Objective To explore the imaging and related clinical characteristics of magnetic resonance （MR） delayed enhancement in patients with ischemic or nonischemic heart disease. Methods Thirty-two cases who underwent MR...Objective To explore the imaging and related clinical characteristics of magnetic resonance （MR） delayed enhancement in patients with ischemic or nonischemic heart disease. Methods Thirty-two cases who underwent MR myocardial cine and delayed enhancement imaging from January 2004 to October 2006 were retrospectively analyzed. The cine sequence imaging included the four-chamber view and the left ventricular short axis view. The delayed enhancement imaging was taken 10 minutes after the infusion of gadolinium from the antecubital vein with a segmented inversion-recovery-prepared Tl-weighted fast gradient echo sequence. Patients underwent coronary computed tomography angiography （CTA） two weeks before or after the MR imaging examination. Combined with clinical history, the clinical and MR imaging characteristics of the patients who had delayed enhancement were analyzed. Results MR delayed enhancement could be found in 16 cases. Among them, 12 cases had ischemic heart disease. Their coronary CTA showed one to three vessel diseases. The delayed enhancement was transmural or subendocardium, and the area of delayed enhancement corresponded well with one or more coronary arteries which had severe stenosis or occlusion. Four cases had nonischemic heart diseases One case was dilated cardiomyopathy, with diffuse small midwall spots in delayed enhancemen and only 30% stenosis of the anterior descending coronary artery in coronary CTA. One case was hypertrophic cardiomyopathy, with delayed enhancement of strip- and patch-shaped at midwall of the hypertrophic myocardiurn. One case was restrictive cardiomyopathy, and the delayed enhancement was located in the area of subendocardium of both the right and left ventricles. Coronary CTA of these two cases were normal The other case was a mass of the lateral wall of the left ventricle, and the delayed enhancement with a clumpy shape was located in the lateral wall of the left ventricle. Conclusions MR myocardial delayed enhancement is not a specific sign of myocardial infarction of ischemic heart disease. Nonischemic heart diseases including all kinds of primary cardiomyopathy and some other diseases affecting myocardium can also cause delayed enhancement, but their characteristics are different. The differentiation of the etiology of the nonischemic heart disease with delayed enhancement relies upon the intimate connection with clinical history and the cine sequence MR images.展开更多
Objective:To investigate the relationship between dynamic contrast-enhanced MRI parameters and tumor angiogenesis in peripheral pulmonary adenocarcinoma.Methods:Thirty-seven patients with pathologic proved pulmonary a...Objective:To investigate the relationship between dynamic contrast-enhanced MRI parameters and tumor angiogenesis in peripheral pulmonary adenocarcinoma.Methods:Thirty-seven patients with pathologic proved pulmonary adenocarcinoma underwent dynamic contrast-enhanced MR Imaging. Microvessel density(MVD) was counted and vascular endothelial growth factor(VEGF) expression was assessed with immunohistochemical method. Dynamic contrast-enhanced MRI-derived parameters, such as peak height(PH), steepest slope(SS), maximum enhancement rate(E max),enhancement rate at 1-6 minutes(E 1-6), were calculated and compared with MVD in pulmonary adenocarcinoma. And the parameters were also compared between VEGF-positive and VEGF-negative pulmonary adenocarcinoma. Results:The microvessel density was 68.31±19.84 in 37 pulmonary adenocarcinoma. The PH, SS, E max, E 1-6 correlated positively with MVD respectively(P<0.001). The strongest relationship was found between SS and MVD(r=0.827,P<0.001). There was a significant difference between MVD of VEGF-positive pulmonary adenocarcinoma (79.47±21.35) and MVD of VEGF-negative pulmonary adenocarcinoma (43.16±17.85)(P<0.001). All the parameters in VEGF-positive pulmonary adenocarcinoma were higher than those in VEGF-negative pulmonary adenocarcinao(P<0.001). Conclusion: Dynamic contrast-enhanced MRI-derived parameters of pulmonary adenocarcinoma correlated positively with MVD. The parameters in VEGF-positive pulmonary adenocarcinoma were higher than those in VEGF-negative pulmonary adenocarcinoma(P<0.001).展开更多
目的:探讨动态对比增强磁共振成像(dynamic contrast-enhanced magnetic resonance imaging,DCE-MRI)定量参数、血清环状RNA-PVT1(circular RNA-PVT1,circPVT1)、环状RNA-DUSP16(circular RNA-DUST16,circDUSP16)水平与胃癌患者病理特...目的:探讨动态对比增强磁共振成像(dynamic contrast-enhanced magnetic resonance imaging,DCE-MRI)定量参数、血清环状RNA-PVT1(circular RNA-PVT1,circPVT1)、环状RNA-DUSP16(circular RNA-DUST16,circDUSP16)水平与胃癌患者病理特征的相关性及临床意义。方法:回顾性选取2022年1月至2024年3月106例镇平县人民医院影像科胃癌患者为恶性组,选取同期同科室106例胃部良性肿瘤患者为良性组。比较组两DCE-MRI定量参数[胃癌容积转移常数(volume transfer constant,K^(trans))、血管外间隙容积比(extravascular gap volume ratio,Ve)、速率常数(rate constant,K_(ep))]、血清circPVT1、circDUSP16水平,和恶性组中DCE-MRI定量参数、血清circPVT1、circDUSP16不同水平患者的临床病理特征。比较不同预后患者临床病理特征、DCE-MRI定量参数、血清circPVT1、circDUSP16水平并分析胃癌患者发生不良预后的影响因素。结果:恶性组K^(trans)、V_(e)、血清circPVT1、circDUSP16水平高于良性组,K_(ep)低于良性组(P<0.05);在病理分期Ⅲ~Ⅳ期、低分化程度、有淋巴结转移例数占比方面相比,K^(trans)、V_(e)、血清circPVT1、circDUSP16高水平患者高于低水平患者,K_(ep)高水平患者低于低水平患者,预后不良患者高于预后良好患者(P<0.05);预后不良患者K^(trans)、V_(e)、血清circPVT1、circDUSP16水平高于预后良好患者,K_(ep)低于预后良好患者(P<0.05);病理分期Ⅲ~Ⅳ期、低分化程度、有淋巴结转移、K^(trans)≥0.19min^(-1)、Ve≥0.45、K_(ep)≥0.47min^(-1)、circPVT1≥4.45、circDUSP16≥1.72均为预后不良的危险因素(P<0.05)。结论:DCE-MRI定量参数、血清circPVT1、circDUSP16水平与胃癌患者临床病理特征、患者预后关系密切,可作为临床预测患者预后的潜在指标。展开更多
目的:探讨磁共振动态对比增强成像(Dynamic contrast-enhanced MRI,DCE-MRI)、弥散加权成像(Diffusion weighted imaging,DWI)联合检查对三阴型乳腺癌的诊断价值.方法:选取128例我院2020年7月至2022年7月就诊的乳腺癌患者作为研究对象....目的:探讨磁共振动态对比增强成像(Dynamic contrast-enhanced MRI,DCE-MRI)、弥散加权成像(Diffusion weighted imaging,DWI)联合检查对三阴型乳腺癌的诊断价值.方法:选取128例我院2020年7月至2022年7月就诊的乳腺癌患者作为研究对象.以手术或病理活检结果为"金标准",将患者分为三阴型乳腺癌组(52例)和非三阴型乳腺癌组(76例).两组入院后均行DCE-MRI、DWI检查,比较两组DCE-MRI、DWI检查定量参数[容量转移常数(Volume transfer constant,Ktrans)、速率常数(Rate constant,Kep)、血管外细胞外间隙容积比(Volume of extracellular space per unit volume of tissue,Ve)]及表观扩散系数(Apparent diffusion coefficient,ADC).统计比较DCE-MRI、DWI单独、联合检查对三阴型乳腺癌的诊断结果、诊断效能,并分析DCE-MRI、DWI单独、联合检查对乳腺癌分期的评估价值.结果:与非三阴型乳腺癌组比较,三阴型乳腺癌组Kep较高,Ve、ADC较低(P<0.05);DCE-MRI、DWI联合诊断阳性患者数量高于单一检测;与DCE-MRI、DWI单独诊断相比,二者联合诊断对于三阴型乳腺癌诊断灵敏度、准确度较高,漏诊率较低(P<0.05);DCE-MRI、DWI联合分期诊断结果与手术或病理活检分期诊断结果一致性Kappa值大于单一方案诊断,具有较高一致性.结论:DCE-MRI、DWI联合检测可提高诊断准确度、灵敏度,降低漏诊率,诊断效能较高.展开更多
文摘Objective To explore the imaging and related clinical characteristics of magnetic resonance （MR） delayed enhancement in patients with ischemic or nonischemic heart disease. Methods Thirty-two cases who underwent MR myocardial cine and delayed enhancement imaging from January 2004 to October 2006 were retrospectively analyzed. The cine sequence imaging included the four-chamber view and the left ventricular short axis view. The delayed enhancement imaging was taken 10 minutes after the infusion of gadolinium from the antecubital vein with a segmented inversion-recovery-prepared Tl-weighted fast gradient echo sequence. Patients underwent coronary computed tomography angiography （CTA） two weeks before or after the MR imaging examination. Combined with clinical history, the clinical and MR imaging characteristics of the patients who had delayed enhancement were analyzed. Results MR delayed enhancement could be found in 16 cases. Among them, 12 cases had ischemic heart disease. Their coronary CTA showed one to three vessel diseases. The delayed enhancement was transmural or subendocardium, and the area of delayed enhancement corresponded well with one or more coronary arteries which had severe stenosis or occlusion. Four cases had nonischemic heart diseases One case was dilated cardiomyopathy, with diffuse small midwall spots in delayed enhancemen and only 30% stenosis of the anterior descending coronary artery in coronary CTA. One case was hypertrophic cardiomyopathy, with delayed enhancement of strip- and patch-shaped at midwall of the hypertrophic myocardiurn. One case was restrictive cardiomyopathy, and the delayed enhancement was located in the area of subendocardium of both the right and left ventricles. Coronary CTA of these two cases were normal The other case was a mass of the lateral wall of the left ventricle, and the delayed enhancement with a clumpy shape was located in the lateral wall of the left ventricle. Conclusions MR myocardial delayed enhancement is not a specific sign of myocardial infarction of ischemic heart disease. Nonischemic heart diseases including all kinds of primary cardiomyopathy and some other diseases affecting myocardium can also cause delayed enhancement, but their characteristics are different. The differentiation of the etiology of the nonischemic heart disease with delayed enhancement relies upon the intimate connection with clinical history and the cine sequence MR images.
文摘Objective:To investigate the relationship between dynamic contrast-enhanced MRI parameters and tumor angiogenesis in peripheral pulmonary adenocarcinoma.Methods:Thirty-seven patients with pathologic proved pulmonary adenocarcinoma underwent dynamic contrast-enhanced MR Imaging. Microvessel density(MVD) was counted and vascular endothelial growth factor(VEGF) expression was assessed with immunohistochemical method. Dynamic contrast-enhanced MRI-derived parameters, such as peak height(PH), steepest slope(SS), maximum enhancement rate(E max),enhancement rate at 1-6 minutes(E 1-6), were calculated and compared with MVD in pulmonary adenocarcinoma. And the parameters were also compared between VEGF-positive and VEGF-negative pulmonary adenocarcinoma. Results:The microvessel density was 68.31±19.84 in 37 pulmonary adenocarcinoma. The PH, SS, E max, E 1-6 correlated positively with MVD respectively(P<0.001). The strongest relationship was found between SS and MVD(r=0.827,P<0.001). There was a significant difference between MVD of VEGF-positive pulmonary adenocarcinoma (79.47±21.35) and MVD of VEGF-negative pulmonary adenocarcinoma (43.16±17.85)(P<0.001). All the parameters in VEGF-positive pulmonary adenocarcinoma were higher than those in VEGF-negative pulmonary adenocarcinao(P<0.001). Conclusion: Dynamic contrast-enhanced MRI-derived parameters of pulmonary adenocarcinoma correlated positively with MVD. The parameters in VEGF-positive pulmonary adenocarcinoma were higher than those in VEGF-negative pulmonary adenocarcinoma(P<0.001).
文摘目的:探讨动态对比增强磁共振成像(dynamic contrast-enhanced magnetic resonance imaging,DCE-MRI)定量参数、血清环状RNA-PVT1(circular RNA-PVT1,circPVT1)、环状RNA-DUSP16(circular RNA-DUST16,circDUSP16)水平与胃癌患者病理特征的相关性及临床意义。方法:回顾性选取2022年1月至2024年3月106例镇平县人民医院影像科胃癌患者为恶性组,选取同期同科室106例胃部良性肿瘤患者为良性组。比较组两DCE-MRI定量参数[胃癌容积转移常数(volume transfer constant,K^(trans))、血管外间隙容积比(extravascular gap volume ratio,Ve)、速率常数(rate constant,K_(ep))]、血清circPVT1、circDUSP16水平,和恶性组中DCE-MRI定量参数、血清circPVT1、circDUSP16不同水平患者的临床病理特征。比较不同预后患者临床病理特征、DCE-MRI定量参数、血清circPVT1、circDUSP16水平并分析胃癌患者发生不良预后的影响因素。结果:恶性组K^(trans)、V_(e)、血清circPVT1、circDUSP16水平高于良性组,K_(ep)低于良性组(P<0.05);在病理分期Ⅲ~Ⅳ期、低分化程度、有淋巴结转移例数占比方面相比,K^(trans)、V_(e)、血清circPVT1、circDUSP16高水平患者高于低水平患者,K_(ep)高水平患者低于低水平患者,预后不良患者高于预后良好患者(P<0.05);预后不良患者K^(trans)、V_(e)、血清circPVT1、circDUSP16水平高于预后良好患者,K_(ep)低于预后良好患者(P<0.05);病理分期Ⅲ~Ⅳ期、低分化程度、有淋巴结转移、K^(trans)≥0.19min^(-1)、Ve≥0.45、K_(ep)≥0.47min^(-1)、circPVT1≥4.45、circDUSP16≥1.72均为预后不良的危险因素(P<0.05)。结论:DCE-MRI定量参数、血清circPVT1、circDUSP16水平与胃癌患者临床病理特征、患者预后关系密切,可作为临床预测患者预后的潜在指标。
文摘目的:探讨磁共振动态对比增强成像(Dynamic contrast-enhanced MRI,DCE-MRI)、弥散加权成像(Diffusion weighted imaging,DWI)联合检查对三阴型乳腺癌的诊断价值.方法:选取128例我院2020年7月至2022年7月就诊的乳腺癌患者作为研究对象.以手术或病理活检结果为"金标准",将患者分为三阴型乳腺癌组(52例)和非三阴型乳腺癌组(76例).两组入院后均行DCE-MRI、DWI检查,比较两组DCE-MRI、DWI检查定量参数[容量转移常数(Volume transfer constant,Ktrans)、速率常数(Rate constant,Kep)、血管外细胞外间隙容积比(Volume of extracellular space per unit volume of tissue,Ve)]及表观扩散系数(Apparent diffusion coefficient,ADC).统计比较DCE-MRI、DWI单独、联合检查对三阴型乳腺癌的诊断结果、诊断效能,并分析DCE-MRI、DWI单独、联合检查对乳腺癌分期的评估价值.结果:与非三阴型乳腺癌组比较,三阴型乳腺癌组Kep较高,Ve、ADC较低(P<0.05);DCE-MRI、DWI联合诊断阳性患者数量高于单一检测;与DCE-MRI、DWI单独诊断相比,二者联合诊断对于三阴型乳腺癌诊断灵敏度、准确度较高,漏诊率较低(P<0.05);DCE-MRI、DWI联合分期诊断结果与手术或病理活检分期诊断结果一致性Kappa值大于单一方案诊断,具有较高一致性.结论:DCE-MRI、DWI联合检测可提高诊断准确度、灵敏度,降低漏诊率,诊断效能较高.
