, grouped spread IDMA (GSIDMA), is proposed. In a GSIDMA system, lower complexity and latency for mobile stations can be achieved by appropriately dividing active users into different groups. The system model of GSIDMA is constructed and followed by analysing on its system capacity, complexity and latency, and bit error rate (BER) performance. The extrinsic information transfer (EXIT) chart is used to analyze the convergence behavior of the iteration process. The grouping method and interleavers-reuse issue for GSIDMA are also discussed preliminarily. The analyses and simulation results indicate that the complexity and latency of the proposed scheme are much lower than those of IDMA, whereas its BER performance is close to the latter. The properties of low complexity and low latency make it more feasible for the practical implementation. 展开更多
关键词 grouped spread interleave division multiple access(GSIDMA) iterative multiuser detector (IMUD) low complexity lowlatency multiple access interference (MAI) mitigation.
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Combined OVX and Concurrent Mechanical Disuse Induced Osteocytes Morphological Alteration, and Mitigation by Mechanobiology and Sclerostin Antibody
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作者 Tony Zhang Yixian Qin 《医用生物力学》 EI CAS CSCD 北大核心 2019年第A01期29-29,共1页
Osteoporosis and osteopenia are major health issues that mainly affect elderly people,women after menopause and immobilized patients.Our previous studies have proved that sclerostin antibody(Scl-Ab)can dramatically en... Osteoporosis and osteopenia are major health issues that mainly affect elderly people,women after menopause and immobilized patients.Our previous studies have proved that sclerostin antibody(Scl-Ab)can dramatically enhance bone formation and reduce bone resorption in a severe osteoporosis rat model with the combination of ovariectomy(OVX)and hindlimb immobilization(HLS).However,the mechanism in the cellular level is unclear.The objective of this study is to assess the effect of Scl-Ab on osteocytic morphology change in a combined OVX and HLS rat model via quantification of long-and short-axis and the ratio and osteocyte volume in midshaft cortical bone.Four-month-old virgin female SD rats were divided into 7 groups(n=11 per group):Sham+Veh,Sham+HLS+Veh,Sham+HLS+Scl-Ab,OVX+Veh,OVX+Scl-Ab,OVX+HLS+Veh,OVX+HLS+Scl-Ab.HLS was performed 2 weeks after sham or OVX surgery;and treatment was initiated at the time of HLS.Scl-Ab(25 mg/kg)or vehicle was subcutaneously injected twice per week for 5 weeks.Femurs were harvested at the end of study and embedded in PMMA and polished for SEM imaging.Cortical bone mid shaft osteocyte number per bone area was quantified under 1K magnification;the ratios between long axis and short axis of osteocytes were quantified under 2K magnification;osteocyte dendrite number and surface area were quantified under 5K magnification.Osteocyte dendrites width was quantified using 10K magnification.All the quantification was done by ImageJ.We have reported that multiple morphological and structural changes in osteocytes,including a decreased osteocyte density and reduced osteocyte dendrite number in HLS,OVX or the combination group and Scl-Ab’s ability to abolish these unfavorable alterations.We continued our SEM analysis on osteocytes and discovered that the oval shape of osteocyte under HLS,OVX or HLS+OVX has been distorted toward a spindle-like shape,with relatively longer long axis and shorter short axis,assuming osteocyte has a perfect spheroid shape.The ratio between long-and short-axis showed an increased trend in OVX and HLS condition,but Scl-Ab inhibited these increases(P<0.001,P<0.01,respectively).The volume decreased in HLS,OVX group,but Scl-Ab maintained osteocytes’volume in HLS condition(P<0.001).It indicates that cortical bone responds to HLS and/or OVX and Scl-Ab treatment via multiple cellular mechanisms,including density of osteocyte,dendrite number and osteocyte shape.The change of osteocyte shape may imply an altered cytoskeleton system within osteocyte and a subsequent disruption of mechanosensing ability for osteocyte,which lead to bone loss macroscopically.These data suggest Scl-Ab’s therapeutic potential could be related with its ability to maintain osteocyte’s morphologic and structural changes induced by OVX,HLS or both. 展开更多
关键词 OVX HLS mitigation by MECHANOBIOLOGY SCLEROSTIN Antibody SCLEROSTIN Combined OVX and Concurrent Mechanical DISUSE Induced OSTEOCYTES Morphological ALTERATION
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SYNERGETIC MITIGATION OF THE RAYLEIGH-TAYLORINSTABILITY BY SHEAR AXIAL FLOWS ANDFINITE LARMOR RADIUS
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作者 HUANG Lin, QIU Xiaoming, JIAN Guangde(Southwestern Institute of Physics, Chengdu 610041) 《核聚变与等离子体物理》 CAS CSCD 北大核心 2003年第2期77-83,共7页
A hybrid model of MHD and kinetic theory is proposed to investigate the synergetic stabilizing effects of sheared axial flow and finite Larmor radius on the RayleighTaylor instability in Zpinch implosions.In our m... A hybrid model of MHD and kinetic theory is proposed to investigate the synergetic stabilizing effects of sheared axial flow and finite Larmor radius on the RayleighTaylor instability in Zpinch implosions.In our model the MHD plasma is considered to respond to a perturbation with exp at frequency ω+ik2⊥ρ2iΩi instead of frequency ω,where k2⊥ρ2i is the finite Larmor radius effects given from the general kinetic theory of magnetized plasma.Therefore linearized continuity and momentum equations include automatically the finite Larmor radius effects.Dispersion relation is derived,which includes the effects of a density discontinuity and the finite Larmor radius as well as a sheared flow that produces the KelvinHelmholtz instability.The dispersion equation is examined in three cases.The results indicate that the synergetic effect of sheared axial flow and the finite Larmor radius can mitigate both the RayleighTaylor instability and the hybrid RayleighTaylor/KelvinHelmholtz instability.Moreover,the synergetic mitigation effect is stronger than either of them acting separately. 展开更多
关键词 等离子体物理 不稳定性 协同缓和效应 有限拉莫尔辐射 散射方程 Z-箍缩 剪切层流动
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气候变化带来的健康风险与感染防控面临的挑战 被引量:3
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作者 叶青 王秋红 吴安华 《中国感染控制杂志》 北大核心 2025年第2期149-157,共9页
气候变化问题是21世纪倍受全球关注的焦点。本文系统梳理了气候变化对人类健康的直接和间接影响,包括以灾害的形式直接造成人体死亡和伤残,以及通过温湿度变化、空气污染、病媒生物地理分布范围改变等途径增加慢性非传染性疾病、感染性... 气候变化问题是21世纪倍受全球关注的焦点。本文系统梳理了气候变化对人类健康的直接和间接影响,包括以灾害的形式直接造成人体死亡和伤残,以及通过温湿度变化、空气污染、病媒生物地理分布范围改变等途径增加慢性非传染性疾病、感染性疾病、精神心理问题、过敏性疾病和营养不良等气候敏感性疾病发病风险。在此基础上,根据全球治理格局背景下医疗机构的应对框架,本文聚焦于医疗机构感染预防与控制领域面临的挑战,从五个方面深入探讨感染预防与控制应对策略,以期为进一步增强医疗系统的气候韧性,保障公众健康提供参考和借鉴。 展开更多
关键词 气候变化 健康风险 感染预防与控制 气候韧性 缓解行动
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