目的探讨eKare in Sight 3D创面管理系统在创面评估中测量的准确性及稳定性,为临床创面测量的应用提供参考。方法选取急、慢性创面40例个,同时选取模拟创面30例个,分别应用传统测量工具及eKare inSight 3D创面管理系统对上述70例个创面...目的探讨eKare in Sight 3D创面管理系统在创面评估中测量的准确性及稳定性,为临床创面测量的应用提供参考。方法选取急、慢性创面40例个,同时选取模拟创面30例个,分别应用传统测量工具及eKare inSight 3D创面管理系统对上述70例个创面的最大长度、最大宽度、最大深度、创面面积及容积进行测量,应用Wilcoxon(W)秩和检验分析两种测量方法的一致性。结果 eKare in Sight 3D创面管理系统与传统测量工具相比,在创面最大长度、最大宽度、最大深度、创面面积及创腔容积测量中差异均无统计学意义(P均>0.05),两者具有较好的一致性。结论 eKare in Sight 3D创面管理系统在创面评估中的测量具有准确性,尤其对于较小浅表创面,可进行更快速便捷的创面评估,同时可对创面进行监测管理。展开更多
Background Cocaine use disorder(CUD)and associated psychosis are major public health issues worldwide,along with high relapse outcome and limited treatment options.Exploring the molecular mechanisms underlying cocaine...Background Cocaine use disorder(CUD)and associated psychosis are major public health issues worldwide,along with high relapse outcome and limited treatment options.Exploring the molecular mechanisms underlying cocaine-induced psychosis(CIP)could supply integrated insights for understanding the pathogenic mechanism and potential novel therapeutic targets.Aims The aim of the study was to explore common alterations of CUD-schizophrenia target genes and identify core risk genes contributing to CIP through data mining and network pharmacology approach.Methods Target genes of CUD were obtained from GeneCards,Comparative Toxicogenomics Database,Swiss Target Prediction platform and PubChem.Schizophrenia-related target genes were derived from DisGeNET,GeneCards,MalaCards and Online Mendelian Inheritance in Man databases.Then,the overlap genes of these two sets were regarded as risk genes contributing to CIP.Based on these CUD-schizophrenia target genes,functional annotation and pathway analysis were performed using the clusterProfiler package in R.Protein-protein interaction network construction and module detection were performed based on the Search Tool for the Retrieval of Interacting Genes(STRING)database and Cytoscape software.Gene expression datasets GSE54839 and GSE93577 were applied for data validation and diagnostic capacity evaluation of interested hub genes.Results A total of 165 CUD-schizophrenia target genes were obtained.These genes were mainly contributing to chemical synaptic transmission,neuropeptide hormone activity,postsynaptic membrane and neuroactive ligand-receptor interaction pathway.Network analysis and validation analysis indicated that BDNF might serve as an important risk gene in mediating CIP.Conclusions This study generates a holistic view of CIP and provides a basis for the identification of potential CUD-schizophrenia target genes involved in the development of CIP.The abnormal expression of BDNF would be a candidate therapeutic target underlying the pathogenesis of CUD and associated CIP.展开更多
How does one teach composition to Chinese college students of English? How does one teach thera to discover ideas for themselves and to put these into English patterns of thought and organization? Can the discovery of...How does one teach composition to Chinese college students of English? How does one teach thera to discover ideas for themselves and to put these into English patterns of thought and organization? Can the discovery of ideas really be taught? Is there a method of teaching whereby the scientific process of writing can be cornbined with the creative art of composition?展开更多
Nanowires, nanofibers and nanotubes have been widely used as the building blocks in micro/nano-electromechanical systems, energy harvesting or storage devices, and small-scaled measurement equipment. We report that th...Nanowires, nanofibers and nanotubes have been widely used as the building blocks in micro/nano-electromechanical systems, energy harvesting or storage devices, and small-scaled measurement equipment. We report that the sur- face effects of these nanobeams have a great impact on their deflection and internal forces. A simply supported nanobeam is taken as an example. For the displacement and shear force of the nanobeam, its dangerous sections are different from those predicted by the conventional beam theory, but for the bending moment, the dangerous section is the same. Moreover, the values of these three quantities for the nanobeam are all distinct from those calculated from the conventional beam model. These analyses shed new light on the stiffness and strength check of nanobeams, which are beneficial to engineer new-types of nano-materials and nano-devices.展开更多
As is known to all, idiom is the language symbols which abound in national cultural connotations. In essence, the translation of idiom is cultural-loaded which bases on the transference of one culture to another. Thus...As is known to all, idiom is the language symbols which abound in national cultural connotations. In essence, the translation of idiom is cultural-loaded which bases on the transference of one culture to another. Thus, the translator's choice on translation strategies will greatly affect the expression of cultural connotations. This thesis aims to study the E-C/C-E translation of idiom from the cultural insight and explore the application of strategies in idiom translation, advocating that foreignization should be given as top priority when conducting idiom translation.展开更多
文摘目的探讨eKare in Sight 3D创面管理系统在创面评估中测量的准确性及稳定性,为临床创面测量的应用提供参考。方法选取急、慢性创面40例个,同时选取模拟创面30例个,分别应用传统测量工具及eKare inSight 3D创面管理系统对上述70例个创面的最大长度、最大宽度、最大深度、创面面积及容积进行测量,应用Wilcoxon(W)秩和检验分析两种测量方法的一致性。结果 eKare in Sight 3D创面管理系统与传统测量工具相比,在创面最大长度、最大宽度、最大深度、创面面积及创腔容积测量中差异均无统计学意义(P均>0.05),两者具有较好的一致性。结论 eKare in Sight 3D创面管理系统在创面评估中的测量具有准确性,尤其对于较小浅表创面,可进行更快速便捷的创面评估,同时可对创面进行监测管理。
基金This work was supported by the National Nature Science Foundation(81771436)Program of Shanghai Academic Research Leader(17XD1403300)+4 种基金Shanghai Municipal Health and Family Planning Commission(2017ZZ02021,2018YQ45 and 20184Y0134)Shanghai Key Laboratory of Psychotic Disorders(13DZ2260500)Shanghai Municipal Science and Technology Major Project(2018SHZDZX05)Shanghai Sailing Program(19YF1442100)Shanghai Mental Health Center Program(2018-QH 02,2020-YJ 06,CRC2018YB02).
文摘Background Cocaine use disorder(CUD)and associated psychosis are major public health issues worldwide,along with high relapse outcome and limited treatment options.Exploring the molecular mechanisms underlying cocaine-induced psychosis(CIP)could supply integrated insights for understanding the pathogenic mechanism and potential novel therapeutic targets.Aims The aim of the study was to explore common alterations of CUD-schizophrenia target genes and identify core risk genes contributing to CIP through data mining and network pharmacology approach.Methods Target genes of CUD were obtained from GeneCards,Comparative Toxicogenomics Database,Swiss Target Prediction platform and PubChem.Schizophrenia-related target genes were derived from DisGeNET,GeneCards,MalaCards and Online Mendelian Inheritance in Man databases.Then,the overlap genes of these two sets were regarded as risk genes contributing to CIP.Based on these CUD-schizophrenia target genes,functional annotation and pathway analysis were performed using the clusterProfiler package in R.Protein-protein interaction network construction and module detection were performed based on the Search Tool for the Retrieval of Interacting Genes(STRING)database and Cytoscape software.Gene expression datasets GSE54839 and GSE93577 were applied for data validation and diagnostic capacity evaluation of interested hub genes.Results A total of 165 CUD-schizophrenia target genes were obtained.These genes were mainly contributing to chemical synaptic transmission,neuropeptide hormone activity,postsynaptic membrane and neuroactive ligand-receptor interaction pathway.Network analysis and validation analysis indicated that BDNF might serve as an important risk gene in mediating CIP.Conclusions This study generates a holistic view of CIP and provides a basis for the identification of potential CUD-schizophrenia target genes involved in the development of CIP.The abnormal expression of BDNF would be a candidate therapeutic target underlying the pathogenesis of CUD and associated CIP.
文摘How does one teach composition to Chinese college students of English? How does one teach thera to discover ideas for themselves and to put these into English patterns of thought and organization? Can the discovery of ideas really be taught? Is there a method of teaching whereby the scientific process of writing can be cornbined with the creative art of composition?
基金Supported by the National Natural Science Foundation of China under Grant Nos 11672334,11672335 and 11611530541the Fundamental Research Funds for the Central Universities under Grant No 15CX08004A
文摘Nanowires, nanofibers and nanotubes have been widely used as the building blocks in micro/nano-electromechanical systems, energy harvesting or storage devices, and small-scaled measurement equipment. We report that the sur- face effects of these nanobeams have a great impact on their deflection and internal forces. A simply supported nanobeam is taken as an example. For the displacement and shear force of the nanobeam, its dangerous sections are different from those predicted by the conventional beam theory, but for the bending moment, the dangerous section is the same. Moreover, the values of these three quantities for the nanobeam are all distinct from those calculated from the conventional beam model. These analyses shed new light on the stiffness and strength check of nanobeams, which are beneficial to engineer new-types of nano-materials and nano-devices.
文摘As is known to all, idiom is the language symbols which abound in national cultural connotations. In essence, the translation of idiom is cultural-loaded which bases on the transference of one culture to another. Thus, the translator's choice on translation strategies will greatly affect the expression of cultural connotations. This thesis aims to study the E-C/C-E translation of idiom from the cultural insight and explore the application of strategies in idiom translation, advocating that foreignization should be given as top priority when conducting idiom translation.
