Objective Doxorubicin(Dox)is an effective antitumor drug,which is limited due to its lethal cardiac injury in clinical application.Exenatide(Exe)is a glucagon-like peptide-1(GLP-1)analog,it can not only regulate blood...Objective Doxorubicin(Dox)is an effective antitumor drug,which is limited due to its lethal cardiac injury in clinical application.Exenatide(Exe)is a glucagon-like peptide-1(GLP-1)analog,it can not only regulate blood glucose,but protect the myocardium by reducing inflammation,oxidative stress and cell apoptosis.Since doxorubicininduced cardiac injury is currently thought to be mainly caused by inflammation,oxidative stress and cell apoptosis,we hypothesized that prophylactic treatment with exenatide may alleviate doxorubicin-induced cardiac injury.展开更多
文摘Objective Doxorubicin(Dox)is an effective antitumor drug,which is limited due to its lethal cardiac injury in clinical application.Exenatide(Exe)is a glucagon-like peptide-1(GLP-1)analog,it can not only regulate blood glucose,but protect the myocardium by reducing inflammation,oxidative stress and cell apoptosis.Since doxorubicininduced cardiac injury is currently thought to be mainly caused by inflammation,oxidative stress and cell apoptosis,we hypothesized that prophylactic treatment with exenatide may alleviate doxorubicin-induced cardiac injury.
