The main constituents of the extract from Yubaizi (the roots of Angelica dahurica)were analyzed by HPLC-MS/MS method,and a total of six cumarins were unequivocally determined.The fragmentation patterns of the cumarins...The main constituents of the extract from Yubaizi (the roots of Angelica dahurica)were analyzed by HPLC-MS/MS method,and a total of six cumarins were unequivocally determined.The fragmentation patterns of the cumarins were found useful for their characterization,and the relative contents of the six compounds were also calculated.展开更多
Identification of two natural coumarin enantiomers for selective inhibition of heat-activated TRPV2 channels,Thermosensitive transient receptor potential vanil oid 2(thermo TRPV2)is a nonselective Ca2+-permeable catio...Identification of two natural coumarin enantiomers for selective inhibition of heat-activated TRPV2 channels,Thermosensitive transient receptor potential vanil oid 2(thermo TRPV2)is a nonselective Ca2+-permeable cation channel broadly expressed,and is implicated in the pathology of diseases such as diabetes and pancreatitis.However,the physiological and pharmacological functions of TRPV2 channels have not been extensively investigated because of the absence of specific modulators and the channel with high-threshold of heat activation.展开更多
文摘The main constituents of the extract from Yubaizi (the roots of Angelica dahurica)were analyzed by HPLC-MS/MS method,and a total of six cumarins were unequivocally determined.The fragmentation patterns of the cumarins were found useful for their characterization,and the relative contents of the six compounds were also calculated.
文摘Identification of two natural coumarin enantiomers for selective inhibition of heat-activated TRPV2 channels,Thermosensitive transient receptor potential vanil oid 2(thermo TRPV2)is a nonselective Ca2+-permeable cation channel broadly expressed,and is implicated in the pathology of diseases such as diabetes and pancreatitis.However,the physiological and pharmacological functions of TRPV2 channels have not been extensively investigated because of the absence of specific modulators and the channel with high-threshold of heat activation.
