Objective To investigate the variations of contingent negative variations(CNV),P_(300)and mismatch negativity(MMN)in depression and anxiety disorders.Methods CNV,P_(300)and MMN were recorded from 44 depressive patient...Objective To investigate the variations of contingent negative variations(CNV),P_(300)and mismatch negativity(MMN)in depression and anxiety disorders.Methods CNV,P_(300)and MMN were recorded from 44 depressive patients using Nicolet Spirit Instrument,and were compared with that of 32 anxiety patients and 28 normal controls(NC).Twenty-one of depressive patients and 18 of anxiety patients were followed up by 2.5 months with the same evoked potentials.Results 1.Compared with NC,all patients in acute episode showed decreased M1 of CNV amplitude,delayed P3 latency and decreased P3 amplitude of Psxo,and delayed MMN latency and decreased MMN amplitude;2.The follow-up study of evoked potentials revealed that abnormal P3 of Psoo and MMN latencies were significant between depressed patients in remission status and NC group but not P3 of P_(300)and MMN amplitudes,and M1 of CNV and P3 of P_(300)amplitudes and P3 of Psoo and MMN latencies are not significant between anxiety patients in remission and NC group.Conclusion Delayed P3 of Psoo and MMN latencies in depression show state and trait markers,while those variations in anxiety correlate with clinical status of anxiety state.展开更多
文摘Objective To investigate the variations of contingent negative variations(CNV),P_(300)and mismatch negativity(MMN)in depression and anxiety disorders.Methods CNV,P_(300)and MMN were recorded from 44 depressive patients using Nicolet Spirit Instrument,and were compared with that of 32 anxiety patients and 28 normal controls(NC).Twenty-one of depressive patients and 18 of anxiety patients were followed up by 2.5 months with the same evoked potentials.Results 1.Compared with NC,all patients in acute episode showed decreased M1 of CNV amplitude,delayed P3 latency and decreased P3 amplitude of Psxo,and delayed MMN latency and decreased MMN amplitude;2.The follow-up study of evoked potentials revealed that abnormal P3 of Psoo and MMN latencies were significant between depressed patients in remission status and NC group but not P3 of P_(300)and MMN amplitudes,and M1 of CNV and P3 of P_(300)amplitudes and P3 of Psoo and MMN latencies are not significant between anxiety patients in remission and NC group.Conclusion Delayed P3 of Psoo and MMN latencies in depression show state and trait markers,while those variations in anxiety correlate with clinical status of anxiety state.
