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Epigenetic origins of metabolic disease:The impact of the maternal condition to the offspring epigenome and later health consequences
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作者 Rhianna C.Laker Mary E.Wlodek +1 位作者 Jessic J.Connelly Zhen Yan 《Food Science and Human Wellness》 SCIE 2013年第1期1-11,共11页
It has long been established that an adverse maternal condition impacts on the developing fetus and predisposes the offspring to develop metabolic and cardiovascular disease in later life.However,the underlying mechan... It has long been established that an adverse maternal condition impacts on the developing fetus and predisposes the offspring to develop metabolic and cardiovascular disease in later life.However,the underlying mechanisms that are initiated during development and contribute to the disease predisposition are understudied.Recently,epigenetic reprogramming in early life has emerged as a promising candidate that could cause altered DNA transcription and gene expression into adulthood and contribute to disease susceptibility.This review will focus on the impact of maternal high fat diet to the offspring in early life and the adult health consequences.We will then discuss the current literature supporting a role for epigenetic modification,such as DNA methylation and histone modifications,as a key mechanism underlying developmental programming.©2013 Beijing Academy of Food Sciences.Production and hosting by Elsevier B.V.All rights reserved. 展开更多
关键词 EPIGENETICS developmental programming Metabolic disease Maternal high-fat diet DNA methylation Histone modifications
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Radon bearing water protection in underground uranium mining--A case study 被引量:4
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作者 Yun Xiaoyou Tang Baoyao +2 位作者 Greg Murdock Brian McGill Brian Mattie 《International Journal of Mining Science and Technology》 SCIE EI CSCD 2017年第4期599-603,共5页
High pressure, radon bearing water has been identified as one of the most critical challenges in mining the high-grade uranium deposit at the Mc Arthur River Operation, Cameco Corporation. The ore deposits are located... High pressure, radon bearing water has been identified as one of the most critical challenges in mining the high-grade uranium deposit at the Mc Arthur River Operation, Cameco Corporation. The ore deposits are located between 490 and 640 m below the surface and surrounded by water bearing Athabasca sandstone, a graphitic P2 fault zone, and highly altered ground. This paper introduces the inflow risk management program at Mc Arthur River Operation, which includes various hydrogeological challenges and the corresponding strategies applied, such as risk-based probe and grout programs(geological, hydrogeological, and geotechnical), ground freezing programs, and comprehensive ground control programs. These programs have been developed, tested, and proven successful over years of mining practices. Working with this world class deposit of high risk and low tolerance, it is believed that these experiences might be beneficial to other mining operations with similar hydrogeological characteristics. 展开更多
关键词 Inflow risk management Geotechnical and development probe and grout programs Dewatering infrastructure Ground freezing Ground control
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