This paper, at the first time, considers the problem of decentralized variable structure control of complex giant singular uncertainty systems by using the property of diagonally dominant matrix and Frobenius-Person t...This paper, at the first time, considers the problem of decentralized variable structure control of complex giant singular uncertainty systems by using the property of diagonally dominant matrix and Frobenius-Person theorem. The splendid selection of switching manifold for each subsystem makes the design relatively straightforward and can be easily realized. An illustrate example is given.展开更多
端粒长度的维持在肿瘤细胞的永生化过程中起到至关重要的作用。约85%的人体肿瘤细胞通过端粒酶延伸端粒,从而获得持续的增殖能力。另外,15%的人体肿瘤细胞通过端粒替代延伸机制(alternative lengthening of telomeres,ALT)延伸端粒。这...端粒长度的维持在肿瘤细胞的永生化过程中起到至关重要的作用。约85%的人体肿瘤细胞通过端粒酶延伸端粒,从而获得持续的增殖能力。另外,15%的人体肿瘤细胞通过端粒替代延伸机制(alternative lengthening of telomeres,ALT)延伸端粒。这两种机制对于维持肿瘤细胞中端粒的长度具有同等重要的意义。人体端粒由富含鸟嘌呤(G)的DNA重复序列组成,该序列在特定的条件下可以形成G-四链体(G4)的结构。此结构的形成可以从根本上抑制端粒酶和ALT对端粒的延伸而达到抗肿瘤的目的。因此,人体端粒G4-DNA作为抗肿瘤靶点的研究是近年来抗肿瘤研究的重要前沿领域之一。该文重点综述人体端粒G4-DNA稳定剂研发的最新研究进展。展开更多
文摘This paper, at the first time, considers the problem of decentralized variable structure control of complex giant singular uncertainty systems by using the property of diagonally dominant matrix and Frobenius-Person theorem. The splendid selection of switching manifold for each subsystem makes the design relatively straightforward and can be easily realized. An illustrate example is given.
基金supported by the National Natural Science Foundation of China(21073143)“Chunhui Project”from the Ministry of Education of China(Z2009-1-71002,Z2009-1-71006)+2 种基金Graduate Starting Seed Fund of Northwestern Polytechnical University(NPU),China(Z2015152)NPU Foundation for Graduate InnovationChina~~
文摘端粒长度的维持在肿瘤细胞的永生化过程中起到至关重要的作用。约85%的人体肿瘤细胞通过端粒酶延伸端粒,从而获得持续的增殖能力。另外,15%的人体肿瘤细胞通过端粒替代延伸机制(alternative lengthening of telomeres,ALT)延伸端粒。这两种机制对于维持肿瘤细胞中端粒的长度具有同等重要的意义。人体端粒由富含鸟嘌呤(G)的DNA重复序列组成,该序列在特定的条件下可以形成G-四链体(G4)的结构。此结构的形成可以从根本上抑制端粒酶和ALT对端粒的延伸而达到抗肿瘤的目的。因此,人体端粒G4-DNA作为抗肿瘤靶点的研究是近年来抗肿瘤研究的重要前沿领域之一。该文重点综述人体端粒G4-DNA稳定剂研发的最新研究进展。
