In a system of systems(SoS),resilience is an important factor in maintaining the functionality,stability,and enhancing the operation effectiveness.From the perspective of resilience,this paper studies the importance o...In a system of systems(SoS),resilience is an important factor in maintaining the functionality,stability,and enhancing the operation effectiveness.From the perspective of resilience,this paper studies the importance of the SoS,and a resilience-based importance measure analysis is conducted to provide suggestions in the design and optimization of the structure of the SoS.In this paper,the components of the SoS are simplified as four kinds of network nodes:sensor,decision point,influencer,and target.In this networked SoS,the number of operation loops is used as the performance indicator,and an approximate algorithm,which is based on eigenvalue of the adjacency matrix,is proposed to calculate the number of operation loops.In order to understand the performance change of the SoS during the attack and defense process in the operations,an integral resilience model is proposed to depict the resilience of the SoS.From different perspectives of enhancing the resilience,different measures,parameters and the corresponding algorithms for the resilience importance of components are proposed.Finally,a case study on an SoS is conducted to verify the validity of the network modelling and the resiliencebased importance analysis method.展开更多
In order to achieve the information fusion in the time domain based on the evidence theory, an evidence combination method in the time domain based on reliability and importance is proposed according to the idea of ev...In order to achieve the information fusion in the time domain based on the evidence theory, an evidence combination method in the time domain based on reliability and importance is proposed according to the idea of evidence discount. Firstly, the distortion of the time-domain evidence is judged based on single exponential smoothing. The real-time reliability of the evidence at the adjacent time is obtained by the real-time reliability assessment method of the evidence based on the credibility decay model.Then, the relative importance of the evidence at the adjacent time is obtained by comprehensively considering improved conflict degree and uncertainty. Finally, based on the criterion of evidence discount and the Dempster’s rule of combination, the evidence combination is carried out to achieve the sequential combination of time-domain evidence. The numerical simulation and analysis show that this method has fully embodied the dynamic characteristics of time-domain evidence combination, and it has strong processing ability for conflict information and anti-disturbing ability.The proposed method has good applicability to information fusion in the time domain.展开更多
It is well-documented that digenetic trematodes exhibit complex life cycles where the definitive hosts are vertebrates—mostly birds,other mammals and reptiles.It is also known that digenetic trematodes are host speci...It is well-documented that digenetic trematodes exhibit complex life cycles where the definitive hosts are vertebrates—mostly birds,other mammals and reptiles.It is also known that digenetic trematodes are host specific,but changes in our feeding habits, agricultural and social practices,have led to human beings infected with parasites that were previously regarded to be of no or insignificant medical importance. The objective of this study was to identify the less known digenetic parasites in the water bodies around Tshwane that may result in possible展开更多
With respect to the subjective factors and nonlinear characteristics inherent in the important identification of fault tree analysis （FTA）, a new important measure of FTA is proposed based on possibilistic informati...With respect to the subjective factors and nonlinear characteristics inherent in the important identification of fault tree analysis （FTA）, a new important measure of FTA is proposed based on possibilistic information entropy. After investigating possibilistic information semantics, measure-theoretic terms, and entropy-like models, a two-dimensional framework has been constructed by combining both the set theory and the measure theory. By adopting the possibilistic assumption in place of the probabilistic one, an axiomatic index of importance is defined in the possibility space and then the modelling principles are presented. An example of the fault tree is thus provided, along with the concordance analysis and other discussions. The more conservative numerical results of importance rankings, which involve the more choices can be viewed as “soft” fault identification under a certain expected value. In the end, extension to evidence space and further research perspectives are discussed.展开更多
In this paper, an importance sampling maximum likelihood(ISML) estimator for direction-of-arrival(DOA) of incoherently distributed(ID) sources is proposed. Starting from the maximum likelihood estimation description o...In this paper, an importance sampling maximum likelihood(ISML) estimator for direction-of-arrival(DOA) of incoherently distributed(ID) sources is proposed. Starting from the maximum likelihood estimation description of the uniform linear array(ULA), a decoupled concentrated likelihood function(CLF) is presented. A new objective function based on CLF which can obtain a closed-form solution of global maximum is constructed according to Pincus theorem. To obtain the optimal value of the objective function which is a complex high-dimensional integral,we propose an importance sampling approach based on Monte Carlo random calculation. Next, an importance function is derived, which can simplify the problem of generating random vector from a high-dimensional probability density function(PDF) to generate random variable from a one-dimensional PDF. Compared with the existing maximum likelihood(ML) algorithms for DOA estimation of ID sources, the proposed algorithm does not require initial estimates, and its performance is closer to CramerRao lower bound(CRLB). The proposed algorithm performs better than the existing methods when the interval between sources to be estimated is small and in low signal to noise ratio(SNR)scenarios.展开更多
OBJECTIVE The specificity of drug therapy in individuals and races has promoted the development and improvement of pharmacogenomics and precision medicine.While there is a few cognition on the minorities in China,espe...OBJECTIVE The specificity of drug therapy in individuals and races has promoted the development and improvement of pharmacogenomics and precision medicine.While there is a few cognition on the minorities in China,especially in Lisu nationality from the Yunnan province.Therefore,we performed the research to improve the role of pharmacogenomics in the Lisu population from the Yunnan province of China.METHODS 54 variants of very important pharmacogenes selected from the PharmGKB database were genotyped in 199 unrelated and healthy Lisu adults from the Yunnan province of China,and then,genotyping data wtih χ^(2) test were analyzed.RESULTS We compared our data with those of other 26 populations from the 1000 Genomes Project,and acquired that the Lisu ethnicity is similar with the CDX(Chinese Dai in Xishuangbanna,China)and CHS(Southern Han Chinese,China).Furthermore,rs776746(CYP3A5),rs1805123(KCNH2),rs4291(ACE),rs1051298(SLC19A1)and rs1065852(CYP2D6)were deemed as the most varying loci.The MAF of“G”at rs1805123(KCNH2)in the Lisu population was the largest with the value of 51.0%.CONCLUSION There are significant differences in single nucleotide polymorphism loci,supplementing the pharmacogenomic information of the Lisu population in Yunnan province,China,and can provide a theoretical basis for individualized medication in the future.展开更多
The regulatory mechanism that controls the sustained cotton fiber cell elo ngation is gradually be-ing elucidated by coupling genome-wide transcriptome profiling with systematic biochemical and physi-ological studies....The regulatory mechanism that controls the sustained cotton fiber cell elo ngation is gradually be-ing elucidated by coupling genome-wide transcriptome profiling with systematic biochemical and physi-ological studies.Very long chain fatty acids(VL CFA),H₂O2,and several types of plant hor mones including ethylene,gibberellin,and brassinolide have been reported to be involved in this process.Here we first identified by proteo mic analy sis a cotto n cy to solicAPX1(GhA PX1)that was specifically accumulated during cotton fiber elongation.展开更多
Integrins are heterodimers that mediate cell adhesion and transduce signals bidirectionally across the cell membrane.Integrins often exist in low affinity(or inactive) states for
The current measurement was exploited in a more efficient way. Firstly, the system equation was updated by introducing a correction term, which depends on the current measurement and can be obtained by running a subop...The current measurement was exploited in a more efficient way. Firstly, the system equation was updated by introducing a correction term, which depends on the current measurement and can be obtained by running a suboptimal filter. Then, a new importance density function(IDF) was defined by the updated system equation. Particles drawn from the new IDF are more likely to be in the significant region of state space and the estimation accuracy can be improved. By using different suboptimal filter, different particle filters(PFs) can be developed in this framework. Extensions of this idea were also proposed by iteratively updating the system equation using particle filter itself, resulting in the iterated particle filter. Simulation results demonstrate the effectiveness of the proposed IDF.展开更多
To verify the effectiveness of the integrated importance measure （IIM） for multi-state coherent systems of k level, the definition and physical meaning of IIM are demonstrated. Then, the improvement potential and Δ...To verify the effectiveness of the integrated importance measure （IIM） for multi-state coherent systems of k level, the definition and physical meaning of IIM are demonstrated. Then, the improvement potential and Δ-importance measures are generalized to multi-state coherent systems based on the system performance level, and the relationships between IIM and traditional importance measures are discussed. The characteristics of IIM are demonstrated in both series and parallel systems. Also, an application to an oil transportation system is given. The comparison results show that： （i） IIM has some useful properties that are not possessed by traditional importance measures; （ii） IIM is effective in evaluating the component role in multi-state systems when the component reliability and the failure rate are simultaneously considered.展开更多
In order to deal with the particle degeneracy and impov- erishment problems existed in particle filters, a modified sequential importance resampling （MSIR） filter is proposed. In this filter, the resampling is trans...In order to deal with the particle degeneracy and impov- erishment problems existed in particle filters, a modified sequential importance resampling （MSIR） filter is proposed. In this filter, the resampling is translated into an evolutional process just like the biological evolution. A particle generator is constructed, which introduces the current measurement information （CMI） into the resampled particles. In the evolution, new particles are first pro- duced through the particle generator, each of which is essentially an unbiased estimation of the current true state. Then, new and old particles are recombined for the sake of raising the diversity among the particles. Finally, those particles who have low quality are eliminated. Through the evolution, all the particles retained are regarded as the optimal ones, and these particles are utilized to update the current state. By using the proposed resampling approach, not only the CMI is incorporated into each resampled particle, but also the particle degeneracy and the loss of diver- sity among the particles are mitigated, resulting in the improved estimation accuracy. Simulation results show the superiorities of the proposed filter over the standard sequential importance re- sampling （SIR） filter, auxiliary particle filter and unscented Kalman particle filter.展开更多
Importance measures in reliability systems are used to identify weak components in contributing to a proper function of the system.Traditional importance measures mainly concerned the changing value of the system reli...Importance measures in reliability systems are used to identify weak components in contributing to a proper function of the system.Traditional importance measures mainly concerned the changing value of the system reliability caused by the change of the reliability of the component,and seldom considered the joint effect of the probability distribution,improvement rate of the object component.This paper studies the rate of the system reliability upgrading with an improvement of the component reliability for the multi-state consecutive k-out-of-n system.To verify the multi-state consecutive k-out-of-n system reliability upgrading by improving one component based on its improvement rate,an increasing potential importance(IPI)and its physical meaning are described at first.Secondly,the relationship between the IPI and Birnbaum importance measures are discussed.And the IPI for some different improvement actions of the component is further discussed.Thirdly,the characteristics of the IPI are analyzed.Finally,an application to an oil pipeline system is given.展开更多
The design, analysis and parallel implementation of particle filter(PF) were investigated. Firstly, to tackle the particle degeneracy problem in the PF, an iterated importance density function(IIDF) was proposed, wher...The design, analysis and parallel implementation of particle filter(PF) were investigated. Firstly, to tackle the particle degeneracy problem in the PF, an iterated importance density function(IIDF) was proposed, where a new term associating with the current measurement information(CMI) was introduced into the expression of the sampled particles. Through the repeated use of the least squares estimate, the CMI can be integrated into the sampling stage in an iterative manner, conducing to the greatly improved sampling quality. By running the IIDF, an iterated PF(IPF) can be obtained. Subsequently, a parallel resampling(PR) was proposed for the purpose of parallel implementation of IPF, whose main idea was the same as systematic resampling(SR) but performed differently. The PR directly used the integral part of the product of the particle weight and particle number as the number of times that a particle was replicated, and it simultaneously eliminated the particles with the smallest weights, which are the two key differences from the SR. The detailed implementation procedures on the graphics processing unit of IPF based on the PR were presented at last. The performance of the IPF, PR and their parallel implementations are illustrated via one-dimensional numerical simulation and practical application of passive radar target tracking.展开更多
基金supported by the National Natural Science Foundation of China(71571004)
文摘In a system of systems(SoS),resilience is an important factor in maintaining the functionality,stability,and enhancing the operation effectiveness.From the perspective of resilience,this paper studies the importance of the SoS,and a resilience-based importance measure analysis is conducted to provide suggestions in the design and optimization of the structure of the SoS.In this paper,the components of the SoS are simplified as four kinds of network nodes:sensor,decision point,influencer,and target.In this networked SoS,the number of operation loops is used as the performance indicator,and an approximate algorithm,which is based on eigenvalue of the adjacency matrix,is proposed to calculate the number of operation loops.In order to understand the performance change of the SoS during the attack and defense process in the operations,an integral resilience model is proposed to depict the resilience of the SoS.From different perspectives of enhancing the resilience,different measures,parameters and the corresponding algorithms for the resilience importance of components are proposed.Finally,a case study on an SoS is conducted to verify the validity of the network modelling and the resiliencebased importance analysis method.
基金supported by the National Natural Science Foundation of China(71571190 71601183+1 种基金 L1534031)the Shanxi Province Natural Science Foundation of China(2014JQ2-7045)
文摘In order to achieve the information fusion in the time domain based on the evidence theory, an evidence combination method in the time domain based on reliability and importance is proposed according to the idea of evidence discount. Firstly, the distortion of the time-domain evidence is judged based on single exponential smoothing. The real-time reliability of the evidence at the adjacent time is obtained by the real-time reliability assessment method of the evidence based on the credibility decay model.Then, the relative importance of the evidence at the adjacent time is obtained by comprehensively considering improved conflict degree and uncertainty. Finally, based on the criterion of evidence discount and the Dempster’s rule of combination, the evidence combination is carried out to achieve the sequential combination of time-domain evidence. The numerical simulation and analysis show that this method has fully embodied the dynamic characteristics of time-domain evidence combination, and it has strong processing ability for conflict information and anti-disturbing ability.The proposed method has good applicability to information fusion in the time domain.
文摘It is well-documented that digenetic trematodes exhibit complex life cycles where the definitive hosts are vertebrates—mostly birds,other mammals and reptiles.It is also known that digenetic trematodes are host specific,but changes in our feeding habits, agricultural and social practices,have led to human beings infected with parasites that were previously regarded to be of no or insignificant medical importance. The objective of this study was to identify the less known digenetic parasites in the water bodies around Tshwane that may result in possible
基金supported by the National Natural Science Foundation of China (60674078).
文摘With respect to the subjective factors and nonlinear characteristics inherent in the important identification of fault tree analysis （FTA）, a new important measure of FTA is proposed based on possibilistic information entropy. After investigating possibilistic information semantics, measure-theoretic terms, and entropy-like models, a two-dimensional framework has been constructed by combining both the set theory and the measure theory. By adopting the possibilistic assumption in place of the probabilistic one, an axiomatic index of importance is defined in the possibility space and then the modelling principles are presented. An example of the fault tree is thus provided, along with the concordance analysis and other discussions. The more conservative numerical results of importance rankings, which involve the more choices can be viewed as “soft” fault identification under a certain expected value. In the end, extension to evidence space and further research perspectives are discussed.
基金supported by the basic research program of Natural Science in Shannxi province of China (2021JQ-369)。
文摘In this paper, an importance sampling maximum likelihood(ISML) estimator for direction-of-arrival(DOA) of incoherently distributed(ID) sources is proposed. Starting from the maximum likelihood estimation description of the uniform linear array(ULA), a decoupled concentrated likelihood function(CLF) is presented. A new objective function based on CLF which can obtain a closed-form solution of global maximum is constructed according to Pincus theorem. To obtain the optimal value of the objective function which is a complex high-dimensional integral,we propose an importance sampling approach based on Monte Carlo random calculation. Next, an importance function is derived, which can simplify the problem of generating random vector from a high-dimensional probability density function(PDF) to generate random variable from a one-dimensional PDF. Compared with the existing maximum likelihood(ML) algorithms for DOA estimation of ID sources, the proposed algorithm does not require initial estimates, and its performance is closer to CramerRao lower bound(CRLB). The proposed algorithm performs better than the existing methods when the interval between sources to be estimated is small and in low signal to noise ratio(SNR)scenarios.
文摘OBJECTIVE The specificity of drug therapy in individuals and races has promoted the development and improvement of pharmacogenomics and precision medicine.While there is a few cognition on the minorities in China,especially in Lisu nationality from the Yunnan province.Therefore,we performed the research to improve the role of pharmacogenomics in the Lisu population from the Yunnan province of China.METHODS 54 variants of very important pharmacogenes selected from the PharmGKB database were genotyped in 199 unrelated and healthy Lisu adults from the Yunnan province of China,and then,genotyping data wtih χ^(2) test were analyzed.RESULTS We compared our data with those of other 26 populations from the 1000 Genomes Project,and acquired that the Lisu ethnicity is similar with the CDX(Chinese Dai in Xishuangbanna,China)and CHS(Southern Han Chinese,China).Furthermore,rs776746(CYP3A5),rs1805123(KCNH2),rs4291(ACE),rs1051298(SLC19A1)and rs1065852(CYP2D6)were deemed as the most varying loci.The MAF of“G”at rs1805123(KCNH2)in the Lisu population was the largest with the value of 51.0%.CONCLUSION There are significant differences in single nucleotide polymorphism loci,supplementing the pharmacogenomic information of the Lisu population in Yunnan province,China,and can provide a theoretical basis for individualized medication in the future.
文摘The regulatory mechanism that controls the sustained cotton fiber cell elo ngation is gradually be-ing elucidated by coupling genome-wide transcriptome profiling with systematic biochemical and physi-ological studies.Very long chain fatty acids(VL CFA),H₂O2,and several types of plant hor mones including ethylene,gibberellin,and brassinolide have been reported to be involved in this process.Here we first identified by proteo mic analy sis a cotto n cy to solicAPX1(GhA PX1)that was specifically accumulated during cotton fiber elongation.
文摘Integrins are heterodimers that mediate cell adhesion and transduce signals bidirectionally across the cell membrane.Integrins often exist in low affinity(or inactive) states for
基金Project(61271296) supported by the National Natural Science Foundation of China
文摘The current measurement was exploited in a more efficient way. Firstly, the system equation was updated by introducing a correction term, which depends on the current measurement and can be obtained by running a suboptimal filter. Then, a new importance density function(IDF) was defined by the updated system equation. Particles drawn from the new IDF are more likely to be in the significant region of state space and the estimation accuracy can be improved. By using different suboptimal filter, different particle filters(PFs) can be developed in this framework. Extensions of this idea were also proposed by iteratively updating the system equation using particle filter itself, resulting in the iterated particle filter. Simulation results demonstrate the effectiveness of the proposed IDF.
基金supported by the National Natural Science Foundation of China (7110111671271170)+2 种基金the National Basic Research Program of China (973 Progrom) (2010CB328000)the National High Technology Research and Development Program of China (863 Progrom) (2012AA040914)the Basic Research Foundation of Northwestern Polytechnical University (JC20120228)
文摘To verify the effectiveness of the integrated importance measure （IIM） for multi-state coherent systems of k level, the definition and physical meaning of IIM are demonstrated. Then, the improvement potential and Δ-importance measures are generalized to multi-state coherent systems based on the system performance level, and the relationships between IIM and traditional importance measures are discussed. The characteristics of IIM are demonstrated in both series and parallel systems. Also, an application to an oil transportation system is given. The comparison results show that： （i） IIM has some useful properties that are not possessed by traditional importance measures; （ii） IIM is effective in evaluating the component role in multi-state systems when the component reliability and the failure rate are simultaneously considered.
基金supported by the National Natural Science Foundation of China(61372136)
文摘In order to deal with the particle degeneracy and impov- erishment problems existed in particle filters, a modified sequential importance resampling （MSIR） filter is proposed. In this filter, the resampling is translated into an evolutional process just like the biological evolution. A particle generator is constructed, which introduces the current measurement information （CMI） into the resampled particles. In the evolution, new particles are first pro- duced through the particle generator, each of which is essentially an unbiased estimation of the current true state. Then, new and old particles are recombined for the sake of raising the diversity among the particles. Finally, those particles who have low quality are eliminated. Through the evolution, all the particles retained are regarded as the optimal ones, and these particles are utilized to update the current state. By using the proposed resampling approach, not only the CMI is incorporated into each resampled particle, but also the particle degeneracy and the loss of diver- sity among the particles are mitigated, resulting in the improved estimation accuracy. Simulation results show the superiorities of the proposed filter over the standard sequential importance re- sampling （SIR） filter, auxiliary particle filter and unscented Kalman particle filter.
基金supported by the National Natural Science Foundation of China(7127117071101116)+1 种基金the National High Technology Research and Development Program of China(863 Progrom)(2012AA040914)the Basic Research Foundation of Northwestern Polytechnical University(JC20120228)
文摘Importance measures in reliability systems are used to identify weak components in contributing to a proper function of the system.Traditional importance measures mainly concerned the changing value of the system reliability caused by the change of the reliability of the component,and seldom considered the joint effect of the probability distribution,improvement rate of the object component.This paper studies the rate of the system reliability upgrading with an improvement of the component reliability for the multi-state consecutive k-out-of-n system.To verify the multi-state consecutive k-out-of-n system reliability upgrading by improving one component based on its improvement rate,an increasing potential importance(IPI)and its physical meaning are described at first.Secondly,the relationship between the IPI and Birnbaum importance measures are discussed.And the IPI for some different improvement actions of the component is further discussed.Thirdly,the characteristics of the IPI are analyzed.Finally,an application to an oil pipeline system is given.
基金Project(61372136) supported by the National Natural Science Foundation of China
文摘The design, analysis and parallel implementation of particle filter(PF) were investigated. Firstly, to tackle the particle degeneracy problem in the PF, an iterated importance density function(IIDF) was proposed, where a new term associating with the current measurement information(CMI) was introduced into the expression of the sampled particles. Through the repeated use of the least squares estimate, the CMI can be integrated into the sampling stage in an iterative manner, conducing to the greatly improved sampling quality. By running the IIDF, an iterated PF(IPF) can be obtained. Subsequently, a parallel resampling(PR) was proposed for the purpose of parallel implementation of IPF, whose main idea was the same as systematic resampling(SR) but performed differently. The PR directly used the integral part of the product of the particle weight and particle number as the number of times that a particle was replicated, and it simultaneously eliminated the particles with the smallest weights, which are the two key differences from the SR. The detailed implementation procedures on the graphics processing unit of IPF based on the PR were presented at last. The performance of the IPF, PR and their parallel implementations are illustrated via one-dimensional numerical simulation and practical application of passive radar target tracking.
