The acquisition,tracking,and pointing(ATP)system is widely used in target tracking,counter-UAV operations,and other related fields.As UAV technology develops,there is a growing demand to enhance the tracking capabilit...The acquisition,tracking,and pointing(ATP)system is widely used in target tracking,counter-UAV operations,and other related fields.As UAV technology develops,there is a growing demand to enhance the tracking capabilities of ATP systems.However,in practical applications,ATP systems face various design constraints and functional limitations,making it infeasible to indefinitely improve hardware performance to meet tracking requirements.As a result,tracking algorithms are required to execute increasingly complex tasks.This study introduces a multi-rate feedforward predictive controller to address issues such as low image feedback frequency and significant delays in ATP systems,which lead to tracking jitter,poor tracking performance,low precision,and target loss.At the same time,the pro-posed approach aims to improve the tracking capabilities of ATP systems for high-speed and highly maneuverable targets under conditions of low sampling feedback rates and high feedback delays.The method suggested is also characterized by its low order,fast response,and robustness to model parameter variations.In this study,an actual ATP system is built for target tracking test,and the proposed algorithm is fully validated in terms of simulation and actual system application verification.Results from both simulations and experiments demonstrate that the method effectively compensates for delays and low sampling rates.For targets with relative angular velocities ranging from 0 to 90°/s and angular accelerations between 0 and 470°/s^(2),the system improved tracking accuracy by 70.0%-89.9%at a sampling frequency of 50 Hz and a delay of 30 m s.Moreover,the compensation algorithm demonstrated consistent performance across actuators with varying characteristics,further confirming its robustness to model insensitivity.In summary,the proposed algorithm considerably enhances the tracking accuracy and capability of ATP systems for high-speed and highly maneuverable targets,reducing the probability of target loss from high speed.This approach offers a practical solution for future multi-target tracking across diverse operational scenarios.展开更多
Multi-user detection (MUD) based on multirate transmission in code division multiple access (CDMA) system is discussed. Under the requirement of signal interference ratio (SIR) detection at base station and framework ...Multi-user detection (MUD) based on multirate transmission in code division multiple access (CDMA) system is discussed. Under the requirement of signal interference ratio (SIR) detection at base station and framework with parallel interference cancellation, a supervision decision algorithm based on pre-decision of probabilistic data association (PDA) and hard decision is proposed. The detection performance is analyzed and simulation is implemented to show that the supervision decision algorithm improves the detection performance effectively.展开更多
As the sampling rates of the inner loop and the outer loop of the target tracking control system are different,a typical digital multi-rate control system was formed.If the traditional single-rate design method was ap...As the sampling rates of the inner loop and the outer loop of the target tracking control system are different,a typical digital multi-rate control system was formed.If the traditional single-rate design method was applied,the low sampling rate loop will seriously impact the dynamical characteristic of the system.After analyzing and calculating the impact law of the low sampling rate loop to the bandwidth and the stability of the tracking system,a kind of multi-rate control system design method was introduced.Corresponding to the different sampling rates of the inner loop and the outer loop,the multi-rate control strategy was constituted by a high sampling rate sub-controller and a low sampling rate sub-controller.The two sub-controllers were designed separately and connected by means of the sampling rate converter.The low sampling rate controller determined the response rapidity of the system,while the high sampling rate controller applied additionally effective control outputs to the system during a sampling interval of the low sampling rate controller.With the introduced high and low sampling rates sub-controllers,the tracking control system can achieve the same performance as a single-rate controller with high sampling rate,yet it works under a much lower sampling rate.The simulation and experimental results show the effectiveness of the introduced multi-rate control design method.It reduces the settling time by 5 times and the over shoot by 4 times compared with the PID control.展开更多
We have developed two 474 THz(633 nm)new iodine stabilized He-Ne lasers with compatible system of third and fifth harmonic locking.The frequency stability is 1.0×10-11/ 1s and 3.5×10-12 / 10s with third harm...We have developed two 474 THz(633 nm)new iodine stabilized He-Ne lasers with compatible system of third and fifth harmonic locking.The frequency stability is 1.0×10-11/ 1s and 3.5×10-12 / 10s with third harmonic locking,and corresponding values are 1.3×10-11/1s and 4.0×10-12/ 10s with fifth harmonic locking.We found that the frequency difference between the same component with third and fifth harmonic locking are from 5 kHz to SO kHz.Our experiment and analysis indicate that the center of fifth harmonic signals is closer to the Lorentzian center in iodine absorption component than one of the third harmonic signals,and the reproducibility with fifth harmonic locking is also better than one with third harmonic locking.展开更多
Background The pink bollworm(Pectinophora gossypiella,PBW)is a major cotton pest,causing economic losses by damaging seeds and fiber.Cotton growers typically use systemic and broad-spectrum insecticides for its manage...Background The pink bollworm(Pectinophora gossypiella,PBW)is a major cotton pest,causing economic losses by damaging seeds and fiber.Cotton growers typically use systemic and broad-spectrum insecticides for its manage-ment,which pose risks to human health and the environment.Consequently,there is a need for eco-friendly alterna-tives.This study evaluates the bio-efficacy of the entomopathogenic fungus Metarhizium anisopliae strain TMBMA1 against pink bollworm and assesses its compatibility with major insecticides.Additionally,to comprehend the dynam-ics of colonization and the infection processes of entomopathogenic fungi(EPF),scanning electron microscopy(SEM)of infected larvae was carried out.Result We challenged the second instar PBW larvae to eight different concentrations(1×10^(3) to 1×10^(10) conidia mL^(-1))of an M.anisopliae strain TMBMA1.The highest mortality(100%)occurred at the higher concentrations i.e.,1×109 and 1×10^(10) spores mL^(-1),while the lowest mortality rate(46.6%)was observed at 1×10^(3) spores mL^(-1) con-centration compared to control(3.33%).TMBMA1’s biocontrol efficacy was validated by Probit analysis,exhibiting an exceptionally low median lethal concentration(LC50)value of 7.1×10^(5).The comparative evaluation revealed that the M.anisopliae strain TMBMA1 performed excellently with insecticide[Cypermethrin 10%(volume fraction)emulsifiable concentrate(EC)at 1 mL·L^(-1) water]giving 100%mortality,both being superior to a commercial prod-uct of M.anisopliae(60%).According to SEM analysis,the EPF strain was profusely colonized on both the internal and external surfaces of PBW larvae.Compatibility studies with insecticides revealed>98%and>96%reduction in the sporulation of M.anisopliae due to the treatment of Emamectin Benzoate 1.5%(mass fraction)+Profenofos 35%(mass fraction)water dispersible granules(WDG)and Profenofos 50%EC,respectively.In contrast,Cypermethrin 10%EC,Emamectin Benzoate 5%(mass fraction)Soluble Granules and Neem Seed Kernel Extract(NSKE)0.15%(volume fraction)treatments reported lower reduction(11.45%,13.79%and 21.21%respectively)in spore production.Conclusion According to the current investigations,the M.anisopliae strain TMBMA1 exhibits high virulence against PBW and offers a promising eco-friendly solution for managing this pest.It shows significant potential to pro-liferate on both external and internal surfaces of PBW.This strain can be integrated into PBW management programs with chemical insecticides,improving pest control and lessening environmental impact.展开更多
The mathematical model of electromagnetic compatibility and the distribution of aircraft antenna system have been investigated. The solutions of the antenna gain and electromagnetic interference margin in the regions ...The mathematical model of electromagnetic compatibility and the distribution of aircraft antenna system have been investigated. The solutions of the antenna gain and electromagnetic interference margin in the regions of low frequency, resonance and high frequency were discussed. By using the basic analytical method of the EMI margin the distributed antenna system can be determined. The main program flow chart of distributed antenna design were given, and illustrated with examples of the microstrip antennas.展开更多
As for the Domino effect dv/dt and electromagnetic interference during the rapid switching course of single-chip switching power supply,this article firstly analyzes electromagnetic interference source,and then diagno...As for the Domino effect dv/dt and electromagnetic interference during the rapid switching course of single-chip switching power supply,this article firstly analyzes electromagnetic interference source,and then diagnoses the essential interaction relationship between interference and switching activity based on the timely and area measured waveform,analyzes and studies the production mechanism and coupling path of interference mode,and sets up circuit model according to the features of transverse mode interference and common mode interference.Put forward different suppression methods finally.展开更多
The application of mixed powders with different mass fraction on laser additive repairing(LAR)can be an effective way to guarantee the performance and functionality of repaired part in time.A convenient and feasible a...The application of mixed powders with different mass fraction on laser additive repairing(LAR)can be an effective way to guarantee the performance and functionality of repaired part in time.A convenient and feasible approach is presented to repair TA15 forgings by employing Ti6Al4V-xTA15 mixed powders in this paper.The performance compatibility of Ti6Al4V-xTA15 powders from the aspects of microhardness,tensile property,heat capacity,thermal expansion coefficient and corrosion resistance with the TA15 forgings was fully investigated.The primaryαlaths were refined and the volume fraction of the secondaryαphase was increased by increasing the mass fraction of TA15 in the mixed Ti6Al4V-xTA15 powders,leading to varied performances.In conclusion,the mixed Ti6Al4V-70%TA15(x=70%)powders is the most suitable candidate and is recommended as the raw material for LAR of TA15 forgings based on overall consideration of the compatibility calculations of the laser repaired zone with the wrought substrate zone.展开更多
The interaction and compatibility between diaminoazofuraz(DAAzF)and some energetic materials are studied by using pressure differential scanning calorimetry(DSC)method.The energetic materials include cyclotetramethyle...The interaction and compatibility between diaminoazofuraz(DAAzF)and some energetic materials are studied by using pressure differential scanning calorimetry(DSC)method.The energetic materials include cyclotetramethylenetetranitramine(HMX),cyclotrimethylenetrinitramine(RDX),nitrocellulose(NC),nitroglycerine(NG),125/100-NC/NG mixture(NC+NG),N-nitrodihydroxyethylaminedinitrate(DINA),aluminum powder(Al),and 3,4-dinitrofurzanfuroxan(DNTF).The results show that there are obvious interactions between DAAzF and DNTF,DINA,HMX or RDX,while weak interactions between DAAzF and NC,NG,NC+NG or Al.According to the evaluated standard of compatibility,the binary systems of DAAzF with NC,NG,NC+NG and Al are compatible,the binary system of it with RDX is slightly sensitive,the binary systems of it with HMX and DINA are sensitive,and the binary system of it with DNTF is hazardous.展开更多
OBJECTIVE To investigate the compatibility of the prescription Rhodiolarosea,Cordycepsmilitaris,and Rhubarb root.METHODS The DIO mice accompanying with insulin resistance,hypercholesterolemia and obesity were induced ...OBJECTIVE To investigate the compatibility of the prescription Rhodiolarosea,Cordycepsmilitaris,and Rhubarb root.METHODS The DIO mice accompanying with insulin resistance,hypercholesterolemia and obesity were induced by high fat diet(HFD)in C57BL/6mice.For evaluating the insulin sensitivity in vivo,the values of serum insulin,HOMA-IR,and the glucose infuse rate(GIR)in hyperinsulinemiceuglycemic clamp test were determined;the time-dependent blood glucose changes were measured after insulin loading in insulin tolerance test(ITT),or after glucose loading in glucose tolerance test(GTT),respectively.Recombinant human protein tyrosine phosphatase 1B(PTP1B)was overexpressed by hGST-PTP1BBL21 E.coli and purified by GST affinity chromatography.The activities of PTP1 Band glutamine:fructose 6-phosphate amidotransferase(GFAT)were measured by the pNPP and GDH method,respectively.The activity ofα-glucosidase was determined with the substrates of p-nitrophenyl-alpha-D-glucopyranoside(pNPG).The IC50 value was calculated using the software GraphPad Prism 5.RESULTS 1st,the standard for the raw materials and for the extraction process of Rhodiolarosea,Cordycepsmilitaris,and Rhubarbroot are formulated according to the inhibition on PTP1 B,α-glucosidase,and GFAT in vitro,and the improvement on impaired glucose tolerance(IGT),hypercholesterolemia,and obesity in vivo,respectively.2nd,the composition was determined by the synergistic effects of Rhodiolarosea,Cordycepsmilitaris,and Rhubarb root on insulin resistance in DIO mice.3rd,in accordance with the IC50 values from the L9(34)and L8(27)orthogonal experiments targeting on PTP1 B and α-glucosidase,respectively,the best rate of Rhodiolarosea∶Cordycepsmilitaris∶Rhubarbroot was selected.4th,the effective dose for the treatment of metabolic syndrome was assessed based on the effects on IGT,hypercholesterolemia,obesity,insulin resistance,respectively,in DIO mice.CONCLUSION The prescription compatibility of Rhodiolarosea,Cordycepsmilitaris,and Rhubarbroot with the rate of 20∶1∶1was formed to treat the metabolic syndrome,such as IGT,hypercholesterolemia,and obesity,with the effective dose of 200 mg·kg-1 by the major mechanism of the improvement on insulin sensitivity.Monarch drug,Rhodiola,can clear away the lung-heat,tonify Qi,resolve stasis and nourish the heart.Adjuvant drug,Cordycepsmilitaris,can tonify the lung Qi and the kidney essence,strong waist and knee,compatibility with Rhodiola to enhance the function of invigorating lung and kidney.Assistant drug,Rhubarb,can clear heat,detoxify,remove blood stasis.These three herbal are compatible to show the effects of tonifying Qi,nourishing essence,cleaning heat,reducing phlegm and resolving masses for the treatment of metabolic syndrome.展开更多
Analyzing systemically more than 550 Li Dong Y uan’s formula of spleen and stomach by using the association rule to mine the in formation relativity between formula, herbal medicine and syndrome.From this we can stud...Analyzing systemically more than 550 Li Dong Y uan’s formula of spleen and stomach by using the association rule to mine the in formation relativity between formula, herbal medicine and syndrome.From this we can study better the compatibility regulations of the展开更多
中药不论在直接抑制肿瘤生长,还是辅助西医治疗肿瘤方面都发挥着不容忽视的作用.本文经检索中国知网、万方、维普、Pubmed、Web of Science等数据库,纳入中药汤剂联合化疗治疗非小细胞肺癌(NSCLC)的随机对照试验,通过Meta、用药规律、...中药不论在直接抑制肿瘤生长,还是辅助西医治疗肿瘤方面都发挥着不容忽视的作用.本文经检索中国知网、万方、维普、Pubmed、Web of Science等数据库,纳入中药汤剂联合化疗治疗非小细胞肺癌(NSCLC)的随机对照试验,通过Meta、用药规律、网络药理学和细胞实验等分析方法系统评价中药联合化疗治疗NSCLC的疗效、安全性及作用机制,最终纳入56篇文献进行统计分析,共4992例患者、57首处方、172味中药.结果显示,中药联合化疗治疗组的1年生存率、肝功能损伤、总有效率、胃肠道不良反应等方面均优于单纯化疗组.用药频次>20的有7味:药味以甘苦为主,药性以寒温为主,主要归为肺经和肝经.得到5个高频药物聚类,关联规则分析得到置信度最高的4条药物组合为:天花粉-麦冬、玉竹-麦冬、北沙参-玉竹-麦冬、白术-黄芪-党参.收集到核心中药成分潜在作用靶点与NSCLC交集靶点126个;PPI分析得到3个核心靶点:AKT1、EGFR、SRC;KEGG分析表明关键通路为PI3K-Akt信号通路;筛选得到3个关键成分:木犀草素、槲皮素、山柰酚;分子对接结果表明关键成分和核心靶点均能稳定结合.细胞实验结果表明,木犀草素可有效抑制A549细胞的增殖、活力和迁移,诱导其发生凋亡,并使其形态发生变化.本文结果表明,中药联合化疗治疗NSCLC可以提高其临床疗效、降低化疗的毒副作用;黄芪、麦冬、党参、北沙参等核心中药多种成分可通过多靶点、多途径协同治疗NSCLC;关键中药的核心成分木犀草素可抑制A549细胞的增殖、活力和迁移,并可诱导其发生凋亡.展开更多
The purpose is to research compound prescribe compatibility of medicines have some influence on anthraquinone which is the gentleman medicine CRC’s valid composition dissolution rate in San Cheng Qi Tang.The method:A...The purpose is to research compound prescribe compatibility of medicines have some influence on anthraquinone which is the gentleman medicine CRC’s valid composition dissolution rate in San Cheng Qi Tang.The method:Adopting respectively RP-HPLC and colorimetric method,measure the content of liberation3-methylchrysazin and 3-methylchrysazin and combined 3-methylchrysazin and 3-methylchrysazin total liberation anthraquinone and total combined anthraquinone in the different decoction water liquid coming from single CRC the different decoction and compatibility of medicines method of San Cheng Qi Tang.The result: Compared with CRC single flavor decoction water,liberation anthraquinone and combined anthraquinone content show differently in the most decoction water liquid,Combined 3-methylchrysazin and combined anthraquinone content in decoction prescribe as follows in proper order decrease:Da Cheng Qi Tang > Xiao San Cheng Qi Tang > Tiao Wei Cheng Qi Tang.The conclusion :Because CRC mate with different medicine material .different decoction method,liberation anthraquinone and combined anthraquinone content in San Cheng Qi Tang change.The combined 3-methylchrysazin and combined anthraquinon content variety order in accordance with its decanta bottom function.展开更多
基金supported by the National Natural Science Foun-dation of China(Grant No.52275099).
文摘The acquisition,tracking,and pointing(ATP)system is widely used in target tracking,counter-UAV operations,and other related fields.As UAV technology develops,there is a growing demand to enhance the tracking capabilities of ATP systems.However,in practical applications,ATP systems face various design constraints and functional limitations,making it infeasible to indefinitely improve hardware performance to meet tracking requirements.As a result,tracking algorithms are required to execute increasingly complex tasks.This study introduces a multi-rate feedforward predictive controller to address issues such as low image feedback frequency and significant delays in ATP systems,which lead to tracking jitter,poor tracking performance,low precision,and target loss.At the same time,the pro-posed approach aims to improve the tracking capabilities of ATP systems for high-speed and highly maneuverable targets under conditions of low sampling feedback rates and high feedback delays.The method suggested is also characterized by its low order,fast response,and robustness to model parameter variations.In this study,an actual ATP system is built for target tracking test,and the proposed algorithm is fully validated in terms of simulation and actual system application verification.Results from both simulations and experiments demonstrate that the method effectively compensates for delays and low sampling rates.For targets with relative angular velocities ranging from 0 to 90°/s and angular accelerations between 0 and 470°/s^(2),the system improved tracking accuracy by 70.0%-89.9%at a sampling frequency of 50 Hz and a delay of 30 m s.Moreover,the compensation algorithm demonstrated consistent performance across actuators with varying characteristics,further confirming its robustness to model insensitivity.In summary,the proposed algorithm considerably enhances the tracking accuracy and capability of ATP systems for high-speed and highly maneuverable targets,reducing the probability of target loss from high speed.This approach offers a practical solution for future multi-target tracking across diverse operational scenarios.
文摘Multi-user detection (MUD) based on multirate transmission in code division multiple access (CDMA) system is discussed. Under the requirement of signal interference ratio (SIR) detection at base station and framework with parallel interference cancellation, a supervision decision algorithm based on pre-decision of probabilistic data association (PDA) and hard decision is proposed. The detection performance is analyzed and simulation is implemented to show that the supervision decision algorithm improves the detection performance effectively.
基金Project(51105372) supported by the National Natural Science Foundation of ChinaProject(JC12-03-01) supported by the Research Plan of National University of Defense Technology,China
文摘As the sampling rates of the inner loop and the outer loop of the target tracking control system are different,a typical digital multi-rate control system was formed.If the traditional single-rate design method was applied,the low sampling rate loop will seriously impact the dynamical characteristic of the system.After analyzing and calculating the impact law of the low sampling rate loop to the bandwidth and the stability of the tracking system,a kind of multi-rate control system design method was introduced.Corresponding to the different sampling rates of the inner loop and the outer loop,the multi-rate control strategy was constituted by a high sampling rate sub-controller and a low sampling rate sub-controller.The two sub-controllers were designed separately and connected by means of the sampling rate converter.The low sampling rate controller determined the response rapidity of the system,while the high sampling rate controller applied additionally effective control outputs to the system during a sampling interval of the low sampling rate controller.With the introduced high and low sampling rates sub-controllers,the tracking control system can achieve the same performance as a single-rate controller with high sampling rate,yet it works under a much lower sampling rate.The simulation and experimental results show the effectiveness of the introduced multi-rate control design method.It reduces the settling time by 5 times and the over shoot by 4 times compared with the PID control.
基金The project is supported by Naural Science Foundation Committee of China
文摘We have developed two 474 THz(633 nm)new iodine stabilized He-Ne lasers with compatible system of third and fifth harmonic locking.The frequency stability is 1.0×10-11/ 1s and 3.5×10-12 / 10s with third harmonic locking,and corresponding values are 1.3×10-11/1s and 4.0×10-12/ 10s with fifth harmonic locking.We found that the frequency difference between the same component with third and fifth harmonic locking are from 5 kHz to SO kHz.Our experiment and analysis indicate that the center of fifth harmonic signals is closer to the Lorentzian center in iodine absorption component than one of the third harmonic signals,and the reproducibility with fifth harmonic locking is also better than one with third harmonic locking.
文摘Background The pink bollworm(Pectinophora gossypiella,PBW)is a major cotton pest,causing economic losses by damaging seeds and fiber.Cotton growers typically use systemic and broad-spectrum insecticides for its manage-ment,which pose risks to human health and the environment.Consequently,there is a need for eco-friendly alterna-tives.This study evaluates the bio-efficacy of the entomopathogenic fungus Metarhizium anisopliae strain TMBMA1 against pink bollworm and assesses its compatibility with major insecticides.Additionally,to comprehend the dynam-ics of colonization and the infection processes of entomopathogenic fungi(EPF),scanning electron microscopy(SEM)of infected larvae was carried out.Result We challenged the second instar PBW larvae to eight different concentrations(1×10^(3) to 1×10^(10) conidia mL^(-1))of an M.anisopliae strain TMBMA1.The highest mortality(100%)occurred at the higher concentrations i.e.,1×109 and 1×10^(10) spores mL^(-1),while the lowest mortality rate(46.6%)was observed at 1×10^(3) spores mL^(-1) con-centration compared to control(3.33%).TMBMA1’s biocontrol efficacy was validated by Probit analysis,exhibiting an exceptionally low median lethal concentration(LC50)value of 7.1×10^(5).The comparative evaluation revealed that the M.anisopliae strain TMBMA1 performed excellently with insecticide[Cypermethrin 10%(volume fraction)emulsifiable concentrate(EC)at 1 mL·L^(-1) water]giving 100%mortality,both being superior to a commercial prod-uct of M.anisopliae(60%).According to SEM analysis,the EPF strain was profusely colonized on both the internal and external surfaces of PBW larvae.Compatibility studies with insecticides revealed>98%and>96%reduction in the sporulation of M.anisopliae due to the treatment of Emamectin Benzoate 1.5%(mass fraction)+Profenofos 35%(mass fraction)water dispersible granules(WDG)and Profenofos 50%EC,respectively.In contrast,Cypermethrin 10%EC,Emamectin Benzoate 5%(mass fraction)Soluble Granules and Neem Seed Kernel Extract(NSKE)0.15%(volume fraction)treatments reported lower reduction(11.45%,13.79%and 21.21%respectively)in spore production.Conclusion According to the current investigations,the M.anisopliae strain TMBMA1 exhibits high virulence against PBW and offers a promising eco-friendly solution for managing this pest.It shows significant potential to pro-liferate on both external and internal surfaces of PBW.This strain can be integrated into PBW management programs with chemical insecticides,improving pest control and lessening environmental impact.
文摘The mathematical model of electromagnetic compatibility and the distribution of aircraft antenna system have been investigated. The solutions of the antenna gain and electromagnetic interference margin in the regions of low frequency, resonance and high frequency were discussed. By using the basic analytical method of the EMI margin the distributed antenna system can be determined. The main program flow chart of distributed antenna design were given, and illustrated with examples of the microstrip antennas.
基金Tianjin Natunal science Foundation of China(No:05YFSYSF033)
文摘As for the Domino effect dv/dt and electromagnetic interference during the rapid switching course of single-chip switching power supply,this article firstly analyzes electromagnetic interference source,and then diagnoses the essential interaction relationship between interference and switching activity based on the timely and area measured waveform,analyzes and studies the production mechanism and coupling path of interference mode,and sets up circuit model according to the features of transverse mode interference and common mode interference.Put forward different suppression methods finally.
基金Project(2019-00899-1-1)supported by the Ministry of Industry and Information Technology of ChinaProject(2021JM-060)supported by the Natural Science Foundation of Shaanxi Province,ChinaProject(3102019QD0409)supported by the Fundamental Research Funds for the Central Universities,China。
文摘The application of mixed powders with different mass fraction on laser additive repairing(LAR)can be an effective way to guarantee the performance and functionality of repaired part in time.A convenient and feasible approach is presented to repair TA15 forgings by employing Ti6Al4V-xTA15 mixed powders in this paper.The performance compatibility of Ti6Al4V-xTA15 powders from the aspects of microhardness,tensile property,heat capacity,thermal expansion coefficient and corrosion resistance with the TA15 forgings was fully investigated.The primaryαlaths were refined and the volume fraction of the secondaryαphase was increased by increasing the mass fraction of TA15 in the mixed Ti6Al4V-xTA15 powders,leading to varied performances.In conclusion,the mixed Ti6Al4V-70%TA15(x=70%)powders is the most suitable candidate and is recommended as the raw material for LAR of TA15 forgings based on overall consideration of the compatibility calculations of the laser repaired zone with the wrought substrate zone.
文摘The interaction and compatibility between diaminoazofuraz(DAAzF)and some energetic materials are studied by using pressure differential scanning calorimetry(DSC)method.The energetic materials include cyclotetramethylenetetranitramine(HMX),cyclotrimethylenetrinitramine(RDX),nitrocellulose(NC),nitroglycerine(NG),125/100-NC/NG mixture(NC+NG),N-nitrodihydroxyethylaminedinitrate(DINA),aluminum powder(Al),and 3,4-dinitrofurzanfuroxan(DNTF).The results show that there are obvious interactions between DAAzF and DNTF,DINA,HMX or RDX,while weak interactions between DAAzF and NC,NG,NC+NG or Al.According to the evaluated standard of compatibility,the binary systems of DAAzF with NC,NG,NC+NG and Al are compatible,the binary system of it with RDX is slightly sensitive,the binary systems of it with HMX and DINA are sensitive,and the binary system of it with DNTF is hazardous.
基金The project supported by National Major Special Project on New Drug Innovation of China(2009ZX09103-4322012ZX09103-101-063+1 种基金2012ZX09301002-004)We also appreciate the support of Novo Nordisk Union Diabetes Research Talent Fund
文摘OBJECTIVE To investigate the compatibility of the prescription Rhodiolarosea,Cordycepsmilitaris,and Rhubarb root.METHODS The DIO mice accompanying with insulin resistance,hypercholesterolemia and obesity were induced by high fat diet(HFD)in C57BL/6mice.For evaluating the insulin sensitivity in vivo,the values of serum insulin,HOMA-IR,and the glucose infuse rate(GIR)in hyperinsulinemiceuglycemic clamp test were determined;the time-dependent blood glucose changes were measured after insulin loading in insulin tolerance test(ITT),or after glucose loading in glucose tolerance test(GTT),respectively.Recombinant human protein tyrosine phosphatase 1B(PTP1B)was overexpressed by hGST-PTP1BBL21 E.coli and purified by GST affinity chromatography.The activities of PTP1 Band glutamine:fructose 6-phosphate amidotransferase(GFAT)were measured by the pNPP and GDH method,respectively.The activity ofα-glucosidase was determined with the substrates of p-nitrophenyl-alpha-D-glucopyranoside(pNPG).The IC50 value was calculated using the software GraphPad Prism 5.RESULTS 1st,the standard for the raw materials and for the extraction process of Rhodiolarosea,Cordycepsmilitaris,and Rhubarbroot are formulated according to the inhibition on PTP1 B,α-glucosidase,and GFAT in vitro,and the improvement on impaired glucose tolerance(IGT),hypercholesterolemia,and obesity in vivo,respectively.2nd,the composition was determined by the synergistic effects of Rhodiolarosea,Cordycepsmilitaris,and Rhubarb root on insulin resistance in DIO mice.3rd,in accordance with the IC50 values from the L9(34)and L8(27)orthogonal experiments targeting on PTP1 B and α-glucosidase,respectively,the best rate of Rhodiolarosea∶Cordycepsmilitaris∶Rhubarbroot was selected.4th,the effective dose for the treatment of metabolic syndrome was assessed based on the effects on IGT,hypercholesterolemia,obesity,insulin resistance,respectively,in DIO mice.CONCLUSION The prescription compatibility of Rhodiolarosea,Cordycepsmilitaris,and Rhubarbroot with the rate of 20∶1∶1was formed to treat the metabolic syndrome,such as IGT,hypercholesterolemia,and obesity,with the effective dose of 200 mg·kg-1 by the major mechanism of the improvement on insulin sensitivity.Monarch drug,Rhodiola,can clear away the lung-heat,tonify Qi,resolve stasis and nourish the heart.Adjuvant drug,Cordycepsmilitaris,can tonify the lung Qi and the kidney essence,strong waist and knee,compatibility with Rhodiola to enhance the function of invigorating lung and kidney.Assistant drug,Rhubarb,can clear heat,detoxify,remove blood stasis.These three herbal are compatible to show the effects of tonifying Qi,nourishing essence,cleaning heat,reducing phlegm and resolving masses for the treatment of metabolic syndrome.
文摘Analyzing systemically more than 550 Li Dong Y uan’s formula of spleen and stomach by using the association rule to mine the in formation relativity between formula, herbal medicine and syndrome.From this we can study better the compatibility regulations of the
文摘中药不论在直接抑制肿瘤生长,还是辅助西医治疗肿瘤方面都发挥着不容忽视的作用.本文经检索中国知网、万方、维普、Pubmed、Web of Science等数据库,纳入中药汤剂联合化疗治疗非小细胞肺癌(NSCLC)的随机对照试验,通过Meta、用药规律、网络药理学和细胞实验等分析方法系统评价中药联合化疗治疗NSCLC的疗效、安全性及作用机制,最终纳入56篇文献进行统计分析,共4992例患者、57首处方、172味中药.结果显示,中药联合化疗治疗组的1年生存率、肝功能损伤、总有效率、胃肠道不良反应等方面均优于单纯化疗组.用药频次>20的有7味:药味以甘苦为主,药性以寒温为主,主要归为肺经和肝经.得到5个高频药物聚类,关联规则分析得到置信度最高的4条药物组合为:天花粉-麦冬、玉竹-麦冬、北沙参-玉竹-麦冬、白术-黄芪-党参.收集到核心中药成分潜在作用靶点与NSCLC交集靶点126个;PPI分析得到3个核心靶点:AKT1、EGFR、SRC;KEGG分析表明关键通路为PI3K-Akt信号通路;筛选得到3个关键成分:木犀草素、槲皮素、山柰酚;分子对接结果表明关键成分和核心靶点均能稳定结合.细胞实验结果表明,木犀草素可有效抑制A549细胞的增殖、活力和迁移,诱导其发生凋亡,并使其形态发生变化.本文结果表明,中药联合化疗治疗NSCLC可以提高其临床疗效、降低化疗的毒副作用;黄芪、麦冬、党参、北沙参等核心中药多种成分可通过多靶点、多途径协同治疗NSCLC;关键中药的核心成分木犀草素可抑制A549细胞的增殖、活力和迁移,并可诱导其发生凋亡.
文摘The purpose is to research compound prescribe compatibility of medicines have some influence on anthraquinone which is the gentleman medicine CRC’s valid composition dissolution rate in San Cheng Qi Tang.The method:Adopting respectively RP-HPLC and colorimetric method,measure the content of liberation3-methylchrysazin and 3-methylchrysazin and combined 3-methylchrysazin and 3-methylchrysazin total liberation anthraquinone and total combined anthraquinone in the different decoction water liquid coming from single CRC the different decoction and compatibility of medicines method of San Cheng Qi Tang.The result: Compared with CRC single flavor decoction water,liberation anthraquinone and combined anthraquinone content show differently in the most decoction water liquid,Combined 3-methylchrysazin and combined anthraquinone content in decoction prescribe as follows in proper order decrease:Da Cheng Qi Tang > Xiao San Cheng Qi Tang > Tiao Wei Cheng Qi Tang.The conclusion :Because CRC mate with different medicine material .different decoction method,liberation anthraquinone and combined anthraquinone content in San Cheng Qi Tang change.The combined 3-methylchrysazin and combined anthraquinon content variety order in accordance with its decanta bottom function.
