目的:研究联合中性粒细胞百分比(Percentage of neutrophils,NEU%)、C-反应蛋白(C-reactive protein,CRP)及白介素-6(Interleukin-6,IL-6)在白血病合并肺部感染中的诊断价值。方法:选取2019年1月到2023年1月在我院收治的81例白血病患者...目的:研究联合中性粒细胞百分比(Percentage of neutrophils,NEU%)、C-反应蛋白(C-reactive protein,CRP)及白介素-6(Interleukin-6,IL-6)在白血病合并肺部感染中的诊断价值。方法:选取2019年1月到2023年1月在我院收治的81例白血病患者作为研究对象。根据感染标准分为未感染组(36例)和感染组(45例)。感染组患者进一步根据感染程度分级,分为轻度感染组(32例)与重度感染组(13例)。对比未感染组和感染组外周血中NEU%、CRP、IL-6水平;对比轻度感染组与重度感染组外周血中NEU%、CRP、IL-6水平;探讨NEU%、CRP、IL-6水平单独及联合检测对白血病合并感染的诊断效能。结果:对比两组外周血中NEU%、CRP、IL-6水平,感染组3个指标均高于未感染组(P<0.05)。轻度感染组中NEU%、CPR、IL-6指标水平均低于重度感染组(P<0.05)。NEU%特异度为50.31%,灵敏度为80.20%,准确度为69.83%,CRP特异度为50.00%,灵敏度为88.37%,准确度为75.69%,IL-6特异度为40.36%,灵敏度为92.32%,准确度为72.32%,三项联合特异度为67.32%,灵敏度为96.51%,准确度为86.62%(P<0.05)。结论:白血病合并肺部感染中联合NEU%、CRP及IL-6水平明显升高,且三者联合对白血病合并肺部感染诊断价值高。展开更多
Objective To investigate the changes of perioperative serum levels of interleukin-6(IL-6), C-reactive protein (CRP), and cortisol, as well as gastric intramucosal pH (pHi) and plasma lactate, aiming to compare systemi...Objective To investigate the changes of perioperative serum levels of interleukin-6(IL-6), C-reactive protein (CRP), and cortisol, as well as gastric intramucosal pH (pHi) and plasma lactate, aiming to compare systemic changes and tissue perfusion during colorectal and orthopaedic surgical procedures. Methods Twenty patients were randomly assigned to two groups, 10 cases of operation on vertebral canal, 10 cases of colorectal radical operation.Venous blood was drawn at 1 day before operation, 2, 4, and 6 hours following skin incision, and 1 day after operation, in order to measure serum IL-6, CRP, and cortisol.pHi and plasma lactate were also measured at the same time points.Results Serum concentrations of IL-6 and cortisol increased gradually following operation, reaching the peak value at 6 hours from the beginning of operation.CRP was not detectable until the first day after operation.Peak concentration of IL-6 had positive relationship with CRP.These variables changed more significantly in colorectal group than that in orthopaedic group (P<0.05).pHi decreased gradually, reaching the lowest level at 4 hours from the beginning of operation, and to more extent in colorectal group than that in orthopaedic group (P<0.05).Conclusion IL-6 may reflect tissue damage more sensitively than CRP.Colorectal surgery might induce systemic disorder to more extent, in terms of immuno-endocrinal aspect as well as tissue perfusion, reflected with pHi.展开更多
就近年来白细胞介素6/非受体酪氨酸蛋白激酶/信号转导和转录激活因子3(interleukin-6/janus activated kinase/signal transducer and activator of transcription 3,IL-6/JAK/STAT3)信号通路在多种消化系统肿瘤中发挥的效应、中药单体...就近年来白细胞介素6/非受体酪氨酸蛋白激酶/信号转导和转录激活因子3(interleukin-6/janus activated kinase/signal transducer and activator of transcription 3,IL-6/JAK/STAT3)信号通路在多种消化系统肿瘤中发挥的效应、中药单体及其活性成分、中药复方对与IL-6/JAK/STAT3信号通路调控有关的消化系统肿瘤中的防治作用进行综述,探究中医药在延缓、阻抑甚至逆转炎-癌转化中发挥的作用,为防治肿瘤提供更有力的理论指导。展开更多
文摘目的:研究联合中性粒细胞百分比(Percentage of neutrophils,NEU%)、C-反应蛋白(C-reactive protein,CRP)及白介素-6(Interleukin-6,IL-6)在白血病合并肺部感染中的诊断价值。方法:选取2019年1月到2023年1月在我院收治的81例白血病患者作为研究对象。根据感染标准分为未感染组(36例)和感染组(45例)。感染组患者进一步根据感染程度分级,分为轻度感染组(32例)与重度感染组(13例)。对比未感染组和感染组外周血中NEU%、CRP、IL-6水平;对比轻度感染组与重度感染组外周血中NEU%、CRP、IL-6水平;探讨NEU%、CRP、IL-6水平单独及联合检测对白血病合并感染的诊断效能。结果:对比两组外周血中NEU%、CRP、IL-6水平,感染组3个指标均高于未感染组(P<0.05)。轻度感染组中NEU%、CPR、IL-6指标水平均低于重度感染组(P<0.05)。NEU%特异度为50.31%,灵敏度为80.20%,准确度为69.83%,CRP特异度为50.00%,灵敏度为88.37%,准确度为75.69%,IL-6特异度为40.36%,灵敏度为92.32%,准确度为72.32%,三项联合特异度为67.32%,灵敏度为96.51%,准确度为86.62%(P<0.05)。结论:白血病合并肺部感染中联合NEU%、CRP及IL-6水平明显升高,且三者联合对白血病合并肺部感染诊断价值高。
文摘Objective To investigate the changes of perioperative serum levels of interleukin-6(IL-6), C-reactive protein (CRP), and cortisol, as well as gastric intramucosal pH (pHi) and plasma lactate, aiming to compare systemic changes and tissue perfusion during colorectal and orthopaedic surgical procedures. Methods Twenty patients were randomly assigned to two groups, 10 cases of operation on vertebral canal, 10 cases of colorectal radical operation.Venous blood was drawn at 1 day before operation, 2, 4, and 6 hours following skin incision, and 1 day after operation, in order to measure serum IL-6, CRP, and cortisol.pHi and plasma lactate were also measured at the same time points.Results Serum concentrations of IL-6 and cortisol increased gradually following operation, reaching the peak value at 6 hours from the beginning of operation.CRP was not detectable until the first day after operation.Peak concentration of IL-6 had positive relationship with CRP.These variables changed more significantly in colorectal group than that in orthopaedic group (P<0.05).pHi decreased gradually, reaching the lowest level at 4 hours from the beginning of operation, and to more extent in colorectal group than that in orthopaedic group (P<0.05).Conclusion IL-6 may reflect tissue damage more sensitively than CRP.Colorectal surgery might induce systemic disorder to more extent, in terms of immuno-endocrinal aspect as well as tissue perfusion, reflected with pHi.
文摘就近年来白细胞介素6/非受体酪氨酸蛋白激酶/信号转导和转录激活因子3(interleukin-6/janus activated kinase/signal transducer and activator of transcription 3,IL-6/JAK/STAT3)信号通路在多种消化系统肿瘤中发挥的效应、中药单体及其活性成分、中药复方对与IL-6/JAK/STAT3信号通路调控有关的消化系统肿瘤中的防治作用进行综述,探究中医药在延缓、阻抑甚至逆转炎-癌转化中发挥的作用,为防治肿瘤提供更有力的理论指导。
