Social interaction with peer pressure is widely studied in social network analysis.Game theory can be utilized to model dynamic social interaction,and one class of game network models assumes that people’s decision p...Social interaction with peer pressure is widely studied in social network analysis.Game theory can be utilized to model dynamic social interaction,and one class of game network models assumes that people’s decision payoff functions hinge on individual covariates and the choices of their friends.However,peer pressure would be misidentified and induce a non-negligible bias when incomplete covariates are involved in the game model.For this reason,we develop a generalized constant peer effects model based on homogeneity structure in dynamic social networks.The new model can effectively avoid bias through homogeneity pursuit and can be applied to a wider range of scenarios.To estimate peer pressure in the model,we first present two algorithms based on the initialize expand merge method and the polynomial-time twostage method to estimate homogeneity parameters.Then we apply the nested pseudo-likelihood method and obtain consistent estimators of peer pressure.Simulation evaluations show that our proposed methodology can achieve desirable and effective results in terms of the community misclassification rate and parameter estimation error.We also illustrate the advantages of our model in the empirical analysis when compared with a benchmark model.展开更多
Multi-agent systems often require good interoperability in the process of completing their assigned tasks.This paper first models the static structure and dynamic behavior of multiagent systems based on layered weight...Multi-agent systems often require good interoperability in the process of completing their assigned tasks.This paper first models the static structure and dynamic behavior of multiagent systems based on layered weighted scale-free community network and susceptible-infected-recovered(SIR)model.To solve the problem of difficulty in describing the changes in the structure and collaboration mode of the system under external factors,a two-dimensional Monte Carlo method and an improved dynamic Bayesian network are used to simulate the impact of external environmental factors on multi-agent systems.A collaborative information flow path optimization algorithm for agents under environmental factors is designed based on the Dijkstra algorithm.A method for evaluating system interoperability is designed based on simulation experiments,providing reference for the construction planning and optimization of organizational application of the system.Finally,the feasibility of the method is verified through case studies.展开更多
Delay aware routing is now widely used to provide efficient network transmission. However, for newly developing or developed mobile communication networks(MCN), only limited delay data can be obtained. In such a netwo...Delay aware routing is now widely used to provide efficient network transmission. However, for newly developing or developed mobile communication networks(MCN), only limited delay data can be obtained. In such a network, the delay is with epistemic uncertainty, which makes the traditional routing scheme based on deterministic theory or probability theory not applicable. Motivated by this problem, the MCN with epistemic uncertainty is first summarized as a dynamic uncertain network based on uncertainty theory, which is widely applied to model epistemic uncertainties. Then by modeling the uncertain end-toend delay, a new delay bounded routing scheme is proposed to find the path with the maximum belief degree that satisfies the delay threshold for the dynamic uncertain network. Finally, a lowEarth-orbit satellite communication network(LEO-SCN) is used as a case to verify the effectiveness of our routing scheme. It is first modeled as a dynamic uncertain network, and then the delay bounded paths with the maximum belief degree are computed and compared under different delay thresholds.展开更多
Accurate 3-D fracture network model for rock mass in dam foundation is of vital importance for stability,grouting and seepage analysis of dam foundation.With the aim of reducing deviation between fracture network mode...Accurate 3-D fracture network model for rock mass in dam foundation is of vital importance for stability,grouting and seepage analysis of dam foundation.With the aim of reducing deviation between fracture network model and measured data,a 3-D fracture network dynamic modeling method based on error analysis was proposed.Firstly,errors of four fracture volume density estimation methods(proposed by ODA,KULATILAKE,MAULDON,and SONG)and that of four fracture size estimation methods(proposed by EINSTEIN,SONG and TONON)were respectively compared,and the optimal methods were determined.Additionally,error index representing the deviation between fracture network model and measured data was established with integrated use of fractal dimension and relative absolute error(RAE).On this basis,the downhill simplex method was used to build the dynamic modeling method,which takes the minimum of error index as objective function and dynamically adjusts the fracture density and size parameters to correct the error index.Finally,the 3-D fracture network model could be obtained which meets the requirements.The proposed method was applied for 3-D fractures simulation in Miao Wei hydropower project in China for feasibility verification and the error index reduced from 2.618 to 0.337.展开更多
This paper proposes second-order consensus protocols with time-delays and gives the measure of the robustness of the protocols to the time-delay existing in the network of agents with second-order dynamics. By employi...This paper proposes second-order consensus protocols with time-delays and gives the measure of the robustness of the protocols to the time-delay existing in the network of agents with second-order dynamics. By employing a frequency domain method, it is proven that the information states and their time derivatives of all the agents in the network achieve consensus asymptotically, respectively, for appropriate communication timedelay if the topology of weighted network is connected. Particularly, a tight upper bound on the communication time-delay that can be tolerated in the dynamic network is found. The consensus protocols are distributed in the sense that each agent only needs information from its neighboring agents, which reduces the complexity of connections between neighboring agents significantly. Numerical simulation results are provided to demonstrate the effectiveness and the sharpness of the theoretical results for second-order consensus in networks in the presence of communication time-delays.展开更多
An adaptive multi-QoS routing algorithm called AMQRA is proposed for dynamic topology networks, such as satellite networks and Ad-hoc networks. The AMQRA is a distributed and mobile-agents-based routing algorithm, whi...An adaptive multi-QoS routing algorithm called AMQRA is proposed for dynamic topology networks, such as satellite networks and Ad-hoc networks. The AMQRA is a distributed and mobile-agents-based routing algorithm, which combines ant quantity system （AQS） with ant colony optimization （ACO） that is used in AntNet routing algorithm. In dynamic topology networks, the AMQRA achieves timely optimization for concave metric QoS constraint and fast convergence. The proposed routing algorithm is simulated in Iridium satellite constellation on OPNET. The results show that AMQRA not only outperforms the AntNet in convergence rate in dynamic topology networks but also can optimize concave metric QoS constraint and reasonably allot bandwidth to the load to avoid networks congestion.展开更多
The manner and conditions of running the decision-making system with self-defense electronic jamming are given. After proposing the scenario of applying discrete dynamic Bayesian network to the decision making with se...The manner and conditions of running the decision-making system with self-defense electronic jamming are given. After proposing the scenario of applying discrete dynamic Bayesian network to the decision making with self-defense electronic jamming, a decision-making model with self-defense electronic jamming based on the discrete dynamic Bayesian network is established. Then jamming decision inferences by the aid of the algorithm of discrete dynamic Bayesian network are carried on. The simulating result shows that this method is able to synthesize different targets which are not predominant. In this way, various features at the same time, as well as the same feature appearing at different time complement mutually; in addition, the accuracy and reliability of electronic jamming decision making are enhanced significantly.展开更多
The accuracy of target threat estimation has a great impact on command decision-making.The Bayesian network,as an effective way to deal with the problem of uncertainty,can be used to track the change of the target thr...The accuracy of target threat estimation has a great impact on command decision-making.The Bayesian network,as an effective way to deal with the problem of uncertainty,can be used to track the change of the target threat level.Unfortunately,the traditional discrete dynamic Bayesian network(DDBN)has the problems of poor parameter learning and poor reasoning accuracy in a small sample environment with partial prior information missing.Considering the finiteness and discreteness of DDBN parameters,a fuzzy k-nearest neighbor(KNN)algorithm based on correlation of feature quantities(CF-FKNN)is proposed for DDBN parameter learning.Firstly,the correlation between feature quantities is calculated,and then the KNN algorithm with fuzzy weight is introduced to fill the missing data.On this basis,a reasonable DDBN structure is constructed by using expert experience to complete DDBN parameter learning and reasoning.Simulation results show that the CF-FKNN algorithm can accurately fill in the data when the samples are seriously missing,and improve the effect of DDBN parameter learning in the case of serious sample missing.With the proposed method,the final target threat assessment results are reasonable,which meets the needs of engineering applications.展开更多
The online diagnosis for aircraft system has always been a difficult problem. This is due to time evolution of system change, uncertainty of sensor measurements, and real-time requirement of diagnostic inference. To a...The online diagnosis for aircraft system has always been a difficult problem. This is due to time evolution of system change, uncertainty of sensor measurements, and real-time requirement of diagnostic inference. To address this problem, two dynamic Bayesian network(DBN) approaches are proposed. One approach prunes the DBN of system, and then uses particle filter(PF) for this pruned DBN(PDBN) to perform online diagnosis. The problem is that estimates from a PF tend to have high variance for small sample sets. Using large sample sets is computationally expensive. The other approach compiles the PDBN into a dynamic arithmetic circuit(DAC) using an offline procedure that is applied only once, and then uses this circuit to provide online diagnosis recursively. This approach leads to the most computational consumption in the offline procedure. The experimental results show that the DAC, compared with the PF for PDBN, not only provides more reliable online diagnosis, but also offers much faster inference.展开更多
This paper studies the global fixed time synchronization of complex dynamical network,including non-identical nodes with disturbances and uncertainties as well as input nonlinearity.First,a novel fixed time sliding ma...This paper studies the global fixed time synchronization of complex dynamical network,including non-identical nodes with disturbances and uncertainties as well as input nonlinearity.First,a novel fixed time sliding manifold is constructed to achieve the fixed time synchronization of complex dynamical network with disturbances and uncertainties.Second,a novel sliding mode controller is proposed to realize the global fixed time reachability of sliding surfaces.The outstanding feature of the designed control is that the fixed convergence time of both reaching and sliding modes can be adjusted to the desired values in advance by choosing the explicit parameters in the controller,which does not rest upon the initial conditions and the topology of the network.Finally,the effectiveness and validity of the obtained results are demonstrated by corresponding numerical simulations.展开更多
The dynamic wireless communication network is a complex network that needs to consider various influence factors including communication devices,radio propagation,network topology,and dynamic behaviors.Existing works ...The dynamic wireless communication network is a complex network that needs to consider various influence factors including communication devices,radio propagation,network topology,and dynamic behaviors.Existing works focus on suggesting simplified reliability analysis methods for these dynamic networks.As one of the most popular modeling methodologies,the dynamic Bayesian network(DBN)is proposed.However,it is insufficient for the wireless communication network which contains temporal and non-temporal events.To this end,we present a modeling methodology for a generalized continuous time Bayesian network(CTBN)with a 2-state conditional probability table(CPT).Moreover,a comprehensive reliability analysis method for communication devices and radio propagation is suggested.The proposed methodology is verified by a reliability analysis of a real wireless communication network.展开更多
Based on consideration of the differential relations between the immeasurable variables and measurable variables in electro-hydraulic servo system,adaptive dynamic recurrent fuzzy neural networks(ADRFNNs) were employe...Based on consideration of the differential relations between the immeasurable variables and measurable variables in electro-hydraulic servo system,adaptive dynamic recurrent fuzzy neural networks(ADRFNNs) were employed to identify the primary uncertainty and the mathematic model of the system was turned into an equivalent linear model with terms of secondary uncertainty.At the same time,gain adaptive sliding mode variable structure control(GASMVSC) was employed to synthesize the control effort.The results show that the unrealization problem caused by some system's immeasurable state variables in traditional fuzzy neural networks(TFNN) taking all state variables as its inputs is overcome.On the other hand,the identification by the ADRFNNs online with high accuracy and the adaptive function of the correction term's gain in the GASMVSC make the system possess strong robustness and improved steady accuracy,and the chattering phenomenon of the control effort is also suppressed effectively.展开更多
OBJECTIVE To investigate the characteristics and regulations of medication in different stages of disease by constructing a dynamic disease network and a cellular feature network spanning from myocardial infarction to...OBJECTIVE To investigate the characteristics and regulations of medication in different stages of disease by constructing a dynamic disease network and a cellular feature network spanning from myocardial infarction to heart failure.METHODS Based on transcrip⁃tome and single-cell sequencing data from a mouse model of left anterior descending coro⁃nary artery ligation,a dynamic early-middle-late network and cellular feature network were con⁃structed by integrating differential gene expres⁃sion trends and biological functions.The robust⁃ness of the perturbation effect of traditional Chi⁃nese medicine(TCM)on the disease network was calculated based on multi-target TCM,and we acquired the foundational data by analyzing the results of effectiveness.The predictive plat⁃form was scrutinized and assessed with regards to the functional attributes of FDA approveddrugs and compound prescriptions,in order to determine the primary stages of intervention and the drug patterns actions in the progression of heart failure.RESULTS In this study,we devel⁃oped a prediction and analysis platform for assessing the efficacy of drugs using a networkbased approach.The accuracy of the system was validated by FDA approved-drugs.It was found that blood-activating drugs,heat-clearing drugs,and phlegm-expelling drugs exhibited favorable intervention effects during the early to middle stages of the disease by investigating the effects of single herbs and TCM prescriptions on disease progression.Similarly,phlegm-expelling drugs,spirit-nourishing drugs,and diuretic showed better intervention effects during the mid⁃dle to late stages.These findings were consis⁃tent with the clinical use of drugs.Analysis of the clustering heatmap results of TCM prescriptions revealed that the formulas aimed at qi stagnation and blood stasis had a strong effect in early stage,while the formulas for qi and yin deficiency and cardiorenal yang deficiency had a strong effect in the middle to late stages.Furthermore,analysis of the single-cell feature network demon⁃strated that TCM had advantages in modulating the changes in fibroblasts,myofibroblasts,endo⁃thelial cells,and granulocytes during the patho⁃logical process.Additionally,most prescriptions exhibited strong perturbation effects on the fea⁃ture network of NK-T cells,granulocytes,macro⁃phages,and myofibroblasts.CONCLUSION This platform quantitatively evaluates the primary action stages and characteristics of TCM and for⁃mulas involved in the dynamic process of myo⁃cardial infarction to heart failure based on the effective prediction of the efficacy of TCM and FDA approved-drugs.It provides reference for the precise clinical application of TCM and formu⁃las with multiple targets and multiple pathways.展开更多
基金supported by the National Nature Science Foundation of China(71771201,72531009,71973001)the USTC Research Funds of the Double First-Class Initiative(FSSF-A-240202).
文摘Social interaction with peer pressure is widely studied in social network analysis.Game theory can be utilized to model dynamic social interaction,and one class of game network models assumes that people’s decision payoff functions hinge on individual covariates and the choices of their friends.However,peer pressure would be misidentified and induce a non-negligible bias when incomplete covariates are involved in the game model.For this reason,we develop a generalized constant peer effects model based on homogeneity structure in dynamic social networks.The new model can effectively avoid bias through homogeneity pursuit and can be applied to a wider range of scenarios.To estimate peer pressure in the model,we first present two algorithms based on the initialize expand merge method and the polynomial-time twostage method to estimate homogeneity parameters.Then we apply the nested pseudo-likelihood method and obtain consistent estimators of peer pressure.Simulation evaluations show that our proposed methodology can achieve desirable and effective results in terms of the community misclassification rate and parameter estimation error.We also illustrate the advantages of our model in the empirical analysis when compared with a benchmark model.
基金supported by the Key R&D Projects in Jiangsu Province(BE2021729)the Key Primary Research Project of Primary Strengthening Program(KYZYJKKCJC23001).
文摘Multi-agent systems often require good interoperability in the process of completing their assigned tasks.This paper first models the static structure and dynamic behavior of multiagent systems based on layered weighted scale-free community network and susceptible-infected-recovered(SIR)model.To solve the problem of difficulty in describing the changes in the structure and collaboration mode of the system under external factors,a two-dimensional Monte Carlo method and an improved dynamic Bayesian network are used to simulate the impact of external environmental factors on multi-agent systems.A collaborative information flow path optimization algorithm for agents under environmental factors is designed based on the Dijkstra algorithm.A method for evaluating system interoperability is designed based on simulation experiments,providing reference for the construction planning and optimization of organizational application of the system.Finally,the feasibility of the method is verified through case studies.
基金National Natural Science Foundation of China (61773044,62073009)National key Laboratory of Science and Technology on Reliability and Environmental Engineering(WDZC2019601A301)。
文摘Delay aware routing is now widely used to provide efficient network transmission. However, for newly developing or developed mobile communication networks(MCN), only limited delay data can be obtained. In such a network, the delay is with epistemic uncertainty, which makes the traditional routing scheme based on deterministic theory or probability theory not applicable. Motivated by this problem, the MCN with epistemic uncertainty is first summarized as a dynamic uncertain network based on uncertainty theory, which is widely applied to model epistemic uncertainties. Then by modeling the uncertain end-toend delay, a new delay bounded routing scheme is proposed to find the path with the maximum belief degree that satisfies the delay threshold for the dynamic uncertain network. Finally, a lowEarth-orbit satellite communication network(LEO-SCN) is used as a case to verify the effectiveness of our routing scheme. It is first modeled as a dynamic uncertain network, and then the delay bounded paths with the maximum belief degree are computed and compared under different delay thresholds.
基金Project(51321065)supported by the Innovative Research Groups of the National Natural Science Foundation of ChinaProject(2013CB035904)supported by the National Basic Research Program of China(973 Program)Project(51439005)supported by the National Natural Science Foundation of China
文摘Accurate 3-D fracture network model for rock mass in dam foundation is of vital importance for stability,grouting and seepage analysis of dam foundation.With the aim of reducing deviation between fracture network model and measured data,a 3-D fracture network dynamic modeling method based on error analysis was proposed.Firstly,errors of four fracture volume density estimation methods(proposed by ODA,KULATILAKE,MAULDON,and SONG)and that of four fracture size estimation methods(proposed by EINSTEIN,SONG and TONON)were respectively compared,and the optimal methods were determined.Additionally,error index representing the deviation between fracture network model and measured data was established with integrated use of fractal dimension and relative absolute error(RAE).On this basis,the downhill simplex method was used to build the dynamic modeling method,which takes the minimum of error index as objective function and dynamically adjusts the fracture density and size parameters to correct the error index.Finally,the 3-D fracture network model could be obtained which meets the requirements.The proposed method was applied for 3-D fractures simulation in Miao Wei hydropower project in China for feasibility verification and the error index reduced from 2.618 to 0.337.
基金supported by the National Natural Science Foundation of China (6057408860274014)
文摘This paper proposes second-order consensus protocols with time-delays and gives the measure of the robustness of the protocols to the time-delay existing in the network of agents with second-order dynamics. By employing a frequency domain method, it is proven that the information states and their time derivatives of all the agents in the network achieve consensus asymptotically, respectively, for appropriate communication timedelay if the topology of weighted network is connected. Particularly, a tight upper bound on the communication time-delay that can be tolerated in the dynamic network is found. The consensus protocols are distributed in the sense that each agent only needs information from its neighboring agents, which reduces the complexity of connections between neighboring agents significantly. Numerical simulation results are provided to demonstrate the effectiveness and the sharpness of the theoretical results for second-order consensus in networks in the presence of communication time-delays.
基金the National Natural Science Foundation of China (60532030)
文摘An adaptive multi-QoS routing algorithm called AMQRA is proposed for dynamic topology networks, such as satellite networks and Ad-hoc networks. The AMQRA is a distributed and mobile-agents-based routing algorithm, which combines ant quantity system （AQS） with ant colony optimization （ACO） that is used in AntNet routing algorithm. In dynamic topology networks, the AMQRA achieves timely optimization for concave metric QoS constraint and fast convergence. The proposed routing algorithm is simulated in Iridium satellite constellation on OPNET. The results show that AMQRA not only outperforms the AntNet in convergence rate in dynamic topology networks but also can optimize concave metric QoS constraint and reasonably allot bandwidth to the load to avoid networks congestion.
基金the National Natural Science Fundation of China (10377014).
文摘The manner and conditions of running the decision-making system with self-defense electronic jamming are given. After proposing the scenario of applying discrete dynamic Bayesian network to the decision making with self-defense electronic jamming, a decision-making model with self-defense electronic jamming based on the discrete dynamic Bayesian network is established. Then jamming decision inferences by the aid of the algorithm of discrete dynamic Bayesian network are carried on. The simulating result shows that this method is able to synthesize different targets which are not predominant. In this way, various features at the same time, as well as the same feature appearing at different time complement mutually; in addition, the accuracy and reliability of electronic jamming decision making are enhanced significantly.
基金supported by the Fundamental Scientific Research Business Expenses for Central Universities(3072021CFJ0803)the Advanced Marine Communication and Information Technology Ministry of Industry and Information Technology Key Laboratory Project(AMCIT21V3).
文摘The accuracy of target threat estimation has a great impact on command decision-making.The Bayesian network,as an effective way to deal with the problem of uncertainty,can be used to track the change of the target threat level.Unfortunately,the traditional discrete dynamic Bayesian network(DDBN)has the problems of poor parameter learning and poor reasoning accuracy in a small sample environment with partial prior information missing.Considering the finiteness and discreteness of DDBN parameters,a fuzzy k-nearest neighbor(KNN)algorithm based on correlation of feature quantities(CF-FKNN)is proposed for DDBN parameter learning.Firstly,the correlation between feature quantities is calculated,and then the KNN algorithm with fuzzy weight is introduced to fill the missing data.On this basis,a reasonable DDBN structure is constructed by using expert experience to complete DDBN parameter learning and reasoning.Simulation results show that the CF-FKNN algorithm can accurately fill in the data when the samples are seriously missing,and improve the effect of DDBN parameter learning in the case of serious sample missing.With the proposed method,the final target threat assessment results are reasonable,which meets the needs of engineering applications.
基金Projects(2010ZD11007,20100751010)supported by Aeronautical Science Foundation of China
文摘The online diagnosis for aircraft system has always been a difficult problem. This is due to time evolution of system change, uncertainty of sensor measurements, and real-time requirement of diagnostic inference. To address this problem, two dynamic Bayesian network(DBN) approaches are proposed. One approach prunes the DBN of system, and then uses particle filter(PF) for this pruned DBN(PDBN) to perform online diagnosis. The problem is that estimates from a PF tend to have high variance for small sample sets. Using large sample sets is computationally expensive. The other approach compiles the PDBN into a dynamic arithmetic circuit(DAC) using an offline procedure that is applied only once, and then uses this circuit to provide online diagnosis recursively. This approach leads to the most computational consumption in the offline procedure. The experimental results show that the DAC, compared with the PF for PDBN, not only provides more reliable online diagnosis, but also offers much faster inference.
文摘This paper studies the global fixed time synchronization of complex dynamical network,including non-identical nodes with disturbances and uncertainties as well as input nonlinearity.First,a novel fixed time sliding manifold is constructed to achieve the fixed time synchronization of complex dynamical network with disturbances and uncertainties.Second,a novel sliding mode controller is proposed to realize the global fixed time reachability of sliding surfaces.The outstanding feature of the designed control is that the fixed convergence time of both reaching and sliding modes can be adjusted to the desired values in advance by choosing the explicit parameters in the controller,which does not rest upon the initial conditions and the topology of the network.Finally,the effectiveness and validity of the obtained results are demonstrated by corresponding numerical simulations.
基金supported by the Chinese Universities Scientific Fund(ZYGX2020ZB022)the National Natural Science Foundation of China(51775090).
文摘The dynamic wireless communication network is a complex network that needs to consider various influence factors including communication devices,radio propagation,network topology,and dynamic behaviors.Existing works focus on suggesting simplified reliability analysis methods for these dynamic networks.As one of the most popular modeling methodologies,the dynamic Bayesian network(DBN)is proposed.However,it is insufficient for the wireless communication network which contains temporal and non-temporal events.To this end,we present a modeling methodology for a generalized continuous time Bayesian network(CTBN)with a 2-state conditional probability table(CPT).Moreover,a comprehensive reliability analysis method for communication devices and radio propagation is suggested.The proposed methodology is verified by a reliability analysis of a real wireless communication network.
基金Project(60634020) supported by the National Natural Science Foundation of China
文摘Based on consideration of the differential relations between the immeasurable variables and measurable variables in electro-hydraulic servo system,adaptive dynamic recurrent fuzzy neural networks(ADRFNNs) were employed to identify the primary uncertainty and the mathematic model of the system was turned into an equivalent linear model with terms of secondary uncertainty.At the same time,gain adaptive sliding mode variable structure control(GASMVSC) was employed to synthesize the control effort.The results show that the unrealization problem caused by some system's immeasurable state variables in traditional fuzzy neural networks(TFNN) taking all state variables as its inputs is overcome.On the other hand,the identification by the ADRFNNs online with high accuracy and the adaptive function of the correction term's gain in the GASMVSC make the system possess strong robustness and improved steady accuracy,and the chattering phenomenon of the control effort is also suppressed effectively.
基金National Science and Technology Major Project (2019YFC1708904)the Fundamental Research Funds for the Central Public Welfare Research Institutes (ZZ13-YQ-048)the Fundamental Research Funds for the Central Public Welfare Research Institutes(ZXKT21008)
文摘OBJECTIVE To investigate the characteristics and regulations of medication in different stages of disease by constructing a dynamic disease network and a cellular feature network spanning from myocardial infarction to heart failure.METHODS Based on transcrip⁃tome and single-cell sequencing data from a mouse model of left anterior descending coro⁃nary artery ligation,a dynamic early-middle-late network and cellular feature network were con⁃structed by integrating differential gene expres⁃sion trends and biological functions.The robust⁃ness of the perturbation effect of traditional Chi⁃nese medicine(TCM)on the disease network was calculated based on multi-target TCM,and we acquired the foundational data by analyzing the results of effectiveness.The predictive plat⁃form was scrutinized and assessed with regards to the functional attributes of FDA approveddrugs and compound prescriptions,in order to determine the primary stages of intervention and the drug patterns actions in the progression of heart failure.RESULTS In this study,we devel⁃oped a prediction and analysis platform for assessing the efficacy of drugs using a networkbased approach.The accuracy of the system was validated by FDA approved-drugs.It was found that blood-activating drugs,heat-clearing drugs,and phlegm-expelling drugs exhibited favorable intervention effects during the early to middle stages of the disease by investigating the effects of single herbs and TCM prescriptions on disease progression.Similarly,phlegm-expelling drugs,spirit-nourishing drugs,and diuretic showed better intervention effects during the mid⁃dle to late stages.These findings were consis⁃tent with the clinical use of drugs.Analysis of the clustering heatmap results of TCM prescriptions revealed that the formulas aimed at qi stagnation and blood stasis had a strong effect in early stage,while the formulas for qi and yin deficiency and cardiorenal yang deficiency had a strong effect in the middle to late stages.Furthermore,analysis of the single-cell feature network demon⁃strated that TCM had advantages in modulating the changes in fibroblasts,myofibroblasts,endo⁃thelial cells,and granulocytes during the patho⁃logical process.Additionally,most prescriptions exhibited strong perturbation effects on the fea⁃ture network of NK-T cells,granulocytes,macro⁃phages,and myofibroblasts.CONCLUSION This platform quantitatively evaluates the primary action stages and characteristics of TCM and for⁃mulas involved in the dynamic process of myo⁃cardial infarction to heart failure based on the effective prediction of the efficacy of TCM and FDA approved-drugs.It provides reference for the precise clinical application of TCM and formu⁃las with multiple targets and multiple pathways.
