Optical field manipulation,an emerging frontier in photonics,demonstrates significant potential in biomedical microscopy,quantum state engineering,and micro-nano fabrication.To address the critical limitations of curr...Optical field manipulation,an emerging frontier in photonics,demonstrates significant potential in biomedical microscopy,quantum state engineering,and micro-nano fabrication.To address the critical limitations of current optical modulation technologies in achieving full-parameter precision control,we proposed a novel approach for dynamic azimuthal optical field modulation based on dual-spiral arrays.By designing spatially interleaved spiral structures with different initial radii while maintaining identical periodic parameters,we achieved continuous optical modulation spanning the full 0-2πrange in azimuthal field distribution.Through rigorous numerical simulations,we systematically established a quantitative correlation between the structural parameters and azimuthal optical field patterns,revealing,for the first time,a quasi-linear relationship between the radius difference and the resultant optical distribution.This theoretical framework advances our fundamental understanding of structured optical field manipulation as well as provides a new paradigm for programmable photonic device design,with distinct technical advantages in super-resolution imaging and optical tweezer systems.展开更多
To deploy sensor nodes over the area of interest,a scheme,named node scattering manipulation,was proposed.It adopted the following method:during node scattering,the initial states of every node,including the velocity ...To deploy sensor nodes over the area of interest,a scheme,named node scattering manipulation,was proposed.It adopted the following method:during node scattering,the initial states of every node,including the velocity and direction,were manipulated so that it would land in a region with a certain probability;every sensor was relocated in order to improve the coverage and connectivity.Simultaneously,to easily analyze the process of scattering sensors,a trajectory model was also proposed.Integrating node scattering manipulation with trajectory model,the node deployment in wireless sensor network was thoroughly renovated,that is,this scheme can scatter sensors.In practice,the scheme was operable compared with the previous achievements.The simulation results demonstrate the superiority and feasibility of the scheme,and also show that the energy consumption for sensors relocation is reduced.展开更多
Development of tools that can manipulate gene expression specifically and efficiently in the trophectoderm（TE） lineage would greatly aid understanding the roles of different genetic pathways in TE versus embryonic l...Development of tools that can manipulate gene expression specifically and efficiently in the trophectoderm（TE） lineage would greatly aid understanding the roles of different genetic pathways in TE versus embryonic lineages. Here, we showed first time that short-term lentivirus infection of porcine blastocysts could lead to rapid expression of transgene specifically in TE cells. Efficient TE-specific gene knockdown could also be achieved by lentivirus-mediated pol III-driven short hairpin RNA（shRNA） and TE-specific gene expression could be temporal controlled efficiently by combining this system with Tet-On system. This lentivirus lineage-specific infection system would facilitate gene function studies in porcine pre-implatation embryos by specifically knockdown or overexpression of these genes in TE.展开更多
Manipulation of terahertz wave by metasurfaces has shown tremendous potential in developing compact and functional terahertz optical devices.Here,we propose complementary bilayer metasurfaces for enhanced terahertz wa...Manipulation of terahertz wave by metasurfaces has shown tremendous potential in developing compact and functional terahertz optical devices.Here,we propose complementary bilayer metasurfaces for enhanced terahertz wave amplitude and phase manipulation.The metasurfaces are composed of one layer of metal cut-wire arrays and one layer of their complementary aperture arrays separated by a dielectric spacer.Through the near-field coupling between transverse magnetic resonances in the metal apertures and electric resonances in the metal cut-wires,the structures can manipulate the cross polarization conversion and phase dispersion of terahertz wave.Particularly,the designed metasurfaces demonstrate a phase delay of 180°between two orthogonal axes with the same transmission amplitude between 0.70 and 1.0 THz,enabling a 45°broadband polarization conversion.When the metal cut-wires are rotated with respect to the apertures or the thickness of the dielectric spacer is changed,the amplitude and phase dispersion of the transmitted terahertz wave can be tuned.Such complementary coupled bilayer metasurfaces offer a new method to control the amplitude and phase dispersion of terahertz wave and promise great potential for applications in terahertz meta-devices.展开更多
Satellites with altitudes below 400 km are called super low altitude satellites(SLAS),often used to achieve responsive imaging tasks.Therefore,it is important for the manipulation of its ground track.Aiming at the pro...Satellites with altitudes below 400 km are called super low altitude satellites(SLAS),often used to achieve responsive imaging tasks.Therefore,it is important for the manipulation of its ground track.Aiming at the problem of ground track manipulation of SLAS,a control method based on tangential impulse thrust is proposed.First,the equation of the longitude difference between SLAS and the target point on the target latitude is derived based on Gauss’s variational equations.On this basis,the influence of the tangential impulse thrust on the ground track’s longitude is derived.Finally,the method for ground track manipulation of SLAS under the tangential impulse thrust is proposed.The simulation results verify the effective-ness of the method,after manipulation,the satellite can visit the target point and revisit it for multiple days.展开更多
Plant regeneration is the first step to cotton biotechnology.We screened over 100 genotypes and found two genotypes,YZ-1 and Y668,which are very easy to regenerate.It takes about 5 to 6
Redacted by Specialty Committee of Heat-sensitive Moxibustion of WFCMS,Standardized Manipulations of Heat-sensitive Moxibustion(HSM).Therapy states the scope,normative references,terms and definitions,preoperative pre...Redacted by Specialty Committee of Heat-sensitive Moxibustion of WFCMS,Standardized Manipulations of Heat-sensitive Moxibustion(HSM).Therapy states the scope,normative references,terms and definitions,preoperative preparations,operation methods and procedure,indications and notice of HSM Therapy.展开更多
Basal level of Animal Production is maintained with regulation of endocrine to concert genetic potential and environmental conditions. This balance can be moved to dramatical imporvements in rate and efficiency of pro...Basal level of Animal Production is maintained with regulation of endocrine to concert genetic potential and environmental conditions. This balance can be moved to dramatical imporvements in rate and efficiency of production as well as composition of the products by biotechnological methods. In this paper, several novel achievements in the last decade are briefly reviewed for refference to further research and application of biotedchnology in animal production.展开更多
OBJECTIVE To investigate the intervention effects of tissue-bone homeostasis manipulation(TBHM)on peripatellar biomechanical parameters and knee joint function in knee osteoarthritis(KOA)patients.METHODS Sixty patient...OBJECTIVE To investigate the intervention effects of tissue-bone homeostasis manipulation(TBHM)on peripatellar biomechanical parameters and knee joint function in knee osteoarthritis(KOA)patients.METHODS Sixty patients with KOA(Kellgren-Lawrence gradeⅡ-Ⅲ)were recruited from the Acupuncture-Moxibustion Rehabilitation Department,Anhui University of Chinese Medicine between October 2024 and May 2025.Participants were randomized into a TBHM group(n=30)or a transcutaneous electrical neuromuscular stimulation(TENS)group(n=30).Using two-way repeated measures ANOVA,biomechanical indicators,including rectus femoris tension,vastus medialis tension,vastus lateralis tension,patellar ligament tension,lateral patellar displacement(LPD),medial patellar displacement(MPD),normalized patellar mobility(LPD/patellar width[PW],MPD/PW),knee flexion range of motion,and functional indicators,including KOOS subscales,time up and go test(TUGT),were compared between groups at baseline and after 6 weeks of intervention.RESULTS After intervention,all biomechanical and knee joint function indicators in the TBHM group were significantly improved(P<0.05,P<0.01),while only the vastus medialis tension,TUGT and KOOS Pain,ADL and QoL scores in the control group were significantly improved(P<0.01).The improvement amplitudes of biomechanical indicators in the TBHM group,including rectus femoris tension,vastus lateralis tension,patellar ligament tension,MPD/PW,LPD/PW and knee flexion range of motion were better than those in the control group(P<0.05,P<0.01).In the functional evaluation,the interaction effects of the TBHM group in all dimensions of the KOOS score and TUGT were statistically significant(P<0.05,P<0.01).Post-hoc simple effect analysis confirmed that there were significant differences in the above indicators between the two groups after intervention(P<0.05),and all indicators showed a significant main effect of time(P<0.01),suggesting that the intervention measures had continuous and cumulative curative effects.CONCLUSION TBHM effectively improves joint function and quality of life in KOA patients by restoring dynamic equilibrium in soft tissue tension and patellar mobility,ultimately achieving the therapeutic goal of concurrent tissue-bone management.展开更多
The ammunition loading system manipulator is susceptible to gear failure due to high-frequency,heavyload reciprocating motions and the absence of protective gear components.After a fault occurs,the distribution of fau...The ammunition loading system manipulator is susceptible to gear failure due to high-frequency,heavyload reciprocating motions and the absence of protective gear components.After a fault occurs,the distribution of fault characteristics under different loads is markedly inconsistent,and data is hard to label,which makes it difficult for the traditional diagnosis method based on single-condition training to generalize to different conditions.To address these issues,the paper proposes a novel transfer discriminant neural network(TDNN)for gear fault diagnosis.Specifically,an optimized joint distribution adaptive mechanism(OJDA)is designed to solve the distribution alignment problem between two domains.To improve the classification effect within the domain and the feature recognition capability for a few labeled data,metric learning is introduced to distinguish features from different fault categories.In addition,TDNN adopts a new pseudo-label training strategy to achieve label replacement by comparing the maximum probability of the pseudo-label with the test result.The proposed TDNN is verified in the experimental data set of the artillery manipulator device,and the diagnosis can achieve 99.5%,significantly outperforming other traditional adaptation methods.展开更多
Metasurfaces provide a potent platform for the dynamic manipulation of electromagnetic waves.Coupled with phase-change materials,they facilitate the creation of versatile metadevices,showcasing various tunable functio...Metasurfaces provide a potent platform for the dynamic manipulation of electromagnetic waves.Coupled with phase-change materials,they facilitate the creation of versatile metadevices,showcasing various tunable functions based on the transition between amorphous and crystalline states.However,the inherent limitation in tunable states imposes constraints on the multiplexing channels of metadevices.Here,this paper introduces a novel approach-a multi-functional metadevice achieved through the two-level control of the encoding phasechange metaatoms.Utilizing the phase-change material Ge_(2)Sb_(2)Se_(4)Te1(GSST)and high refractive-index liquid diiodomethane(CH_(2)I_(2)),this paper showcases precise control over electromagnetic wave manipulation.The GSST state governs the tunable function,switching it ON and OFF,while the presence of liquid in the hole dictates the deflection angle when the tunable function is active.Importantly,our tunable coding metasurface exhibits robust performance across a broad wavelength spectrum.The incorporation of high refractive-index liquid extends the regulatory dimension of the metadevice,enabling dynamic switching of encoding bit levels.This two-level tunable metadevice,rooted in phase-change materials,presents a promising avenue for the dynamic control of functions.展开更多
Aiming at the shortcoming that the traditional industrial manipulator using off-line programming cannot change along with the change of external environment,the key technologies such as machine vision and manipulator ...Aiming at the shortcoming that the traditional industrial manipulator using off-line programming cannot change along with the change of external environment,the key technologies such as machine vision and manipulator control are studied,and a complete manipulator vision tracking system is designed.Firstly,Denavit-Hartenberg(D-H)parameters method is used to construct the model of the manipulator and analyze the forward and inverse kinematics equations of the manipulator.At the same time,a binocular camera is used to obtain the threedimensional position of the target.Secondly,in order to make the manipulator track the target more accurately,the fuzzy adaptive square root unscented Kalman filter(FSRUKF)is proposed to estimate the target state.Finally,the manipulator tracking system is built by using the position-based visual servo.The simulation experiments show that FSRUKF converges faster and with less error than the square root unscented Kalman filter(SRUKF),which meets the application requirements of the manipulator tracking system,and basically meets the application requirements of the manipulator tracking system in the practical experiments.展开更多
Since the advent of transgenic technology,the incorporation of gene(s)encoding traits of economic importance in cotton is being practiced worldwide.However,factors like recalcitrant nature of cotton cultivars,in vitro...Since the advent of transgenic technology,the incorporation of gene(s)encoding traits of economic importance in cotton is being practiced worldwide.However,factors like recalcitrant nature of cotton cultivars,in vitro regeneration via tissue culture(especially via somatic embryogenesis),genotype dependency,long and toilsome protocols impede the pace of development of transgenic cotton.Besides that,types and age of explants,media composition,plant growth regulators and other environmental factors affect in vitro cotton regeneration significantly.The studies of genetic control of in vitro regeneration in plants have elucidated the role of certain transcription factor genes that are induced and expressed during somatic embryogenesis.Among these transcription factors,BABY BOOM(BBM)plays a very important role in signal transduction pathway,leading to cell differentiation and somatic embryos formation.The role of BBM has been established in plant cell proliferation,growth and development even without exogenous growth regulators.This review intends to provide an informative summary of regeneration and transformation problems in cotton and the latest developments in utilization of BBM transcription factors in cotton.We believe that the use of BBM will not only ease cotton genetic improvement but will also accelerate cotton breeding programmes.展开更多
Many cancer gene therapy strategies arevaccination strategies aiming at the induction ofcytolytic immune responses against the malignantcells. These strategies include modification of thetumour cells by transfection w...Many cancer gene therapy strategies arevaccination strategies aiming at the induction ofcytolytic immune responses against the malignantcells. These strategies include modification of thetumour cells by transfection with the genes of co-stimulatory molecules for cytotoxic T lymphocytes(CTL) such as IL-2 and B7, or manipulation ofbystander cells like autologous fibroblasts byintroduction of cytokine genes and subsequent co-展开更多
Interspecific introgression contributessignificantly to genetic improvement of cotton(Gossypium hirsutum L.).Cytogenetics hasfigured prominently in the creation ofinterspecific hybrids,synthetic polyploids,backcrosses...Interspecific introgression contributessignificantly to genetic improvement of cotton(Gossypium hirsutum L.).Cytogenetics hasfigured prominently in the creation ofinterspecific hybrids,synthetic polyploids,backcrosses,and other stocks essential to early-and mid-stage manipulation of germplasm展开更多
Forestation in the increasingly urbanized area generates a huge demand for ornamental tree stocks, requiring new approach to promote the cultural efficiency of highly valued seedlings. Chitosan oligosaccharide(COS) is...Forestation in the increasingly urbanized area generates a huge demand for ornamental tree stocks, requiring new approach to promote the cultural efficiency of highly valued seedlings. Chitosan oligosaccharide(COS) is one of biodegradable natural plant growth modifier derived from chitin and an abundant water insoluble biopolymer. In this study, Buddhist pine(Podocarpus macrophyllus)(PM) and Northeast yew(Taxus cuspidata)(TC) were cultured with or without COS addition from 1 July to 17 November 2016. Relative to the TC seedlings, the PM seedlings had greater growth of height and biomass which was found to be negatively correlated with the changes of nitrogen(N) and phosphorus(P) concentrations in shoot during the culture. Only those TC seedlings treated without COS addition had higher proportion of decline in the initial N concentration than that in the PM seedlings. Root P concentration declined less in Buddhist pine seedlings than that in Northeast yew seedlings treated with COS. By 17 of November 2016, both N and P seemed to have been diluted in the PM seedlings and exceed the demand in the TC seedlings. In conclusion, COS had the potential to be used for the culture of ornamental tree seedlings to promote nutrient utilization for shoot biomass accumulation, but more specific effect on nutrient allocation and utilization need to be confirmed by more studies.展开更多
In order to obtain direct solutions of parallel manipulator without divergence in real time,a modified global Newton-Raphson(MGNR) algorithm was proposed for forward kinematics analysis of six-degree-of-freedom(DOF) p...In order to obtain direct solutions of parallel manipulator without divergence in real time,a modified global Newton-Raphson(MGNR) algorithm was proposed for forward kinematics analysis of six-degree-of-freedom(DOF) parallel manipulator.Based on geometrical frame of parallel manipulator,the highly nonlinear equations of kinematics were derived using analytical approach.The MGNR algorithm was developed for the nonlinear equations based on Tailor expansion and Newton-Raphson iteration.The procedure of MGNR algorithm was programmed in Matlab/Simulink and compiled to a real-time computer with Microsoft visual studio.NET for implementation.The performance of the MGNR algorithms for 6-DOF parallel manipulator was analyzed and confirmed.Applying the MGNR algorithm,the real generalized pose of moving platform is solved by using the set of given positions of actuators.The theoretical analysis and numerical results indicate that the presented method can achieve the numerical convergent solution in less than 1 ms with high accuracy(1×10-9 m in linear motion and 1×10-9 rad in angular motion),even the initial guess value is far from the root.展开更多
In order to present a new method for analyzing the reliability of a two-link flexible robot manipulator,Lagrange dynamics differential equations of the two-link flexible robot manipulator were established by using the...In order to present a new method for analyzing the reliability of a two-link flexible robot manipulator,Lagrange dynamics differential equations of the two-link flexible robot manipulator were established by using the integrated modal method and the multi-body system dynamics method.By using the Monte Carlo method,the random sample values of the dynamic parameters were obtained and Lagrange dynamics differential equations were solved for each random sample value which revealed their displacement,speed and acceleration.On this basis,dynamic stresses and deformations were obtained.By taking the maximum values of the stresses and the deformations as output responses and the random sample values of dynamic parameters as input quantities,extremum response surface functions were established.A number of random samples were then obtained by using the Monte Carlo method and then the reliability was analyzed by using the extremum response surface method.The results show that the extremum response surface method is an efficient and fast reliability analysis method with high-accuracy for the two-link flexible robot manipulator.展开更多
The essential requirements of the end-effector of large space manipulator are capabilities of misalignment tolerance and soft capture.According to these requirements,an end-effector prototype combining the tendon-shea...The essential requirements of the end-effector of large space manipulator are capabilities of misalignment tolerance and soft capture.According to these requirements,an end-effector prototype combining the tendon-sheath transmission system with steel cable snaring mechanism was manufactured.An analysis method based on the coordinate transformation and the projection of key points of the mechanical interface was proposed,and it was a guideline of the end-effector design.Furthermore,the tendon-sheath transmission system was employed in the capture subassembly to reduce the inertia of the capture mechanism and enlarge the capture space.The capabilities of misalignment tolerance and soft capture were validated through the dynamic simulation in ADAMS software.The results of the capture simulation and experiment show that the end-effector has outstanding capabilities of misalignment tolerance and soft capture.The translation misalignments in radial directions are±100 mm,and angular misalignments about pitch and yaw are±15°.展开更多
文摘Optical field manipulation,an emerging frontier in photonics,demonstrates significant potential in biomedical microscopy,quantum state engineering,and micro-nano fabrication.To address the critical limitations of current optical modulation technologies in achieving full-parameter precision control,we proposed a novel approach for dynamic azimuthal optical field modulation based on dual-spiral arrays.By designing spatially interleaved spiral structures with different initial radii while maintaining identical periodic parameters,we achieved continuous optical modulation spanning the full 0-2πrange in azimuthal field distribution.Through rigorous numerical simulations,we systematically established a quantitative correlation between the structural parameters and azimuthal optical field patterns,revealing,for the first time,a quasi-linear relationship between the radius difference and the resultant optical distribution.This theoretical framework advances our fundamental understanding of structured optical field manipulation as well as provides a new paradigm for programmable photonic device design,with distinct technical advantages in super-resolution imaging and optical tweezer systems.
基金Project(2007AA01Z224) supported by National High-Tech Research and Development Program of China
文摘To deploy sensor nodes over the area of interest,a scheme,named node scattering manipulation,was proposed.It adopted the following method:during node scattering,the initial states of every node,including the velocity and direction,were manipulated so that it would land in a region with a certain probability;every sensor was relocated in order to improve the coverage and connectivity.Simultaneously,to easily analyze the process of scattering sensors,a trajectory model was also proposed.Integrating node scattering manipulation with trajectory model,the node deployment in wireless sensor network was thoroughly renovated,that is,this scheme can scatter sensors.In practice,the scheme was operable compared with the previous achievements.The simulation results demonstrate the superiority and feasibility of the scheme,and also show that the energy consumption for sensors relocation is reduced.
基金Supported by the Scientifi c Research Fund of Heilongjiang Provincial Education Department(11551039)
文摘Development of tools that can manipulate gene expression specifically and efficiently in the trophectoderm（TE） lineage would greatly aid understanding the roles of different genetic pathways in TE versus embryonic lineages. Here, we showed first time that short-term lentivirus infection of porcine blastocysts could lead to rapid expression of transgene specifically in TE cells. Efficient TE-specific gene knockdown could also be achieved by lentivirus-mediated pol III-driven short hairpin RNA（shRNA） and TE-specific gene expression could be temporal controlled efficiently by combining this system with Tet-On system. This lentivirus lineage-specific infection system would facilitate gene function studies in porcine pre-implatation embryos by specifically knockdown or overexpression of these genes in TE.
基金supported in part by the National Research Foundation, Prime Minister’s Office,Singapore under its Competitive Research Program (CRP Award No. NRF-CRP10-2012-04)in part by EDB, Singapore with grant No. S15-1322-IAF OSTIn-SIAG
文摘Manipulation of terahertz wave by metasurfaces has shown tremendous potential in developing compact and functional terahertz optical devices.Here,we propose complementary bilayer metasurfaces for enhanced terahertz wave amplitude and phase manipulation.The metasurfaces are composed of one layer of metal cut-wire arrays and one layer of their complementary aperture arrays separated by a dielectric spacer.Through the near-field coupling between transverse magnetic resonances in the metal apertures and electric resonances in the metal cut-wires,the structures can manipulate the cross polarization conversion and phase dispersion of terahertz wave.Particularly,the designed metasurfaces demonstrate a phase delay of 180°between two orthogonal axes with the same transmission amplitude between 0.70 and 1.0 THz,enabling a 45°broadband polarization conversion.When the metal cut-wires are rotated with respect to the apertures or the thickness of the dielectric spacer is changed,the amplitude and phase dispersion of the transmitted terahertz wave can be tuned.Such complementary coupled bilayer metasurfaces offer a new method to control the amplitude and phase dispersion of terahertz wave and promise great potential for applications in terahertz meta-devices.
基金supported by the National Natural Science Foundation of China(11972130)the Heilongjiang Touyan Team Program(11972130).
文摘Satellites with altitudes below 400 km are called super low altitude satellites(SLAS),often used to achieve responsive imaging tasks.Therefore,it is important for the manipulation of its ground track.Aiming at the problem of ground track manipulation of SLAS,a control method based on tangential impulse thrust is proposed.First,the equation of the longitude difference between SLAS and the target point on the target latitude is derived based on Gauss’s variational equations.On this basis,the influence of the tangential impulse thrust on the ground track’s longitude is derived.Finally,the method for ground track manipulation of SLAS under the tangential impulse thrust is proposed.The simulation results verify the effective-ness of the method,after manipulation,the satellite can visit the target point and revisit it for multiple days.
文摘Plant regeneration is the first step to cotton biotechnology.We screened over 100 genotypes and found two genotypes,YZ-1 and Y668,which are very easy to regenerate.It takes about 5 to 6
文摘Redacted by Specialty Committee of Heat-sensitive Moxibustion of WFCMS,Standardized Manipulations of Heat-sensitive Moxibustion(HSM).Therapy states the scope,normative references,terms and definitions,preoperative preparations,operation methods and procedure,indications and notice of HSM Therapy.
文摘Basal level of Animal Production is maintained with regulation of endocrine to concert genetic potential and environmental conditions. This balance can be moved to dramatical imporvements in rate and efficiency of production as well as composition of the products by biotechnological methods. In this paper, several novel achievements in the last decade are briefly reviewed for refference to further research and application of biotedchnology in animal production.
文摘OBJECTIVE To investigate the intervention effects of tissue-bone homeostasis manipulation(TBHM)on peripatellar biomechanical parameters and knee joint function in knee osteoarthritis(KOA)patients.METHODS Sixty patients with KOA(Kellgren-Lawrence gradeⅡ-Ⅲ)were recruited from the Acupuncture-Moxibustion Rehabilitation Department,Anhui University of Chinese Medicine between October 2024 and May 2025.Participants were randomized into a TBHM group(n=30)or a transcutaneous electrical neuromuscular stimulation(TENS)group(n=30).Using two-way repeated measures ANOVA,biomechanical indicators,including rectus femoris tension,vastus medialis tension,vastus lateralis tension,patellar ligament tension,lateral patellar displacement(LPD),medial patellar displacement(MPD),normalized patellar mobility(LPD/patellar width[PW],MPD/PW),knee flexion range of motion,and functional indicators,including KOOS subscales,time up and go test(TUGT),were compared between groups at baseline and after 6 weeks of intervention.RESULTS After intervention,all biomechanical and knee joint function indicators in the TBHM group were significantly improved(P<0.05,P<0.01),while only the vastus medialis tension,TUGT and KOOS Pain,ADL and QoL scores in the control group were significantly improved(P<0.01).The improvement amplitudes of biomechanical indicators in the TBHM group,including rectus femoris tension,vastus lateralis tension,patellar ligament tension,MPD/PW,LPD/PW and knee flexion range of motion were better than those in the control group(P<0.05,P<0.01).In the functional evaluation,the interaction effects of the TBHM group in all dimensions of the KOOS score and TUGT were statistically significant(P<0.05,P<0.01).Post-hoc simple effect analysis confirmed that there were significant differences in the above indicators between the two groups after intervention(P<0.05),and all indicators showed a significant main effect of time(P<0.01),suggesting that the intervention measures had continuous and cumulative curative effects.CONCLUSION TBHM effectively improves joint function and quality of life in KOA patients by restoring dynamic equilibrium in soft tissue tension and patellar mobility,ultimately achieving the therapeutic goal of concurrent tissue-bone management.
文摘The ammunition loading system manipulator is susceptible to gear failure due to high-frequency,heavyload reciprocating motions and the absence of protective gear components.After a fault occurs,the distribution of fault characteristics under different loads is markedly inconsistent,and data is hard to label,which makes it difficult for the traditional diagnosis method based on single-condition training to generalize to different conditions.To address these issues,the paper proposes a novel transfer discriminant neural network(TDNN)for gear fault diagnosis.Specifically,an optimized joint distribution adaptive mechanism(OJDA)is designed to solve the distribution alignment problem between two domains.To improve the classification effect within the domain and the feature recognition capability for a few labeled data,metric learning is introduced to distinguish features from different fault categories.In addition,TDNN adopts a new pseudo-label training strategy to achieve label replacement by comparing the maximum probability of the pseudo-label with the test result.The proposed TDNN is verified in the experimental data set of the artillery manipulator device,and the diagnosis can achieve 99.5%,significantly outperforming other traditional adaptation methods.
基金Supported by the Strategic Priority Research Program(B)of Chinese Academy of Sciences(XDB0580000,XDB43010200)National Natural Science Foundation of China(62222514,62350073,U2341226,61991440)+6 种基金National Key Research and Development Program of China(2023YFA1406900)Shanghai Science and Technology Committee(23ZR1482000,22JC1402900,22ZR1472700)Natural Science Foundation of Zhejiang Province(LR22F050004)Shanghai Municipal Science and Technology Major Project(2019SHZDZX01)Youth Innovation Promotion Association(Y2021070)and International Partnership Program(112GJHZ2022002FN)of Chinese Academy of SciencesShanghai Human Resources and Social Security Bureau(2022670)China Postdoctoral Science Foundation(2023T160661,2022TQ0353 and 2022M713261).
文摘Metasurfaces provide a potent platform for the dynamic manipulation of electromagnetic waves.Coupled with phase-change materials,they facilitate the creation of versatile metadevices,showcasing various tunable functions based on the transition between amorphous and crystalline states.However,the inherent limitation in tunable states imposes constraints on the multiplexing channels of metadevices.Here,this paper introduces a novel approach-a multi-functional metadevice achieved through the two-level control of the encoding phasechange metaatoms.Utilizing the phase-change material Ge_(2)Sb_(2)Se_(4)Te1(GSST)and high refractive-index liquid diiodomethane(CH_(2)I_(2)),this paper showcases precise control over electromagnetic wave manipulation.The GSST state governs the tunable function,switching it ON and OFF,while the presence of liquid in the hole dictates the deflection angle when the tunable function is active.Importantly,our tunable coding metasurface exhibits robust performance across a broad wavelength spectrum.The incorporation of high refractive-index liquid extends the regulatory dimension of the metadevice,enabling dynamic switching of encoding bit levels.This two-level tunable metadevice,rooted in phase-change materials,presents a promising avenue for the dynamic control of functions.
基金supported by Natural Science Basic Research Program of Shaanxi(2022JQ-593)Key Research and Development Program of Shaanxi(2022GY-089)。
文摘Aiming at the shortcoming that the traditional industrial manipulator using off-line programming cannot change along with the change of external environment,the key technologies such as machine vision and manipulator control are studied,and a complete manipulator vision tracking system is designed.Firstly,Denavit-Hartenberg(D-H)parameters method is used to construct the model of the manipulator and analyze the forward and inverse kinematics equations of the manipulator.At the same time,a binocular camera is used to obtain the threedimensional position of the target.Secondly,in order to make the manipulator track the target more accurately,the fuzzy adaptive square root unscented Kalman filter(FSRUKF)is proposed to estimate the target state.Finally,the manipulator tracking system is built by using the position-based visual servo.The simulation experiments show that FSRUKF converges faster and with less error than the square root unscented Kalman filter(SRUKF),which meets the application requirements of the manipulator tracking system,and basically meets the application requirements of the manipulator tracking system in the practical experiments.
基金No any funds were received from any agency for this study.
文摘Since the advent of transgenic technology,the incorporation of gene(s)encoding traits of economic importance in cotton is being practiced worldwide.However,factors like recalcitrant nature of cotton cultivars,in vitro regeneration via tissue culture(especially via somatic embryogenesis),genotype dependency,long and toilsome protocols impede the pace of development of transgenic cotton.Besides that,types and age of explants,media composition,plant growth regulators and other environmental factors affect in vitro cotton regeneration significantly.The studies of genetic control of in vitro regeneration in plants have elucidated the role of certain transcription factor genes that are induced and expressed during somatic embryogenesis.Among these transcription factors,BABY BOOM(BBM)plays a very important role in signal transduction pathway,leading to cell differentiation and somatic embryos formation.The role of BBM has been established in plant cell proliferation,growth and development even without exogenous growth regulators.This review intends to provide an informative summary of regeneration and transformation problems in cotton and the latest developments in utilization of BBM transcription factors in cotton.We believe that the use of BBM will not only ease cotton genetic improvement but will also accelerate cotton breeding programmes.
文摘Many cancer gene therapy strategies arevaccination strategies aiming at the induction ofcytolytic immune responses against the malignantcells. These strategies include modification of thetumour cells by transfection with the genes of co-stimulatory molecules for cytotoxic T lymphocytes(CTL) such as IL-2 and B7, or manipulation ofbystander cells like autologous fibroblasts byintroduction of cytokine genes and subsequent co-
文摘Interspecific introgression contributessignificantly to genetic improvement of cotton(Gossypium hirsutum L.).Cytogenetics hasfigured prominently in the creation ofinterspecific hybrids,synthetic polyploids,backcrosses,and other stocks essential to early-and mid-stage manipulation of germplasm
基金supported by the National Natural Science Foundation of China(31600496)The National Key Research and Development Program of China(2016YFC0500307)
文摘Forestation in the increasingly urbanized area generates a huge demand for ornamental tree stocks, requiring new approach to promote the cultural efficiency of highly valued seedlings. Chitosan oligosaccharide(COS) is one of biodegradable natural plant growth modifier derived from chitin and an abundant water insoluble biopolymer. In this study, Buddhist pine(Podocarpus macrophyllus)(PM) and Northeast yew(Taxus cuspidata)(TC) were cultured with or without COS addition from 1 July to 17 November 2016. Relative to the TC seedlings, the PM seedlings had greater growth of height and biomass which was found to be negatively correlated with the changes of nitrogen(N) and phosphorus(P) concentrations in shoot during the culture. Only those TC seedlings treated without COS addition had higher proportion of decline in the initial N concentration than that in the PM seedlings. Root P concentration declined less in Buddhist pine seedlings than that in Northeast yew seedlings treated with COS. By 17 of November 2016, both N and P seemed to have been diluted in the PM seedlings and exceed the demand in the TC seedlings. In conclusion, COS had the potential to be used for the culture of ornamental tree seedlings to promote nutrient utilization for shoot biomass accumulation, but more specific effect on nutrient allocation and utilization need to be confirmed by more studies.
基金Project(HgdJG00401D04) supported by National 921 Manned Space Project Foundation of ChinaProject(SKLRS200803B) supported by the Self-Planned Task Foundation of State Key Laboratory of Robotics and System (HIT) of China+1 种基金Project(CDAZ98502211) supported by China’s "World Class University (985)" Project FoundationProject(50975055) supported by the National Natural Science Foundation of China
文摘In order to obtain direct solutions of parallel manipulator without divergence in real time,a modified global Newton-Raphson(MGNR) algorithm was proposed for forward kinematics analysis of six-degree-of-freedom(DOF) parallel manipulator.Based on geometrical frame of parallel manipulator,the highly nonlinear equations of kinematics were derived using analytical approach.The MGNR algorithm was developed for the nonlinear equations based on Tailor expansion and Newton-Raphson iteration.The procedure of MGNR algorithm was programmed in Matlab/Simulink and compiled to a real-time computer with Microsoft visual studio.NET for implementation.The performance of the MGNR algorithms for 6-DOF parallel manipulator was analyzed and confirmed.Applying the MGNR algorithm,the real generalized pose of moving platform is solved by using the set of given positions of actuators.The theoretical analysis and numerical results indicate that the presented method can achieve the numerical convergent solution in less than 1 ms with high accuracy(1×10-9 m in linear motion and 1×10-9 rad in angular motion),even the initial guess value is far from the root.
基金Project(2006AA04Z405)supported by the National High Technology Research and Development Program of ChinaProject(3102019)supported by Beijing Municipal Natural Science Foundation,China
文摘In order to present a new method for analyzing the reliability of a two-link flexible robot manipulator,Lagrange dynamics differential equations of the two-link flexible robot manipulator were established by using the integrated modal method and the multi-body system dynamics method.By using the Monte Carlo method,the random sample values of the dynamic parameters were obtained and Lagrange dynamics differential equations were solved for each random sample value which revealed their displacement,speed and acceleration.On this basis,dynamic stresses and deformations were obtained.By taking the maximum values of the stresses and the deformations as output responses and the random sample values of dynamic parameters as input quantities,extremum response surface functions were established.A number of random samples were then obtained by using the Monte Carlo method and then the reliability was analyzed by using the extremum response surface method.The results show that the extremum response surface method is an efficient and fast reliability analysis method with high-accuracy for the two-link flexible robot manipulator.
基金Project(2006AA04Z228) supported by National Hi-tech Research and Development Program of China
文摘The essential requirements of the end-effector of large space manipulator are capabilities of misalignment tolerance and soft capture.According to these requirements,an end-effector prototype combining the tendon-sheath transmission system with steel cable snaring mechanism was manufactured.An analysis method based on the coordinate transformation and the projection of key points of the mechanical interface was proposed,and it was a guideline of the end-effector design.Furthermore,the tendon-sheath transmission system was employed in the capture subassembly to reduce the inertia of the capture mechanism and enlarge the capture space.The capabilities of misalignment tolerance and soft capture were validated through the dynamic simulation in ADAMS software.The results of the capture simulation and experiment show that the end-effector has outstanding capabilities of misalignment tolerance and soft capture.The translation misalignments in radial directions are±100 mm,and angular misalignments about pitch and yaw are±15°.
