Based on the working principle and the damping characteristic of hydraulic shock absorber, a fluid structure interaction method was presented, which was used to analyze the microcosmic and high-frequency processing me...Based on the working principle and the damping characteristic of hydraulic shock absorber, a fluid structure interaction method was presented, which was used to analyze the microcosmic and high-frequency processing mechanism of fluid structure interaction between circulation valve and liquid of hydraulic shock absorber. The fluid mesh distortion was controlled by the CEL language, and the fluid struc^tre interaction mathematical model was established. The finite element model was established by ANSYS CFX software and was analyzed by dynamic mesh technique. The local sensitive computational area was meshed by prismatic grid, which could reduce the negative volume problem during the simulation. The circulation valve and liquid of hydraulic shock absorber were simulated and analyzed under the condition of sinusoidal inlet velocity loads. Flow characteristic and dynamics characteristic were obtained. The pressure distribution and the displacement of circulation value were obtained, and the acceleration curve of circulation valve was simulated and analyzed. The conformity of the final simulation results with the experimental datum indicates that this method is accurate and reliable to analyze the dynamics characteristic between circulation valve and liquid of hydraulic shock absorber, which can provide a theoretical foundation for optimizing hydraulic shock absorber in the future.展开更多
A safe,economical treatment of hazardous chromium-bearing vanadate residue(CVR)will significantly benefit the clean production of chromate-bearing salts.This study investigated recovery of sodium vanadate and sodium c...A safe,economical treatment of hazardous chromium-bearing vanadate residue(CVR)will significantly benefit the clean production of chromate-bearing salts.This study investigated recovery of sodium vanadate and sodium chromate from CVR in sodium bicarbonate solution.Results indicate that the stability of calcium vanadate and calcium chromate depends on pH and[HCO3?].CaV2O6?4H2O transforms into CaV2O6?4H2O,CaV2O6?2H2O,CaV2O6,Ca2V2O7?2H2O,and Ca5(VO4)3(OH)when pH increases from 7.51 to 12.32.Increasing pH and reducing CVR dosage improve the vanadate extraction rate,and high V2O5 and Na2Cr2O7?2H2O extraction rates are achieved in dilute NaHCO3 solution.Moreover,addition of NaOH positively contributes to the recovery of vanadate and chromate from CVR.Over 95%V2O5 and Na2Cr2O7?2H2O in CVR can be extracted from 60 g/L NaHCO3 and 30 g/L NaOH solutions at 90°C for 2 h.In order to reduce the hazardous residue containing chromate after recovery of CVR,calcium circulation is presented.Results show that more than 60%lime can be saved with fresh residue addition to remove vanadate from sodium chromate solution due to the active CaCO3.Moreover,no lime is required in removal of vanadate when the roasting residue is added.Therefore,a novel process is developed for utilization of CVR.展开更多
The start-up of external circulationadded internal circulation(IC) reactor was finished in 26 d, 32 d fewer than that of IC reactor. To evaluate the influence of the added external circulation on the development of gr...The start-up of external circulationadded internal circulation(IC) reactor was finished in 26 d, 32 d fewer than that of IC reactor. To evaluate the influence of the added external circulation on the development of granular sludge, the characteristics of the granular sludge taken from the two tested laboratory-scale reactors during start-up were studied. The results show that the added external circulation can enhance biomass granulation, accelerate granule development and improve sludge characteristics. At the end of start-up, the granular size of sludge in external circulation-added IC reactor greatly increases with a size distribution much better than that of sludge in IC reactor. The granular sludge originated from external circulationadded IC reactor contains more extracellular polymers and has a greater settling velocity than that from IC reactor. Methanogenic activity of the granular sludge from the external circulationadded IC reactor started 26 d ago reaches 358.23mL·g -1 ·d -1 , 1.66 and 1.20 times as great as that of the sludge from the IC reactor started 26 d and 58 d ago respectively.展开更多
A discontinuity of magnetic circuits according to the end effect is generated in the permanent magnet linear synchronous motor （PMLSM）. Due to the unbalanced back electro-motive force （EMF） and impedance produced,...A discontinuity of magnetic circuits according to the end effect is generated in the permanent magnet linear synchronous motor （PMLSM）. Due to the unbalanced back electro-motive force （EMF） and impedance produced, unbalanced current is generated. The cireulatin8 current, which is caused by a decrease in the thrust, is generated by the unbalanced current. The optimal design of auxiliary-teeth at the end of the mover was carried out to solve the unbalance of phase by using design of experiment （DOE）, and compared with the basic model through finite element analysis （FEA）. As a result, the auxiliary-teeth model compensates for the decrease of thrust caused by the unbalanced phase. Also, this model is proven to reduce the detent force by the vibration and noise of the PMLSM and copper loss caused by the circulating current.展开更多
At airports, runway operation is the limiting factor for the overall throughput; specifically the fixed and overly conservative ICAO wake turbulence separation minima. The wake turbulence hazardous flows can dissipate...At airports, runway operation is the limiting factor for the overall throughput; specifically the fixed and overly conservative ICAO wake turbulence separation minima. The wake turbulence hazardous flows can dissipate quicker because of decay due to air turbulence or be transported out of the way on oncoming traffic by cross-wind, yet wake turbulence separation minima do not take into account wind conditions. Indeed, for safety reasons, most airports assume a worst-case scenario and use conservative separations; the interval between aircraft taking off or landing therefore often amounts to several minutes. However, with the aid of accurate wind data and precise measurements of wake vortex by radar sensors, more efficient intervals can be set, particularly when weather conditions are stable. Depending on traffic volume, these adjustments can generate capacity gains, which have major commercial benefits. This paper presents the use of Electronic scanning radar for detecting wake vortices. In this method, the raindrops Doppler spectrogram is used to retrieve the strength of the wake vortex. Numerical simulation are performed to establish an empirical model used during the retrieval method. This paper presents also the results obtained during the trials of the PARIS-CDG data set recorded from October 2014 to November 2015 with an X-band RADAR developed and deployed by THALES.展开更多
OBJECTIVE Our previous studies demonstrated that various ingredients from the traditional Chinese medicine(TCM)for promoting blood circulation and removing blood stasis,as exemplified by cryptotanshinone and salvianol...OBJECTIVE Our previous studies demonstrated that various ingredients from the traditional Chinese medicine(TCM)for promoting blood circulation and removing blood stasis,as exemplified by cryptotanshinone and salvianolic acid B,exerted striking effects on modulating angiogenesis and vascular permeability,which suggests that they may be effective in treating vascular leak-driven diseases(e.g.tumor,cerebral cavernous malformation and diabetic retinopathy).However,the lack of reliable and advanced technologies and models sets up difficult hurdles for better understanding the role of TCM for promoting blood circulation and removing blood stasis.To this end,this study is to outline numerous cutting-edge platforms that can be utilized for exploring the function of TCM for promoting blood circulation and removing blood stasis in vascular leak-driven diseases.METHODS Two-photon laser scanning fluorescence microscopy was used to observe the interactions between neutrophils and blood vessels in a real-time manner.Dynamic flow system was employed to mimic the in vivo behaviors of neutrophils.RIP1-Tag5 spontaneous pancreatic cancer model was used to study the function of tumor blood vessels.CCM2ECKO(deletion of CCM2 in endothelial cells)mice were employed to establish the cerebral cavernous malformation(CCM)animal model.Micro-computed tomography(micro-CT)was utilized to assess the CCM lesion.Müller cell-knockout mouse model was used to study the progression of diabetic retinopathy.Vascular permeability in this model was assessed by fluorescein angiography.RESULTS The interactions between neutrophils and endothelial cells involve a series of complicated processes,including rolling,adhesion,intraluminal crawling and transmigration,which were all monitored in vivo by two-photon laser scanning fluorescence microscopy in a real-time manner.Dynamic flow system was capable of recapitulating the biological behaviors of neutrophils in vitro.Tumor vascular function in particular vascular perfusion could be assessed in the RIP1-Tag5 spontaneous pancreatic cancer model.In terms of CCM studies,specific deletion of CCM2 in endothelial cells resulted in the initiation of CCM lesion.The size and number of CCM lesions could be visualized and quantified by micro-CT.Furthermore,the Müller cell-knockout mouse model was able to precisely reflect the clinical symptoms of diabetic retinopathy.Vascular leak could be monitored at different time points using fluorescein angiography.CONCLUSION An array of high technologies and animal models can be used in investigating the occurrence and progression of multiple vascular leak-driven diseases.The pre-clinical and clinical studies of TCM for promoting blood circulation and removing blood stasis provide fundamental support for the application of the above-mentioned platforms,with the purpose of uncovering the scientific basis of TCM for promoting blood circulation and removing blood stasis.展开更多
The summer and winter circulations in the South China Sea (SCS) including the surface elevation and water temperature are simulated using the model described by Cai and Li (1996) with the monthly mean wind stress and ...The summer and winter circulations in the South China Sea (SCS) including the surface elevation and water temperature are simulated using the model described by Cai and Li (1996) with the monthly mean wind stress and air temperature field at the 1000 mb level from the European Centre for Medium-Range Weather Forecasts as inputs. The boundary conditions at Bashi Channel and Taiwan Strait are taken from the simulation results of the Kuroshio using the same numerical model with a grid size of 0.5°×0.5° and the results of Cai and Li (1996) as boundary conditions. The computational domain for the present paper is between 100°E and 123°E and between 4.5°N and 27°N. The horizontal resolution is 0.25°×0.25° and the vertical variations of the velocity components are resolved by 6 layers The computed steady flow, temperature and elevation fields are consistent with the corresponding fields observed. In particular, the temperature and elevation fields of the South China Sea Warm Current (SCSWC) have been successfully simulated. The paths of the branch of the Kuroshio entering the South China Sea (SCSBK) through Bashi Channel in winter and summer are discussed It is found that the SCSBK flows southward to the southern SCS from the coast of the Guangdong Province. A portion of the SCSBK returns to the Bashi Channel and subdivides again in deep waters in winter with a branch flows to the south along the coast of the Philippines instead of flowing back to the Pacific In addition, our results confirm the existence of a eastward current to the northeast of Dongsha in summer with the Kuroshio as its source as suggested by Huang et al. Since the value of the eddy viscosity adopted for the simulation of the Kuroshio is on the high side, resulting in a weaker west boundary current in the western Pacific as the boundary conditions for the present simulations, some deviations from the actual situations are expected although the results are in general consistent with observations.展开更多
Base on dynamic analysis for a Front Wheel Assist (FWA) tractor, a method of calculating and analyzing on the critical angle of steering for a FWA tractor is described in this paper. The mathematical model is also est...Base on dynamic analysis for a Front Wheel Assist (FWA) tractor, a method of calculating and analyzing on the critical angle of steering for a FWA tractor is described in this paper. The mathematical model is also established here. The critical steering angle which is a important parameter affecting the steering performance for a FWA tractor is defined in the article.展开更多
The subversive nature of information war lies not only in the information itself, but also in the circulation and application of information. It has always been a challenge to quantitatively analyze the function and e...The subversive nature of information war lies not only in the information itself, but also in the circulation and application of information. It has always been a challenge to quantitatively analyze the function and effect of information flow through command, control, communications, computer, kill, intelligence,surveillance, reconnaissance (C4KISR) system. In this work, we propose a framework of force of information influence and the methods for calculating the force of information influence between C4KISR nodes of sensing, intelligence processing,decision making and fire attack. Specifically, the basic concept of force of information influence between nodes in C4KISR system is formally proposed and its mathematical definition is provided. Then, based on the information entropy theory, the model of force of information influence between C4KISR system nodes is constructed. Finally, the simulation experiments have been performed under an air defense and attack scenario. The experimental results show that, with the proposed force of information influence framework, we can effectively evaluate the contribution of information circulation through different C4KISR system nodes to the corresponding tasks. Our framework of force of information influence can also serve as an effective tool for the design and dynamic reconfiguration of C4KISR system architecture.展开更多
Cancer metastasis is the leading cause of death in cancer patients worldwide and one of the major challenges in treating cancer.Circulating tumor cells(CTCs)play a pivotal role in cancer metastasis.However,the content...Cancer metastasis is the leading cause of death in cancer patients worldwide and one of the major challenges in treating cancer.Circulating tumor cells(CTCs)play a pivotal role in cancer metastasis.However,the content of CTCs in peripheral blood is minimal,so the detection of CTCs in real samples is extremely challenging.Therefore,efficient enrichment and early detection of CTCs are essential to achieve timely diagnosis of diseases.In this work,we constructed an innovative and sensitive single-nanoparticle collision electrochemistry(SNCE)biosensor for the detection of MCF-7 cells(human breast cancer cells)by immunomagnetic separation technique and liposome signal amplification strategy.Liposomes embedded with platinum nanoparticles(Pt NPs)were used as signal probes,and homemade gold ultramicroelectrodes(Au UME)were used as the working electrodes.The effective collision between Pt NPs and UME would produce distinguishable step-type current.MCF-7 cells were accurately quantified according to the relationship between cell concentration and collision frequency(the number of step-type currents generated per unit time),realizing highly sensitive and specific detection of MCF-7 cells.The SNCE biosensor has a linear range of 10 cells·mL^(-1)to 10^(5) cells·mL^(-1)with a detection limit as low as 5 cells·mL^(-1).In addition,the successful detection of MCF-7 cells in complex samples showed that the SNCE biosensors have great potential for patient sample detection.展开更多
基于HYCOM(Hybrid Coordinate Oceanic Circulation Model),以OFES(OGCM for the Earth Simulator)资料为参考,分析了KPP、MY2.5、KT三种不同混合方案对北太平洋西边界流系的模拟结果的影响。结果表明:三种不同混合方案模拟的上层海洋...基于HYCOM(Hybrid Coordinate Oceanic Circulation Model),以OFES(OGCM for the Earth Simulator)资料为参考,分析了KPP、MY2.5、KT三种不同混合方案对北太平洋西边界流系的模拟结果的影响。结果表明:三种不同混合方案模拟的上层海洋平均流场与OFES资料相似,但在流向和流幅上略有差异,其中KPP方案模拟的流速与OFES资料最为接近,MY2.5方案次之,KT方案与其差别最大。通过代表性断面上流速的对比分析,对模式就北赤道流、棉兰老流、棉兰老潜流、黑潮的模拟效果进行比较,KPP方案模拟的效果同前人的观测和研究最为接近。分析了北赤道流,棉兰老流,棉兰老潜流,黑潮的流量的季节变化特征,其中KPP方案与OFES资料计算的棉兰老流和棉兰老潜流的季节变化特征与前人描述比较一致,表现为春强秋弱。KPP方案和OFES资料的计算结果表明,北赤道流和棉兰老流大致上是同向变化的,而在冬季棉兰老流同黑潮的变化基本上是一致的。展开更多
A simplified dual-pressure ammonia-water absorption power cycle(DPAPC-a) using low grade energy resources is presented and analyzed.This cycle uses turbine exhaust heat to distill the basic solution for desorption.The...A simplified dual-pressure ammonia-water absorption power cycle(DPAPC-a) using low grade energy resources is presented and analyzed.This cycle uses turbine exhaust heat to distill the basic solution for desorption.The structure of the cycle is simple which comprises evaporator,turbine,regenerator(desorber),absorber,pump and throttle valves for both diluted solution and vapor.And it is of high efficiency,because the working medium has large temperature difference in evaporation and small temperature difference in absorptive condensation,which can match the sensible exothermal heat resource and the cooling water simultaneously.Orthogonal calculation was made to investigate the influence of the working concentration,the basic concentration and the circulation multiple on the cycle performance,with 85-110 ℃ heat resource and 20-32 ℃ cooling water.An optimum scheme was given in the condition of 110 ℃ sensitive heat resource and 20 ℃ cooling water,with the working concentration of 0.6,basic concentration of 0.385,and circulation multiple of 5.The thermal efficiency and the power recovery efficiency are 8.06 % and 6.66%,respectively.The power recovery efficiency of the DPAPC-a is 28.8% higher than that of the steam Rankine cycle(SRC) and 12.7% higher than that of ORC(R134a) under the optimized situation.展开更多
The liquid ion exchange method, solid salt melt method and dry-wet circulation method were used to prepare natural porous antimicrobial materials with natural minerals, such as zeolite, spilite, palygorskite and montm...The liquid ion exchange method, solid salt melt method and dry-wet circulation method were used to prepare natural porous antimicrobial materials with natural minerals, such as zeolite, spilite, palygorskite and montmorillonite, respectively. Atomic absorption spectrum and X-ray diffraction analysis were carried out to investigate the effects of Ag^＋ , Cu^2＋ and Zn^2＋ on antimicrobial abilities of natural porous minerals, and the effect of preparation method on ion exchange capacity of antimicrobial material, respectively. The results show that for the ion exchange capacity, clay mineral is higher than fibrous mineral, i.e. both zeolite and montmorillonite are higher; the antimicrobial ability of material with Ag^＋ is the bests the exchange capacities of materials with Cu^2＋ or Zn^2＋ are all higher, but the antimicrobial ability of Cu^2＋ is better than that of Zn^2＋ .展开更多
Many geotechnical structures,such as the subgrade of high-speed railway,are extremely sensitive to micro deformations.As one of the most commonly used indexes in China to evaluate the potential swelling level of expan...Many geotechnical structures,such as the subgrade of high-speed railway,are extremely sensitive to micro deformations.As one of the most commonly used indexes in China to evaluate the potential swelling level of expansive soils,the effectiveness and accuracy of free swelling ratio should be highly required.However,due to the deficiency of geotechnical test regulations for the free swelling ratio test,non-negligible variation difference is often observed among the test results of the same type of soil samples.Thus,a series of laboratory tests are conducted to figure out the influences of soil particle size,initial soil temperature,and wet-dry circulation on the free swelling ratio of expansive soils.The results show that the initial soil temperature exerts an obvious influence on free swelling ratio and a relative weak influence on soil mass of expansive soil with the micro soil particle size(d<0.075 mm),and the correlation becomes unclear when soil particle size is within the range of 0.075 mm≤d<0.500 mm.A larger particle size of expansive soils induces a larger free swelling ratio and soil mass in the soil measuring cup regardless of initial soil temperature.However,the enlarging amplitude decreases as the particle size of expansive soils increases.There is a progressive enlargement of free swelling ratio at the first two wet-dry cycles and then it attenuates gradually when the number of wetdry cycles further increases.展开更多
基金Project(51275542) supported by the National Natural Science Foundation of Chinaproject(CDJXS12110010) supported by the Fundamental Research Funds for the Central Universities of China
文摘Based on the working principle and the damping characteristic of hydraulic shock absorber, a fluid structure interaction method was presented, which was used to analyze the microcosmic and high-frequency processing mechanism of fluid structure interaction between circulation valve and liquid of hydraulic shock absorber. The fluid mesh distortion was controlled by the CEL language, and the fluid struc^tre interaction mathematical model was established. The finite element model was established by ANSYS CFX software and was analyzed by dynamic mesh technique. The local sensitive computational area was meshed by prismatic grid, which could reduce the negative volume problem during the simulation. The circulation valve and liquid of hydraulic shock absorber were simulated and analyzed under the condition of sinusoidal inlet velocity loads. Flow characteristic and dynamics characteristic were obtained. The pressure distribution and the displacement of circulation value were obtained, and the acceleration curve of circulation valve was simulated and analyzed. The conformity of the final simulation results with the experimental datum indicates that this method is accurate and reliable to analyze the dynamics characteristic between circulation valve and liquid of hydraulic shock absorber, which can provide a theoretical foundation for optimizing hydraulic shock absorber in the future.
基金Project(51274242)supported by the National Natural Science Foundation of ChinaProject(2015CX001)supported by the Innovation-driven Plan of Central South University,China
文摘A safe,economical treatment of hazardous chromium-bearing vanadate residue(CVR)will significantly benefit the clean production of chromate-bearing salts.This study investigated recovery of sodium vanadate and sodium chromate from CVR in sodium bicarbonate solution.Results indicate that the stability of calcium vanadate and calcium chromate depends on pH and[HCO3?].CaV2O6?4H2O transforms into CaV2O6?4H2O,CaV2O6?2H2O,CaV2O6,Ca2V2O7?2H2O,and Ca5(VO4)3(OH)when pH increases from 7.51 to 12.32.Increasing pH and reducing CVR dosage improve the vanadate extraction rate,and high V2O5 and Na2Cr2O7?2H2O extraction rates are achieved in dilute NaHCO3 solution.Moreover,addition of NaOH positively contributes to the recovery of vanadate and chromate from CVR.Over 95%V2O5 and Na2Cr2O7?2H2O in CVR can be extracted from 60 g/L NaHCO3 and 30 g/L NaOH solutions at 90°C for 2 h.In order to reduce the hazardous residue containing chromate after recovery of CVR,calcium circulation is presented.Results show that more than 60%lime can be saved with fresh residue addition to remove vanadate from sodium chromate solution due to the active CaCO3.Moreover,no lime is required in removal of vanadate when the roasting residue is added.Therefore,a novel process is developed for utilization of CVR.
文摘The start-up of external circulationadded internal circulation(IC) reactor was finished in 26 d, 32 d fewer than that of IC reactor. To evaluate the influence of the added external circulation on the development of granular sludge, the characteristics of the granular sludge taken from the two tested laboratory-scale reactors during start-up were studied. The results show that the added external circulation can enhance biomass granulation, accelerate granule development and improve sludge characteristics. At the end of start-up, the granular size of sludge in external circulation-added IC reactor greatly increases with a size distribution much better than that of sludge in IC reactor. The granular sludge originated from external circulationadded IC reactor contains more extracellular polymers and has a greater settling velocity than that from IC reactor. Methanogenic activity of the granular sludge from the external circulationadded IC reactor started 26 d ago reaches 358.23mL·g -1 ·d -1 , 1.66 and 1.20 times as great as that of the sludge from the IC reactor started 26 d and 58 d ago respectively.
基金supported by the Second Stage of Brain Korea 21 Projects and Changwon National University in 2009-2010
文摘A discontinuity of magnetic circuits according to the end effect is generated in the permanent magnet linear synchronous motor （PMLSM）. Due to the unbalanced back electro-motive force （EMF） and impedance produced, unbalanced current is generated. The cireulatin8 current, which is caused by a decrease in the thrust, is generated by the unbalanced current. The optimal design of auxiliary-teeth at the end of the mover was carried out to solve the unbalance of phase by using design of experiment （DOE）, and compared with the basic model through finite element analysis （FEA）. As a result, the auxiliary-teeth model compensates for the decrease of thrust caused by the unbalanced phase. Also, this model is proven to reduce the detent force by the vibration and noise of the PMLSM and copper loss caused by the circulating current.
文摘At airports, runway operation is the limiting factor for the overall throughput; specifically the fixed and overly conservative ICAO wake turbulence separation minima. The wake turbulence hazardous flows can dissipate quicker because of decay due to air turbulence or be transported out of the way on oncoming traffic by cross-wind, yet wake turbulence separation minima do not take into account wind conditions. Indeed, for safety reasons, most airports assume a worst-case scenario and use conservative separations; the interval between aircraft taking off or landing therefore often amounts to several minutes. However, with the aid of accurate wind data and precise measurements of wake vortex by radar sensors, more efficient intervals can be set, particularly when weather conditions are stable. Depending on traffic volume, these adjustments can generate capacity gains, which have major commercial benefits. This paper presents the use of Electronic scanning radar for detecting wake vortices. In this method, the raindrops Doppler spectrogram is used to retrieve the strength of the wake vortex. Numerical simulation are performed to establish an empirical model used during the retrieval method. This paper presents also the results obtained during the trials of the PARIS-CDG data set recorded from October 2014 to November 2015 with an X-band RADAR developed and deployed by THALES.
文摘OBJECTIVE Our previous studies demonstrated that various ingredients from the traditional Chinese medicine(TCM)for promoting blood circulation and removing blood stasis,as exemplified by cryptotanshinone and salvianolic acid B,exerted striking effects on modulating angiogenesis and vascular permeability,which suggests that they may be effective in treating vascular leak-driven diseases(e.g.tumor,cerebral cavernous malformation and diabetic retinopathy).However,the lack of reliable and advanced technologies and models sets up difficult hurdles for better understanding the role of TCM for promoting blood circulation and removing blood stasis.To this end,this study is to outline numerous cutting-edge platforms that can be utilized for exploring the function of TCM for promoting blood circulation and removing blood stasis in vascular leak-driven diseases.METHODS Two-photon laser scanning fluorescence microscopy was used to observe the interactions between neutrophils and blood vessels in a real-time manner.Dynamic flow system was employed to mimic the in vivo behaviors of neutrophils.RIP1-Tag5 spontaneous pancreatic cancer model was used to study the function of tumor blood vessels.CCM2ECKO(deletion of CCM2 in endothelial cells)mice were employed to establish the cerebral cavernous malformation(CCM)animal model.Micro-computed tomography(micro-CT)was utilized to assess the CCM lesion.Müller cell-knockout mouse model was used to study the progression of diabetic retinopathy.Vascular permeability in this model was assessed by fluorescein angiography.RESULTS The interactions between neutrophils and endothelial cells involve a series of complicated processes,including rolling,adhesion,intraluminal crawling and transmigration,which were all monitored in vivo by two-photon laser scanning fluorescence microscopy in a real-time manner.Dynamic flow system was capable of recapitulating the biological behaviors of neutrophils in vitro.Tumor vascular function in particular vascular perfusion could be assessed in the RIP1-Tag5 spontaneous pancreatic cancer model.In terms of CCM studies,specific deletion of CCM2 in endothelial cells resulted in the initiation of CCM lesion.The size and number of CCM lesions could be visualized and quantified by micro-CT.Furthermore,the Müller cell-knockout mouse model was able to precisely reflect the clinical symptoms of diabetic retinopathy.Vascular leak could be monitored at different time points using fluorescein angiography.CONCLUSION An array of high technologies and animal models can be used in investigating the occurrence and progression of multiple vascular leak-driven diseases.The pre-clinical and clinical studies of TCM for promoting blood circulation and removing blood stasis provide fundamental support for the application of the above-mentioned platforms,with the purpose of uncovering the scientific basis of TCM for promoting blood circulation and removing blood stasis.
文摘The summer and winter circulations in the South China Sea (SCS) including the surface elevation and water temperature are simulated using the model described by Cai and Li (1996) with the monthly mean wind stress and air temperature field at the 1000 mb level from the European Centre for Medium-Range Weather Forecasts as inputs. The boundary conditions at Bashi Channel and Taiwan Strait are taken from the simulation results of the Kuroshio using the same numerical model with a grid size of 0.5°×0.5° and the results of Cai and Li (1996) as boundary conditions. The computational domain for the present paper is between 100°E and 123°E and between 4.5°N and 27°N. The horizontal resolution is 0.25°×0.25° and the vertical variations of the velocity components are resolved by 6 layers The computed steady flow, temperature and elevation fields are consistent with the corresponding fields observed. In particular, the temperature and elevation fields of the South China Sea Warm Current (SCSWC) have been successfully simulated. The paths of the branch of the Kuroshio entering the South China Sea (SCSBK) through Bashi Channel in winter and summer are discussed It is found that the SCSBK flows southward to the southern SCS from the coast of the Guangdong Province. A portion of the SCSBK returns to the Bashi Channel and subdivides again in deep waters in winter with a branch flows to the south along the coast of the Philippines instead of flowing back to the Pacific In addition, our results confirm the existence of a eastward current to the northeast of Dongsha in summer with the Kuroshio as its source as suggested by Huang et al. Since the value of the eddy viscosity adopted for the simulation of the Kuroshio is on the high side, resulting in a weaker west boundary current in the western Pacific as the boundary conditions for the present simulations, some deviations from the actual situations are expected although the results are in general consistent with observations.
文摘Base on dynamic analysis for a Front Wheel Assist (FWA) tractor, a method of calculating and analyzing on the critical angle of steering for a FWA tractor is described in this paper. The mathematical model is also established here. The critical steering angle which is a important parameter affecting the steering performance for a FWA tractor is defined in the article.
基金supported by the Natural Science Foundation Research Plan of Shanxi Province (2023JCQN0728)。
文摘The subversive nature of information war lies not only in the information itself, but also in the circulation and application of information. It has always been a challenge to quantitatively analyze the function and effect of information flow through command, control, communications, computer, kill, intelligence,surveillance, reconnaissance (C4KISR) system. In this work, we propose a framework of force of information influence and the methods for calculating the force of information influence between C4KISR nodes of sensing, intelligence processing,decision making and fire attack. Specifically, the basic concept of force of information influence between nodes in C4KISR system is formally proposed and its mathematical definition is provided. Then, based on the information entropy theory, the model of force of information influence between C4KISR system nodes is constructed. Finally, the simulation experiments have been performed under an air defense and attack scenario. The experimental results show that, with the proposed force of information influence framework, we can effectively evaluate the contribution of information circulation through different C4KISR system nodes to the corresponding tasks. Our framework of force of information influence can also serve as an effective tool for the design and dynamic reconfiguration of C4KISR system architecture.
基金supported by the National Natural Science Foundation of China(Nos.22274037,22376055 and 21904032)the Natural Science Foundation of Hubei Province(2022CFB383)。
文摘Cancer metastasis is the leading cause of death in cancer patients worldwide and one of the major challenges in treating cancer.Circulating tumor cells(CTCs)play a pivotal role in cancer metastasis.However,the content of CTCs in peripheral blood is minimal,so the detection of CTCs in real samples is extremely challenging.Therefore,efficient enrichment and early detection of CTCs are essential to achieve timely diagnosis of diseases.In this work,we constructed an innovative and sensitive single-nanoparticle collision electrochemistry(SNCE)biosensor for the detection of MCF-7 cells(human breast cancer cells)by immunomagnetic separation technique and liposome signal amplification strategy.Liposomes embedded with platinum nanoparticles(Pt NPs)were used as signal probes,and homemade gold ultramicroelectrodes(Au UME)were used as the working electrodes.The effective collision between Pt NPs and UME would produce distinguishable step-type current.MCF-7 cells were accurately quantified according to the relationship between cell concentration and collision frequency(the number of step-type currents generated per unit time),realizing highly sensitive and specific detection of MCF-7 cells.The SNCE biosensor has a linear range of 10 cells·mL^(-1)to 10^(5) cells·mL^(-1)with a detection limit as low as 5 cells·mL^(-1).In addition,the successful detection of MCF-7 cells in complex samples showed that the SNCE biosensors have great potential for patient sample detection.
文摘基于HYCOM(Hybrid Coordinate Oceanic Circulation Model),以OFES(OGCM for the Earth Simulator)资料为参考,分析了KPP、MY2.5、KT三种不同混合方案对北太平洋西边界流系的模拟结果的影响。结果表明:三种不同混合方案模拟的上层海洋平均流场与OFES资料相似,但在流向和流幅上略有差异,其中KPP方案模拟的流速与OFES资料最为接近,MY2.5方案次之,KT方案与其差别最大。通过代表性断面上流速的对比分析,对模式就北赤道流、棉兰老流、棉兰老潜流、黑潮的模拟效果进行比较,KPP方案模拟的效果同前人的观测和研究最为接近。分析了北赤道流,棉兰老流,棉兰老潜流,黑潮的流量的季节变化特征,其中KPP方案与OFES资料计算的棉兰老流和棉兰老潜流的季节变化特征与前人描述比较一致,表现为春强秋弱。KPP方案和OFES资料的计算结果表明,北赤道流和棉兰老流大致上是同向变化的,而在冬季棉兰老流同黑潮的变化基本上是一致的。
基金Project(50976022) supported by the National Natural Science Foundation of ChinaProject(BY2011155) supported by Science and Technology Innovation and Transformation of Achievements of Special Fund of Jiangsu Province, China
文摘A simplified dual-pressure ammonia-water absorption power cycle(DPAPC-a) using low grade energy resources is presented and analyzed.This cycle uses turbine exhaust heat to distill the basic solution for desorption.The structure of the cycle is simple which comprises evaporator,turbine,regenerator(desorber),absorber,pump and throttle valves for both diluted solution and vapor.And it is of high efficiency,because the working medium has large temperature difference in evaporation and small temperature difference in absorptive condensation,which can match the sensible exothermal heat resource and the cooling water simultaneously.Orthogonal calculation was made to investigate the influence of the working concentration,the basic concentration and the circulation multiple on the cycle performance,with 85-110 ℃ heat resource and 20-32 ℃ cooling water.An optimum scheme was given in the condition of 110 ℃ sensitive heat resource and 20 ℃ cooling water,with the working concentration of 0.6,basic concentration of 0.385,and circulation multiple of 5.The thermal efficiency and the power recovery efficiency are 8.06 % and 6.66%,respectively.The power recovery efficiency of the DPAPC-a is 28.8% higher than that of the steam Rankine cycle(SRC) and 12.7% higher than that of ORC(R134a) under the optimized situation.
文摘The liquid ion exchange method, solid salt melt method and dry-wet circulation method were used to prepare natural porous antimicrobial materials with natural minerals, such as zeolite, spilite, palygorskite and montmorillonite, respectively. Atomic absorption spectrum and X-ray diffraction analysis were carried out to investigate the effects of Ag^＋ , Cu^2＋ and Zn^2＋ on antimicrobial abilities of natural porous minerals, and the effect of preparation method on ion exchange capacity of antimicrobial material, respectively. The results show that for the ion exchange capacity, clay mineral is higher than fibrous mineral, i.e. both zeolite and montmorillonite are higher; the antimicrobial ability of material with Ag^＋ is the bests the exchange capacities of materials with Cu^2＋ or Zn^2＋ are all higher, but the antimicrobial ability of Cu^2＋ is better than that of Zn^2＋ .
基金Project(2016M591957) supported by the China Postdoctoral Science FoundationProjects(51878667,51678571)supported by the National Natural Science Foundation of ChinaProject(2017XKQY050) supported by the Fundamental Research Funds for the Central Universities,China。
文摘Many geotechnical structures,such as the subgrade of high-speed railway,are extremely sensitive to micro deformations.As one of the most commonly used indexes in China to evaluate the potential swelling level of expansive soils,the effectiveness and accuracy of free swelling ratio should be highly required.However,due to the deficiency of geotechnical test regulations for the free swelling ratio test,non-negligible variation difference is often observed among the test results of the same type of soil samples.Thus,a series of laboratory tests are conducted to figure out the influences of soil particle size,initial soil temperature,and wet-dry circulation on the free swelling ratio of expansive soils.The results show that the initial soil temperature exerts an obvious influence on free swelling ratio and a relative weak influence on soil mass of expansive soil with the micro soil particle size(d<0.075 mm),and the correlation becomes unclear when soil particle size is within the range of 0.075 mm≤d<0.500 mm.A larger particle size of expansive soils induces a larger free swelling ratio and soil mass in the soil measuring cup regardless of initial soil temperature.However,the enlarging amplitude decreases as the particle size of expansive soils increases.There is a progressive enlargement of free swelling ratio at the first two wet-dry cycles and then it attenuates gradually when the number of wetdry cycles further increases.
