The hazardous substance Neu5Gc(N-glycolylneuraminic acid), which is rich in red meat, is related to chronic inflammation but is hard to eliminate. Here, electrical stimulation, as a food-friendly nonthermal processing...The hazardous substance Neu5Gc(N-glycolylneuraminic acid), which is rich in red meat, is related to chronic inflammation but is hard to eliminate. Here, electrical stimulation, as a food-friendly nonthermal processing technology, was applied to red meat samples to reduce the Neu5Gc content. To explore the Neu5Gc structure changes during this process, electronic structure parameters were evaluated, and AIM( atom in molecules) theory and DFT(density function theory) calculations were further used. The results showed that the content of Nue5Gc in red meat can be reduced by(74.24 ± 0.69)% at 120 V for 50 s, with little impact on the meat texture and color. Theoretical calculations indicated that the Neu5Gc molecule becomes very unstable under electrical stimulation by increasing the O-H bond length, reactive activity, strength of intermolecular dipole forces and total energy through reducing the values of bond dissociation energy and strength of intramolecular hydrogen bonds. Overall, this research provides an economical method to effectively control red meat safety.展开更多
目的:系统评价经皮神经电刺激(TENS)对脑卒中患者上肢功能的影响。方法:全面检索8个数据库,包括中国知网、中国维普、万方、PubMed、Web of Science、EMBASE、Cochrane Library、CINAHL,严格按照纳入排除标准进行文献的筛选。采用Cochr...目的:系统评价经皮神经电刺激(TENS)对脑卒中患者上肢功能的影响。方法:全面检索8个数据库,包括中国知网、中国维普、万方、PubMed、Web of Science、EMBASE、Cochrane Library、CINAHL,严格按照纳入排除标准进行文献的筛选。采用Cochrane系统对纳入文献进行质量评价,采用Revman 5.4.1软件进行Meta分析。结果:共纳入了11项随机对照研究,包括559名患者,Meta分析结果显示,TENS可以提高脑卒中上肢功能障碍患者的Fugl-Meyer上肢评估(FMA-UE)量表评分(MD=5.77,95%CI:3.12,8.42)、降低改良Ashworth肌张力评定(MAS)量表评分(MD=-0.38,95%CI:-0.65,-0.11)、提高改良Barthel指数(MBI)评分(MD=10.68,95%CI:8.28,13.09)。亚组分析结果显示,是否偏瘫不是产生异质性的来源。结论:TENS可以提高脑卒中上肢功能障碍患者的FMA-UE量表和MBI评分,降低MAS量表评分,对脑卒中患者的上肢功能恢复有积极影响。展开更多
基金the National Natural Science Foundation of China (No. 31660496)the High-level innovative talents training project of Guizhou province-“Hundred” level talents (QKHPTRC[2016]5662)。
文摘The hazardous substance Neu5Gc(N-glycolylneuraminic acid), which is rich in red meat, is related to chronic inflammation but is hard to eliminate. Here, electrical stimulation, as a food-friendly nonthermal processing technology, was applied to red meat samples to reduce the Neu5Gc content. To explore the Neu5Gc structure changes during this process, electronic structure parameters were evaluated, and AIM( atom in molecules) theory and DFT(density function theory) calculations were further used. The results showed that the content of Nue5Gc in red meat can be reduced by(74.24 ± 0.69)% at 120 V for 50 s, with little impact on the meat texture and color. Theoretical calculations indicated that the Neu5Gc molecule becomes very unstable under electrical stimulation by increasing the O-H bond length, reactive activity, strength of intermolecular dipole forces and total energy through reducing the values of bond dissociation energy and strength of intramolecular hydrogen bonds. Overall, this research provides an economical method to effectively control red meat safety.
文摘目的:系统评价经皮神经电刺激(TENS)对脑卒中患者上肢功能的影响。方法:全面检索8个数据库,包括中国知网、中国维普、万方、PubMed、Web of Science、EMBASE、Cochrane Library、CINAHL,严格按照纳入排除标准进行文献的筛选。采用Cochrane系统对纳入文献进行质量评价,采用Revman 5.4.1软件进行Meta分析。结果:共纳入了11项随机对照研究,包括559名患者,Meta分析结果显示,TENS可以提高脑卒中上肢功能障碍患者的Fugl-Meyer上肢评估(FMA-UE)量表评分(MD=5.77,95%CI:3.12,8.42)、降低改良Ashworth肌张力评定(MAS)量表评分(MD=-0.38,95%CI:-0.65,-0.11)、提高改良Barthel指数(MBI)评分(MD=10.68,95%CI:8.28,13.09)。亚组分析结果显示,是否偏瘫不是产生异质性的来源。结论:TENS可以提高脑卒中上肢功能障碍患者的FMA-UE量表和MBI评分,降低MAS量表评分,对脑卒中患者的上肢功能恢复有积极影响。
