Objective To observe the characteristics of sensory gating P50 in patients with first-episode schizophrenia(Sch). Methods Auditory evoked potentials P50 were recorded in 92 normal controls(NC)and 66 schizophrenia pati...Objective To observe the characteristics of sensory gating P50 in patients with first-episode schizophrenia(Sch). Methods Auditory evoked potentials P50 were recorded in 92 normal controls(NC)and 66 schizophrenia patients by the conditioning/testing paradigm presented with auditory double clicks stimuli, using American Nicolet Bravo instrument. Results Compared with NC, schizophrenia patients showed decreased S1-P50 amplitude(NC:[6±3]μV, Sch: [3±2]μV, P<0.01), increased S2-P50 amplitude(NC: [2±1]μV, Sch: [4±2]μV, P<0.01), higher S2/S1 ratio(NC: [42±21]%, Sch: [81±40]%, P<0.01), decreased S2-S1(NC: [3±2]μV, Sch: [2±1]μV, P<0.05) and 100(1-S2/S1) (NC: [58±21]%, Sch: [19±17]%, P<0.01), suggesting that patients had sensory gating deficits. Conclusion The first-episode schizophrenia patients had sensory gating deficits, reflecting by auditory evoked potential P50.展开更多
OBJECTIVE Tenuifolin is a natu⁃ral neuroprotective compound isolated from Polygala tenuifolia Willd,which have a long history of being used in mental illness therapy in China.Acute or chronic administration of NMDA re...OBJECTIVE Tenuifolin is a natu⁃ral neuroprotective compound isolated from Polygala tenuifolia Willd,which have a long history of being used in mental illness therapy in China.Acute or chronic administration of NMDA recep⁃tor blocker MK-801 is a validated animal model for the positive,negative and cognitive symp⁃toms of schizophrenia.This study aimed to inves⁃tigate the antipsychotic effects and possible mechanism of tenuifolin in MK-801-treated mice.METHODS Sensorimotor gating deficit and hyper⁃locomotion,which implying positive symptoms,were assessed by prepulse inhibition(PPI)test and open field test.Social withdrawal,a main character of negative symptoms,was assessed by social interaction tests.Cognitive deficit was assessed by novel object recognition(NOR)test.The level of glutamate decarboxylase(GAD),GABA and monoamines were detected by West⁃ern blotting or HPLC-ECD.RESULTS Acute administration of MK-801(0.1 mg·kg^(-1),sc)could significantly induce hyperlocomotion and prepulse inhibition(PPI)deficit in mice,which could be reversed by the treatment of tenuifolin(40 and 80 mg·kg^(-1),ig).Moreover,tenuifolin ameliorated social withdrawal and cognitive deficit induced by the chronic administration of MK-801(0.3 mg·kg^(-1) per day,sc,14 d followed by 7 d washout period).In addition,tenuifolin reversed the reduction in GAD and GABA induced by MK-801 and normal⁃ized dopamine,serotonin and norepinephrine in the prefrontal cortex.CONCLUSION These results provided persuasive evidence that tenui⁃folin has multiple antipsychotic-like effects in ani⁃mal model of schizophrenia and its underlying mechanism may be associated with its potential effects on GABA function in the prefrontal cortex.展开更多
目的探讨以阴性症状为主(predominant negative symptoms,PNS)精神分裂症患者的纹状体静息态功能连接(resting-state functional connectivity,rsFC)改变及与阴性症状的关系。方法54例PNS精神分裂症患者和61例健康对照接受静息态功能磁...目的探讨以阴性症状为主(predominant negative symptoms,PNS)精神分裂症患者的纹状体静息态功能连接(resting-state functional connectivity,rsFC)改变及与阴性症状的关系。方法54例PNS精神分裂症患者和61例健康对照接受静息态功能磁共振扫描,完成一般资料收集及阳性与阴性症状量表(Positive and Negative Syndrome Scale,PANSS)、阴性症状量表(Scale for the Assessment of Negative Symptoms,SANS)、时间性愉快体验量表(Temporal Experience of Pleasure Scale,TEPS)评定。选择12个纹状体亚区为感兴趣区(regions of interest,ROIs),分析各ROI与全脑体素的rsFC,并提取差异脑区的rsFC值与阴性症状行Pearson相关分析。结果与健康对照相比,PNS精神分裂症患者右背尾壳核与右脑岛、左额中回(middle frontal gyrus,MFG)、右内侧和旁扣带回(median cingulate and paracingulate gyri,MCC)之间,左背尾壳核与右壳核、左脑岛、左MFG之间,右背喙壳核与双侧MFG、左脑岛、右MCC之间,左背喙壳核与右脑岛、左中央沟盖之间,右腹喙壳核与双侧壳核、左MFG、右MCC之间,左腹喙壳核与右脑岛、左壳核、双侧MFG、右MCC、左顶下缘角回之间,及左腹侧尾状核下部/伏隔核与右脑岛、左前扣带回(胼胝体上部)、双侧楔前叶之间的rsFC降低(体素水平P<0.001未校正,簇水平FWE校正,P_(FWE)<0.05/12=0.004)。未发现PNS精神分裂症患者较健康对照rsFC增强的脑区,也未发现与SANS、TEPS量表相关的rsFC(P_(Bonferroni)>0.05)。结论PNS精神分裂症患者存在广泛的皮层-纹状体功能连接异常,主要是壳核与MFG、MCC、岛叶之间rsFC异常降低。展开更多
文摘Objective To observe the characteristics of sensory gating P50 in patients with first-episode schizophrenia(Sch). Methods Auditory evoked potentials P50 were recorded in 92 normal controls(NC)and 66 schizophrenia patients by the conditioning/testing paradigm presented with auditory double clicks stimuli, using American Nicolet Bravo instrument. Results Compared with NC, schizophrenia patients showed decreased S1-P50 amplitude(NC:[6±3]μV, Sch: [3±2]μV, P<0.01), increased S2-P50 amplitude(NC: [2±1]μV, Sch: [4±2]μV, P<0.01), higher S2/S1 ratio(NC: [42±21]%, Sch: [81±40]%, P<0.01), decreased S2-S1(NC: [3±2]μV, Sch: [2±1]μV, P<0.05) and 100(1-S2/S1) (NC: [58±21]%, Sch: [19±17]%, P<0.01), suggesting that patients had sensory gating deficits. Conclusion The first-episode schizophrenia patients had sensory gating deficits, reflecting by auditory evoked potential P50.
文摘OBJECTIVE Tenuifolin is a natu⁃ral neuroprotective compound isolated from Polygala tenuifolia Willd,which have a long history of being used in mental illness therapy in China.Acute or chronic administration of NMDA recep⁃tor blocker MK-801 is a validated animal model for the positive,negative and cognitive symp⁃toms of schizophrenia.This study aimed to inves⁃tigate the antipsychotic effects and possible mechanism of tenuifolin in MK-801-treated mice.METHODS Sensorimotor gating deficit and hyper⁃locomotion,which implying positive symptoms,were assessed by prepulse inhibition(PPI)test and open field test.Social withdrawal,a main character of negative symptoms,was assessed by social interaction tests.Cognitive deficit was assessed by novel object recognition(NOR)test.The level of glutamate decarboxylase(GAD),GABA and monoamines were detected by West⁃ern blotting or HPLC-ECD.RESULTS Acute administration of MK-801(0.1 mg·kg^(-1),sc)could significantly induce hyperlocomotion and prepulse inhibition(PPI)deficit in mice,which could be reversed by the treatment of tenuifolin(40 and 80 mg·kg^(-1),ig).Moreover,tenuifolin ameliorated social withdrawal and cognitive deficit induced by the chronic administration of MK-801(0.3 mg·kg^(-1) per day,sc,14 d followed by 7 d washout period).In addition,tenuifolin reversed the reduction in GAD and GABA induced by MK-801 and normal⁃ized dopamine,serotonin and norepinephrine in the prefrontal cortex.CONCLUSION These results provided persuasive evidence that tenui⁃folin has multiple antipsychotic-like effects in ani⁃mal model of schizophrenia and its underlying mechanism may be associated with its potential effects on GABA function in the prefrontal cortex.
文摘目的探讨以阴性症状为主(predominant negative symptoms,PNS)精神分裂症患者的纹状体静息态功能连接(resting-state functional connectivity,rsFC)改变及与阴性症状的关系。方法54例PNS精神分裂症患者和61例健康对照接受静息态功能磁共振扫描,完成一般资料收集及阳性与阴性症状量表(Positive and Negative Syndrome Scale,PANSS)、阴性症状量表(Scale for the Assessment of Negative Symptoms,SANS)、时间性愉快体验量表(Temporal Experience of Pleasure Scale,TEPS)评定。选择12个纹状体亚区为感兴趣区(regions of interest,ROIs),分析各ROI与全脑体素的rsFC,并提取差异脑区的rsFC值与阴性症状行Pearson相关分析。结果与健康对照相比,PNS精神分裂症患者右背尾壳核与右脑岛、左额中回(middle frontal gyrus,MFG)、右内侧和旁扣带回(median cingulate and paracingulate gyri,MCC)之间,左背尾壳核与右壳核、左脑岛、左MFG之间,右背喙壳核与双侧MFG、左脑岛、右MCC之间,左背喙壳核与右脑岛、左中央沟盖之间,右腹喙壳核与双侧壳核、左MFG、右MCC之间,左腹喙壳核与右脑岛、左壳核、双侧MFG、右MCC、左顶下缘角回之间,及左腹侧尾状核下部/伏隔核与右脑岛、左前扣带回(胼胝体上部)、双侧楔前叶之间的rsFC降低(体素水平P<0.001未校正,簇水平FWE校正,P_(FWE)<0.05/12=0.004)。未发现PNS精神分裂症患者较健康对照rsFC增强的脑区,也未发现与SANS、TEPS量表相关的rsFC(P_(Bonferroni)>0.05)。结论PNS精神分裂症患者存在广泛的皮层-纹状体功能连接异常,主要是壳核与MFG、MCC、岛叶之间rsFC异常降低。
