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基于p38MAPK-PPARγ/NF-κB信号通路探讨消肿止痛合剂对血管内皮细胞bEND-3凋亡的影响 被引量:2
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作者 朱克玉 宋渊 +4 位作者 梁旭东 沈稼轩 张团庄 乔靖 刘涛 《辽宁中医杂志》 CAS 北大核心 2024年第4期149-152,I0002,共5页
目的从细胞及信号通路层面探讨消肿止痛合剂对皮瓣缺血再灌注损伤中血管内皮细胞凋亡的影响。方法血管内皮细胞bEND-3培养。TNF-α体外细胞凋亡诱导模型建立并将细胞分为:p38MAPK抑制剂组、PPARγ抑制剂组、NF-κB抑制剂组、模型对照组... 目的从细胞及信号通路层面探讨消肿止痛合剂对皮瓣缺血再灌注损伤中血管内皮细胞凋亡的影响。方法血管内皮细胞bEND-3培养。TNF-α体外细胞凋亡诱导模型建立并将细胞分为:p38MAPK抑制剂组、PPARγ抑制剂组、NF-κB抑制剂组、模型对照组、空白组。微丝绿色荧光探针观察细胞骨架微丝。RT-PCR法检测血管内皮细胞bEND-3细胞中p38MAPK、PPARγ、IκBα、NF-κBmRNA的表达。结果空白组中p38MAPK、PPARγ、IκBα、NF-κB的表达量无明显差异,模型对照组中p38MAPK与NF-κB的表达量最高,与模型对照组相比,p38MAPK抑制剂组bEnd.3细胞中p38MAPK与NF-κB的表达被抑制,PPARγ、IκBα表达量升高(P<0.05);PPARγ抑制剂组中PPARγ、IκBα、NF-κB的表达被抑制,p38MAPK表达量升高(P<0.05),NF-κB抑制剂组中p38MAPK与NF-κB的表达被抑制,IκBα与PPARγ的表达量升高(P<0.05);与空白组相比,p38MAPK抑制剂组与NF-κB抑制剂组中p38MAPK、PPARγ、IκBα、NF-κB的表达量升高(P<0.05),PPARγ抑制剂组中p38MAPK与NF-κB表达量明显升高,PPARγ、IκBα表达被抑制(P<0.05)。结论消肿止痛合剂可抑制bEND-3细胞凋亡,其机制与影响可能与p38MAPK-PPARγ/NF-κB信号通路有关。 展开更多
关键词 消肿止痛合剂 bend-3细胞 信号通路 皮瓣
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Defects detection in typical positions of bend pipes using low-frequency ultrasonic guided wave 被引量:2
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作者 罗更生 谭建平 +1 位作者 汪亮 许焰 《Journal of Central South University》 SCIE EI CAS CSCD 2015年第10期3860-3867,共8页
In order to analyze the possibility of detecting defects in bend pipe using low-frequency ultrasonic guided wave, the propagation of T(0,1) mode and L(0,2) mode through straight-curved-straight pipe sections was studi... In order to analyze the possibility of detecting defects in bend pipe using low-frequency ultrasonic guided wave, the propagation of T(0,1) mode and L(0,2) mode through straight-curved-straight pipe sections was studied. FE(finite element) models of bend pipe without defects and those with defects were introduced to analyze energy distribution, mode transition and defect detection of ultrasonic guided wave. FE simulation results were validated by experiments of four different bend pipes with circumferential defects in different positions. It is shown that most energy of T(0,1) mode or L(0,2) mode focuses on extrados of bend but little passes through intrados of bend, and T(0,1) mode or L(0,2) mode is converted to other possible non-axisymmetric modes when propagating through the bend and the defect after bend respectively. Furthermore, L(0,2) mode is more sensitive to circumferential notch than T(0,1) mode. The results of this work are beneficial for practical testing of pipes. 展开更多
关键词 low-frequency ultrasonic guided wave bend pipe extrados of bend intrados of bend FE(finite element) simulation experimental investigation
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小鼠脑微血管内皮细胞株bEnd.3的细胞特征及基因表达谱分析 被引量:13
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作者 乐飞 张国平 +2 位作者 金惠铭 史连国 殷莲华 《中国病理生理杂志》 CAS CSCD 北大核心 2004年第8期1340-1344,共5页
目的 :对一种小鼠脑组织来源的血管内皮细胞株bEnd .3的主要细胞特征进行研究并做血管内皮细胞生物学功能基因芯片分析。方法 :利用倒置显微镜、扫描和透射电子显微镜观察细胞形态特征 ;免疫细胞化学法显示血管内皮细胞特异性表面标志 ;... 目的 :对一种小鼠脑组织来源的血管内皮细胞株bEnd .3的主要细胞特征进行研究并做血管内皮细胞生物学功能基因芯片分析。方法 :利用倒置显微镜、扫描和透射电子显微镜观察细胞形态特征 ;免疫细胞化学法显示血管内皮细胞特异性表面标志 ;ELISA定量检测PGE2 ;流式细胞术、MTT法研究增殖和凋亡、血管内皮细胞基因芯片研究正常培养bEnd 3基因表达谱。结果 :bEnd 3具备多种典型的微血管内皮细胞 (MVEC)特征 :细胞呈多边形或梭型、呈铺路石样生长 ;存在管腔样结构 (TLS)和毛细血管样网络 ,细胞表面有丰富的微绒毛 ;vW因子、CD34阳性 ;CD31、CD36、CD10 5等也有不同程度的表达 ;细胞高水平分泌前列腺素E2 (PGE2 ) ;多种与正常血管功能密切相关的基因也有不同程度的表达。结论 :bEnd .3保留了MVEC的基本特性 ,可用于心脑血管疾病。 展开更多
关键词 bend.3细胞 内皮 von WILLEBRAND因子 抗原 CD34 寡核苷酸序列分析
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CXCR4/SDF-1轴调节人肺腺癌PC-9细胞对Bends细胞血脑屏障模型功能的影响 被引量:5
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作者 李鸿茹 涂洵崴 +2 位作者 陈正伟 陈愉生 韩莉莉 《中国肿瘤生物治疗杂志》 CAS CSCD 北大核心 2020年第5期528-533,共6页
目的:通过建立体外血脑屏障(blood brain barrier,BBB)模型,探讨人肺腺癌PC-9细胞在CXCR4/SDF-1轴作用下对BBB紧密连接蛋白的影响。方法:利用永生化的小鼠脑微血管内皮细胞Bends进行单层培养,建立体外BBB模型;通过跨内皮细胞电阻(transe... 目的:通过建立体外血脑屏障(blood brain barrier,BBB)模型,探讨人肺腺癌PC-9细胞在CXCR4/SDF-1轴作用下对BBB紧密连接蛋白的影响。方法:利用永生化的小鼠脑微血管内皮细胞Bends进行单层培养,建立体外BBB模型;通过跨内皮细胞电阻(transendothelial electrical resistance,TEER)测定及荧光素钠通透性实验判定体外BBB模型的功能状态以及观察PC-9细胞对体外BBB模型功能的影响。Western blotting检测PC-9细胞在CXCR4抑制剂AMD3100、SDF-1单独或联合(1μg/ml AMD3100,100 ng/ml SDF-1,AMD3100+SDF-1)作用下对BBB模型功能和内皮细胞紧密连接蛋白表达的影响,Transwell迁移实验检测CXCR4/SDF-1轴对PC-9细胞跨BBB模型细胞层迁移能力的影响。结果:Bends细胞单层培养可形成紧密连接的"屏障"并产生较高的TEER,第96 h达到(182.13±5.19)Ω·cm^2;同时行荧光色钠通透性实验结果显示,BBB具有良好屏障性能,其通透率低于空白对照组(P<0.05)。PC-9细胞作用后,BBB模型TEER逐渐降低,第24 h降至(46.7±4.35)Ω·cm^2;同时BBB通透率较作用前显著提高(P<0.05)。PC-9细胞在AMD3100作用下能够上调内皮细胞紧密连接蛋白的表达(P<0.05);AMD3100处理组的PC-9细胞穿过BBB的细胞数较空白组明显减少[(43±2)vs(81±2)个,P<0.05]。结论:AMD3100能够减弱PC-9细胞对Bends细胞建立的体外BBB模型紧密连接的破坏能力。 展开更多
关键词 肺腺癌 PC-9细胞 血脑屏障 bends细胞 紧密连接 跨内皮细胞电阻 迁移 CXCR4/SDF-1轴
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Extending application of asymmetric semi-circular bend specimen to investigate mixed mode Ⅰ/Ⅱ fracture behavior of granite 被引量:7
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作者 WU Qiu-hong XIE Cheng-long +4 位作者 XIE You-sheng ZHAO Yan-lin LI Xue-feng LIU Jie WENG Lei 《Journal of Central South University》 SCIE EI CAS CSCD 2022年第4期1289-1304,共16页
The asymmetric semi-circular bend(ASCB)specimen has been proposed to investigate the cracking behavior in different geo and construction materials and attracted the attention of researchers due to its advantages.Howev... The asymmetric semi-circular bend(ASCB)specimen has been proposed to investigate the cracking behavior in different geo and construction materials and attracted the attention of researchers due to its advantages.However,there are few studies on the fracture toughness determination of rock materials.In this work,a series of fracture tests were performed with the ASCB specimens made of granite.The onset of fracture,crack initiation angle and crack propagating trajectory was analyzed in detail combined with several mixed mode fracture criteria.The influence of the crack length on the mode Ⅰ/Ⅱ fracture toughness was studied.A comparison between the fracture toughness ratios predicted by varying criteria and experimental results was conducted.The relationship between experimentally determined crack initiation angles and curves of the generalized maximum tangential stress(GMTS)criterion was obtained.The fracture process of the specimen was recorded with the high-speed camera.The shortcomings of the ASCB specimens for the fracture toughness determination of rock materials were discussed.The results may provide a reference for analysis of mixed mode I and II fracture behavior of brittle materials. 展开更多
关键词 asymmetric semi-circular bend specimen rock fracture toughness crack growth trajectory crack initiation angle semi-circular bending generalized maximum tangential stress criterion
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Effect of bending temperatures on the microstructure and springback of a TRIP steel sheet 被引量:3
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作者 Natthasak Pornputsiri Kannachai Kanlayasiri 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2020年第5期980-987,共8页
Transformation-induced plasticity(TRIP)steel possesses high strength and formability,enabling the use of a thinner gauge material and allowing for the fabrication of complex shapes.In this research,we measured the eff... Transformation-induced plasticity(TRIP)steel possesses high strength and formability,enabling the use of a thinner gauge material and allowing for the fabrication of complex shapes.In this research,we measured the effect of bending temperatures on the microstructure and air-bending springback angle of TRIP steel at temperatures from 25 to 600C.Real-time in situ X-ray diffraction and scanning electron microscopy were used for pre-and postbending analysis.As the prebending temperature increased from 25C to 600C,the retained austenite(RA)volume fraction decreased,and the RA transformed to bainite at temperatures above 400C.The springback angle was positively correlated with the prebending RA volume fraction,with the smallest springback angle achieved at 400C.Additionally,the springback angle was positively correlated with the bending angle,because the RA transformation ratio contributed to increased strain hardening.Further microstructure analysis revealed that the RA became elongated in the tension direction as the bending temperatures increased. 展开更多
关键词 TRIP steel In situ X-ray diffraction Phase transformation bending temperature SPRINGBACK Air-bending test
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活血定眩胶囊含药血清对氧糖剥夺诱导的bEnd.3细胞铁死亡的影响 被引量:7
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作者 王凯 宋敏 +3 位作者 宋志靖 李金益 范凯 海云翔 《中国病理生理杂志》 CAS CSCD 北大核心 2022年第3期420-426,共7页
目的:探讨活血定眩胶囊(HXDX)对氧糖剥夺(OGD)诱导小鼠脑微血管内皮细胞株bEnd.3铁死亡的影响。方法:将bEnd.3细胞分为空白对照(control)组、OGD组、OGD+铁死亡抑制剂ferrostatin-1(Fer-1)组及OGD+HXDX组,control组细胞正常培养,其他组... 目的:探讨活血定眩胶囊(HXDX)对氧糖剥夺(OGD)诱导小鼠脑微血管内皮细胞株bEnd.3铁死亡的影响。方法:将bEnd.3细胞分为空白对照(control)组、OGD组、OGD+铁死亡抑制剂ferrostatin-1(Fer-1)组及OGD+HXDX组,control组细胞正常培养,其他组建立OGD模型,OGD+Fer-1组和OGD+HXDX组分别加入1μmol/L Fer-1和10%HXDX含药血清后OGD处理6 h。FerroOrange探针测定细胞内Fe^(2+)水平,DCFH-DA探针检测活性氧(ROS)含量,试剂盒检测超氧化物歧化酶(SOD)活性及丙二醛(MDA)和谷胱甘肽(GSH)水平,Western blot检测核因子E2相关因子2(Nrf2)、铁蛋白重链1(FTH1)、谷胱甘肽过氧化物酶4(GPX4)、长链脂酰辅酶A合成酶4(ACSL4)、环加氧酶2(COX2)和NADPH氧化酶1(NOX1)蛋白表达。结果:与control组比较,OGD组bEnd.3细胞内Fe^(2+)荧光强度与ROS含量显著增加;SOD活性降低,GSH表达下降,MDA含量显著增高(P<0.05);FTH1和GPX4表达降低,ACSL4、COX2和NOX1表达升高(P<0.05),Nrf2无显著差异。HXDX含药血清处理后,Fe^(2+)水平和ROS含量显著降低(P<0.05);SOD活性和GSH含量显著升高,MDA水平显著降低(P<0.05);Nrf2、FTH1与GPX4蛋白的表达显著增高(P<0.05),COX2和NOX1蛋白表达降低(P<0.05),ACSL4无显著差异。结论:活血定眩胶囊可抑制体外OGD诱导的bEnd.3细胞铁死亡,其机制与降低细胞内Fe^(2+)和ROS含量、减轻脂质过氧化及调控铁死亡相关蛋白表达有关。 展开更多
关键词 椎动脉型颈椎病 活血定眩胶囊 bend.3细胞 氧糖剥夺 铁死亡
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黄芪水蛭提取物小肠吸收液对连二亚硫酸钠致Bend.3细胞缺氧复氧损伤后炎症因子动态变化的影响 被引量:3
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作者 崔煦然 刘钊 钟菊迎 《辽宁中医杂志》 CAS 2020年第9期133-137,共5页
目的探讨黄芪水蛭提取物小肠吸收液对小鼠脑微血管内皮细胞(Bend.3)正常细胞及连二亚硫酸钠所致缺氧复氧损伤后Bend.3细胞炎症因子动态变化的影响。方法实验首先采用肠囊外翻法制备受试小肠吸收液;其次,采用CCK-8法,检测不同浓度的小肠... 目的探讨黄芪水蛭提取物小肠吸收液对小鼠脑微血管内皮细胞(Bend.3)正常细胞及连二亚硫酸钠所致缺氧复氧损伤后Bend.3细胞炎症因子动态变化的影响。方法实验首先采用肠囊外翻法制备受试小肠吸收液;其次,采用CCK-8法,检测不同浓度的小肠吸收液对Bend.3细胞存活率的影响;采用酶联免疫吸附法,检测小肠吸收液对细胞缺氧复氧损伤后细胞炎症因子TNF-α、IL-1β、IL-6、T-cell的动态表达量的影响。结果各药物干预组,细胞状态优于模型组。药物组小肠吸收液可提高损伤细胞的增殖率最高达到54.02%。各药物干预组,TNF-α含量在4~24 h均维持较低表达,与模型对照组比较,差异均有统计学意义(P <0.05,P <0.01);IL-6含量在8~24 h维持不同程度的低表达水平(P <0.05,P <0.01);T-cell含量在8 h呈现低表达水平(P <0.05,P <0.01);中、小剂量组IL-1β的含量,在24 h与模型组比较差异有统计学意义(P <0.05)。结论在本次试验条件下,黄芪水蛭小肠吸收液对正常Bend.3细胞无影响;对模型细胞炎症因子的表达量有一定的降低作用,表明黄芪水蛭小肠吸收液对Bend.3细胞缺氧复氧损伤后的炎症反应有改善作用。 展开更多
关键词 黄芪水蛭提取物 小肠吸收液 bend.3细胞 缺氧复氧 炎症
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Finite element analysis of contact fatigue and bending fatigue of a theoretical assembling straight bevel gear pair 被引量:15
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作者 邓松 华林 +1 位作者 韩星会 黄松 《Journal of Central South University》 SCIE EI CAS 2013年第2期279-292,共14页
The aim of this work is to propose a 3D FE model of a theoretical assembling straight bevel gear pair to analyze the contact fatigue on the tooth surface and the bending fatigue in the tooth root. Based on the cumulat... The aim of this work is to propose a 3D FE model of a theoretical assembling straight bevel gear pair to analyze the contact fatigue on the tooth surface and the bending fatigue in the tooth root. Based on the cumulative fatigue criterion and the stress-life equation, the key meshing states of the gear pair were investigated for the contact fatigue and the bending fatigue. Then, the reliability of the proposed model was proved by comparing the calculation result with the simulation result. Further study was performed to analyze the variation of the contact fatigue stress and the bending fatigue stress under different loads. Furthermore, the roles of the driving pinion and the driven gear pair were evaluated in the fatigue life of the straight bevel gear pair and the main fatigue failure mode was determined for the significant gear. The results show that the fatigue failure of the driving pinion is the main fatigue failure for the straight bevel gear pair and the bending fatigue failure is the main fatigue failure for the driving pinion. 展开更多
关键词 straight bevel gear finite element method contact fatigue bending fatigue
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Rock bending creep and disturbance effects 被引量:3
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作者 付志亮 郑颖人 刘元雪 《Journal of Central South University》 SCIE EI CAS 2008年第S1期438-442,共5页
The bending creep and its disturbance effects of red sandstone rock beam and oil shale rock beam were studied by adopting the self-developed gravitation level style rock creep test machine and bending creep test syste... The bending creep and its disturbance effects of red sandstone rock beam and oil shale rock beam were studied by adopting the self-developed gravitation level style rock creep test machine and bending creep test system,and the constitutive equations were established.It is found that fracture morphology of rock beams under no disturbance load is regular,cracking position of fractures is on part of loading concentration,the crack starts from a neutral plane.However,fracture morphology of rock beams under disturbance load is irregular,cracking position of fractures deviates from a neutral plane.Delayed instability of rock beam occurs for some time under constant disturbance load.When disturbance load is beyond a certain range,suddenly instability of occurs rock beam in a certain time.The results show that there is a guiding significance for creep stability in the geotechnical engineering fields. 展开更多
关键词 ROCK beam bendING CREEP DISTURBANCE load GRAVITY DELAYED instability
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Improvement for design of beam structures in large vibrating screen considering bending and random vibration 被引量:7
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作者 彭利平 刘初升 +2 位作者 宋宝成 武继达 王帅 《Journal of Central South University》 SCIE EI CAS CSCD 2015年第9期3380-3388,共9页
Demand for large vibrating screen is huge in the mineral processing industry. As bending and random vibration are not considered in a traditional design method for beam structures of a large vibrating screen, fatigue ... Demand for large vibrating screen is huge in the mineral processing industry. As bending and random vibration are not considered in a traditional design method for beam structures of a large vibrating screen, fatigue damage occurs frequently to affect the screening performance. This work aims to conduct a systematic mechanics analysis of the beam structures and improve the design method. Total motion of a beam structure in screening process can be decomposed into the traditional followed rigid translation(FRT), bending vibration(BV) and axial linear-distributed random rigid translation(ALRRT) excited by the side-plates. When treated as a generalized single-degree-of-freedom(SDOF) elastic system analytically, the BV can be solved by the Rayleigh's method. Stochastic analysis for random process is conducted for the detailed ALRRT calculation. Expressions for the mechanics property, namely, the shearing force and bending-moment with respect to BV and ALRRT, are derived, respectively. Experimental and numerical investigations demonstrate that the largest BV exists at the beam center and can be nearly ignored in comparison with the FRT during a simplified engineering design. With the BV and FRT considered, the mechanics property accords well with the practical situation with the maximum error of 6.33%, which is less than that obtained by traditional method. 展开更多
关键词 large vibrating screen BEAM bending vibration random vibration mechanics analysis
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Bending stress of rolling element in elastic composite cylindrical roller bearing 被引量:11
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作者 姚齐水 杨文 +1 位作者 于德介 余江鸿 《Journal of Central South University》 SCIE EI CAS 2013年第12期3437-3444,共8页
A new structure design method of elastic composite cylindrical roller bearing is proposed, in which PTFE is embedded into a hollow cylindrical rolling element, according to the principle of creative combinations and t... A new structure design method of elastic composite cylindrical roller bearing is proposed, in which PTFE is embedded into a hollow cylindrical rolling element, according to the principle of creative combinations and through innovation research on cylindrical roller bearing structure. In order to systematically investigate the inner wall bending stress of the rolling element in elastic composite cylindrical roller bearing, finite element analysis on different elastic composite cylindrical rolling elements was conducted. The results show that, the bending stress of the elastic composite cylindrical rolling increases along with the increase of hollowness with the same filling material. The bending stress of the elastic composite cylindrical rolling element decreases along with the increase of the elasticity modulus of the material under the same physical dimension. Under the same load, on hollow cylindrical rolling element, the maximum bending tensile stress values of the elastic composite cylindrical rolling element after material filling at 0° and 180° are 8.2% and 9.5%, respectively, lower than those of the deep cavity hollow cylindrical rolling element. In addition, the maximum bending-compressive stress value at 90° is decreased by 6.1%. 展开更多
关键词 elastic composite cylindrical roller bearing hollowness (degree of filling) finite element analysis bending stress rolling element
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Deformation behaviors of 21-6-9 stainless steel tube numerical control bending under different friction conditions 被引量:10
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作者 方军 鲁世强 +1 位作者 王克鲁 姚正军 《Journal of Central South University》 SCIE EI CAS CSCD 2015年第8期2864-2874,共11页
For contact dominated numerical control(NC) bending process of tube, the effect of friction on bending deformation behaviors should be focused on to achieve precision bending forming. A three dimensional(3D) elastic-p... For contact dominated numerical control(NC) bending process of tube, the effect of friction on bending deformation behaviors should be focused on to achieve precision bending forming. A three dimensional(3D) elastic-plastic finite element(FE) model of NC bending process was established under ABAQUS/Explicit platform, and its reliability was validated by the experiment. Then, numerical study on bending deformation behaviors under different frictions between tube and various dies was explored from multiple aspects such as wrinkling, wall thickness change and cross section deformation. The results show that the large friction of wiper die-tube reduces the wrinkling wave ratio η and cross section deformation degree ΔD and increases the wall thinning degree Δt. The large friction of mandrel-tube causes large η, Δt and ΔD, and the onset of wrinkling near clamp die. The large friction of pressure die-tube reduces Δt and ΔD, and the friction on this interface has little effect on η. The large friction of bending die-tube reduces η and ΔD, and the friction on this interface has little effect on Δt. The reasonable friction coefficients on wiper die-tube, mandrel-tube, pressure die-tube and bending die-tube of 21-6-9(0Cr21Ni6Mn9N) stainless steel tube in NC bending are 0.05-0.15, 0.05-0.15, 0.25-0.35 and 0.25-0.35, respectively. The results can provide a guideline for applying the friction conditions to establish the robust bending environment for stable and precise bending deformation of tube bending. 展开更多
关键词 21-6-9 stainless steel tube FRICTION deformation behaviors numerical control bending finite element simulation
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Effects of bending on heat transfer performance of axial micro-grooved heat pipe 被引量:5
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作者 蒋乐伦 汤勇 潘敏强 《Journal of Central South University》 SCIE EI CAS 2011年第2期580-586,共7页
Heat pipe is always bent in the typical application of electronic heat dissipation at high heat flux,which greatly affects its heat transfer performance. The capillary limit of heat transport in the bent micro-grooved... Heat pipe is always bent in the typical application of electronic heat dissipation at high heat flux,which greatly affects its heat transfer performance. The capillary limit of heat transport in the bent micro-grooved heat pipes was analyzed in the vapor pressure drop,the liquid pressure drop and the interaction of the vapor with wick fluid. The bent heat pipes were fabricated and tested from the bending angle,the bending position and the bending radius. The results show that temperature difference and thermal resistance increase while the heat transfer capacity of the heat pipe decreases,with the increase of the bending angles and the bending position closer to the vapor section. However,the effects of bending radius can be ignored. The result agrees well with the predicted equations. 展开更多
关键词 electronics cooling system axial micro-grooved heat pipe bendING heat transfer performance
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Preset model of bending force for 6-high reversing cold rolling mill based on genetic algorithm 被引量:4
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作者 曹建国 徐小照 +3 位作者 张杰 宋木清 宫贵良 曾伟 《Journal of Central South University》 SCIE EI CAS 2011年第5期1487-1492,共6页
The hydraulic roll-bending device was studied, which was widely used in modem cold rolling mills to regulate the strip flatness. The loaded roll gap crown mathematic model and the strip crown mathematic model of the r... The hydraulic roll-bending device was studied, which was widely used in modem cold rolling mills to regulate the strip flatness. The loaded roll gap crown mathematic model and the strip crown mathematic model of the reversing cold rolling process were established, and the deformation model of roll stack system of the 6-high 1 250 mm high crown (HC) reversing cold rolling mill was built by slit beam method. The simulation results show that, the quadratic component of strip crown decreases nearly linearly with the increase of the work roll bending force, when the shifting value of intermediate roll is determined by the rolling process. From the first pass to the fifth pass of reversing rolling process, the crown controllability of bending force is gradually weakened. Base on analyzing the relationship among the main factors associated with roll-bending force in reversing multi-pass rolling, such as strip width and rolling force, a preset mathematic model of bending force is developed by genetic algorithm. The simulation data demonstrate that the relative deviation of flatness criterions in each rolling pass is improved significantly and the mean relative deviation of all five passes is decreased from 25.1% to 1.7%. The model can keep good shape in multi-pass reversing cold rolling process with the high prediction accuracy and can be used to guide the production process. 展开更多
关键词 cold rolling mill STRIP bending force mathematic model genetic algorithm
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Failure analysis of polycrystalline diamond compact cutters for breaking rock by bending waves theory 被引量:7
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作者 龚声武 赵伏军 《Journal of Central South University of Technology》 EI 2008年第1期112-116,共5页
The breakage mechanism of the polycrystalline diamond compact(PDC) cutters was analyzed by the energy theory of bending waves. The cutting tests of granite block were conducted on a multifunctional testing device by u... The breakage mechanism of the polycrystalline diamond compact(PDC) cutters was analyzed by the energy theory of bending waves. The cutting tests of granite block were conducted on a multifunctional testing device by using the cutter at three kinds of negative fore angles of 30°, 45° and 60°. The results show that, when the edge of the PDC layer is broken, the layer of tungsten cobalt is broken a little under the angle of 30°, while the layer of tungsten cobalt is broken continuously under the angle of 60°, their maximum depths are about 2 and 7 mm respectively in the two cases. The eccentric distance mainly depends on the negative fore angle of the cutter. When the cutter thrusts into the rock under an attack angle of 60°, the energy of bending waves reaches the maximum since the eccentric distance is the maximum. So the damage of cutter is the most serious. This test result is consistent with the conclusion of theoretical analysis well. The eccentric distance from the axial line of cutter to the point of action between the rock and cutter has great effect on the breakage of the cutter. Thus during the process of cutting, the eccentric distance should be reduced to improve the service life of PDC cutters. 展开更多
关键词 polycrystalline diamond compact failure analysis breaking test energy theory of bending waves
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A Study on 3D FE Simulation Method of NC Bending Process of Thin-walled Tube 被引量:3
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作者 ZHAN Mei 1, YANG He 1, JIANG Zhi-qiang 2, ZHAO Zhen-son g 1, LIN Yan 1 (1. College of Materials Science and Engineering, Northwestern Polytech nical University, Xi’an 710072, China 2. Xi’an Heavy Machinery Research Institute, Xi’an 71003 2, China) 《厦门大学学报(自然科学版)》 CAS CSCD 北大核心 2002年第S1期73-74,共2页
The numerical control (NC) precision bending process of thin-walled tube is on e of advanced plastic forming processes with high efficiency, forming precision, strength/weight ratio and low cost, thus it is playing mo... The numerical control (NC) precision bending process of thin-walled tube is on e of advanced plastic forming processes with high efficiency, forming precision, strength/weight ratio and low cost, thus it is playing more and more important role in manufacturing parts in aerospace and automobile industries. However, the determination of parameters crucial to make sure tube parts qualified is heavil y experience-based and involves repeated trial-and-errors in practice, which makes the production efficiency reduce drastically and does not fulfill the deve lopment of high technology. With quick development of computer technology and gr adual perfect of plastic forming theory, computer numerical simulation based on finite element method (FEM) has become one of important tools of researching and developing plastic forming technology. Development trend of NC precision bendin g process of tube is simulating its forming process by FEM. Because NC tube bend ing is of 3D nature, it is of great importance to analyze the forming mechanism and find out the influence law of forming parameters on forming process in the N C precision bending process of thin-walled tube quantitatively by 3D FE simulat ion. Based on the rigid-plastic finite element method (FEM) principle, a 3-dimens ional (3D) rigid-plastic FE simulation system named TBS -3D (tube bending simu lation by 3D FEM) for the NC bending process of thin-walled tube has been devel oped, a reasonable FEM model has been established. By use of this FEM simulation system, a NC bending process of thin-walled has been simulated. And deformed m eshes under different bending stages, stress distribution along bending directio n, relationship between maximal wall thickness changing ratio and bending angle have been obtained. And then some forming laws of NC tube bending obtained are a s follows: (1) NC bending process make tube elongate to some extent; (2) Charact eristic of stress distribution is that the outer area is undergoing tensile stre ss, the inner area is undergoing compression stress, and stress neutral layer mo ves close to the inner area, which is in good accordance with the practice; (3) Maximal wall thinning ratio in the outer tensile area changes only a little with increase of bending angle, and maximal wall thickening ratio in the inner compr ession area increases linearly with bending angle. The above results show that 3 D FE simulation is an important and valid tool of analyzing NC bending process o f tube, this research is beneficial for the practical tube bending process, and it may serve as a significant guide to the practice of the relevant processes. 展开更多
关键词 tube forming NC bending process 3D FE simulatio n
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Bending performance of TRC-strengthened RC beams with secondary load under chloride erosion 被引量:4
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作者 YU Yu-lin YIN Shi-ping NA Ming-wang 《Journal of Central South University》 SCIE EI CAS CSCD 2019年第1期196-206,共11页
Textile reinforced concrete(TRC)has good bearing capacity,crack resistance and corrosion resistance and it is suitable for repairing and reinforcing concrete structures in harsh marine environments.The four-point bend... Textile reinforced concrete(TRC)has good bearing capacity,crack resistance and corrosion resistance and it is suitable for repairing and reinforcing concrete structures in harsh marine environments.The four-point bending method was used to analyze the influence of the salt concentration,the damage degree and the coupled effect of the environment and load on the bending performance of TRC-strengthened beams with a secondary load.The results showed that as the salt concentration increased,the crack width and mid-span deflection of the beam quickly increased,and its bearing capacity decreased.As the damage degree increased,the early-stage crack development and mid-span deflection of the beam were less affected and the ultimate bearing capacity significantly decreased.In addition,the coupled effect of the environment and load on the beams with a secondary load was significant.As the sustained load increased,the ultimate bearing capacity of the strengthened beam decreased,and cracks developed faster in the later stage.In addition,the mid-span deflection of the beam decreased at the same load level because of the influence of the initial deflection due to the sustained load corrosion. 展开更多
关键词 textile reinforced concrete bending performance secondary load sustained load corrosion
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Bending behaviour of lightweight aggregate concrete-filled steel tube spatial truss beam 被引量:4
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作者 傅中秋 吉伯海 +1 位作者 朱伟 葛汉彬 《Journal of Central South University》 SCIE EI CAS CSCD 2016年第8期2110-2117,共8页
A lightweight aggregate concrete-filled steel tube(LACFST) spatial truss beam was tested under bending load. The performance was studied by the analysis of the beam deflection and strains in its chords and webs. Accor... A lightweight aggregate concrete-filled steel tube(LACFST) spatial truss beam was tested under bending load. The performance was studied by the analysis of the beam deflection and strains in its chords and webs. According to the test results, several assumptions were made to deduce the bearing capacity calculation method based on the force balance of the whole section. An optimal dimension relationship for the truss beam chords was proposed and verified by finite element analysis. Results show that the LACFST spatial truss beam failed after excessive deflection. The strain distribution agreed with Bernoulli-Euler theoretical prediction. The truss beam flexural bearing capacity calculation results matched test evidence with only a 3% difference between the two. Finite element analyses with different chord dimensions show that the ultimate bearing capacity increases as the chord dimensions increase when the chords have a diameter smaller than optimal one; otherwise, it remains almost unchanged as the chord dimensions increase. 展开更多
关键词 lightweight aggregate concrete-filled steel tube spatial truss beam bending behaviour bearing capacity
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Bending analysis and control of rolled plate during snake hot rolling 被引量:6
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作者 张涛 吴运新 +2 位作者 龚海 郑细昭 蒋绍松 《Journal of Central South University》 SCIE EI CAS CSCD 2015年第7期2463-2469,共7页
In order to study the bending behavior of aluminum alloy 7050 thick plate during snake hot rolling, several coupled thermo-mechanical finite element(FE) models were established. Effects of different initial thicknesse... In order to study the bending behavior of aluminum alloy 7050 thick plate during snake hot rolling, several coupled thermo-mechanical finite element(FE) models were established. Effects of different initial thicknesses, pass reductions, speed ratios and offset distances on the bending value of the plate were analyzed. ‘Quasi smooth plate' and optimum offset distance were defined and quasi smooth plate could be acquired by adjusting offset distance, and then bending control equation was fitted. The results show that bending value of the plate as well as the extent of the increase grows with the increase of pass reduction and decrease of initial thickness; the bending value firstly increases and then keeps steady with the ascending speed ratio; the bending value can be reduced by enlarging the offset distance. The optimum offset distance varies for different rolling parameters and it is augmented with the increase of pass reduction and speed ratio and the decrease of initial thickness. A proper offset distance for different rolling parameters can be calculated by the bending control equation and this equation can be a guidance to acquire a quasi smooth plate. The FEM results agree well with experimental results. 展开更多
关键词 snake hot rolling bending analysis quasi smooth plate optimum offset distance bending control equation
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