Aim:The oxidized low-density lipoprotein(OxLDL) plays an important role in atherosclerosis yet it remains unclear if it damages circulating erythrocytes. Method: In this study。
OBJECTIVE Normal male aging is associated with declines in levels of the sex steroid hormone testosterone. A large body of evidence supports a neurotrophic role for testosterone in central nervous system. Lipoprotein ...OBJECTIVE Normal male aging is associated with declines in levels of the sex steroid hormone testosterone. A large body of evidence supports a neurotrophic role for testosterone in central nervous system. Lipoprotein lipase(LPL) is also expressed in the brain with highest levels found in the pyramidal cells of the hippocampus, we previous reported LPL-deficient mice exhibited memory disfunction. Testosterone is known to be largely converted to estradiol following aromatization within the hippocampus. Although testosterone has been implicated in lipid metabolism, it remains elusive whether testosterone can regulate brain LPL through DNA methylation mechanism. In order to clarify DNA methylation control exerted by testosterone over LPL gene in central nervous system, and its effect on lipid metabolism, we examined the adult male rat hippocampus to determine whether castration induced testosterone deficiency can affect lipid profile and LPL gene expression through its altered methylation pattern. METHODS Model of aging with declines in levels of the sex steroid hormone testosterone was performed as our previous description. RESULTS(1) Serum testosterone and brain testosterone levels were significantly decreased, which were restored to the control level after testosterone replacement,respectively(P<0.01);(2) Androgen deficiency was not found in Morris water maze and motor performance, however, androgen deficiency increases neurological and cognitive impairment in aged rats.(3)Decreased expression of olfactory marker protein(OMP) in olfactory bulb of SD rats treated with androgen deficiency.(4) The expression of Fox O3 and OMP in the olfactory bulb of androgen deficient rats was down-regulated, accompanied by dysfunction of the olfactory limbic system.(5) Decreased LPL m RNA level and inversely increased LPL promoter methylation level were observed following androgen deficiency and reserved by testosterone replacement.(6) In contrast, androgen deficiency slightly increased estrogen receptor beta(ERβ) m RNA levels and significantly decreased its promoter methylation levels within the hippocampus, and reserved as well by testosterone replacement. CONCLUSION(1) LPL in synaptic plasticity and contributes to a better understanding of the LPL function in the brain, where altered LPL levels are related to learning and memory impairment.(2) Androgen and Fox O3 play an important role in the olfactory cognitive process of the nervous system.(3) LPL expression in hippocampus is actively maintained by sex steroid hormones and that DNA methylation modification may contribute to this homeostatic regulation.展开更多
Background and Objective Elevated serum levels of lipoprotein(Lp[a]) has recently been proposed as a marker of cardiovascular risk.We aimed to determine the role of Lp(a) on long-term clinical outcomes in patients wit...Background and Objective Elevated serum levels of lipoprotein(Lp[a]) has recently been proposed as a marker of cardiovascular risk.We aimed to determine the role of Lp(a) on long-term clinical outcomes in patients with ST elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI).展开更多
Objective This work is designed to fabricate a new low density lipoprotein(LDL)absorbent through a mussel-inspired approach and to evaluate the blood compatibility and adsorption clearance,capacity and selectivity of ...Objective This work is designed to fabricate a new low density lipoprotein(LDL)absorbent through a mussel-inspired approach and to evaluate the blood compatibility and adsorption clearance,capacity and selectivity of this technique in vitro.Methods Heparin immobilized cellulose(HeTaCe)hydrogels were fabricated through a mussel-inspired approach.Fourier transform infrared spectroscopy,X-ray photoelectron spectroscopy,thermo gravimetric analysis were used to characterize the chemical compositions of the hydrogels.展开更多
Objective Increased transcytosis of low-density lipoprotein (LDL)across the endothelium and oxidation of LDL deposited within the subendothelial space are crucial early events in atherogenesis. C1q/TNF-related protein...Objective Increased transcytosis of low-density lipoprotein (LDL)across the endothelium and oxidation of LDL deposited within the subendothelial space are crucial early events in atherogenesis. C1q/TNF-related protein (CTRP) 5 is a novel secreted glycoprotein and its biological functions are largely undefined.展开更多
After 1500 male and female broiler chickens from a pure line were selected on the basis of plasma very low density lipoprotein (VLDL) concentration at 8 weeks of age,abdominal fat(AF),liver fat,body weight,meat traits...After 1500 male and female broiler chickens from a pure line were selected on the basis of plasma very low density lipoprotein (VLDL) concentration at 8 weeks of age,abdominal fat(AF),liver fat,body weight,meat traits and plasma lipids were determined,and effects of interaction between genotype and nutrition on AF and its correlated traits were studied.1) It was efficient to select against AF on the basis of plasma VLDL concentration.The indirect response of gizzard fat was the greatest,and that of liver fat was the second.AF was decreased,whereas liver fat was increased,feed conversion efficiency during growing period were improved, body weight and meat traits were both not influenced by selecting for low plasma VLDL concentration.2) Nutrition had significant effect on fat deposition and growth performance.Interaction between line and diet had evident effect on AF and its correlated traits.In general,diet had greater effect on H-VLDL line than L-VLDL line,namely chickens of L-VLDL line were less sensitive to diet than those of H-VLDL line.3) Due to high coefficients of variation of plasma VLDL and AF in H-VLDL and L-VLDL lines in the first generation.It will be possible that plasma VLDL is to be selected continuously to breed low fat line of broiler chickens of which the feed conversion efficiency is much better.Moreover,family combined with individual selection should be adopted during future generation selection and breeding because of significant family difference in plasma VLDL concentration.展开更多
The reproductive performance and abdominal fat of the high VLDL (H-VLDL) and low VLDL (L-VLDL) lines were studied after divergent selection for plasma very low density lipoprotein (VLDL) concentration in broiler chick...The reproductive performance and abdominal fat of the high VLDL (H-VLDL) and low VLDL (L-VLDL) lines were studied after divergent selection for plasma very low density lipoprotein (VLDL) concentration in broiler chickens at 8 weeks of age. It was shown that the main reproductive traits were higher in L-VLDL line than H-VLDL line. The beneficial correlated responses of the reproductive traits were produced by the selection for plasma VLDL. 1) Plasma VLDL concentration was significantly correlated with abdominal fat (r=0.50, P<0.01), ahich was higher than that with plasma triglyceride concentration. There was a significant difference in abdominal fat between both lines but age increase or food restriction may decrease this difference. The H-VLDL line had about twice as much abdominal fat as had L-VLDL at 8 weeks of age, while its mean body weight was similar to that of the L-VLDL line from birtl to the end of laying. 2) Mortality from apparently stress-related causes by food restriction for H-VLDL line females began to increase from 15 weeks of age and was 21% (38/180) higher compared with 13% (23/180) for L-VLDL line females. 3) Age of 5% Lying for L-VLDL line was 3 days less than that of H-VLDL line, age of 50% Lying was 37 days less for L-VLDL line than H-VLDL line, and the age of laying peak was similiar in both lines. Rate of lay at peak in L-VLDL and H-VLDL lines were 70.3%, 66.4%, respectively. 4) Fertility rate in L-VLDL line was significantly higher than that of H-VLDL line at 27 weeks of age (P=0.01) and there was a little difference in fertility rates between H-VLDL and L-VLDL line during late laying period. There were no significant differences between H-VLDL and L-VLDL lines in of day-old healthy the numbers chicks and hatchabilities of fertile and total eggs wheres mean numbers of healthy day-old chicks per hen were more is L-VLDL line than in H-VLDL line. 5) Under food restriction, egg production was higher in L-VLDL line than in H-VLDL line. It should be emphasized that the rate and amount of egg production in L-VLDL line were both significant higher than in H-VLDL line during early laying period (from 23 to 43 weeks of age, P<0.01). The mean egg production of LF line hens was ll eggs more than that of HF line ones throughtout the laying period (from 23 to 62 weeks of age). 6) Eggs in L-VLDL line were slightly heavier than those in H-VLDL line. Feed conversion (FC) ratio for L-VLDL line was lower than that in H-VLDL line betwen 23 and 62 weeks of age (5.01 and 5.46, respectively), especially FC ratio of L-VLDL line was significantly lower than that of HF line during 23 and 43 weeks of age (P<0.01). Also FC efficiency of breeding hens was higher in L-VLDL line than in H-VLDL line.展开更多
目的分析急性脑梗死(acute cerebral infarction,ACI)患者小而密低密度脂蛋白(small dense low-density lipoprotein,sd-LDL)及脂蛋白(a)水平与颈动脉斑块稳定性的关系。方法回顾性选取2020年2月至2024年2月河北省人民医院收治的老年AC...目的分析急性脑梗死(acute cerebral infarction,ACI)患者小而密低密度脂蛋白(small dense low-density lipoprotein,sd-LDL)及脂蛋白(a)水平与颈动脉斑块稳定性的关系。方法回顾性选取2020年2月至2024年2月河北省人民医院收治的老年ACI患者160例,所有患者行颈部彩色多普勒超声检查,依据颈动脉斑块情况分为无斑块组43例、稳定斑块组56例和不稳定斑块组61例,另取同期河北省人民医院健康体检者40例作为对照组,比较4组临床资料、sd-LDL、脂蛋白(a)水平,评估sd-LDL、脂蛋白(a)水平对不稳定斑块的预测价值。结果与无斑块组比较,稳定斑块组和不稳定斑块组美国国立卫生研究院卒中量表(National Institute of Health Stroke Scale,NIHSS)评分、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)显著升高,不稳定斑块组总胆固醇显著升高,高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)显著降低,对照组NIHSS评分、总胆固醇、三酰甘油、LDL-C显著降低,HDL-C显著升高,差异有统计学意义(P<0.05);与稳定斑块组比较,不稳定斑块组NIHSS评分、LDL-C、sdLDL、脂蛋白(a)显著升高,HDL-C显著降低,对照组脂蛋白(a)显著降低,差异有统计学意义(P<0.05)。Pearson相关性分析显示,sd-LDL、脂蛋白(a)水平与NIHSS评分、总胆固醇、三酰甘油、LDL-C呈显著正相关(P<0.05,P<0.01),与HDL-C呈显著负相关(P<0.01)。二元logistic回归分析显示,NIHSS评分、LDL-C、sd-LDL、脂蛋白(a)是ACI患者颈动脉不稳定斑块形成的危险因素,HDL-C是保护因素(P<0.01)。ROC曲线结果显示,sd-LDL、脂蛋白(a)及联合检测对颈动脉斑块稳定性预测的ROC曲线下面积分别为0.830、0.847、0.921,联合检测的敏感性高于sd-LDL、脂蛋白(a)单项指标检测(93.44%vs 88.52%、86.89%,P=0.000)。结论血浆sd-LDL、脂蛋白(a)水平与ACI患者颈动脉斑块稳定性具有一定关联性,可作为临床相关参考指标。展开更多
目的探究血浆致动脉粥样硬化指数(atherogenic index of plasma,AIP)与代谢功能障碍相关脂肪性肝病(metabolism-associated steatotic liver disease,MASLD)的关系,评估AIP作为MASLD风险预测指标的潜在价值,为早期预防和临床干预提供参...目的探究血浆致动脉粥样硬化指数(atherogenic index of plasma,AIP)与代谢功能障碍相关脂肪性肝病(metabolism-associated steatotic liver disease,MASLD)的关系,评估AIP作为MASLD风险预测指标的潜在价值,为早期预防和临床干预提供参考。方法纳入2021年6月至2023年5月西安交通大学第二附属医院4850名健康体检者。按AIP四分位数将全体受试者由低到高分为4组(Q1~Q4),比较各组间生化指标与MASLD患病率。采用Logistic回归、亚组分析、限制性立方样条(restricted cubic splines,RCS)等方法探究AIP与MASLD之间的相关性。结果共纳入4850例受试者,MASLD患病率为26.08%(1265例)。Q1~Q4组MASLD的患病率分别为4.0%、13.8%、30.8%、55.6%,患病率随AIP四分位数组级升高而呈显著递增趋势(P<0.001)。与Q1组相比,Q2~Q4组男性占比、身体质量指数(body mass index,BMI)、吸烟者占比、超重肥胖占比、腹型肥胖占比、糖尿病前期占比、高血压占比、血尿酸及脂肪肝指数(fatty liver index,FLI)水平均明显增加,差异有统计学意义(P<0.001)。随着AIP的增加,血清总胆固醇、三酰甘油、低密度脂蛋白胆固醇水平显著增加,高密度脂蛋白胆固醇水平则显著降低(P<0.001)。RCS曲线显示随着AIP增加,MASLD的患病风险显著增加,AIP与MASLD患病风险之间呈线性关系。Logistic回归显示,在调整混杂因素后,Q4组中MASLD发生风险为Q1组的8.71倍(OR=8.71,95%CI:6.20~12.23,P<0.001)。建立的复合模型具有更高的判别性能(AUC=0.883,95%CI:0.873~0.892)。交互作用分析提示AIP与BMI、高血压及糖尿病前期存在显著交互作用(P<0.05),在无上述代谢异常的人群中,AIP与MASLD的关联更为显著。结论AIP升高与MASLD发病风险增加显著相关,尤其在BMI正常组、血压正常组及血糖正常组中关联更强,提示AIP有望作为MASLD早期筛查的潜在指标。展开更多
基金supported by National Natural Science Foundation of China(NSFC10572159)supported by "111 Project" entitled "Biomechanics&Tissue Repair Engineering"(No.:B06023)Chongqing Science&Technology Council(CSTC 2006ba5010)
文摘Aim:The oxidized low-density lipoprotein(OxLDL) plays an important role in atherosclerosis yet it remains unclear if it damages circulating erythrocytes. Method: In this study。
基金NBRD Program of China(2016YFC1306302 2016YFC1305903)+3 种基金National Natural Science Foundation of China(81571044 81471633 61450004 and 81171015)
文摘OBJECTIVE Normal male aging is associated with declines in levels of the sex steroid hormone testosterone. A large body of evidence supports a neurotrophic role for testosterone in central nervous system. Lipoprotein lipase(LPL) is also expressed in the brain with highest levels found in the pyramidal cells of the hippocampus, we previous reported LPL-deficient mice exhibited memory disfunction. Testosterone is known to be largely converted to estradiol following aromatization within the hippocampus. Although testosterone has been implicated in lipid metabolism, it remains elusive whether testosterone can regulate brain LPL through DNA methylation mechanism. In order to clarify DNA methylation control exerted by testosterone over LPL gene in central nervous system, and its effect on lipid metabolism, we examined the adult male rat hippocampus to determine whether castration induced testosterone deficiency can affect lipid profile and LPL gene expression through its altered methylation pattern. METHODS Model of aging with declines in levels of the sex steroid hormone testosterone was performed as our previous description. RESULTS(1) Serum testosterone and brain testosterone levels were significantly decreased, which were restored to the control level after testosterone replacement,respectively(P<0.01);(2) Androgen deficiency was not found in Morris water maze and motor performance, however, androgen deficiency increases neurological and cognitive impairment in aged rats.(3)Decreased expression of olfactory marker protein(OMP) in olfactory bulb of SD rats treated with androgen deficiency.(4) The expression of Fox O3 and OMP in the olfactory bulb of androgen deficient rats was down-regulated, accompanied by dysfunction of the olfactory limbic system.(5) Decreased LPL m RNA level and inversely increased LPL promoter methylation level were observed following androgen deficiency and reserved by testosterone replacement.(6) In contrast, androgen deficiency slightly increased estrogen receptor beta(ERβ) m RNA levels and significantly decreased its promoter methylation levels within the hippocampus, and reserved as well by testosterone replacement. CONCLUSION(1) LPL in synaptic plasticity and contributes to a better understanding of the LPL function in the brain, where altered LPL levels are related to learning and memory impairment.(2) Androgen and Fox O3 play an important role in the olfactory cognitive process of the nervous system.(3) LPL expression in hippocampus is actively maintained by sex steroid hormones and that DNA methylation modification may contribute to this homeostatic regulation.
文摘Background and Objective Elevated serum levels of lipoprotein(Lp[a]) has recently been proposed as a marker of cardiovascular risk.We aimed to determine the role of Lp(a) on long-term clinical outcomes in patients with ST elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI).
文摘Objective This work is designed to fabricate a new low density lipoprotein(LDL)absorbent through a mussel-inspired approach and to evaluate the blood compatibility and adsorption clearance,capacity and selectivity of this technique in vitro.Methods Heparin immobilized cellulose(HeTaCe)hydrogels were fabricated through a mussel-inspired approach.Fourier transform infrared spectroscopy,X-ray photoelectron spectroscopy,thermo gravimetric analysis were used to characterize the chemical compositions of the hydrogels.
文摘Objective Increased transcytosis of low-density lipoprotein (LDL)across the endothelium and oxidation of LDL deposited within the subendothelial space are crucial early events in atherogenesis. C1q/TNF-related protein (CTRP) 5 is a novel secreted glycoprotein and its biological functions are largely undefined.
文摘After 1500 male and female broiler chickens from a pure line were selected on the basis of plasma very low density lipoprotein (VLDL) concentration at 8 weeks of age,abdominal fat(AF),liver fat,body weight,meat traits and plasma lipids were determined,and effects of interaction between genotype and nutrition on AF and its correlated traits were studied.1) It was efficient to select against AF on the basis of plasma VLDL concentration.The indirect response of gizzard fat was the greatest,and that of liver fat was the second.AF was decreased,whereas liver fat was increased,feed conversion efficiency during growing period were improved, body weight and meat traits were both not influenced by selecting for low plasma VLDL concentration.2) Nutrition had significant effect on fat deposition and growth performance.Interaction between line and diet had evident effect on AF and its correlated traits.In general,diet had greater effect on H-VLDL line than L-VLDL line,namely chickens of L-VLDL line were less sensitive to diet than those of H-VLDL line.3) Due to high coefficients of variation of plasma VLDL and AF in H-VLDL and L-VLDL lines in the first generation.It will be possible that plasma VLDL is to be selected continuously to breed low fat line of broiler chickens of which the feed conversion efficiency is much better.Moreover,family combined with individual selection should be adopted during future generation selection and breeding because of significant family difference in plasma VLDL concentration.
文摘The reproductive performance and abdominal fat of the high VLDL (H-VLDL) and low VLDL (L-VLDL) lines were studied after divergent selection for plasma very low density lipoprotein (VLDL) concentration in broiler chickens at 8 weeks of age. It was shown that the main reproductive traits were higher in L-VLDL line than H-VLDL line. The beneficial correlated responses of the reproductive traits were produced by the selection for plasma VLDL. 1) Plasma VLDL concentration was significantly correlated with abdominal fat (r=0.50, P<0.01), ahich was higher than that with plasma triglyceride concentration. There was a significant difference in abdominal fat between both lines but age increase or food restriction may decrease this difference. The H-VLDL line had about twice as much abdominal fat as had L-VLDL at 8 weeks of age, while its mean body weight was similar to that of the L-VLDL line from birtl to the end of laying. 2) Mortality from apparently stress-related causes by food restriction for H-VLDL line females began to increase from 15 weeks of age and was 21% (38/180) higher compared with 13% (23/180) for L-VLDL line females. 3) Age of 5% Lying for L-VLDL line was 3 days less than that of H-VLDL line, age of 50% Lying was 37 days less for L-VLDL line than H-VLDL line, and the age of laying peak was similiar in both lines. Rate of lay at peak in L-VLDL and H-VLDL lines were 70.3%, 66.4%, respectively. 4) Fertility rate in L-VLDL line was significantly higher than that of H-VLDL line at 27 weeks of age (P=0.01) and there was a little difference in fertility rates between H-VLDL and L-VLDL line during late laying period. There were no significant differences between H-VLDL and L-VLDL lines in of day-old healthy the numbers chicks and hatchabilities of fertile and total eggs wheres mean numbers of healthy day-old chicks per hen were more is L-VLDL line than in H-VLDL line. 5) Under food restriction, egg production was higher in L-VLDL line than in H-VLDL line. It should be emphasized that the rate and amount of egg production in L-VLDL line were both significant higher than in H-VLDL line during early laying period (from 23 to 43 weeks of age, P<0.01). The mean egg production of LF line hens was ll eggs more than that of HF line ones throughtout the laying period (from 23 to 62 weeks of age). 6) Eggs in L-VLDL line were slightly heavier than those in H-VLDL line. Feed conversion (FC) ratio for L-VLDL line was lower than that in H-VLDL line betwen 23 and 62 weeks of age (5.01 and 5.46, respectively), especially FC ratio of L-VLDL line was significantly lower than that of HF line during 23 and 43 weeks of age (P<0.01). Also FC efficiency of breeding hens was higher in L-VLDL line than in H-VLDL line.
文摘目的分析急性脑梗死(acute cerebral infarction,ACI)患者小而密低密度脂蛋白(small dense low-density lipoprotein,sd-LDL)及脂蛋白(a)水平与颈动脉斑块稳定性的关系。方法回顾性选取2020年2月至2024年2月河北省人民医院收治的老年ACI患者160例,所有患者行颈部彩色多普勒超声检查,依据颈动脉斑块情况分为无斑块组43例、稳定斑块组56例和不稳定斑块组61例,另取同期河北省人民医院健康体检者40例作为对照组,比较4组临床资料、sd-LDL、脂蛋白(a)水平,评估sd-LDL、脂蛋白(a)水平对不稳定斑块的预测价值。结果与无斑块组比较,稳定斑块组和不稳定斑块组美国国立卫生研究院卒中量表(National Institute of Health Stroke Scale,NIHSS)评分、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)显著升高,不稳定斑块组总胆固醇显著升高,高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)显著降低,对照组NIHSS评分、总胆固醇、三酰甘油、LDL-C显著降低,HDL-C显著升高,差异有统计学意义(P<0.05);与稳定斑块组比较,不稳定斑块组NIHSS评分、LDL-C、sdLDL、脂蛋白(a)显著升高,HDL-C显著降低,对照组脂蛋白(a)显著降低,差异有统计学意义(P<0.05)。Pearson相关性分析显示,sd-LDL、脂蛋白(a)水平与NIHSS评分、总胆固醇、三酰甘油、LDL-C呈显著正相关(P<0.05,P<0.01),与HDL-C呈显著负相关(P<0.01)。二元logistic回归分析显示,NIHSS评分、LDL-C、sd-LDL、脂蛋白(a)是ACI患者颈动脉不稳定斑块形成的危险因素,HDL-C是保护因素(P<0.01)。ROC曲线结果显示,sd-LDL、脂蛋白(a)及联合检测对颈动脉斑块稳定性预测的ROC曲线下面积分别为0.830、0.847、0.921,联合检测的敏感性高于sd-LDL、脂蛋白(a)单项指标检测(93.44%vs 88.52%、86.89%,P=0.000)。结论血浆sd-LDL、脂蛋白(a)水平与ACI患者颈动脉斑块稳定性具有一定关联性,可作为临床相关参考指标。
文摘目的探究血浆致动脉粥样硬化指数(atherogenic index of plasma,AIP)与代谢功能障碍相关脂肪性肝病(metabolism-associated steatotic liver disease,MASLD)的关系,评估AIP作为MASLD风险预测指标的潜在价值,为早期预防和临床干预提供参考。方法纳入2021年6月至2023年5月西安交通大学第二附属医院4850名健康体检者。按AIP四分位数将全体受试者由低到高分为4组(Q1~Q4),比较各组间生化指标与MASLD患病率。采用Logistic回归、亚组分析、限制性立方样条(restricted cubic splines,RCS)等方法探究AIP与MASLD之间的相关性。结果共纳入4850例受试者,MASLD患病率为26.08%(1265例)。Q1~Q4组MASLD的患病率分别为4.0%、13.8%、30.8%、55.6%,患病率随AIP四分位数组级升高而呈显著递增趋势(P<0.001)。与Q1组相比,Q2~Q4组男性占比、身体质量指数(body mass index,BMI)、吸烟者占比、超重肥胖占比、腹型肥胖占比、糖尿病前期占比、高血压占比、血尿酸及脂肪肝指数(fatty liver index,FLI)水平均明显增加,差异有统计学意义(P<0.001)。随着AIP的增加,血清总胆固醇、三酰甘油、低密度脂蛋白胆固醇水平显著增加,高密度脂蛋白胆固醇水平则显著降低(P<0.001)。RCS曲线显示随着AIP增加,MASLD的患病风险显著增加,AIP与MASLD患病风险之间呈线性关系。Logistic回归显示,在调整混杂因素后,Q4组中MASLD发生风险为Q1组的8.71倍(OR=8.71,95%CI:6.20~12.23,P<0.001)。建立的复合模型具有更高的判别性能(AUC=0.883,95%CI:0.873~0.892)。交互作用分析提示AIP与BMI、高血压及糖尿病前期存在显著交互作用(P<0.05),在无上述代谢异常的人群中,AIP与MASLD的关联更为显著。结论AIP升高与MASLD发病风险增加显著相关,尤其在BMI正常组、血压正常组及血糖正常组中关联更强,提示AIP有望作为MASLD早期筛查的潜在指标。
