目的探讨氢质子磁共振波谱(proton magnetic resonance spectroscopy,1H-MRS)联合术中磁共振(in-traoperative magnetic resonance imaging,iMRI)导航在颅内病变穿刺活检的应用。方法使用兼具有1H-MRS功能的1.5 T术中磁共振系统,并配有...目的探讨氢质子磁共振波谱(proton magnetic resonance spectroscopy,1H-MRS)联合术中磁共振(in-traoperative magnetic resonance imaging,iMRI)导航在颅内病变穿刺活检的应用。方法使用兼具有1H-MRS功能的1.5 T术中磁共振系统,并配有导航计算机成像系统。26例颅内病变患者,先使用1H-MRS分析病灶组织生化及代谢情况,然后在iMRI导航引导下根据病变不同部位代谢情况对病变相应区域进行穿刺活检。结果 26例患者穿刺成功,25例病变组织获得组织病理学诊断。所有病例术中及术后均未出现明显并发症如严重出血、新发神经功能障碍等。结论 1H-MRS分析能提供病变的代谢信息,并帮助确定最佳活检取材点,iMRI导航能精确定位,并在术中明确取材位置和排除出血等并发症,1H-MRS联合iMRI导航在颅内病变活检是一种精准、有效、安全的技术。展开更多
Glioma is the most common type of primary tumors in the brain,histologically varying from low grade to high grade.Physiological regional heterogeneity also has been well documented in glioma.Hypercellularity,pleomorph...Glioma is the most common type of primary tumors in the brain,histologically varying from low grade to high grade.Physiological regional heterogeneity also has been well documented in glioma.Hypercellularity,pleomorphism,vascular endothelial proliferation,mitotic activity,and necrosis are important histopathological characteristics,which determine tumor grading and its malignancy.Advanced MR imaging currently provides in vivo physiological and metabolic information including chemical composition,cerebral blood volume,perfusion,vascular permeability,and water mobility,which reflect those pathophysiological features of brain glioma to some extent.To date,MR spectroscopy,diffusion weighted imaging,perfusion weighted imaging and other new MRI techniques have many advantages on tumor grading,monitoring malignant transformation,predicting prognosis,and differentiating between tumor recurrence and malignant progression.展开更多
目的探讨活体心肌氢质子磁共振波谱(proton magnetic resonance spectroscopy,1H-MRS)扫描的可行性。方法采用1.5T磁共振扫描仪对100名志愿者进行心肌1H-MRS扫描,分析所得谱线。结果 100名志愿者均完成检查,水峰位于4.7ppm,显示率为100%...目的探讨活体心肌氢质子磁共振波谱(proton magnetic resonance spectroscopy,1H-MRS)扫描的可行性。方法采用1.5T磁共振扫描仪对100名志愿者进行心肌1H-MRS扫描,分析所得谱线。结果 100名志愿者均完成检查,水峰位于4.7ppm,显示率为100%,胆碱(choline,Cho)峰位于3.2ppm,显示率为86%,肌酸(creatine,Cr)峰位于3.0ppm,显示率为90%,甘油三酯(triglyceride,TG)峰位于0.9～1.6ppm,显示率为98%。共86例可见上述所有波峰,以代谢物的峰高与水峰峰高的比值表示代谢物含量,根据86例谱线计算出Cho含量为1.94%,Cr含量为1.95%,TG含量为9.41%。结论 1H-MRS可以检测活体心肌相关代谢产物。展开更多
文摘目的探讨氢质子磁共振波谱(proton magnetic resonance spectroscopy,1H-MRS)联合术中磁共振(in-traoperative magnetic resonance imaging,iMRI)导航在颅内病变穿刺活检的应用。方法使用兼具有1H-MRS功能的1.5 T术中磁共振系统,并配有导航计算机成像系统。26例颅内病变患者,先使用1H-MRS分析病灶组织生化及代谢情况,然后在iMRI导航引导下根据病变不同部位代谢情况对病变相应区域进行穿刺活检。结果 26例患者穿刺成功,25例病变组织获得组织病理学诊断。所有病例术中及术后均未出现明显并发症如严重出血、新发神经功能障碍等。结论 1H-MRS分析能提供病变的代谢信息,并帮助确定最佳活检取材点,iMRI导航能精确定位,并在术中明确取材位置和排除出血等并发症,1H-MRS联合iMRI导航在颅内病变活检是一种精准、有效、安全的技术。
文摘目的探讨高胆红素血症患儿不同胆红素水平与MRI信号强度之间的关系。方法 2014年7月～2015年10月,60例新生儿根据血清总胆红素（TSB）水平分为组Ⅰ（TSB 17.1～34.2μmol/L）16例,组Ⅱ（TSB〉34.2～340μmol/L）34例,组Ⅲ（TSB〉340μmol/L）10例。行头部3.0 T MRI检查,测量双侧苍白球T_1WI序列信号强度。结果组Ⅲ双侧苍白球信号强度高于组Ⅰ、组Ⅱ（t〉2.0,P〈0.05）。双侧苍白球T_1WI序列信号强度与TSB水平呈正相关（r=0.408,P〈0.05）。结论双侧苍白球T_1WI序列信号强度增高可为诊断新生儿高胆红素脑病提供定量参考。
文摘Glioma is the most common type of primary tumors in the brain,histologically varying from low grade to high grade.Physiological regional heterogeneity also has been well documented in glioma.Hypercellularity,pleomorphism,vascular endothelial proliferation,mitotic activity,and necrosis are important histopathological characteristics,which determine tumor grading and its malignancy.Advanced MR imaging currently provides in vivo physiological and metabolic information including chemical composition,cerebral blood volume,perfusion,vascular permeability,and water mobility,which reflect those pathophysiological features of brain glioma to some extent.To date,MR spectroscopy,diffusion weighted imaging,perfusion weighted imaging and other new MRI techniques have many advantages on tumor grading,monitoring malignant transformation,predicting prognosis,and differentiating between tumor recurrence and malignant progression.
