Ship outfitting is a key process in shipbuilding.Efficient and high-quality ship outfitting is a top priority for modern shipyards.These activities are conducted at different stations of shipyards.The outfitting plan ...Ship outfitting is a key process in shipbuilding.Efficient and high-quality ship outfitting is a top priority for modern shipyards.These activities are conducted at different stations of shipyards.The outfitting plan is one of the crucial issues in shipbuilding.In this paper,production scheduling and material ordering with endogenous uncertainty of the outfitting process are investigated.The uncertain factors in outfitting equipment production are usually decision-related,which leads to difficulties in addressing uncertainties in the outfitting production workshops before production is conducted according to plan.This uncertainty is regarded as endogenous uncertainty and can be treated as non-anticipativity constraints in the model.To address this problem,a stochastic two-stage programming model with endogenous uncertainty is established to optimize the outfitting job scheduling and raw material ordering process.A practical case of the shipyard of China Merchants Heavy Industry Co.,Ltd.is used to evaluate the performance of the proposed method.Satisfactory results are achieved at the lowest expected total cost as the complete kit rate of outfitting equipment is improved and emergency replenishment is reduced.展开更多
Constructing a cross-border power energy system with multiagent power energy as an alliance is important for studying cross-border power-trading markets.This study considers multiple neighboring countries in the form ...Constructing a cross-border power energy system with multiagent power energy as an alliance is important for studying cross-border power-trading markets.This study considers multiple neighboring countries in the form of alliances,introduces neighboring countries’exchange rates into the cross-border multi-agent power-trading market and proposes a method to study each agent’s dynamic decision-making behavior based on evolutionary game theory.To this end,this study uses three national agents as examples,constructs a tripartite evolutionary game model,and analyzes the evolution process of the decision-making behavior of each agent member state under the initial willingness value,cost of payment,and additional revenue of the alliance.This research helps realize cross-border energy operations so that the transaction agent can achieve greater trade profits and provides a theoretical basis for cooperation and stability between multiple agents.展开更多
Dry-cured meat products are considerably popular around the world due to unique flavor.Proteolysis is one of the enzymatic reactions from which flavor substances are derived,which is affected by endogenous proteases.T...Dry-cured meat products are considerably popular around the world due to unique flavor.Proteolysis is one of the enzymatic reactions from which flavor substances are derived,which is affected by endogenous proteases.The purpose aimed to reveal the potential relationship between endogenous proteases and key flavor substances in dry-cured pork coppa in this paper.The dynamic changes of endogenous proteases activity,free amino acids,and volatiles during dry-cured pork coppa processing were characterized.The results showed that 5 kinds of free amino acids,Glu,Lys,Val,Ala,and Leu,were identified as significant contributors to taste.Meanwhile,key volatiles,such as hexanal,nonanal,octanal,benzaldehyde,3-methyl butanoic acid,2-methyl propanoic acid,and ethyl octanoate,greatly contributed to the flavor characteristics of dry-cured pork coppa.Further partial correlation analysis was performed to better elucidate the relationship among parameters.The results revealed that close relationship between endogenous proteases and key substances.RAP not only significantly affected the accumulation of key active-amino acids,but also affected the accumulation of ethyl octanoate,2,3-pentanedione,and 2,3-octanedione by regulating the accumulation of octanoic acid and Leu.In addition,cathepsin B and D,DPP II,DPP IV and RAP notably affected accumulation of hexanal.展开更多
Deciphering the context-specific relationship between sequence and function is a major challenge in genomics.Existing tools for inducing locus-specific hypermutation and evolution in the native genome context are limi...Deciphering the context-specific relationship between sequence and function is a major challenge in genomics.Existing tools for inducing locus-specific hypermutation and evolution in the native genome context are limited.Here we present a programmable platform for long-range,locus-specific hypermutation called helicase-assisted continuous editing(HACE).HACE leverages CRISPR-Cas9 to target a processive helicase-deaminase fusion that incurs mutations across large(>1000-base pair)genomic intervals.We applied HACE to identify mutations in mitogen-activated protein kinase kinase 1(MEK1)that confer kinase inhibitor resistance,to dissect the impact of individual variants in splicing factor 3B subunit 1(SF3B1)-dependent missplicing,and to evaluate noncoding variants in a stimulation-dependent immune enhancer of CD69.HACE provides a powerful tool for investigating coding and noncoding variants,uncovering combinatorial sequence-to-function relationships,and evolving new biological functions.展开更多
Combining the heuristic algorithm （HA） developed based on the specific knowledge of the cooperative multiple target attack （CMTA） tactics and the particle swarm optimization （PSO）, a heuristic particle swarm opt...Combining the heuristic algorithm （HA） developed based on the specific knowledge of the cooperative multiple target attack （CMTA） tactics and the particle swarm optimization （PSO）, a heuristic particle swarm optimization （HPSO） algorithm is proposed to solve the decision-making （DM） problem. HA facilitates to search the local optimum in the neighborhood of a solution, while the PSO algorithm tends to explore the search space for possible solutions. Combining the advantages of HA and PSO, HPSO algorithms can find out the global optimum quickly and efficiently. It obtains the DM solution by seeking for the optimal assignment of missiles of friendly fighter aircrafts （FAs） to hostile FAs. Simulation results show that the proposed algorithm is superior to the general PSO algorithm and two GA based algorithms in searching for the best solution to the DM problem.展开更多
Based on analyzing the influences of a slicing scheme on stair-stepping effect, supporting structure, efficiency and deformation, etc. , analytical hierarchical process （AHP） combining with fuzzy synthetic evaluatio...Based on analyzing the influences of a slicing scheme on stair-stepping effect, supporting structure, efficiency and deformation, etc. , analytical hierarchical process （AHP） combining with fuzzy synthetic evaluation is introduced to make decision in slicing schemes for a processing part. The application in determining the slicing scheme for a computer mouse during prototyping shows that the method increases the rationality during decision- making and improves quality and efficiency for the prototyping part.展开更多
In presented fuzzy multi-attribute decision-making （FMADM） problems, the information about attribute weights is interval numbers and the decision maker （DM） has fuzzy complementary preference relation on alternati...In presented fuzzy multi-attribute decision-making （FMADM） problems, the information about attribute weights is interval numbers and the decision maker （DM） has fuzzy complementary preference relation on alternatives. Firstly, the decision-making information based on the subjective preference information in the form of the fuzzy complementary judgment matrix is uniform by using a translation function. Then an objective programming model is established. Attribute weights are obtained by solving the model, thus the fuzzy overall values of alternatives are derived by using the additive weighting method. Secondly, the ranking approach of alternatives is proposed based on the degree of similarity between the fuzzy positive ideal solution of alternatives （FPISA） and the fuzzy overall values. The method can sufficiently utilize the objective information of alternatives and meet the subjective requirements of the DM as much as possible. It is easy to be operated and implemented on a computer. Finally, the proposed method is applied to the project evaluation in the venture investment.展开更多
Autonomy, a key property associated with the agent, is an important topic in the current research of the agent theory. Although no definition of the agent autonomy is universally accepted, an important aspect of the a...Autonomy, a key property associated with the agent, is an important topic in the current research of the agent theory. Although no definition of the agent autonomy is universally accepted, an important aspect of the agent autonomy is the decision-making capability of the agents. This paper investigates the autonomy of the agent, presents a framework for autonomous agent and discusses its decision-making process. Started with introducing a language for representing autonomous agent, a framework is proposed for modeling autonomous agent based on a BDI model and the situation calculus. Finally, a kind of decision-making process of the autonomous agent is presented.展开更多
‘Zhongqiusucui’ jujube secondary shoots were treated with 3-indolebutyric acid(IBA) at three concentrations, 500, 1000 and 1500 mg/L. Results show that IBA could significantly enhance rooting and root characteristic...‘Zhongqiusucui’ jujube secondary shoots were treated with 3-indolebutyric acid(IBA) at three concentrations, 500, 1000 and 1500 mg/L. Results show that IBA could significantly enhance rooting and root characteristics of cuttings and were best with IBA at 1500 mg/L. In the rooting process, the formation of adventitious roots was related to the consumption and accumulation of nutrients(soluble sugars and proteins) and the changes in endogenous hormones in phloem, leaf tips and leaf bases. The rooting of cuttings had a positive correlation with the consumption of soluble sugars during the period of callus formation and with the accumulation of soluble sugars during adventitious root formation and growth. Rooting was positively related to the breakdown of soluble proteins in the phloem when the callus formed, and had a positive correlation with its accumulation during adventitious root formation and growth. Leaf tips and leaf bases showed a reverse trend in changes of soluble protein. However, together with the phloem, leaf tips and leaf bases regulated and controlled the formation and development of adventitious roots. The main activities of soluble proteins exist in the leaf tips as this was the main source of soluble proteins. The relation between rooting and IAA(indole-3-acetic acid) content in phloem was positive and thus a high concentration of IAA could benefit the induction and formation of adventitious roots. However, rooting was negatively related with ABA(abscisic acid) and GA(gibberellic acid) and a high concentration of both could inhibit the induction and formation of adventitious roots. Rooting had a positive correlation with phloem IAA/ABA ratios, and higher ratios could improve rooting. Low concentrations of ZR(zeatin riboside) triggered the induction of adventitious roots, while higher concentrations promoted root growth.Endogenous hormones in leaf tips and bases had an impact on rooting. The activities of endogenous hormones mainly existed in leaf tips because they play a major role in the production and consumption of IAA and its ABA content increased during rooting. The ZR in leaf tips influenced the rooting of cuttings, especially in the callus formation and rooting stage. Leaf tips were the main source of GA.展开更多
To determine the relationship between female sterility of Pinus tabulaeformis Carr. and plant hormones, content changes of several endogenous plant hormones in a female-sterile clone and a normal clone were analyzed d...To determine the relationship between female sterility of Pinus tabulaeformis Carr. and plant hormones, content changes of several endogenous plant hormones in a female-sterile clone and a normal clone were analyzed during the key period of female gametophyte abortion in mutant clones. The change of ABA content showed a similar pattern between normal and mutant clones, but the ABA content of the mutant clone was always much higher than that of the normal clone. In the normal clone, the IAA content decreased significantly at the early stage of the period and reached its minimum during the first ten days of April and stabilized thereafter. The endogenous ZR levels increased sharply at the early stages and reached a maximum in the middle of April, then decreased dramatically. The IAA and ZR contents of the mutant clone did not change perceptively through the entire period. We conclude that the high levels of ABA and the deficit of IAA and ZR may be the reasons of female gametophyte abortion in the female-sterile clones of P. tabulaeformis.展开更多
The information security and functional safety are fundamental issues of wireless communications sytems.The endogenous security principle based on Dynamic Heterogeneous Redundancy provides a direction for the developm...The information security and functional safety are fundamental issues of wireless communications sytems.The endogenous security principle based on Dynamic Heterogeneous Redundancy provides a direction for the development of wireless communication security and safety technology.This paper introduces the concept of wireless endogenous security from the following four aspects.First,we sorts out the endogenous security problems faced by the current wireless communications system,and then analyzes the endogenous security and safety attributes of the wireless channel.After that,the endogenous security and safety structure of the wireless communications system is given,and finally the applications of the existing wireless communication endogenous security and safety functions are listed.展开更多
Elemental calcium plays an important role in human physiology. In order to study the relationship between Ca-intake, Ca-chemical formulation, and Ca-absorptivity, a balance experiment using a ^(41)Ca tracer technique ...Elemental calcium plays an important role in human physiology. In order to study the relationship between Ca-intake, Ca-chemical formulation, and Ca-absorptivity, a balance experiment using a ^(41)Ca tracer technique in SD rats was conducted to measure the endogenous fecal calcium and true absorption of calcium. Apparent absorption of calcium was measured as a control to the endogenous calcium labeling experiment. These results show that by using ^(41)Ca labeled endogenous calcium in vivo, researchers could obtain the true calcium absorption data without extrinsic labeling. Therefore, the method was not affected by the chemical structure or type of calcium supplement and might be used in evaluating the absorptivity of marketed calcium supplements.展开更多
Game theory can be applied to the air combat decision-making problem of multiple unmanned combat air vehicles(UCAVs).However,it is difficult to have satisfactory decision-making results completely relying on air comba...Game theory can be applied to the air combat decision-making problem of multiple unmanned combat air vehicles(UCAVs).However,it is difficult to have satisfactory decision-making results completely relying on air combat situation information,because there is a lot of time-sensitive information in a complex air combat environment.In this paper,a constraint strategy game approach is developed to generate intelligent decision-making for multiple UCAVs in complex air combat environment with air combat situation information and time-sensitive information.Initially,a constraint strategy game is employed to model attack-defense decision-making problem in complex air combat environment.Then,an algorithm is proposed for solving the constraint strategy game based on linear programming and linear inequality(CSG-LL).Finally,an example is given to illustrate the effectiveness of the proposed approach.展开更多
A decision-making problem of missile-target assignment with a novel particle swarm optimization algorithm is proposed when it comes to a multiple target collaborative combat situation.The threat function is establishe...A decision-making problem of missile-target assignment with a novel particle swarm optimization algorithm is proposed when it comes to a multiple target collaborative combat situation.The threat function is established to describe air combat situation.Optimization function is used to find an optimal missile-target assignment.An improved particle swarm optimization algorithm is utilized to figure out the optimization function with less parameters,which is based on the adaptive random learning approach.According to the coordinated attack tactics,there are some adjustments to the assignment.Simulation example results show that it is an effective algorithm to handle with the decision-making problem of the missile-target assignment(MTA)in air combat.展开更多
The open and broadcast nature of wireless channels leads to the inherent security problem of information leakage in wireless communication.We can utilize endogenous security functions to resolve this problem.The funda...The open and broadcast nature of wireless channels leads to the inherent security problem of information leakage in wireless communication.We can utilize endogenous security functions to resolve this problem.The fundamental solution is channel-based mechanisms,like physical layer secret keys.Unfortunately,current investigations have not fully exploited the randomness of wireless channels,making secret key rates not high.Consequently,user data can be encrypted by reducing the data rate to match the secret key rate.Based on the analysis of the endogenous wireless security principle,we proposed that the channel-based endogenous secret key rate can nearly match the maximum data rate in the fast-fading environments.After that,we validated the proposition in an instantiation system with multiple phase shift keying(MPSK)inputs from the perspectives of both theoretical analysis and simulation experiments.The results indicate that it is possible to accomplish the onetime pad without decreasing the data rate via channelbased endogenous keys.Besides,we can realize highspeed endogenously secure transmission by introducing independent channels in the domains of frequency,space,or time.The conclusions derived provide a new idea for wireless security and promote the application of the endogenous security theory.展开更多
The maintenance of an aero-engine usually includes three levels,and the maintenance cost and period greatly differ depending on the different maintenance levels.To plan a reasonable maintenance budget program, airline...The maintenance of an aero-engine usually includes three levels,and the maintenance cost and period greatly differ depending on the different maintenance levels.To plan a reasonable maintenance budget program, airlines would like to predict the maintenance level of aero-engine before repairing in terms of performance parameters,which can provide more economic benefits.The maintenance level decision rules are mined using the historical maintenance data of a civil aero-engine based on the rough set theory,and a variety of possible models of updating rules produced by newly increased maintenance cases added to the historical maintenance case database are investigated by the means of incremental machine learning.The continuously updated rules can provide reasonable guidance suggestions for engineers and decision support for planning a maintenance budget program before repairing. The results of an example show that the decision rules become more typical and robust,and they are more accurate to predict the maintenance level of an aero-engine module as the maintenance data increase,which illustrates the feasibility of the represented method.展开更多
BACKGROUND:To promote the shared decision-making(SDM)between patients and doctors in pediatric outpatient departments,this study was designed to validate artificial intelligence(AI)-initiated medical tests for childre...BACKGROUND:To promote the shared decision-making(SDM)between patients and doctors in pediatric outpatient departments,this study was designed to validate artificial intelligence(AI)-initiated medical tests for children with fever.METHODS:We designed an AI model,named Xiaoyi,to suggest necessary tests for a febrile child before visiting a pediatric outpatient clinic.We calculated the sensitivity,specificity,and F1 score to evaluate the efficacy of Xiaoyi’s recommendations.The patients were divided into the rejection and acceptance groups.Then we analyzed the rejected examination items in order to obtain the corresponding reasons.RESULTS:We recruited a total of 11,867 children with fever who had used Xiaoyi in outpatient clinics.The recommended examinations given by Xiaoyi for 10,636(89.6%)patients were qualified.The average F1 score reached 0.94.A total of 58.4%of the patients accepted Xiaoyi’s suggestions(acceptance group),and 41.6%refused(rejection group).Imaging examinations were rejected by most patients(46.7%).The tests being time-consuming were rejected by 2,133 patients(43.2%),including rejecting pathogen studies in 1,347 patients(68.5%)and image studies in 732 patients(31.8%).The difficulty of sampling was the main reason for rejecting routine tests(41.9%).CONCLUSION:Our model has high accuracy and acceptability in recommending medical tests to febrile pediatric patients,and is worth promoting in facilitating SDM.展开更多
Based on effectiveness analysis , a novel method is presented for combat aircraft top-hierarchy concept evaluation and decision-making. Applying multi-criterion decision-making ( MCDM ) and analytic hierarchy process ...Based on effectiveness analysis , a novel method is presented for combat aircraft top-hierarchy concept evaluation and decision-making. Applying multi-criterion decision-making ( MCDM ) and analytic hierarchy process , the new method can help to overcome the limitations of existing evaluation systems and decision-make methods.The proposed method includes the following process :( 1 ) Establish a multi-criterion and multi-hierarchy evaluation attribute system by introducing combat effectiveness ;( 2 ) Assign weight to the attributes and normalize them ;( 3 ) Evaluate and decision-make top-hierarchy aircraft concept based on effectiveness to reach a satisfactory design by comprehensively applying four multi-criterion decision-making methodologies , i.e.grey correlation projection method , weighted summation method , weighted quadrature method and ideal solution decision-making method , while considering the attribute hierarchy system and the logical relations among the attributes.Finally , an example is given to indicate the validity and feasibility of the proposed method.展开更多
The Space-Air-Ground Integrated Network(SAGIN) realizes the integration of space, air,and ground networks, obtaining the global communication coverage.Software-Defined Networking(SDN) architecture in SAGIN has become ...The Space-Air-Ground Integrated Network(SAGIN) realizes the integration of space, air,and ground networks, obtaining the global communication coverage.Software-Defined Networking(SDN) architecture in SAGIN has become a promising solution to guarantee the Quality of Service(QoS).However, the current routing algorithms mainly focus on the QoS of the service, rarely considering the security requirement of flow. To realize the secure transmission of flows in SAGIN, we propose an intelligent flow forwarding scheme with endogenous security based on Mimic Defense(ESMD-Flow). In this scheme, SDN controller will evaluate the reliability of nodes and links, isolate malicious nodes based on the reliability evaluation value, and adapt multipath routing strategy to ensure that flows are always forwarded along the most reliable multiple paths. In addition, in order to meet the security requirement of flows, we introduce the programming data plane to design a multiprotocol forwarding strategy for realizing the multiprotocol dynamic forwarding of flows. ESMD-Flow can reduce the network attack surface and improve the secure transmission capability of flows by implementing multipath routing and multi-protocol hybrid forwarding mechanism. The extensive simulations demonstrate that ESMD-Flow can significantly improve the average path reliability for routing and increase the difficulty of network eavesdropping while improving the network throughput and reducing the average packet delay.展开更多
The integration of digital twin(DT)and 6G edge intelligence provides accurate forecasting for distributed resources control in smart park.However,the adverse impact of model poisoning attacks on DT model training cann...The integration of digital twin(DT)and 6G edge intelligence provides accurate forecasting for distributed resources control in smart park.However,the adverse impact of model poisoning attacks on DT model training cannot be ignored.To address this issue,we firstly construct the models of DT model training and model poisoning attacks.An optimization problem is formulated to minimize the weighted sum of the DT loss function and DT model training delay.Then,the problem is transformed and solved by the proposed Multi-timescAle endogenouS securiTy-aware DQN-based rEsouRce management algorithm(MASTER)based on DT-assisted state information evaluation and attack detection.MASTER adopts multi-timescale deep Q-learning(DQN)networks to jointly schedule local training epochs and devices.It actively adjusts resource management strategies based on estimated attack probability to achieve endogenous security awareness.Simulation results demonstrate that MASTER has excellent performances in DT model training accuracy and delay.展开更多
基金supported in part by the High-tech ship scientific research project of the Ministry of Industry and Information Technology of the People’s Republic of China,and the National Nature Science Foundation of China(Grant No.71671113)the Science and Technology Department of Shaanxi Province(No.2020GY-219)the Ministry of Education Collaborative Project of Production,Learning and Research(No.201901024016).
文摘Ship outfitting is a key process in shipbuilding.Efficient and high-quality ship outfitting is a top priority for modern shipyards.These activities are conducted at different stations of shipyards.The outfitting plan is one of the crucial issues in shipbuilding.In this paper,production scheduling and material ordering with endogenous uncertainty of the outfitting process are investigated.The uncertain factors in outfitting equipment production are usually decision-related,which leads to difficulties in addressing uncertainties in the outfitting production workshops before production is conducted according to plan.This uncertainty is regarded as endogenous uncertainty and can be treated as non-anticipativity constraints in the model.To address this problem,a stochastic two-stage programming model with endogenous uncertainty is established to optimize the outfitting job scheduling and raw material ordering process.A practical case of the shipyard of China Merchants Heavy Industry Co.,Ltd.is used to evaluate the performance of the proposed method.Satisfactory results are achieved at the lowest expected total cost as the complete kit rate of outfitting equipment is improved and emergency replenishment is reduced.
基金National Key R&D Program of China(Grant No.2022YFB2703500)National Natural Science Foundation of China(Grant No.52277104)+2 种基金National Key R&D Program of Yunnan Province(202303AC100003)Applied Basic Research Foundation of Yunnan Province (202301AT070455, 202101AT070080)Revitalizing Talent Support Program of Yunnan Province (KKRD202204024).
文摘Constructing a cross-border power energy system with multiagent power energy as an alliance is important for studying cross-border power-trading markets.This study considers multiple neighboring countries in the form of alliances,introduces neighboring countries’exchange rates into the cross-border multi-agent power-trading market and proposes a method to study each agent’s dynamic decision-making behavior based on evolutionary game theory.To this end,this study uses three national agents as examples,constructs a tripartite evolutionary game model,and analyzes the evolution process of the decision-making behavior of each agent member state under the initial willingness value,cost of payment,and additional revenue of the alliance.This research helps realize cross-border energy operations so that the transaction agent can achieve greater trade profits and provides a theoretical basis for cooperation and stability between multiple agents.
基金financially supported by the National Natural Science Foundation of China(32001728,32172248)the Taishan Industrial Experts Program+1 种基金the Guizhou High-level Innovative Talent Training Project(Qianke Cooperation Platform Talent number[2016]5662)Guizhou Science and Technology Innovation Talent Team of Ecological Characteristic Meat Products.(QKHPTRC[2020]5004)。
文摘Dry-cured meat products are considerably popular around the world due to unique flavor.Proteolysis is one of the enzymatic reactions from which flavor substances are derived,which is affected by endogenous proteases.The purpose aimed to reveal the potential relationship between endogenous proteases and key flavor substances in dry-cured pork coppa in this paper.The dynamic changes of endogenous proteases activity,free amino acids,and volatiles during dry-cured pork coppa processing were characterized.The results showed that 5 kinds of free amino acids,Glu,Lys,Val,Ala,and Leu,were identified as significant contributors to taste.Meanwhile,key volatiles,such as hexanal,nonanal,octanal,benzaldehyde,3-methyl butanoic acid,2-methyl propanoic acid,and ethyl octanoate,greatly contributed to the flavor characteristics of dry-cured pork coppa.Further partial correlation analysis was performed to better elucidate the relationship among parameters.The results revealed that close relationship between endogenous proteases and key substances.RAP not only significantly affected the accumulation of key active-amino acids,but also affected the accumulation of ethyl octanoate,2,3-pentanedione,and 2,3-octanedione by regulating the accumulation of octanoic acid and Leu.In addition,cathepsin B and D,DPP II,DPP IV and RAP notably affected accumulation of hexanal.
文摘Deciphering the context-specific relationship between sequence and function is a major challenge in genomics.Existing tools for inducing locus-specific hypermutation and evolution in the native genome context are limited.Here we present a programmable platform for long-range,locus-specific hypermutation called helicase-assisted continuous editing(HACE).HACE leverages CRISPR-Cas9 to target a processive helicase-deaminase fusion that incurs mutations across large(>1000-base pair)genomic intervals.We applied HACE to identify mutations in mitogen-activated protein kinase kinase 1(MEK1)that confer kinase inhibitor resistance,to dissect the impact of individual variants in splicing factor 3B subunit 1(SF3B1)-dependent missplicing,and to evaluate noncoding variants in a stimulation-dependent immune enhancer of CD69.HACE provides a powerful tool for investigating coding and noncoding variants,uncovering combinatorial sequence-to-function relationships,and evolving new biological functions.
文摘Combining the heuristic algorithm （HA） developed based on the specific knowledge of the cooperative multiple target attack （CMTA） tactics and the particle swarm optimization （PSO）, a heuristic particle swarm optimization （HPSO） algorithm is proposed to solve the decision-making （DM） problem. HA facilitates to search the local optimum in the neighborhood of a solution, while the PSO algorithm tends to explore the search space for possible solutions. Combining the advantages of HA and PSO, HPSO algorithms can find out the global optimum quickly and efficiently. It obtains the DM solution by seeking for the optimal assignment of missiles of friendly fighter aircrafts （FAs） to hostile FAs. Simulation results show that the proposed algorithm is superior to the general PSO algorithm and two GA based algorithms in searching for the best solution to the DM problem.
基金Supported by the Science and Technology Support Key Project of Jiangsu Province (DE2008365)~~
文摘Based on analyzing the influences of a slicing scheme on stair-stepping effect, supporting structure, efficiency and deformation, etc. , analytical hierarchical process （AHP） combining with fuzzy synthetic evaluation is introduced to make decision in slicing schemes for a processing part. The application in determining the slicing scheme for a computer mouse during prototyping shows that the method increases the rationality during decision- making and improves quality and efficiency for the prototyping part.
文摘In presented fuzzy multi-attribute decision-making （FMADM） problems, the information about attribute weights is interval numbers and the decision maker （DM） has fuzzy complementary preference relation on alternatives. Firstly, the decision-making information based on the subjective preference information in the form of the fuzzy complementary judgment matrix is uniform by using a translation function. Then an objective programming model is established. Attribute weights are obtained by solving the model, thus the fuzzy overall values of alternatives are derived by using the additive weighting method. Secondly, the ranking approach of alternatives is proposed based on the degree of similarity between the fuzzy positive ideal solution of alternatives （FPISA） and the fuzzy overall values. The method can sufficiently utilize the objective information of alternatives and meet the subjective requirements of the DM as much as possible. It is easy to be operated and implemented on a computer. Finally, the proposed method is applied to the project evaluation in the venture investment.
文摘Autonomy, a key property associated with the agent, is an important topic in the current research of the agent theory. Although no definition of the agent autonomy is universally accepted, an important aspect of the agent autonomy is the decision-making capability of the agents. This paper investigates the autonomy of the agent, presents a framework for autonomous agent and discusses its decision-making process. Started with introducing a language for representing autonomous agent, a framework is proposed for modeling autonomous agent based on a BDI model and the situation calculus. Finally, a kind of decision-making process of the autonomous agent is presented.
基金supported by the national 948 subject ‘Introduction of fresh-eating jujube cultivar and new cultivating technology from Israel(2012-4-61)’
文摘‘Zhongqiusucui’ jujube secondary shoots were treated with 3-indolebutyric acid(IBA) at three concentrations, 500, 1000 and 1500 mg/L. Results show that IBA could significantly enhance rooting and root characteristics of cuttings and were best with IBA at 1500 mg/L. In the rooting process, the formation of adventitious roots was related to the consumption and accumulation of nutrients(soluble sugars and proteins) and the changes in endogenous hormones in phloem, leaf tips and leaf bases. The rooting of cuttings had a positive correlation with the consumption of soluble sugars during the period of callus formation and with the accumulation of soluble sugars during adventitious root formation and growth. Rooting was positively related to the breakdown of soluble proteins in the phloem when the callus formed, and had a positive correlation with its accumulation during adventitious root formation and growth. Leaf tips and leaf bases showed a reverse trend in changes of soluble protein. However, together with the phloem, leaf tips and leaf bases regulated and controlled the formation and development of adventitious roots. The main activities of soluble proteins exist in the leaf tips as this was the main source of soluble proteins. The relation between rooting and IAA(indole-3-acetic acid) content in phloem was positive and thus a high concentration of IAA could benefit the induction and formation of adventitious roots. However, rooting was negatively related with ABA(abscisic acid) and GA(gibberellic acid) and a high concentration of both could inhibit the induction and formation of adventitious roots. Rooting had a positive correlation with phloem IAA/ABA ratios, and higher ratios could improve rooting. Low concentrations of ZR(zeatin riboside) triggered the induction of adventitious roots, while higher concentrations promoted root growth.Endogenous hormones in leaf tips and bases had an impact on rooting. The activities of endogenous hormones mainly existed in leaf tips because they play a major role in the production and consumption of IAA and its ABA content increased during rooting. The ZR in leaf tips influenced the rooting of cuttings, especially in the callus formation and rooting stage. Leaf tips were the main source of GA.
基金Supported by the National Natural Science Foundation of China (Grant No. 30371144) and Postgraduate Foundation of Beijing Forestry University
文摘To determine the relationship between female sterility of Pinus tabulaeformis Carr. and plant hormones, content changes of several endogenous plant hormones in a female-sterile clone and a normal clone were analyzed during the key period of female gametophyte abortion in mutant clones. The change of ABA content showed a similar pattern between normal and mutant clones, but the ABA content of the mutant clone was always much higher than that of the normal clone. In the normal clone, the IAA content decreased significantly at the early stage of the period and reached its minimum during the first ten days of April and stabilized thereafter. The endogenous ZR levels increased sharply at the early stages and reached a maximum in the middle of April, then decreased dramatically. The IAA and ZR contents of the mutant clone did not change perceptively through the entire period. We conclude that the high levels of ABA and the deficit of IAA and ZR may be the reasons of female gametophyte abortion in the female-sterile clones of P. tabulaeformis.
基金National Natural Science Foundation of China(No.61941114 and No.61521003)Key Universities and Academic Disciplines Contruction Project。
文摘The information security and functional safety are fundamental issues of wireless communications sytems.The endogenous security principle based on Dynamic Heterogeneous Redundancy provides a direction for the development of wireless communication security and safety technology.This paper introduces the concept of wireless endogenous security from the following four aspects.First,we sorts out the endogenous security problems faced by the current wireless communications system,and then analyzes the endogenous security and safety attributes of the wireless channel.After that,the endogenous security and safety structure of the wireless communications system is given,and finally the applications of the existing wireless communication endogenous security and safety functions are listed.
基金supported by the National Nature Science Foundation of China(No.11375272)
文摘Elemental calcium plays an important role in human physiology. In order to study the relationship between Ca-intake, Ca-chemical formulation, and Ca-absorptivity, a balance experiment using a ^(41)Ca tracer technique in SD rats was conducted to measure the endogenous fecal calcium and true absorption of calcium. Apparent absorption of calcium was measured as a control to the endogenous calcium labeling experiment. These results show that by using ^(41)Ca labeled endogenous calcium in vivo, researchers could obtain the true calcium absorption data without extrinsic labeling. Therefore, the method was not affected by the chemical structure or type of calcium supplement and might be used in evaluating the absorptivity of marketed calcium supplements.
基金supported by Major Projects for Science and Technology Innovation 2030(Grant No.2018AA0100800)Equipment Pre-research Foundation of Laboratory(Grant No.61425040104)in part by Jiangsu Province“333”project under Grant BRA2019051.
文摘Game theory can be applied to the air combat decision-making problem of multiple unmanned combat air vehicles(UCAVs).However,it is difficult to have satisfactory decision-making results completely relying on air combat situation information,because there is a lot of time-sensitive information in a complex air combat environment.In this paper,a constraint strategy game approach is developed to generate intelligent decision-making for multiple UCAVs in complex air combat environment with air combat situation information and time-sensitive information.Initially,a constraint strategy game is employed to model attack-defense decision-making problem in complex air combat environment.Then,an algorithm is proposed for solving the constraint strategy game based on linear programming and linear inequality(CSG-LL).Finally,an example is given to illustrate the effectiveness of the proposed approach.
基金jointly granted by the Science and Technology on Avionics Integration Laboratory and the Aeronautical Science Foundation of China (No. 2016ZC15008)
文摘A decision-making problem of missile-target assignment with a novel particle swarm optimization algorithm is proposed when it comes to a multiple target collaborative combat situation.The threat function is established to describe air combat situation.Optimization function is used to find an optimal missile-target assignment.An improved particle swarm optimization algorithm is utilized to figure out the optimization function with less parameters,which is based on the adaptive random learning approach.According to the coordinated attack tactics,there are some adjustments to the assignment.Simulation example results show that it is an effective algorithm to handle with the decision-making problem of the missile-target assignment(MTA)in air combat.
基金funded by the National Key R&D Program of China under Grant 2017YFB0801903the National Natural Science Foundation of China under Grant 61871404,61701538,61521003Doctoral Fund of Ministry of Education of China under Grant 2019M663994。
文摘The open and broadcast nature of wireless channels leads to the inherent security problem of information leakage in wireless communication.We can utilize endogenous security functions to resolve this problem.The fundamental solution is channel-based mechanisms,like physical layer secret keys.Unfortunately,current investigations have not fully exploited the randomness of wireless channels,making secret key rates not high.Consequently,user data can be encrypted by reducing the data rate to match the secret key rate.Based on the analysis of the endogenous wireless security principle,we proposed that the channel-based endogenous secret key rate can nearly match the maximum data rate in the fast-fading environments.After that,we validated the proposition in an instantiation system with multiple phase shift keying(MPSK)inputs from the perspectives of both theoretical analysis and simulation experiments.The results indicate that it is possible to accomplish the onetime pad without decreasing the data rate via channelbased endogenous keys.Besides,we can realize highspeed endogenously secure transmission by introducing independent channels in the domains of frequency,space,or time.The conclusions derived provide a new idea for wireless security and promote the application of the endogenous security theory.
基金Supported by the National Natural Science Foundation of China(60939003)
文摘The maintenance of an aero-engine usually includes three levels,and the maintenance cost and period greatly differ depending on the different maintenance levels.To plan a reasonable maintenance budget program, airlines would like to predict the maintenance level of aero-engine before repairing in terms of performance parameters,which can provide more economic benefits.The maintenance level decision rules are mined using the historical maintenance data of a civil aero-engine based on the rough set theory,and a variety of possible models of updating rules produced by newly increased maintenance cases added to the historical maintenance case database are investigated by the means of incremental machine learning.The continuously updated rules can provide reasonable guidance suggestions for engineers and decision support for planning a maintenance budget program before repairing. The results of an example show that the decision rules become more typical and robust,and they are more accurate to predict the maintenance level of an aero-engine module as the maintenance data increase,which illustrates the feasibility of the represented method.
基金This study was supported by the Science and Technology Innovation-Biomedical Supporting Program of Shanghai Science and Technology Committee(19441904400)Program for artificial intelligence innovation and development of Shanghai Municipal Commission of Economy and Informatization(2020-RGZN-02048).
文摘BACKGROUND:To promote the shared decision-making(SDM)between patients and doctors in pediatric outpatient departments,this study was designed to validate artificial intelligence(AI)-initiated medical tests for children with fever.METHODS:We designed an AI model,named Xiaoyi,to suggest necessary tests for a febrile child before visiting a pediatric outpatient clinic.We calculated the sensitivity,specificity,and F1 score to evaluate the efficacy of Xiaoyi’s recommendations.The patients were divided into the rejection and acceptance groups.Then we analyzed the rejected examination items in order to obtain the corresponding reasons.RESULTS:We recruited a total of 11,867 children with fever who had used Xiaoyi in outpatient clinics.The recommended examinations given by Xiaoyi for 10,636(89.6%)patients were qualified.The average F1 score reached 0.94.A total of 58.4%of the patients accepted Xiaoyi’s suggestions(acceptance group),and 41.6%refused(rejection group).Imaging examinations were rejected by most patients(46.7%).The tests being time-consuming were rejected by 2,133 patients(43.2%),including rejecting pathogen studies in 1,347 patients(68.5%)and image studies in 732 patients(31.8%).The difficulty of sampling was the main reason for rejecting routine tests(41.9%).CONCLUSION:Our model has high accuracy and acceptability in recommending medical tests to febrile pediatric patients,and is worth promoting in facilitating SDM.
文摘Based on effectiveness analysis , a novel method is presented for combat aircraft top-hierarchy concept evaluation and decision-making. Applying multi-criterion decision-making ( MCDM ) and analytic hierarchy process , the new method can help to overcome the limitations of existing evaluation systems and decision-make methods.The proposed method includes the following process :( 1 ) Establish a multi-criterion and multi-hierarchy evaluation attribute system by introducing combat effectiveness ;( 2 ) Assign weight to the attributes and normalize them ;( 3 ) Evaluate and decision-make top-hierarchy aircraft concept based on effectiveness to reach a satisfactory design by comprehensively applying four multi-criterion decision-making methodologies , i.e.grey correlation projection method , weighted summation method , weighted quadrature method and ideal solution decision-making method , while considering the attribute hierarchy system and the logical relations among the attributes.Finally , an example is given to indicate the validity and feasibility of the proposed method.
基金supported by the National Key Research and Development Program of China under Grant 2020YFB1804803the National Natural Science Foundation of China under Grant 61872382the Research and Development Program in Key Areas of Guangdong Province under Grant No.2018B010113001。
文摘The Space-Air-Ground Integrated Network(SAGIN) realizes the integration of space, air,and ground networks, obtaining the global communication coverage.Software-Defined Networking(SDN) architecture in SAGIN has become a promising solution to guarantee the Quality of Service(QoS).However, the current routing algorithms mainly focus on the QoS of the service, rarely considering the security requirement of flow. To realize the secure transmission of flows in SAGIN, we propose an intelligent flow forwarding scheme with endogenous security based on Mimic Defense(ESMD-Flow). In this scheme, SDN controller will evaluate the reliability of nodes and links, isolate malicious nodes based on the reliability evaluation value, and adapt multipath routing strategy to ensure that flows are always forwarded along the most reliable multiple paths. In addition, in order to meet the security requirement of flows, we introduce the programming data plane to design a multiprotocol forwarding strategy for realizing the multiprotocol dynamic forwarding of flows. ESMD-Flow can reduce the network attack surface and improve the secure transmission capability of flows by implementing multipath routing and multi-protocol hybrid forwarding mechanism. The extensive simulations demonstrate that ESMD-Flow can significantly improve the average path reliability for routing and increase the difficulty of network eavesdropping while improving the network throughput and reducing the average packet delay.
基金supported by the Science and Technology Project of State Grid Corporation of China under Grant Number 52094021N010 (5400-202199534A-05-ZN)。
文摘The integration of digital twin(DT)and 6G edge intelligence provides accurate forecasting for distributed resources control in smart park.However,the adverse impact of model poisoning attacks on DT model training cannot be ignored.To address this issue,we firstly construct the models of DT model training and model poisoning attacks.An optimization problem is formulated to minimize the weighted sum of the DT loss function and DT model training delay.Then,the problem is transformed and solved by the proposed Multi-timescAle endogenouS securiTy-aware DQN-based rEsouRce management algorithm(MASTER)based on DT-assisted state information evaluation and attack detection.MASTER adopts multi-timescale deep Q-learning(DQN)networks to jointly schedule local training epochs and devices.It actively adjusts resource management strategies based on estimated attack probability to achieve endogenous security awareness.Simulation results demonstrate that MASTER has excellent performances in DT model training accuracy and delay.
