One novel complex of （）99mTc-salicylidene-tyrosine Schiff base was designed and synthesized, and its biodistribution was investigated. The theoretical simulation revealed that the cis- and trans-（isomers） might co...One novel complex of （）99mTc-salicylidene-tyrosine Schiff base was designed and synthesized, and its biodistribution was investigated. The theoretical simulation revealed that the cis- and trans-（isomers） might co-exist in aqueous solution. A yield higher than 90% under the optimal condition of synthesis was obtained. Good water-solubility was demonstrated. Very little uptakes in muscle, brain, heart and S-180 sarcoma, as well as very rapid blood clearance were revealed in mice. Good accumulation in bone was shown. At 1 h postinjection the bone uptake was 10.9%ID/g. At 3 and 5 h postinjection, bone-to-muscle ratios were 19.0 and 9.3, and bone-to-blood ratios were 31.6 and 28.9, respectively. The result indicates a bone imaging potency of the complex.展开更多
Positive electrospray ionization tandem mass spectrometry was applied to study four newly synthesized(12-aminodehydroabietylamine)acetamide-substituted salicylidene Schiff bases(ADASSSB).The results showed that the MS...Positive electrospray ionization tandem mass spectrometry was applied to study four newly synthesized(12-aminodehydroabietylamine)acetamide-substituted salicylidene Schiff bases(ADASSSB).The results showed that the MSn characteristics of ADASSSB can be used for their qualitative and quantitative analysis.展开更多
A new Schiff base derived from tyrosine and salicylidene and its copper(Ⅱ ) complex have been synthesized and characterized by elemental analyses,molar conductances,thermal analyses,infrared spectra,electronic spectr...A new Schiff base derived from tyrosine and salicylidene and its copper(Ⅱ ) complex have been synthesized and characterized by elemental analyses,molar conductances,thermal analyses,infrared spectra,electronic spectra and EPR spectra.The composition of the complex is K[CuL(Ac)]· H2O, where L=H13C16NO4. EPR spectra of the copper(Ⅱ ) complex were investigated in various solvents at different temperatures.It is found that the linewidth of four hyperfine lines on solution spectra at room temperature is unequal and changes with mⅠ ,this could be satisfactorily explained by the relaxation effect.The relaxation time and the relaxation rate were calculated.By using spectral parameters from solution spectra at low temperature,the bonding parameters of Cu(Ⅱ ) complex were calculated.The bonding characterization and stability of the complex were disscussed.The results show that the in-planeσ-bond and the in-planeπ-bond in the complex all play an important role.展开更多
The crystal structure of [Cu(sal ala)bipy]·CH 3OH·2H 2O (sal ala: salicylaldehyde alaninato, bipy: 2,2′ bipyridine), a potential anticancer agent and tumor imaging agent, is determined at 123 K. The complex...The crystal structure of [Cu(sal ala)bipy]·CH 3OH·2H 2O (sal ala: salicylaldehyde alaninato, bipy: 2,2′ bipyridine), a potential anticancer agent and tumor imaging agent, is determined at 123 K. The complex crystallizes in triclinic, space group P - 1. The cell dimensions are a =0 894 8(2) nm, b =0 973 1(2) nm, c =1 263 2(3) nm; α =78 06(3)°, β =78 02(3)°, γ =88 22(3)°; V =1 052 6(4) nm 3, M r=479 99, Z =2, ρ c=1 514 g·cm -3 . The total number of 4 313 independent reflections with I>2σ(I) are used for the structure determination. The final R is 0 075 8 and R w is 0 179.The central Cu 2+ ion is penta coordinated by tridentate Schiff base and bidentate bipy, resulting in a distorted square pyramid coordination polyhedron. Three kinds of hydrogen bonds are revealed.展开更多
文摘One novel complex of （）99mTc-salicylidene-tyrosine Schiff base was designed and synthesized, and its biodistribution was investigated. The theoretical simulation revealed that the cis- and trans-（isomers） might co-exist in aqueous solution. A yield higher than 90% under the optimal condition of synthesis was obtained. Good water-solubility was demonstrated. Very little uptakes in muscle, brain, heart and S-180 sarcoma, as well as very rapid blood clearance were revealed in mice. Good accumulation in bone was shown. At 1 h postinjection the bone uptake was 10.9%ID/g. At 3 and 5 h postinjection, bone-to-muscle ratios were 19.0 and 9.3, and bone-to-blood ratios were 31.6 and 28.9, respectively. The result indicates a bone imaging potency of the complex.
文摘Positive electrospray ionization tandem mass spectrometry was applied to study four newly synthesized(12-aminodehydroabietylamine)acetamide-substituted salicylidene Schiff bases(ADASSSB).The results showed that the MSn characteristics of ADASSSB can be used for their qualitative and quantitative analysis.
文摘A new Schiff base derived from tyrosine and salicylidene and its copper(Ⅱ ) complex have been synthesized and characterized by elemental analyses,molar conductances,thermal analyses,infrared spectra,electronic spectra and EPR spectra.The composition of the complex is K[CuL(Ac)]· H2O, where L=H13C16NO4. EPR spectra of the copper(Ⅱ ) complex were investigated in various solvents at different temperatures.It is found that the linewidth of four hyperfine lines on solution spectra at room temperature is unequal and changes with mⅠ ,this could be satisfactorily explained by the relaxation effect.The relaxation time and the relaxation rate were calculated.By using spectral parameters from solution spectra at low temperature,the bonding parameters of Cu(Ⅱ ) complex were calculated.The bonding characterization and stability of the complex were disscussed.The results show that the in-planeσ-bond and the in-planeπ-bond in the complex all play an important role.
文摘The crystal structure of [Cu(sal ala)bipy]·CH 3OH·2H 2O (sal ala: salicylaldehyde alaninato, bipy: 2,2′ bipyridine), a potential anticancer agent and tumor imaging agent, is determined at 123 K. The complex crystallizes in triclinic, space group P - 1. The cell dimensions are a =0 894 8(2) nm, b =0 973 1(2) nm, c =1 263 2(3) nm; α =78 06(3)°, β =78 02(3)°, γ =88 22(3)°; V =1 052 6(4) nm 3, M r=479 99, Z =2, ρ c=1 514 g·cm -3 . The total number of 4 313 independent reflections with I>2σ(I) are used for the structure determination. The final R is 0 075 8 and R w is 0 179.The central Cu 2+ ion is penta coordinated by tridentate Schiff base and bidentate bipy, resulting in a distorted square pyramid coordination polyhedron. Three kinds of hydrogen bonds are revealed.
