In recent years,with the accelerating development of the socialist market economy and the process of globalization,corruption has appeared and become more and more serious,causing serious harm to the interests of the ...In recent years,with the accelerating development of the socialist market economy and the process of globalization,corruption has appeared and become more and more serious,causing serious harm to the interests of the state and people,so the construction of a clean and honest government draws people’s attention.The doctrine of evil human nature of Syun Zih explained profound theories concerning the nature of human beings and the view of interest with simple language,from which the origin of the construction of a clean and honest government could be found.As a result,we can have a right starting point,representing the fundamental interests of the overwhelming majority of people in the long-term exploration.The doctrine of evil human nature of Syun Zih plays an irreplaceable role in the correct understanding and analysis of the construction of a clean and honest government and the construction of the incorrupt government culture.展开更多
目的现代研究表明免疫细胞在缺血性中风(IS)发生发展过程中具有重要作用,当前对于中医正邪理论的内在机制尚未阐明,不少研究认为免疫细胞介导的免疫平衡可能是中医正邪理论的重要机制之一。利用孟德尔随机化(MR)分析验证免疫细胞对IS的...目的现代研究表明免疫细胞在缺血性中风(IS)发生发展过程中具有重要作用,当前对于中医正邪理论的内在机制尚未阐明,不少研究认为免疫细胞介导的免疫平衡可能是中医正邪理论的重要机制之一。利用孟德尔随机化(MR)分析验证免疫细胞对IS的因果关系,并进一步探讨正邪理论的内在机理。方法基于公开的遗传数据,将免疫细胞作为工具变量进行双样本MR分析,探索731个免疫细胞表型与IS患病风险之间的因果关系。将逆方差加权(IVW)方法作为主要方法用作标准分析,使用加权中位数、MR-Egger、Simple mode和Weighted mode作为补充,Cochrans Q检验异质性、MR-Egger截距检验测试水平多效性。结果经FDR校正后,发现仍有11个免疫细胞表型具有统计学意义(经FDR校正的p<0.05):其中CD27 on memory B cell、CD27 on sw mem、CD27 on CD24^(+)CD27^(+)、CD27 on IgD^(-)CD38^(dim)、CD27 on IgD^(-)CD38-、CD27 on IgD^(-)CD38br、CD25 on IgD^(+)和CD25 on IgD^(+)CD38^(dim)对IS的起危险作用;CD40 on CD14-CD16^(+)monocyte、CD40 on CD14^(+)CD16-monocyte、CD40 on CD14^(+)CD16^(+)monocyte对IS起保护作用。其中8个在B细胞组,3个在单核细胞组。以B细胞上的CD27、CD25和单核细胞上的CD40为显著。结论通过遗传学手段证实了免疫细胞在IS中发挥关键作用,为阐明正邪理论的内在机理提供一定的参考。展开更多
文摘In recent years,with the accelerating development of the socialist market economy and the process of globalization,corruption has appeared and become more and more serious,causing serious harm to the interests of the state and people,so the construction of a clean and honest government draws people’s attention.The doctrine of evil human nature of Syun Zih explained profound theories concerning the nature of human beings and the view of interest with simple language,from which the origin of the construction of a clean and honest government could be found.As a result,we can have a right starting point,representing the fundamental interests of the overwhelming majority of people in the long-term exploration.The doctrine of evil human nature of Syun Zih plays an irreplaceable role in the correct understanding and analysis of the construction of a clean and honest government and the construction of the incorrupt government culture.
文摘目的现代研究表明免疫细胞在缺血性中风(IS)发生发展过程中具有重要作用,当前对于中医正邪理论的内在机制尚未阐明,不少研究认为免疫细胞介导的免疫平衡可能是中医正邪理论的重要机制之一。利用孟德尔随机化(MR)分析验证免疫细胞对IS的因果关系,并进一步探讨正邪理论的内在机理。方法基于公开的遗传数据,将免疫细胞作为工具变量进行双样本MR分析,探索731个免疫细胞表型与IS患病风险之间的因果关系。将逆方差加权(IVW)方法作为主要方法用作标准分析,使用加权中位数、MR-Egger、Simple mode和Weighted mode作为补充,Cochrans Q检验异质性、MR-Egger截距检验测试水平多效性。结果经FDR校正后,发现仍有11个免疫细胞表型具有统计学意义(经FDR校正的p<0.05):其中CD27 on memory B cell、CD27 on sw mem、CD27 on CD24^(+)CD27^(+)、CD27 on IgD^(-)CD38^(dim)、CD27 on IgD^(-)CD38-、CD27 on IgD^(-)CD38br、CD25 on IgD^(+)和CD25 on IgD^(+)CD38^(dim)对IS的起危险作用;CD40 on CD14-CD16^(+)monocyte、CD40 on CD14^(+)CD16-monocyte、CD40 on CD14^(+)CD16^(+)monocyte对IS起保护作用。其中8个在B细胞组,3个在单核细胞组。以B细胞上的CD27、CD25和单核细胞上的CD40为显著。结论通过遗传学手段证实了免疫细胞在IS中发挥关键作用,为阐明正邪理论的内在机理提供一定的参考。
