Objective To explore the optimal administration route of tranexamic acid(TXA)in shoulder arthroscopic surgery.Methods Patients undergoing arthroscopic rotator cuff repair were randomly divided into four groups:control...Objective To explore the optimal administration route of tranexamic acid(TXA)in shoulder arthroscopic surgery.Methods Patients undergoing arthroscopic rotator cuff repair were randomly divided into four groups:control group(without TXA treatment),intravenous group(TXA was intravenously administered 10 minutes before surgery),irrigation group(TXA was added to the irrigation fluid during subacromial decompression and acromioplasty),and intravenous plus irrigation group(TXA was applied both intravenously and via intra-articular irrigation).The primary outcome was visual clarity assessed with visual analog scale(VAS)score,and the secondary outcomes included irrigation fluid consumption and time to subacromial decompression and acromioplasty procedure.Results There were 134 patients enrolled in the study,including 33 in the control group,35 in the intravenous group,32 in the irrigation group,and 34 in the intravenous plus irrigation group.The median and interquartile range of VAS scores for the intravenous,irrigation,and intravenous plus irrigation groups were 2.70(2.50,2.86)(Z=-3.677,P=0.002),2.67(2.50,2.77)(Z=-3.058,P<0.001),and 2.91(2.75,3.00)(Z=-6.634,P<0.001),respectively,significantly higher than that of the control group[2.44(2.37,2.53)].Moreover,the control group consumed more irrigation fluid than the intravenous group,irrigation group,and intravenous plus irrigation group(all P<0.05).The intravenous plus irrigation group consumed less irrigation fluid than either the intravenous group or the irrigation group(both P<0.001).There was no difference in subacromial decompression and acromioplasty operative time among the four groups.Conclusion TXA applied both topically and systematically can improve intraoperative visual clarity,and the combined application is more effective.展开更多
随着摩尔定律的放缓,通过制程微缩来提高芯片性能越来越难,基于芯粒集成的先进封装方案的重要性随之日益显现。尤其是在一些高算力芯片产品的设计上,采用芯粒集成已逐渐成为设计者们一个绕不开的性能提高手段。在2.5D先进封装方案中,CoW...随着摩尔定律的放缓,通过制程微缩来提高芯片性能越来越难,基于芯粒集成的先进封装方案的重要性随之日益显现。尤其是在一些高算力芯片产品的设计上,采用芯粒集成已逐渐成为设计者们一个绕不开的性能提高手段。在2.5D先进封装方案中,CoWoS-S(chip on wafer on substrate)封装因其高带宽、低延迟及丰富的成功量产案例而被广泛应用于片上系统芯片(SoC-system on chip)与高带宽内存(HBM-high bandwidth memory)的互连。然而,在CoWoS-S技术的硅中介层设计过程中,设计人员将面临严苛的信号完整性与电源完整性的综合挑战。为了解决这些挑战,Cadence作为EDA领域的创新者和领导者,开发了完整的EDA解决方案,以协助设计人员完成硅中介层的设计及签核任务。本文将介绍如何利用Cadence EDA解决方案来高效率地实现CoWoS-S硅中介层的设计与签核,内容聚焦于大电流区域的电源完整性设计以及HBM互连区域的信号完整性设计。展开更多
文摘Objective To explore the optimal administration route of tranexamic acid(TXA)in shoulder arthroscopic surgery.Methods Patients undergoing arthroscopic rotator cuff repair were randomly divided into four groups:control group(without TXA treatment),intravenous group(TXA was intravenously administered 10 minutes before surgery),irrigation group(TXA was added to the irrigation fluid during subacromial decompression and acromioplasty),and intravenous plus irrigation group(TXA was applied both intravenously and via intra-articular irrigation).The primary outcome was visual clarity assessed with visual analog scale(VAS)score,and the secondary outcomes included irrigation fluid consumption and time to subacromial decompression and acromioplasty procedure.Results There were 134 patients enrolled in the study,including 33 in the control group,35 in the intravenous group,32 in the irrigation group,and 34 in the intravenous plus irrigation group.The median and interquartile range of VAS scores for the intravenous,irrigation,and intravenous plus irrigation groups were 2.70(2.50,2.86)(Z=-3.677,P=0.002),2.67(2.50,2.77)(Z=-3.058,P<0.001),and 2.91(2.75,3.00)(Z=-6.634,P<0.001),respectively,significantly higher than that of the control group[2.44(2.37,2.53)].Moreover,the control group consumed more irrigation fluid than the intravenous group,irrigation group,and intravenous plus irrigation group(all P<0.05).The intravenous plus irrigation group consumed less irrigation fluid than either the intravenous group or the irrigation group(both P<0.001).There was no difference in subacromial decompression and acromioplasty operative time among the four groups.Conclusion TXA applied both topically and systematically can improve intraoperative visual clarity,and the combined application is more effective.
文摘随着摩尔定律的放缓,通过制程微缩来提高芯片性能越来越难,基于芯粒集成的先进封装方案的重要性随之日益显现。尤其是在一些高算力芯片产品的设计上,采用芯粒集成已逐渐成为设计者们一个绕不开的性能提高手段。在2.5D先进封装方案中,CoWoS-S(chip on wafer on substrate)封装因其高带宽、低延迟及丰富的成功量产案例而被广泛应用于片上系统芯片(SoC-system on chip)与高带宽内存(HBM-high bandwidth memory)的互连。然而,在CoWoS-S技术的硅中介层设计过程中,设计人员将面临严苛的信号完整性与电源完整性的综合挑战。为了解决这些挑战,Cadence作为EDA领域的创新者和领导者,开发了完整的EDA解决方案,以协助设计人员完成硅中介层的设计及签核任务。本文将介绍如何利用Cadence EDA解决方案来高效率地实现CoWoS-S硅中介层的设计与签核,内容聚焦于大电流区域的电源完整性设计以及HBM互连区域的信号完整性设计。
