Objective To investigate the effects of simvastatin compared with standard treatment on cardiovascular outcomes and all-cause mortality in high-risk hypertensive patients with a high–normal level of total cholesterol...Objective To investigate the effects of simvastatin compared with standard treatment on cardiovascular outcomes and all-cause mortality in high-risk hypertensive patients with a high–normal level of total cholesterol(TC).Methods In a randomized,open-label,blinded-endpoint trial,hypertensive patients at high risk for cardiovascular events from 180 clinical centers in China were assigned to receive treatment with amlodipine plus amiloride/hydrochlorothiazide(n=6,776)or telmisartan(n=6,766).展开更多
妊娠期高血压疾病(hypertensive disorders of pregnancy,HDP)对于母胎的影响已较明确,但正常高值血压和HDP的关系以及和母胎不良妊娠结局间的关系尚不明确。本文对2021年1—12月期间在复旦大学附属妇产科医院单胎分娩的孕妇进行的回顾...妊娠期高血压疾病(hypertensive disorders of pregnancy,HDP)对于母胎的影响已较明确,但正常高值血压和HDP的关系以及和母胎不良妊娠结局间的关系尚不明确。本文对2021年1—12月期间在复旦大学附属妇产科医院单胎分娩的孕妇进行的回顾性研究,将产检到分娩入院前血压<130/80 mmHg的孕妇纳入正常血压组,血压在130~139/80~89 mmHg的孕妇纳入正常高值血压组,并根据血压开始升高的孕周分为正常高值血压(20周前)组及正常高值血压(20周后)组。分析这3组患者的基本资料、HDP发病情况及母胎不良结局,发现与正常血压组相比,20周前和20周后正常高值血压组的HDP发病率均显著增加,特别是正常高值血压(20周后)组增加更为明显。正常高值血压(20周前)组医疗性早产和小于胎龄儿(small for gestational age,SGA)的风险增加。本研究为制定更严格的血压监管策略提供了理论依据,有助于降低母儿的不良妊娠结局的发生率。展开更多
文摘Objective To investigate the effects of simvastatin compared with standard treatment on cardiovascular outcomes and all-cause mortality in high-risk hypertensive patients with a high–normal level of total cholesterol(TC).Methods In a randomized,open-label,blinded-endpoint trial,hypertensive patients at high risk for cardiovascular events from 180 clinical centers in China were assigned to receive treatment with amlodipine plus amiloride/hydrochlorothiazide(n=6,776)or telmisartan(n=6,766).
文摘妊娠期高血压疾病(hypertensive disorders of pregnancy,HDP)对于母胎的影响已较明确,但正常高值血压和HDP的关系以及和母胎不良妊娠结局间的关系尚不明确。本文对2021年1—12月期间在复旦大学附属妇产科医院单胎分娩的孕妇进行的回顾性研究,将产检到分娩入院前血压<130/80 mmHg的孕妇纳入正常血压组,血压在130~139/80~89 mmHg的孕妇纳入正常高值血压组,并根据血压开始升高的孕周分为正常高值血压(20周前)组及正常高值血压(20周后)组。分析这3组患者的基本资料、HDP发病情况及母胎不良结局,发现与正常血压组相比,20周前和20周后正常高值血压组的HDP发病率均显著增加,特别是正常高值血压(20周后)组增加更为明显。正常高值血压(20周前)组医疗性早产和小于胎龄儿(small for gestational age,SGA)的风险增加。本研究为制定更严格的血压监管策略提供了理论依据,有助于降低母儿的不良妊娠结局的发生率。
