Objective To explore the contrast-enhanced ultrasonographic features for quantitative assessment of hepatic fibrosis. Methods 86 patients with chronic viral hepatitis B were enrolled in this study from March 2007 to A...Objective To explore the contrast-enhanced ultrasonographic features for quantitative assessment of hepatic fibrosis. Methods 86 patients with chronic viral hepatitis B were enrolled in this study from March 2007 to August 2009. The patients were classified into 5 groups (S0-S4) according to fibrosis stage evaluated with ultrasound guided liver biopsy. New contrast-enhanced ultrasonography (CEUS) features including area under the time-intensity curve (TIC) of portal venous phase/hepatic arterial phase (Qp/Qa) and intensity of portal venous phase/hepatic arterial phase (Ip/Ia) were used to detect the blood supply ratio (portal vein/hepatic artery) in each group. Arrival time of portal vein trunk (Tp) and decreasing rate of TIC (β ) were also analyzed. Results Qp/Qa and Ip/Ia decreased from S0 to S4, while Tp and β increased. These 4 features were significantly correlated with the degree of fibrosis (P<0.001) and were significantly different among the five groups (P<0.001). Sensitivity and specificity of Ip/Ia were 80% and 86% for groups ≥S1, 75% and 86% for groups ≥ S2, 71% and 84% for groups ≥ S3, and 76% and 80% for group S4, respectively. Sensitivity and specificity of Qp/Qa were 70% and 88% for groups ≥ S1, 80% and 76% for groups ≥ S2, 74% and 70% for groups ≥ S3, and 81% and 95% for group S4, respectively. Conclusion Ip/Ia and Qp/Qa could be adopted as reliable, non-invasive features for quantitative assessment of hepatic fibrosis.展开更多
An abrupt decline in respiratory function often presents in patients unable to undergo imaging procedures,especially in critical care settings.Consequently,evaluation using transthoracic lung ultrasonography has been ...An abrupt decline in respiratory function often presents in patients unable to undergo imaging procedures,especially in critical care settings.Consequently,evaluation using transthoracic lung ultrasonography has been developed to promptly diagnose the patient's respiratory conditions at bedside,gaining increasing attention for its utility.However,conventional transthoracic ultrasonography may face challenges in directly accessing the thorax.展开更多
Objective：To introduce a new better contrast-enhanced MR angiographic metnod, named 3D time-resolved imaging of contrast kinetics （3D-TRICKS）. Methods： TRICKS is a high temporal resolution （2-6 s） MR angiographi...Objective：To introduce a new better contrast-enhanced MR angiographic metnod, named 3D time-resolved imaging of contrast kinetics （3D-TRICKS）. Methods： TRICKS is a high temporal resolution （2-6 s） MR angiographic technique using a short TR（4 ms） and TE（1.5 ms）, partial echo sampling, in which central part of k-space is updated more frequently than the peripheral part. TRICKS pre-contrast mask 3D images are firstly scanned, and then the bolus injecting of Gd-DTPA, 15-20 sequential 3D images are acquired. The reconstructed 3D images, subtraction of contrast 3D images with mask images, are conceptually similar to a catheter-based intra-arterial digital subtraction angiographic series （DSA）. Thirty patients underwent contrast-enhanced MR angiography using 3D-TRICKS. Results： Totally 12 vertebral arteries were well displayed on TRICKS, in which 7 were normal, 1 demonstrated bilateral vertebral artery stenosis, 4 had unilateral vertebral artery stenosis and 1 was accompanied with the same lateral carotid artery bifurcation stenosis. Four cases of bilateral renal arteries were normal, 1 transplanted kidney artery showed as normal and 1 transplanted kidney artery showed stenosis. 2 cerebral arteries were normal, 1 had sagittal sinus thrombosis and 1 displayed intracranial arteriovenous malformation. 3 pulmonary arteries were normal, 1 showed pulmonary artery thrombosis and 1 revealed pulmonary sequestration＇s abnormal feeding artery and draining vein. One left lower limb fibrolipoma showed feeding artery. One displayed radial-ulnar artery artificial fistula stenosis. One revealed left antebrachium hemangioma. Conclusion： TRICKS can clearly delineate most body vascular system and reveal most vascular abnormality. It possesses convenience and high successful rate, which make it the first choice of displaying most vascular abnormality.展开更多
目的探讨超声造影联合血脂检测评价颈动脉易损斑块对缺血性脑卒中患者的预测价值。方法本研究为前瞻性研究,选择2023年1月至2024年5月佛山市南海区第四人民医院确诊的颈动脉易损斑块患者120例,其中缺血性脑卒中患者60例为研究组,无缺血...目的探讨超声造影联合血脂检测评价颈动脉易损斑块对缺血性脑卒中患者的预测价值。方法本研究为前瞻性研究,选择2023年1月至2024年5月佛山市南海区第四人民医院确诊的颈动脉易损斑块患者120例,其中缺血性脑卒中患者60例为研究组,无缺血性脑卒中患者60例为对照组。分别对2组进行常规超声、超声造影及血脂检查,分析研究组与对照组、研究组不同血流分级患者不稳定斑块积分比、斑块最大长度、斑块最大厚度、溃疡斑、面积狭窄、狭窄处峰值流速、阻力指数及血脂水平的差异。采用ROC曲线分析,并计算曲线下面积(the area under curve,AUC)。结果研究组与对照组不稳定斑块积分比、斑块最大长度、斑块最大厚度、溃疡斑、面积狭窄、狭窄处峰值流速、阻力指数、血流特征比较,差异有统计学意义(P<0.01)。研究组三酰甘油(triglyceride,TG)、总胆固醇(total cholesterol,TC)、低密度胆固醇(low density lipoprotein,LDL)、水平明显高于对照组,高密度胆固醇(high density lipoprotein,HDL)水平明显低于对照组(P<0.01)。研究组不同血流分级患者不稳定斑块积分比、斑块最大长度、斑块最大厚度、溃疡斑、面积狭窄、狭窄处峰值流速、阻力指数比较,差异有统计学意义(P<0.05,P<0.01)。研究组不同血流分级患者TC、TG、LDL、HDL水平比较,差异有统计学意义(P<0.01)。研究组血流分级Ⅲ级、Ⅱ级、Ⅰ级患者TC、TG、LDL依次降低,HDL依次升高(P<0.01)。Pearman相关性分析显示,血流分级与TC、TG、LDL水平呈正相关(r=0.456,r=0.652,r=0.362,P=0.000),与HDL水平呈负相关(r=-0.256,P=0.000)。ROC曲线分析显示,超声造影血流分级与血脂水平联合检测对颈动脉易损斑块缺血性脑卒中患者诊断的AUC明显高于单独检测,通过截断值分析,颈动脉易损斑块缺血性脑卒中患者超声造影血流分级为Ⅱ级以上,TC为5.22 mmol/L,TG为2.33 mmol/L,LDL为2.78 mmol/L,HDL为0.82 mmol/L。结论超声造影血流较高等级结合血脂水平异常表达可能可以作为缺血性脑卒中患者的预测指标。展开更多
基金Supported by PhD Programs Foundation of Ministry of Education of China (No. 20090001110092)
文摘Objective To explore the contrast-enhanced ultrasonographic features for quantitative assessment of hepatic fibrosis. Methods 86 patients with chronic viral hepatitis B were enrolled in this study from March 2007 to August 2009. The patients were classified into 5 groups (S0-S4) according to fibrosis stage evaluated with ultrasound guided liver biopsy. New contrast-enhanced ultrasonography (CEUS) features including area under the time-intensity curve (TIC) of portal venous phase/hepatic arterial phase (Qp/Qa) and intensity of portal venous phase/hepatic arterial phase (Ip/Ia) were used to detect the blood supply ratio (portal vein/hepatic artery) in each group. Arrival time of portal vein trunk (Tp) and decreasing rate of TIC (β ) were also analyzed. Results Qp/Qa and Ip/Ia decreased from S0 to S4, while Tp and β increased. These 4 features were significantly correlated with the degree of fibrosis (P<0.001) and were significantly different among the five groups (P<0.001). Sensitivity and specificity of Ip/Ia were 80% and 86% for groups ≥S1, 75% and 86% for groups ≥ S2, 71% and 84% for groups ≥ S3, and 76% and 80% for group S4, respectively. Sensitivity and specificity of Qp/Qa were 70% and 88% for groups ≥ S1, 80% and 76% for groups ≥ S2, 74% and 70% for groups ≥ S3, and 81% and 95% for group S4, respectively. Conclusion Ip/Ia and Qp/Qa could be adopted as reliable, non-invasive features for quantitative assessment of hepatic fibrosis.
文摘An abrupt decline in respiratory function often presents in patients unable to undergo imaging procedures,especially in critical care settings.Consequently,evaluation using transthoracic lung ultrasonography has been developed to promptly diagnose the patient's respiratory conditions at bedside,gaining increasing attention for its utility.However,conventional transthoracic ultrasonography may face challenges in directly accessing the thorax.
文摘Objective：To introduce a new better contrast-enhanced MR angiographic metnod, named 3D time-resolved imaging of contrast kinetics （3D-TRICKS）. Methods： TRICKS is a high temporal resolution （2-6 s） MR angiographic technique using a short TR（4 ms） and TE（1.5 ms）, partial echo sampling, in which central part of k-space is updated more frequently than the peripheral part. TRICKS pre-contrast mask 3D images are firstly scanned, and then the bolus injecting of Gd-DTPA, 15-20 sequential 3D images are acquired. The reconstructed 3D images, subtraction of contrast 3D images with mask images, are conceptually similar to a catheter-based intra-arterial digital subtraction angiographic series （DSA）. Thirty patients underwent contrast-enhanced MR angiography using 3D-TRICKS. Results： Totally 12 vertebral arteries were well displayed on TRICKS, in which 7 were normal, 1 demonstrated bilateral vertebral artery stenosis, 4 had unilateral vertebral artery stenosis and 1 was accompanied with the same lateral carotid artery bifurcation stenosis. Four cases of bilateral renal arteries were normal, 1 transplanted kidney artery showed as normal and 1 transplanted kidney artery showed stenosis. 2 cerebral arteries were normal, 1 had sagittal sinus thrombosis and 1 displayed intracranial arteriovenous malformation. 3 pulmonary arteries were normal, 1 showed pulmonary artery thrombosis and 1 revealed pulmonary sequestration＇s abnormal feeding artery and draining vein. One left lower limb fibrolipoma showed feeding artery. One displayed radial-ulnar artery artificial fistula stenosis. One revealed left antebrachium hemangioma. Conclusion： TRICKS can clearly delineate most body vascular system and reveal most vascular abnormality. It possesses convenience and high successful rate, which make it the first choice of displaying most vascular abnormality.
文摘目的探讨超声造影联合血脂检测评价颈动脉易损斑块对缺血性脑卒中患者的预测价值。方法本研究为前瞻性研究,选择2023年1月至2024年5月佛山市南海区第四人民医院确诊的颈动脉易损斑块患者120例,其中缺血性脑卒中患者60例为研究组,无缺血性脑卒中患者60例为对照组。分别对2组进行常规超声、超声造影及血脂检查,分析研究组与对照组、研究组不同血流分级患者不稳定斑块积分比、斑块最大长度、斑块最大厚度、溃疡斑、面积狭窄、狭窄处峰值流速、阻力指数及血脂水平的差异。采用ROC曲线分析,并计算曲线下面积(the area under curve,AUC)。结果研究组与对照组不稳定斑块积分比、斑块最大长度、斑块最大厚度、溃疡斑、面积狭窄、狭窄处峰值流速、阻力指数、血流特征比较,差异有统计学意义(P<0.01)。研究组三酰甘油(triglyceride,TG)、总胆固醇(total cholesterol,TC)、低密度胆固醇(low density lipoprotein,LDL)、水平明显高于对照组,高密度胆固醇(high density lipoprotein,HDL)水平明显低于对照组(P<0.01)。研究组不同血流分级患者不稳定斑块积分比、斑块最大长度、斑块最大厚度、溃疡斑、面积狭窄、狭窄处峰值流速、阻力指数比较,差异有统计学意义(P<0.05,P<0.01)。研究组不同血流分级患者TC、TG、LDL、HDL水平比较,差异有统计学意义(P<0.01)。研究组血流分级Ⅲ级、Ⅱ级、Ⅰ级患者TC、TG、LDL依次降低,HDL依次升高(P<0.01)。Pearman相关性分析显示,血流分级与TC、TG、LDL水平呈正相关(r=0.456,r=0.652,r=0.362,P=0.000),与HDL水平呈负相关(r=-0.256,P=0.000)。ROC曲线分析显示,超声造影血流分级与血脂水平联合检测对颈动脉易损斑块缺血性脑卒中患者诊断的AUC明显高于单独检测,通过截断值分析,颈动脉易损斑块缺血性脑卒中患者超声造影血流分级为Ⅱ级以上,TC为5.22 mmol/L,TG为2.33 mmol/L,LDL为2.78 mmol/L,HDL为0.82 mmol/L。结论超声造影血流较高等级结合血脂水平异常表达可能可以作为缺血性脑卒中患者的预测指标。
