Current pharmacological therapies used in clinical practice for individuals with cardiac, hepatic, renal or pulmonary fibrosis do not show desirable effects; therefore, new targets of therapy are urgently required. Mi...Current pharmacological therapies used in clinical practice for individuals with cardiac, hepatic, renal or pulmonary fibrosis do not show desirable effects; therefore, new targets of therapy are urgently required. Mitochon- dria play pivotal role in energy production, metabolism, serving as storage tanks of calcium ions and cell fate deter- mination. Recent results of our experiments and other authors＇ studies suggest that the electron transport chain dys- function, electron leakage increasing, the accumulation of fragmented mitochondria, and the impairment in the mi- tophagy system contribute to pathogenesis of tissue fibrosis. Mitochondria targeting compounds exert promise in trea- ring and attenuating the progress of these diseases, indicating potential strategies to target mitochondria in the treat- ment of tissue fibrosis.展开更多
文摘Current pharmacological therapies used in clinical practice for individuals with cardiac, hepatic, renal or pulmonary fibrosis do not show desirable effects; therefore, new targets of therapy are urgently required. Mitochon- dria play pivotal role in energy production, metabolism, serving as storage tanks of calcium ions and cell fate deter- mination. Recent results of our experiments and other authors＇ studies suggest that the electron transport chain dys- function, electron leakage increasing, the accumulation of fragmented mitochondria, and the impairment in the mi- tophagy system contribute to pathogenesis of tissue fibrosis. Mitochondria targeting compounds exert promise in trea- ring and attenuating the progress of these diseases, indicating potential strategies to target mitochondria in the treat- ment of tissue fibrosis.
