OBJECTIVE To explore the curative effect and mechanism of Yiqi Huoxue decoction in the treatment of coronary heart disease with Qi deficiency and blood stasis syndrome.METHODS The patients with coronary heart disease ...OBJECTIVE To explore the curative effect and mechanism of Yiqi Huoxue decoction in the treatment of coronary heart disease with Qi deficiency and blood stasis syndrome.METHODS The patients with coronary heart disease of Qi deficiency and blood stasis syndrome were treated with Yiqi Huoxue decoction for 3 months,and the changes of cardiac function were observed.61 serum samples(including 29 cases of disease group and 32 cases of Yiqi Huoxue expression group)were analyzed by non labeled proteomics.The disease group was used as the control group,and the protein with expression level difference of more than 1.2 folds(P<0.05)was screened.The molecular function,biological pathway and protein interaction of the different proteins were analyzed by bioinformatics,so as to identify the molecular and biological pathway of Yiqi Huoxue decoction in the treatment of coronary heart disease with Qi deficiency and blood stasis syndrome.RESULTS Clinical treatment found that Yiqi Huoxue decoction can improve TCM syndrome score and left ventricular ejection fraction,regulate blood glucose and blood lipid levels,prolong thrombin time,and improve heart function.The results of proteomic quantitative analysis showed that there were 69 proteins with different expression levels in the disease group.Bioinformatics analysis results showed that Yiqi Huoxue decoction may regulate ApoA1,alpha-2 and other proteins to act on HDL assembly,platelet degradation,PI3K Akt signaling pathway,and then play a therapeutic role in coronary heart disease with Qi deficiency and blood stasis syndrome.CONCLUSION Yiqi Huoxue decoction can effectively improved the heart function decline caused by Qi deficiency and blood stasis syndrome of coronary heart disease.It mainly act on energy metabolism and platelet activation pathway by activating HDL assembly and platelet degradation signal pathway proteins.This study can provide reference for the follow-up treatment mechanism of Qi deficiency and blood stasis syndrome of coronary heart disease.展开更多
目的:探讨解毒降糖复瘫汤联合针灸在脑梗死急性期合并糖尿病患者(气虚血瘀型)治疗中的应用价值。方法:所有脑梗死急性期合并糖尿病患者(气虚血瘀型)均于2020年10月至2022年9月在南昌市洪都中医院就诊并随机分为两组,两组均69例,对照组...目的:探讨解毒降糖复瘫汤联合针灸在脑梗死急性期合并糖尿病患者(气虚血瘀型)治疗中的应用价值。方法:所有脑梗死急性期合并糖尿病患者(气虚血瘀型)均于2020年10月至2022年9月在南昌市洪都中医院就诊并随机分为两组,两组均69例,对照组采用西医常规治疗,观察组联合解毒降糖复瘫汤及针灸治疗,治疗2周后比较疗效。结果:与治疗前比较,治疗后两组血清超氧化物歧化酶(SOD)、血管内皮生长因子(VEGF)、脑源性神经营养因子(BDNF)均升高;血清基质金属蛋白酶-9(MMP-9)、IL-6、空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)均降低;Barthel指数(BI)均升高,改良Rankin评分(mRS)、神经功能缺损评分(NIHSS)均降低(P<0.05)。与对照组比较,治疗后观察组血清SOD、VEGF、BDNF等指标水平更高;MMP-9、IL-6、FBG、2 h PG、HbA1c更低;BI更高,mRS、NIHSS更低,差异具有统计学意义(P<0.05);观察组总有效率为94.20%(65/69),高于对照组的84.06%(58/69)(P<0.05)。结论:联合解毒降糖复瘫汤及针灸治疗有助于促进脑梗死急性期合并糖尿病患者(气虚血瘀型)脑部供血,纠正氧化应激失衡,调控血糖水平,提高临床疗效。展开更多
目的观察老年气虚血瘀型脑梗死衰弱患者治疗中加味补中益气活血汤联合醒脑开窍针合老十针对其营养状态、神经功能的影响。方法选取老年气虚血瘀型脑梗死衰弱患者120例,以随机数字表法分为常规组(常规治疗+加味补中益气活血汤+常规针刺)6...目的观察老年气虚血瘀型脑梗死衰弱患者治疗中加味补中益气活血汤联合醒脑开窍针合老十针对其营养状态、神经功能的影响。方法选取老年气虚血瘀型脑梗死衰弱患者120例,以随机数字表法分为常规组(常规治疗+加味补中益气活血汤+常规针刺)60例,试验组(常规治疗+加味补中益气活血汤+醒脑开窍针合老十针)60例。比较两组治疗前、后中医证候积分、神经功能、血液流变学指标及营养状态;比较两组临床疗效及不良反应。结果治疗后两组中医主症积分、次症积分、总分,美国国立卫生研究院卒中量表(National institute of health stroke scale,NIHSS)评分、氧化低密度脂蛋白(Oxidized low density lipoprotein,ox-LDL)、神经元核抗原(Neuron-specific nuclear protein,NeuN)、全血黏度(Blood viscosity,BV)、全血还原黏度(Blood reduction viscosity,BRV)、血浆黏度(Plasma visocosity,PV)均较治疗前降低(P<0.05),试验组均较常规组降低(P<0.05)。治疗后两组微型营养评估量表(Mini nutrition assessment,MNA)评分、白蛋白(Albumin,ALB)、前白蛋白(Prealbumin,PA)均较治疗前升高(P<0.05),试验组均较常规组升高(P<0.05)。试验组临床疗效等级分布及总有效率均较常规组升高(P<0.05)。常规组无明显不良反应,试验组1例针刺部位红肿,未干预即好转。结论老年气虚血瘀型脑梗死衰弱患者治疗中加味补中益气活血汤联合醒脑开窍针合老十针可改善患者中医证候、神经功能、血液流变学指标及营养状态,提高临床疗效,且安全性高。展开更多
基金National Natural Science Foundation of China(82030124)and National Key Basic Research Special Foundation of China(2015CB554400)。
文摘OBJECTIVE To explore the curative effect and mechanism of Yiqi Huoxue decoction in the treatment of coronary heart disease with Qi deficiency and blood stasis syndrome.METHODS The patients with coronary heart disease of Qi deficiency and blood stasis syndrome were treated with Yiqi Huoxue decoction for 3 months,and the changes of cardiac function were observed.61 serum samples(including 29 cases of disease group and 32 cases of Yiqi Huoxue expression group)were analyzed by non labeled proteomics.The disease group was used as the control group,and the protein with expression level difference of more than 1.2 folds(P<0.05)was screened.The molecular function,biological pathway and protein interaction of the different proteins were analyzed by bioinformatics,so as to identify the molecular and biological pathway of Yiqi Huoxue decoction in the treatment of coronary heart disease with Qi deficiency and blood stasis syndrome.RESULTS Clinical treatment found that Yiqi Huoxue decoction can improve TCM syndrome score and left ventricular ejection fraction,regulate blood glucose and blood lipid levels,prolong thrombin time,and improve heart function.The results of proteomic quantitative analysis showed that there were 69 proteins with different expression levels in the disease group.Bioinformatics analysis results showed that Yiqi Huoxue decoction may regulate ApoA1,alpha-2 and other proteins to act on HDL assembly,platelet degradation,PI3K Akt signaling pathway,and then play a therapeutic role in coronary heart disease with Qi deficiency and blood stasis syndrome.CONCLUSION Yiqi Huoxue decoction can effectively improved the heart function decline caused by Qi deficiency and blood stasis syndrome of coronary heart disease.It mainly act on energy metabolism and platelet activation pathway by activating HDL assembly and platelet degradation signal pathway proteins.This study can provide reference for the follow-up treatment mechanism of Qi deficiency and blood stasis syndrome of coronary heart disease.
文摘目的:探讨解毒降糖复瘫汤联合针灸在脑梗死急性期合并糖尿病患者(气虚血瘀型)治疗中的应用价值。方法:所有脑梗死急性期合并糖尿病患者(气虚血瘀型)均于2020年10月至2022年9月在南昌市洪都中医院就诊并随机分为两组,两组均69例,对照组采用西医常规治疗,观察组联合解毒降糖复瘫汤及针灸治疗,治疗2周后比较疗效。结果:与治疗前比较,治疗后两组血清超氧化物歧化酶(SOD)、血管内皮生长因子(VEGF)、脑源性神经营养因子(BDNF)均升高;血清基质金属蛋白酶-9(MMP-9)、IL-6、空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)均降低;Barthel指数(BI)均升高,改良Rankin评分(mRS)、神经功能缺损评分(NIHSS)均降低(P<0.05)。与对照组比较,治疗后观察组血清SOD、VEGF、BDNF等指标水平更高;MMP-9、IL-6、FBG、2 h PG、HbA1c更低;BI更高,mRS、NIHSS更低,差异具有统计学意义(P<0.05);观察组总有效率为94.20%(65/69),高于对照组的84.06%(58/69)(P<0.05)。结论:联合解毒降糖复瘫汤及针灸治疗有助于促进脑梗死急性期合并糖尿病患者(气虚血瘀型)脑部供血,纠正氧化应激失衡,调控血糖水平,提高临床疗效。
文摘目的观察老年气虚血瘀型脑梗死衰弱患者治疗中加味补中益气活血汤联合醒脑开窍针合老十针对其营养状态、神经功能的影响。方法选取老年气虚血瘀型脑梗死衰弱患者120例,以随机数字表法分为常规组(常规治疗+加味补中益气活血汤+常规针刺)60例,试验组(常规治疗+加味补中益气活血汤+醒脑开窍针合老十针)60例。比较两组治疗前、后中医证候积分、神经功能、血液流变学指标及营养状态;比较两组临床疗效及不良反应。结果治疗后两组中医主症积分、次症积分、总分,美国国立卫生研究院卒中量表(National institute of health stroke scale,NIHSS)评分、氧化低密度脂蛋白(Oxidized low density lipoprotein,ox-LDL)、神经元核抗原(Neuron-specific nuclear protein,NeuN)、全血黏度(Blood viscosity,BV)、全血还原黏度(Blood reduction viscosity,BRV)、血浆黏度(Plasma visocosity,PV)均较治疗前降低(P<0.05),试验组均较常规组降低(P<0.05)。治疗后两组微型营养评估量表(Mini nutrition assessment,MNA)评分、白蛋白(Albumin,ALB)、前白蛋白(Prealbumin,PA)均较治疗前升高(P<0.05),试验组均较常规组升高(P<0.05)。试验组临床疗效等级分布及总有效率均较常规组升高(P<0.05)。常规组无明显不良反应,试验组1例针刺部位红肿,未干预即好转。结论老年气虚血瘀型脑梗死衰弱患者治疗中加味补中益气活血汤联合醒脑开窍针合老十针可改善患者中医证候、神经功能、血液流变学指标及营养状态,提高临床疗效,且安全性高。
