OBJECTIVE To review the application of nanoparticles modified with angiopep-2,providing theoretical guidance for the diagnosis and treatment of glioma. METHODS According to domestic and foreign research reports of nan...OBJECTIVE To review the application of nanoparticles modified with angiopep-2,providing theoretical guidance for the diagnosis and treatment of glioma. METHODS According to domestic and foreign research reports of nanoparticles modified with angiopep-2 in recent years,the application in the diagnosis and treatment of glioma was summarized and analyzed. RESULTS Angiopep-2 can be modified to the surface of nanoparticles loaded with imaging agents or chemotherapeutic agents,which can significantly improve the imaging effect of glioma and achieve targeted drug delivery. CONCLUSION Angiopep-2 exhibits a high brain penetration capability in blood brain barrier and in glioma cells. The nanoparticles modified with angiopep-2 can delivery various imaging agents and chemotherapeutic agents to glioma cells,the dual-targeting delivery systems can provide theoretical guidance for the diagnosis and treatment of glioma.展开更多
文摘OBJECTIVE To review the application of nanoparticles modified with angiopep-2,providing theoretical guidance for the diagnosis and treatment of glioma. METHODS According to domestic and foreign research reports of nanoparticles modified with angiopep-2 in recent years,the application in the diagnosis and treatment of glioma was summarized and analyzed. RESULTS Angiopep-2 can be modified to the surface of nanoparticles loaded with imaging agents or chemotherapeutic agents,which can significantly improve the imaging effect of glioma and achieve targeted drug delivery. CONCLUSION Angiopep-2 exhibits a high brain penetration capability in blood brain barrier and in glioma cells. The nanoparticles modified with angiopep-2 can delivery various imaging agents and chemotherapeutic agents to glioma cells,the dual-targeting delivery systems can provide theoretical guidance for the diagnosis and treatment of glioma.
