To investigate the mechanism of action of Chinese herbal medicine, the immunocells of Harder＇s glands were observed. The healthy Hy-Line Brown chickens of 12-day-old were divided into three groups randomly. The chick...To investigate the mechanism of action of Chinese herbal medicine, the immunocells of Harder＇s glands were observed. The healthy Hy-Line Brown chickens of 12-day-old were divided into three groups randomly. The chickens in group 1 and 2 drank the water with 0.5% and 1% Chinese herbal medicine immunopromoter every day. The chickens in group 3 as control drank pure water. The Harder＇s glands of the chickens from 0.5% group, 1% group and control group at 24, 36 and 48 d after drinking medicine respectively were made into histological section. And then the histological sections were observed histologically. The results showed that Chinese herbal medicine could increase the quantity of the immunocells in glandular organs conspicuously. Immunopotentiator of Chinese herbal medicine could promote the amount and growth of secreted immunoglobuline and elevate the immune level of the orgamsm, and the effect of 1% group was higher than that of 0.5% group.展开更多
Background and objective cyclin D1 is a member of the cyclin family,and it has been proven that it plaied an important role in tumorigenesis,invasion and metastasis.We performed a retrospective study on the cyclin D1 ...Background and objective cyclin D1 is a member of the cyclin family,and it has been proven that it plaied an important role in tumorigenesis,invasion and metastasis.We performed a retrospective study on the cyclin D1 expression in non-small cell lung cancer(NSCLC)according to the clinical characteristics.Methods One hundred fifteen postsurgical NSCLC patients were investigated.Immunohistochemistry was used to evaluate the cyclin D1 expression.Results Overall survival was significantly lower in patients with cyclin D1-high expression of tumors than those with cyclin D1 low expression of tumors(χ2=5.132,P=0.023).In early stage patients(stage I,II),the overall survival was significantly lower in patients with cyclin D1-high expression of tumors than those with cyclin D1-low expression of tumors(χ2=6.863,P=0.009).cyclin D1 status(hazard ratio=0.630;P=0.035),differentiation(hazard ratio=0.399;P<0.001),and pTNM(hazard ratio=1.576;P<0.001)to be independent prognostic factors for NSCLC patients.Specifically,the cyclin D1 status(hazard ratio=0.188;P=0.008)was a significant prognostic factor for patients with stage I NSCLCs.Conclusion cyclin D1 expression is an independent prognosis factor for postoperative patient in stage I,II NSCLCs.展开更多
40 thyroid specimens from Tru-cut needle biopsy and surgerywere analyzed by APAAP immunohistochemical technique.It was shown thatthe expression of HLA-DR antigen on thyroid follicular cells (TFC) wasinvolved in almost...40 thyroid specimens from Tru-cut needle biopsy and surgerywere analyzed by APAAP immunohistochemical technique.It was shown thatthe expression of HLA-DR antigen on thyroid follicular cells (TFC) wasinvolved in almost every patient.The degree of DR expression was signifi-cantly higher in autoimmune thyroiditis (AIT) than in Graves’ disease (GD)and in nontoxic goiter (NTG),The level of DR expression on TFC not onlycorrelated markedly with degree of MNC infiltration,but more so with degreeof DR expression on intrathyroidal infiltrates,suggesting that aberrant DR ex-pression in vivo may be related to the activation of intrathyroidal T cells.展开更多
基金Supported by Hebei Science and Technology Offi ce Programme (07220401D)
文摘To investigate the mechanism of action of Chinese herbal medicine, the immunocells of Harder＇s glands were observed. The healthy Hy-Line Brown chickens of 12-day-old were divided into three groups randomly. The chickens in group 1 and 2 drank the water with 0.5% and 1% Chinese herbal medicine immunopromoter every day. The chickens in group 3 as control drank pure water. The Harder＇s glands of the chickens from 0.5% group, 1% group and control group at 24, 36 and 48 d after drinking medicine respectively were made into histological section. And then the histological sections were observed histologically. The results showed that Chinese herbal medicine could increase the quantity of the immunocells in glandular organs conspicuously. Immunopotentiator of Chinese herbal medicine could promote the amount and growth of secreted immunoglobuline and elevate the immune level of the orgamsm, and the effect of 1% group was higher than that of 0.5% group.
文摘Background and objective cyclin D1 is a member of the cyclin family,and it has been proven that it plaied an important role in tumorigenesis,invasion and metastasis.We performed a retrospective study on the cyclin D1 expression in non-small cell lung cancer(NSCLC)according to the clinical characteristics.Methods One hundred fifteen postsurgical NSCLC patients were investigated.Immunohistochemistry was used to evaluate the cyclin D1 expression.Results Overall survival was significantly lower in patients with cyclin D1-high expression of tumors than those with cyclin D1 low expression of tumors(χ2=5.132,P=0.023).In early stage patients(stage I,II),the overall survival was significantly lower in patients with cyclin D1-high expression of tumors than those with cyclin D1-low expression of tumors(χ2=6.863,P=0.009).cyclin D1 status(hazard ratio=0.630;P=0.035),differentiation(hazard ratio=0.399;P<0.001),and pTNM(hazard ratio=1.576;P<0.001)to be independent prognostic factors for NSCLC patients.Specifically,the cyclin D1 status(hazard ratio=0.188;P=0.008)was a significant prognostic factor for patients with stage I NSCLCs.Conclusion cyclin D1 expression is an independent prognosis factor for postoperative patient in stage I,II NSCLCs.
文摘40 thyroid specimens from Tru-cut needle biopsy and surgerywere analyzed by APAAP immunohistochemical technique.It was shown thatthe expression of HLA-DR antigen on thyroid follicular cells (TFC) wasinvolved in almost every patient.The degree of DR expression was signifi-cantly higher in autoimmune thyroiditis (AIT) than in Graves’ disease (GD)and in nontoxic goiter (NTG),The level of DR expression on TFC not onlycorrelated markedly with degree of MNC infiltration,but more so with degreeof DR expression on intrathyroidal infiltrates,suggesting that aberrant DR ex-pression in vivo may be related to the activation of intrathyroidal T cells.
