Background and objective Recent studies have showed that combination of chemotherapy and radiotherapy might result in better outcome for locally advanced non-small cell lung cancer (NSCLC). The aim of this study is to...Background and objective Recent studies have showed that combination of chemotherapy and radiotherapy might result in better outcome for locally advanced non-small cell lung cancer (NSCLC). The aim of this study is to determine the maximal tolerance dose (MTD) and efficacy of full-dose gemcitabine and oxaliplatin when given concurrently with 3-dimentional radiation therapy (3D-RT) for locally advanced NSCLC. Methods Oxaliplatin was administered at a fixed dose of 130mg/m^2, and gemcitabine was administered at a starting dose of 800mg/m^2 with an incremental dose gradient of 200mg/m^2 for 3 dose levels. MTD was defined as the immediate dose level lower than the dose at which dose-limiting toxicity (DLT) occurred in more than one-third of the patients. The chemotherapy was administered at 3-week cycle. The RT was given as 3-D conformal manner at a single daily dose of 2Gy for 5 days per week. Results Twenty-two patients were evaluable and distributed to three different dose levels: 6 at level 1, 8 at level 2 and 8 at level 3. Pulmonary toxicity, esophageal and hematologic toxicity were the main DLT. Grade Ⅲ acute pulmonary toxicity occurred in one patient each at level 2 and level 3, both with V20>20%, and grade Ⅲ esophagitis in two patients at level 3. The MTD of gemcitabine in this study was 1000mg/m^2. The overall response rate was 75.0% (9/12). The 1- and 2-year survival rate was 70.0% and 30.5% respectively. The median time to progression was 8.7 months (range 5--11.8 months). Conclusion With reduced radiation volume, gemcitabine of 1000mg/m^2 in combination with oxaliplatin of 130mg/m^2 was effective and could be safely administered for NSCLC.展开更多
The paper proposes a decentralized concurrent transmission strategy in shared channels based on an incomplete information game in Ad Hoc networks.Based on the nodal channel quality,the game can work out a channel gain...The paper proposes a decentralized concurrent transmission strategy in shared channels based on an incomplete information game in Ad Hoc networks.Based on the nodal channel quality,the game can work out a channel gain threshold,which decides the candidates for taking part in the concurrent transmission.The utility formula is made for maximizing the overall throughput based on channel quality variation.For an achievable Bayesian Nash equilibrium（BNE） solution,this paper further prices the selfish players in utility functions for attempting to improve the channel gain one-sidedly.Accordingly,this game allows each node to distributedly decide whether to transmit concurrently with others depending on the Nash equilibrium（NE）.Besides,to make the proposed game practical,this paper next presents an efficient particle swarm optimization（PSO） model to fasten the otherwise very slow convergence procedure due to the large computational complexity.Numerical results show the proposed approach is feasible to increase concurrent transmission opportunities for active nodes and the convergence can be swiftly obtained with a few of iteration times by the proposed PSO algorithm.展开更多
Military petroleum equipment, as the special device a nd tool for petroleum storage, transportation, filling, chemical analysis, detec tion and maintenance for the army, is an important means and basis of petroleum in...Military petroleum equipment, as the special device a nd tool for petroleum storage, transportation, filling, chemical analysis, detec tion and maintenance for the army, is an important means and basis of petroleum indemnificatory. To adapt to modern war in high-tech conditions, the petroleum equipment have to develop towards higher reliability, adaptability, maneuverabil ity, standardization, container and cell type with versatile multi-functions. As a new design theory and design process, concurrent engineering may prod uce remarkable benefit when applying to product development. With the aid of the state-of-the-art modeling and simulation technology, it foresees the future or even the whole life cycle of the products designed. Based on wide statistics and survey, the product design period is reduced by 1/2～1/3 with concurrent des i gn process. The application of concurrent design process in new petroleum equi pment development shall greatly accelerate the petroleum equipment updating an d promote their indemnificatory.展开更多
Concurrent multipath transfer（CMT） using stream control transmission protocol（SCTP） multihoming has become an appealing option to increase the throughput and improve the performance of increasingly bandwidth-hungr...Concurrent multipath transfer（CMT） using stream control transmission protocol（SCTP） multihoming has become an appealing option to increase the throughput and improve the performance of increasingly bandwidth-hungry applications.To investigate the rate allocation for applications in CMT,this paper analyzes the capacities of paths shared by competing sources,then proposes the rate allocation model for elastic flows based on the framework of network utility maximization（NUM）.In order to obtain the global optimum of the model,a distributed algorithm is presented which depends only on local available information.Simulation results confirm that the proposed algorithm can achieve the global optimum within reasonable convergence times.展开更多
Osteoporosis and osteopenia are major health issues that mainly affect elderly people,women after menopause and immobilized patients.Our previous studies have proved that sclerostin antibody(Scl-Ab)can dramatically en...Osteoporosis and osteopenia are major health issues that mainly affect elderly people,women after menopause and immobilized patients.Our previous studies have proved that sclerostin antibody(Scl-Ab)can dramatically enhance bone formation and reduce bone resorption in a severe osteoporosis rat model with the combination of ovariectomy(OVX)and hindlimb immobilization(HLS).However,the mechanism in the cellular level is unclear.The objective of this study is to assess the effect of Scl-Ab on osteocytic morphology change in a combined OVX and HLS rat model via quantification of long-and short-axis and the ratio and osteocyte volume in midshaft cortical bone.Four-month-old virgin female SD rats were divided into 7 groups(n=11 per group):Sham+Veh,Sham+HLS+Veh,Sham+HLS+Scl-Ab,OVX+Veh,OVX+Scl-Ab,OVX+HLS+Veh,OVX+HLS+Scl-Ab.HLS was performed 2 weeks after sham or OVX surgery;and treatment was initiated at the time of HLS.Scl-Ab(25 mg/kg)or vehicle was subcutaneously injected twice per week for 5 weeks.Femurs were harvested at the end of study and embedded in PMMA and polished for SEM imaging.Cortical bone mid shaft osteocyte number per bone area was quantified under 1K magnification;the ratios between long axis and short axis of osteocytes were quantified under 2K magnification;osteocyte dendrite number and surface area were quantified under 5K magnification.Osteocyte dendrites width was quantified using 10K magnification.All the quantification was done by ImageJ.We have reported that multiple morphological and structural changes in osteocytes,including a decreased osteocyte density and reduced osteocyte dendrite number in HLS,OVX or the combination group and Scl-Ab’s ability to abolish these unfavorable alterations.We continued our SEM analysis on osteocytes and discovered that the oval shape of osteocyte under HLS,OVX or HLS+OVX has been distorted toward a spindle-like shape,with relatively longer long axis and shorter short axis,assuming osteocyte has a perfect spheroid shape.The ratio between long-and short-axis showed an increased trend in OVX and HLS condition,but Scl-Ab inhibited these increases(P<0.001,P<0.01,respectively).The volume decreased in HLS,OVX group,but Scl-Ab maintained osteocytes’volume in HLS condition(P<0.001).It indicates that cortical bone responds to HLS and/or OVX and Scl-Ab treatment via multiple cellular mechanisms,including density of osteocyte,dendrite number and osteocyte shape.The change of osteocyte shape may imply an altered cytoskeleton system within osteocyte and a subsequent disruption of mechanosensing ability for osteocyte,which lead to bone loss macroscopically.These data suggest Scl-Ab’s therapeutic potential could be related with its ability to maintain osteocyte’s morphologic and structural changes induced by OVX,HLS or both.展开更多
The relation between technology parameters and performance index of the wheat three-stage concurrent-flow drying technology is studied by use of quadratic orthogonial rotate combinative experiment design method.The op...The relation between technology parameters and performance index of the wheat three-stage concurrent-flow drying technology is studied by use of quadratic orthogonial rotate combinative experiment design method.The optimum parameters of drying technology are obtained by nonlinear optimize corresponding regression model and test.All experiment was finished in concurrent-flow grain drying experiment table.The results of this study will be significant for designing energy-saving grain drying machine.展开更多
In parallel real-time database systems, concurrency control protocols must satisfy time constraints as well as the integrity constraints. The authors present a validation concurrency control(VCC) protocol, which can e...In parallel real-time database systems, concurrency control protocols must satisfy time constraints as well as the integrity constraints. The authors present a validation concurrency control(VCC) protocol, which can enhance the performance of real-time concurrency control mechanism by reducing the number of transactions that might miss their deadlines, and compare the performance of validation concurrency control protocol with that of HP2PL(High priority two phase locking) protocol and OCC-TI-WAIT-50(Optimistic concurrency control-time interval-wait-50) protocol under shared-disk architecture by simulation. The simulation results reveal that the protocol the author presented can effectively reduce the number of transactions restarting which might miss their deadlines and performs better than HP2PL and OCC-TI-WAIT-50. It works well when arrival rate of transaction is lesser than threshold. However, due to resource contention the percentage of missing deadline increases sharply when arrival rate is greater than the threshold.展开更多
因大量采用分布式、综合化、模块化方案,复杂电子系统极易出现共因故障和故障并发等新问题,传统测试性参数确定方法难以解决。针对这一问题,提出一种基于着色广义随机Petri网(colored generalized stochastic Petri nets,CGSPN)的复杂...因大量采用分布式、综合化、模块化方案,复杂电子系统极易出现共因故障和故障并发等新问题,传统测试性参数确定方法难以解决。针对这一问题,提出一种基于着色广义随机Petri网(colored generalized stochastic Petri nets,CGSPN)的复杂电子系统测试性参数确定新方法。首先,综合需求信息、约束边界和维修保障等要求,建立电子系统两层级CGSPN模型,引入着色,实现不同模块各种状态的实时追踪和故障并发处理,通过广义随机处理共因故障的随机不确定性;然后,利用着色和可用度探索一种带有冗余设计的测试性参数处理手段,丰富测试性体系;最后,构建一种不同模块、各种状态融合的并行分析技术,统一系统层和模块层之间的状态转移关系,避免分阶段串行处理和等效替换。以通信导航识别系统为例进行实例分析,所提方法比传统方法具有更好的可用性和有效性。展开更多
世界卫生组织(World Health Organization, WHO)强调通过健康促进、疾病预防和早诊早治以提升健康水平。由于疾病种类繁多、观点错杂,病机往往呈现为“多元化”的势态,尤其重大慢病、疑难重症、复合共病更是与复合体质状态密切关联,故...世界卫生组织(World Health Organization, WHO)强调通过健康促进、疾病预防和早诊早治以提升健康水平。由于疾病种类繁多、观点错杂,病机往往呈现为“多元化”的势态,尤其重大慢病、疑难重症、复合共病更是与复合体质状态密切关联,故而从“体病相关”切入探讨是突破疾病预测、预防以及治疗瓶颈的关键。基于多年的研究提出“五行十态体质”创新观点;遵循“天人相应”规律,将传统六十甲子周期理论运用于体质状态研究,综合考虑五运六气交互承制、天干地支本属系统、正化对化、天地二甲子、运气的平气状态等关键因素对人体五脏六腑功能的影响,运用传统“医算法”,依据“生克制化”“胜复郁发”“淫胜郁复”之气机升降特点,详细分析了基础体质与后天体质状态的关联;重视始生之时、疾病始发时、传变时、欲解时以及就诊时等不同节点的运气格局对人体的影响,以揭示体质特异性与相应系统疾病的易感性以及脏腑复合病机主、次标本的关系,预判健康状态与疾病不同阶段的病机、病势演变,为临床疾病的预测、预防、个体化干预以及群体化防治提供指导思路。展开更多
文摘Background and objective Recent studies have showed that combination of chemotherapy and radiotherapy might result in better outcome for locally advanced non-small cell lung cancer (NSCLC). The aim of this study is to determine the maximal tolerance dose (MTD) and efficacy of full-dose gemcitabine and oxaliplatin when given concurrently with 3-dimentional radiation therapy (3D-RT) for locally advanced NSCLC. Methods Oxaliplatin was administered at a fixed dose of 130mg/m^2, and gemcitabine was administered at a starting dose of 800mg/m^2 with an incremental dose gradient of 200mg/m^2 for 3 dose levels. MTD was defined as the immediate dose level lower than the dose at which dose-limiting toxicity (DLT) occurred in more than one-third of the patients. The chemotherapy was administered at 3-week cycle. The RT was given as 3-D conformal manner at a single daily dose of 2Gy for 5 days per week. Results Twenty-two patients were evaluable and distributed to three different dose levels: 6 at level 1, 8 at level 2 and 8 at level 3. Pulmonary toxicity, esophageal and hematologic toxicity were the main DLT. Grade Ⅲ acute pulmonary toxicity occurred in one patient each at level 2 and level 3, both with V20>20%, and grade Ⅲ esophagitis in two patients at level 3. The MTD of gemcitabine in this study was 1000mg/m^2. The overall response rate was 75.0% (9/12). The 1- and 2-year survival rate was 70.0% and 30.5% respectively. The median time to progression was 8.7 months (range 5--11.8 months). Conclusion With reduced radiation volume, gemcitabine of 1000mg/m^2 in combination with oxaliplatin of 130mg/m^2 was effective and could be safely administered for NSCLC.
基金supported by the National Natural Science Foundation of China (6120113361172055+6 种基金60832005U083500461072067)the Postdoctoral Science Foundation of China (20100481323)the Program for New Century Excellent Talents (NCET-11-0691)the "111 Project"of China (B08038)the Foundation of Guangxi Key Lab of Wireless Wideband Communication & Signal Processing (11105)
文摘The paper proposes a decentralized concurrent transmission strategy in shared channels based on an incomplete information game in Ad Hoc networks.Based on the nodal channel quality,the game can work out a channel gain threshold,which decides the candidates for taking part in the concurrent transmission.The utility formula is made for maximizing the overall throughput based on channel quality variation.For an achievable Bayesian Nash equilibrium（BNE） solution,this paper further prices the selfish players in utility functions for attempting to improve the channel gain one-sidedly.Accordingly,this game allows each node to distributedly decide whether to transmit concurrently with others depending on the Nash equilibrium（NE）.Besides,to make the proposed game practical,this paper next presents an efficient particle swarm optimization（PSO） model to fasten the otherwise very slow convergence procedure due to the large computational complexity.Numerical results show the proposed approach is feasible to increase concurrent transmission opportunities for active nodes and the convergence can be swiftly obtained with a few of iteration times by the proposed PSO algorithm.
文摘Military petroleum equipment, as the special device a nd tool for petroleum storage, transportation, filling, chemical analysis, detec tion and maintenance for the army, is an important means and basis of petroleum indemnificatory. To adapt to modern war in high-tech conditions, the petroleum equipment have to develop towards higher reliability, adaptability, maneuverabil ity, standardization, container and cell type with versatile multi-functions. As a new design theory and design process, concurrent engineering may prod uce remarkable benefit when applying to product development. With the aid of the state-of-the-art modeling and simulation technology, it foresees the future or even the whole life cycle of the products designed. Based on wide statistics and survey, the product design period is reduced by 1/2～1/3 with concurrent des i gn process. The application of concurrent design process in new petroleum equi pment development shall greatly accelerate the petroleum equipment updating an d promote their indemnificatory.
基金supported by the National Natural Science Foundation of China (60833002)the National Basic Research Program of China (973 Program) (2007CB307100)+2 种基金the National High Technology Research and Development Program of China (863 Program) (2007AA01Z202)the Program for Changjiang Scholars and Innovative Research Team in University (IRT0707)the Program of Introducing Talents of Discipline to Universities (111 Project) (B08002)
文摘Concurrent multipath transfer（CMT） using stream control transmission protocol（SCTP） multihoming has become an appealing option to increase the throughput and improve the performance of increasingly bandwidth-hungry applications.To investigate the rate allocation for applications in CMT,this paper analyzes the capacities of paths shared by competing sources,then proposes the rate allocation model for elastic flows based on the framework of network utility maximization（NUM）.In order to obtain the global optimum of the model,a distributed algorithm is presented which depends only on local available information.Simulation results confirm that the proposed algorithm can achieve the global optimum within reasonable convergence times.
文摘Osteoporosis and osteopenia are major health issues that mainly affect elderly people,women after menopause and immobilized patients.Our previous studies have proved that sclerostin antibody(Scl-Ab)can dramatically enhance bone formation and reduce bone resorption in a severe osteoporosis rat model with the combination of ovariectomy(OVX)and hindlimb immobilization(HLS).However,the mechanism in the cellular level is unclear.The objective of this study is to assess the effect of Scl-Ab on osteocytic morphology change in a combined OVX and HLS rat model via quantification of long-and short-axis and the ratio and osteocyte volume in midshaft cortical bone.Four-month-old virgin female SD rats were divided into 7 groups(n=11 per group):Sham+Veh,Sham+HLS+Veh,Sham+HLS+Scl-Ab,OVX+Veh,OVX+Scl-Ab,OVX+HLS+Veh,OVX+HLS+Scl-Ab.HLS was performed 2 weeks after sham or OVX surgery;and treatment was initiated at the time of HLS.Scl-Ab(25 mg/kg)or vehicle was subcutaneously injected twice per week for 5 weeks.Femurs were harvested at the end of study and embedded in PMMA and polished for SEM imaging.Cortical bone mid shaft osteocyte number per bone area was quantified under 1K magnification;the ratios between long axis and short axis of osteocytes were quantified under 2K magnification;osteocyte dendrite number and surface area were quantified under 5K magnification.Osteocyte dendrites width was quantified using 10K magnification.All the quantification was done by ImageJ.We have reported that multiple morphological and structural changes in osteocytes,including a decreased osteocyte density and reduced osteocyte dendrite number in HLS,OVX or the combination group and Scl-Ab’s ability to abolish these unfavorable alterations.We continued our SEM analysis on osteocytes and discovered that the oval shape of osteocyte under HLS,OVX or HLS+OVX has been distorted toward a spindle-like shape,with relatively longer long axis and shorter short axis,assuming osteocyte has a perfect spheroid shape.The ratio between long-and short-axis showed an increased trend in OVX and HLS condition,but Scl-Ab inhibited these increases(P<0.001,P<0.01,respectively).The volume decreased in HLS,OVX group,but Scl-Ab maintained osteocytes’volume in HLS condition(P<0.001).It indicates that cortical bone responds to HLS and/or OVX and Scl-Ab treatment via multiple cellular mechanisms,including density of osteocyte,dendrite number and osteocyte shape.The change of osteocyte shape may imply an altered cytoskeleton system within osteocyte and a subsequent disruption of mechanosensing ability for osteocyte,which lead to bone loss macroscopically.These data suggest Scl-Ab’s therapeutic potential could be related with its ability to maintain osteocyte’s morphologic and structural changes induced by OVX,HLS or both.
文摘The relation between technology parameters and performance index of the wheat three-stage concurrent-flow drying technology is studied by use of quadratic orthogonial rotate combinative experiment design method.The optimum parameters of drying technology are obtained by nonlinear optimize corresponding regression model and test.All experiment was finished in concurrent-flow grain drying experiment table.The results of this study will be significant for designing energy-saving grain drying machine.
文摘In parallel real-time database systems, concurrency control protocols must satisfy time constraints as well as the integrity constraints. The authors present a validation concurrency control(VCC) protocol, which can enhance the performance of real-time concurrency control mechanism by reducing the number of transactions that might miss their deadlines, and compare the performance of validation concurrency control protocol with that of HP2PL(High priority two phase locking) protocol and OCC-TI-WAIT-50(Optimistic concurrency control-time interval-wait-50) protocol under shared-disk architecture by simulation. The simulation results reveal that the protocol the author presented can effectively reduce the number of transactions restarting which might miss their deadlines and performs better than HP2PL and OCC-TI-WAIT-50. It works well when arrival rate of transaction is lesser than threshold. However, due to resource contention the percentage of missing deadline increases sharply when arrival rate is greater than the threshold.
文摘因大量采用分布式、综合化、模块化方案,复杂电子系统极易出现共因故障和故障并发等新问题,传统测试性参数确定方法难以解决。针对这一问题,提出一种基于着色广义随机Petri网(colored generalized stochastic Petri nets,CGSPN)的复杂电子系统测试性参数确定新方法。首先,综合需求信息、约束边界和维修保障等要求,建立电子系统两层级CGSPN模型,引入着色,实现不同模块各种状态的实时追踪和故障并发处理,通过广义随机处理共因故障的随机不确定性;然后,利用着色和可用度探索一种带有冗余设计的测试性参数处理手段,丰富测试性体系;最后,构建一种不同模块、各种状态融合的并行分析技术,统一系统层和模块层之间的状态转移关系,避免分阶段串行处理和等效替换。以通信导航识别系统为例进行实例分析,所提方法比传统方法具有更好的可用性和有效性。
文摘世界卫生组织(World Health Organization, WHO)强调通过健康促进、疾病预防和早诊早治以提升健康水平。由于疾病种类繁多、观点错杂,病机往往呈现为“多元化”的势态,尤其重大慢病、疑难重症、复合共病更是与复合体质状态密切关联,故而从“体病相关”切入探讨是突破疾病预测、预防以及治疗瓶颈的关键。基于多年的研究提出“五行十态体质”创新观点;遵循“天人相应”规律,将传统六十甲子周期理论运用于体质状态研究,综合考虑五运六气交互承制、天干地支本属系统、正化对化、天地二甲子、运气的平气状态等关键因素对人体五脏六腑功能的影响,运用传统“医算法”,依据“生克制化”“胜复郁发”“淫胜郁复”之气机升降特点,详细分析了基础体质与后天体质状态的关联;重视始生之时、疾病始发时、传变时、欲解时以及就诊时等不同节点的运气格局对人体的影响,以揭示体质特异性与相应系统疾病的易感性以及脏腑复合病机主、次标本的关系,预判健康状态与疾病不同阶段的病机、病势演变,为临床疾病的预测、预防、个体化干预以及群体化防治提供指导思路。
