OBJECTIVE To use network pharmacology to predict and analyze the mechanism of Aconite-Ginger against myocardial ischemia.METHODS TCMSP was used to collect the active compounds of Aconite-Ginger and predict the targets...OBJECTIVE To use network pharmacology to predict and analyze the mechanism of Aconite-Ginger against myocardial ischemia.METHODS TCMSP was used to collect the active compounds of Aconite-Ginger and predict the targets of active compounds.At the same time,target sites of anti-myocardial ischemic injury drugs were collected using DisGeNET and CTD database,and then active compounds and target sites were compared.Analyze and screen out the targets of AconiteGinger anti-cardiac machine ischemia.GO,KEGG analysis and Aconite-Ginger drug molecule-target were performed on selected targets using MAS 3.0 and Cytoscape 3.3.0 software.RESULTS 27 common targets of Aconite-Ginger anti-ischemia ischemia and 63 signal pathways were predicted.CONCLUSION Aconite-Ginger mainly regulates calcium signal transduction,apoptosis and MAPK signaling pathway,which can also regulate through toll-like receptors,Fc epsilon RI and other signal pathways,so it is speculated that it may participate in regulation Apoptosis,inflammatory response,enhancement of myocardial function,etc.,thereby exerting an anti-ischemic effect.It laid a good foundation for further revealing its mechanism of action.展开更多
基金supported by Shaanxi Provincial Administration of Traditional Chinese Medicine project(JCPT007)
文摘OBJECTIVE To use network pharmacology to predict and analyze the mechanism of Aconite-Ginger against myocardial ischemia.METHODS TCMSP was used to collect the active compounds of Aconite-Ginger and predict the targets of active compounds.At the same time,target sites of anti-myocardial ischemic injury drugs were collected using DisGeNET and CTD database,and then active compounds and target sites were compared.Analyze and screen out the targets of AconiteGinger anti-cardiac machine ischemia.GO,KEGG analysis and Aconite-Ginger drug molecule-target were performed on selected targets using MAS 3.0 and Cytoscape 3.3.0 software.RESULTS 27 common targets of Aconite-Ginger anti-ischemia ischemia and 63 signal pathways were predicted.CONCLUSION Aconite-Ginger mainly regulates calcium signal transduction,apoptosis and MAPK signaling pathway,which can also regulate through toll-like receptors,Fc epsilon RI and other signal pathways,so it is speculated that it may participate in regulation Apoptosis,inflammatory response,enhancement of myocardial function,etc.,thereby exerting an anti-ischemic effect.It laid a good foundation for further revealing its mechanism of action.
