A lightweight aggregate concrete-filled steel tube(LACFST) spatial truss beam was tested under bending load. The performance was studied by the analysis of the beam deflection and strains in its chords and webs. Accor...A lightweight aggregate concrete-filled steel tube(LACFST) spatial truss beam was tested under bending load. The performance was studied by the analysis of the beam deflection and strains in its chords and webs. According to the test results, several assumptions were made to deduce the bearing capacity calculation method based on the force balance of the whole section. An optimal dimension relationship for the truss beam chords was proposed and verified by finite element analysis. Results show that the LACFST spatial truss beam failed after excessive deflection. The strain distribution agreed with Bernoulli-Euler theoretical prediction. The truss beam flexural bearing capacity calculation results matched test evidence with only a 3% difference between the two. Finite element analyses with different chord dimensions show that the ultimate bearing capacity increases as the chord dimensions increase when the chords have a diameter smaller than optimal one; otherwise, it remains almost unchanged as the chord dimensions increase.展开更多
To study the effect of interface behaviour on the mechanical properties and damage evolution of PBX under combined tension-shear loading, the present work establishes the numerical model of a PBX three-phase hybrid sy...To study the effect of interface behaviour on the mechanical properties and damage evolution of PBX under combined tension-shear loading, the present work establishes the numerical model of a PBX three-phase hybrid system, which introduces a nonlinear plastic damage cohesion model to study the mechanical response and damage process. The parameters in the model were fitted and calibrated.Taking the crack growth rate as the feature, the damage state in each stage was determined, and the damage instability criterion was given. The effects of interfacial tensile strength and shear strength on the damage process of PBX were studied. On this basis, serrated and hemispherical structures interface of PBX has been developed, which affects the damage process and instability during the loading process.The results indicate that damage state response of PBX experiences the process of stable load bearing,unstable propagation, and complete failure. At the critical moment of instability, the overall equivalent effective strain of material reaches 3024 με and instability loading displacement reaches 0.39 mm. The increase of interfacial tensile strength and shear strength significantly inhibits the damage of PBX. The effect of interfacial shear strength on critical instability of PBX is approximately 1.7 times that of the interfacial tensile strength. Further, interface opening along the normal direction is the main damage form at the interface. Serrated and hemispherical rough interfaces can significantly inhibit propagation of cracks, and the load bearing capacity is improved by 22% and 9.7%, respectively. Appropriate improvement of the roughness of the interface structure can effectively improve the mechanical properties. It is significantly important to have a better understanding of deformation, damage and failure mechanisms of PBX and to improve our predictive ability.展开更多
Rock bolts have been widely used in slopes as a reinforcement measure.Modelling the shear mechanical behaviours of bolted rock joints is very complicated due to the complex factors that affect the axial force and shea...Rock bolts have been widely used in slopes as a reinforcement measure.Modelling the shear mechanical behaviours of bolted rock joints is very complicated due to the complex factors that affect the axial force and shear force on the bolts.Rock bolts under shear action exhibit the guide rail effect;that is,the rock mass slides along the rock bolt as if the rock bolt is a rail.The normal stress can inhibit the guide rail effect and reduce the axial force on bolts.However,this factor is not considered by the existing analysis models.Shear tests of bolted joints under different normal stresses were carried out in the laboratory.During the test,the axial force on each point monitored on the bolt was recorded by a strain gauge,and the attenuation trend of the strain was studied.An analytical model that considers the inhibition of the bolt rail effect due to an increase in the normal stress was proposed to predict the shear mechanical behaviour of rock bolted joints.The new model accommodates the bolt shear behaviours in the elastic stage and plastic stage,and the estimated values agree well with the results of the direct shear tests in the laboratory.The validation shows that the proposed model can effectively describe the deformation characteristics of the bolts in the shear tests.展开更多
Geogrid has been extensively used in geotechnical engineering practice due to its effectiveness and economy. Deep insight into the interaction between the backfill soil and the geogrid is of great importance for prope...Geogrid has been extensively used in geotechnical engineering practice due to its effectiveness and economy. Deep insight into the interaction between the backfill soil and the geogrid is of great importance for proper design and construction of geogrid reinforced earth structures. Based on the calibrated model of sand and geogrid, a series of numerical pullout tests are conducted using PFC^(3D) under special considerations of particle angularity and aperture geometry of the geogrid. In this work, interface characteristics regarding the displacement and contact force developed among particles and the deformation and force distribution along the geogrid are all visualized with PFC^(3D) simulations so that new understanding on how geogrid-soil interaction develops under pullout loads can be obtained. Meanwhile, a new variable named fabric anisotropy coefficient is introduced to evaluate the inherent relationship between macroscopic strength and microscopic fabric anisotropy. A correlation analysis is adopted to compare the accuracy between the newly-proposed coefficient and the most commonly used one. Furthermore, additional pullout tests on geogrid with four different joint protrusion heights have been conducted to investigate what extent and how vertical reinforcement elements may result in reinforcement effects from perspectives of bearing resistance contribution, energy dissipation, as well as volumetric response. Numerical results show that both the magnitude and the directional variation of normal contact forces govern the development of macroscopic strength and the reinforcing effects of joint protrusion height can be attributed to the accelerated energy dissipation across the particle assembly and the intensive mobilization of the geogrid.展开更多
The effect of T6I6 treatment on the dynamic mechanical and microstructure behaviour of Al-Si-Mg-Cu cast alloy was investigated using split Hopkinson pressure bar(SHPB), transmission electron microscopy(TEM), and highr...The effect of T6I6 treatment on the dynamic mechanical and microstructure behaviour of Al-Si-Mg-Cu cast alloy was investigated using split Hopkinson pressure bar(SHPB), transmission electron microscopy(TEM), and highresolution transmission electron microscopy(HRTEM). Besides, the impact resistances of T6I6 and T6 motor shells of new energy vehicles made of Al-Si-Mg-Cu cast alloy were compared using a trolley crash test. The results indicated that the main strengthening-phases of the T6 peak-aged and T6I6 peak-aged alloy were GP zone and β″ precipitates. T6I6treatment can increase the density and size of β″ precipitates in peak-aged alloy and enhance both its tensile strength(σb)and elongation(δ). The dynamic toughness values of T6I6 samples are 50.34 MJ/m^(3) at 2000 s^(-1) and 177.34 MJ/m^(3) at 5000 s^(-1) which are 20% and 12% higher than those of T6 samples, respectively. Compared with a T6 shell, the overall deformation of T6I6 shell is more uniform during the crash test. At an impact momentum of 3.5×10;kg·m/s, the T6I6shell breaks down at 0.38 s which is 0.10 s later than the T6 shell.展开更多
Fatigue is usually the cause for the cracks identified at bridge elements in service. With an increase in the introduction of corrugated steel web girders in recent highway bridge construction, the understanding of th...Fatigue is usually the cause for the cracks identified at bridge elements in service. With an increase in the introduction of corrugated steel web girders in recent highway bridge construction, the understanding of the fatigue behaviour of welded details in such structures becomes an important issue for the design. The typical welded details were represented as welded joints assembled by longitudinal corrugated plates. All the experiments were performed under fatigue loading using a servo-control testing machine. The test results from the failure mode observation with the aid of infrared thermo-graph technology show that the failure manner of these welded joints is comparable to that of the corrugated steel web beams reported previously. It is indicated from the stiffness degradation analysis that the welded joints with larger corrugation angle have higher stiffness and greater stiffness degradation in the notable stiffness degradation range. It is shown from the test S-N relations based on the free regression and forced regression analyses that there is a good linear dependence between lg(N) and lg(ΔS). It is also demonstrated that the proposed fracture mechanics analytical model is able to give a prediction slightly lower but on the safe side for the mean stresses at 2 million cycles of the test welded joints.展开更多
In the present study a phenomenological constitutive model is developed to describe the flow behaviour of 20MnMoNi55 low carbon reactor pressure vessel (RPV) steel at sub-zero temperature under different strain rates....In the present study a phenomenological constitutive model is developed to describe the flow behaviour of 20MnMoNi55 low carbon reactor pressure vessel (RPV) steel at sub-zero temperature under different strain rates. A set of uniaxial tensile tests is done with the variation of strain rates and temperature ranging from 10^-4s^-1 to 10^-1s^-1 and -80℃ to 140℃ respectively. From the experimental data, family of flow curves at different temperatures and strain rates are generated and fitted exponentially. The strain rate and temperature dependence of the coefficients of the exponential flow curves are extracted from these curves and characterised through a general phenomenological constitutive coupled equation. The coefficients of this coupled equation are optimised using genetic algorithm. Finite element simulation of tensile tests at different strain rates and temperatures are done using this coupled equation in material model of Abaqus FEA software and validated with experimental results. The novelties of proposed model are:(a) it can predict precisely the flow behaviour of tensile tests (b) it is a simple form of equation where fitting parameters are both function of strain rate ratio and temperature ratio,(c) it has ability to characterize flow behaviour with decreasing subzero temperatures and increasing strain rates.展开更多
Two experiments were carried out to study the grunting of sows during nursing and the sucking behaviour of piglets. In experimental Ⅰ,six Yorkshire sows and their litters were observed and managed in farrowing crate...Two experiments were carried out to study the grunting of sows during nursing and the sucking behaviour of piglets. In experimental Ⅰ,six Yorkshire sows and their litters were observed and managed in farrowing crates.In experimental Ⅱ,six Harbin White sows and their litters were selected and housed in farrowing pens.The behaviours and activities of the sows during nursing and the activities of piglets during sucking were recorded with a portable video camera(Panasonic NV-VX22EN) The results showed that the characteristic patterns of grunting by the sows consist of an initial period of rhythmic grunting at a fairly constant rate and followed by a period of more rapid grunting,and then a decline in grunting rate toward the completion of nursing.The pattern of vocalization showed by the mothers bears a reliable synchronization to the sucking behaviour of the piglets.The rate of grunting varied little during jostling for teat and nosing the udder.The beginning of slow sucking usually occurred during or just after the increase in grunt rate.The rapid sucking began 15～25 seconds after the period of most rapid grunting,following the decrease of grunt rate.afterwards the nursing ended.There were individualities found in sows'grunting patterns. It is found that vocalizations attracted the piglets to the sows and synchronized sucking activities of piglets,but the results indicated that the premassaging time and numbers of piglets engaging massaging influenced the grunting pattern and the onset of the milk ejection.As more piglets were involved the massaging,the higher the grunting rate peak,the faster the milk ejection.展开更多
Machine gun barrels differ from their rifle counterparts in terms of profile.To support high rates of sustained fire,machine gun barrels are made thicker in order to dissipate more heat and maintain their flexural rig...Machine gun barrels differ from their rifle counterparts in terms of profile.To support high rates of sustained fire,machine gun barrels are made thicker in order to dissipate more heat and maintain their flexural rigidity and thus accuracy,but on other hand they also contribute in weight addition to weapon.This investigation deals with comparison between a conventional machine gun barrel and an improved innovative design having T-fins,both having same weight and chambered in 5.56×45 NATO ammunition,to compare their structural and harmonic characteristics which were parameterized by factors such as modal spectrum,directional deformation at muzzle ends during a single shot fire and harmonic behaviour at corresponding range of exciting frequencies.The solid models of both the barrels having same weight,were created using Solidworks.The continuous input data functions were generated by MATLAB using the field tested discreet data points.The generated velocity-distance functions were converted into time dependent functions using integration algorithms to calculate transient parameters such as time steps,excitation frequency range,angle of rotation of projectile and its angular velocity.The dynamic condition simulated the varying nature of forces due to eccentricity in projectile and this data was fed to a time step study using ANSYS transient structural work bench followed by modal and harmonic analysis.The results showed a significant reduction in muzzle end deformation which thus proved that the T-finned barrel,although had same weight as that of the conventional one,but had better structural and harmonic characteristics,and hence it would inherit better firing accuracy.展开更多
Three breeds of sows were observed to investigate the relationship between Single Nucleotide Polymorphisms（SNPs） in Mu Opioid Receptor（MOR）and stereotypic behaviour,such as,sham-chewing,bar biting and standing sti...Three breeds of sows were observed to investigate the relationship between Single Nucleotide Polymorphisms（SNPs） in Mu Opioid Receptor（MOR）and stereotypic behaviour,such as,sham-chewing,bar biting and standing still in order to better understand the mechanism of stereotypic development of the animals in restrained conditions.MOR exon 2 partial sequences were amplified to analyze single nucleotide polymorphisms by PCR-SSCP.One SNP,a silence mutant was found.A significant difference （P〈0.01）was found in the frequency of genotypes in these 3 breeds where only the BB genotype,which was identical to that published in GenBank,was found in the Duroc breed,while no AA genotype was found in Landrace,3 genotypes AA,BB and AB were found in Yorkshire.The result also indicated that the individuals with AA and AB genotypes tended to be more active in sham-chewing than those with the BB genotype（P〈0.05）.The overall results of this study suggested that sham-chewing of sows may be subjected to both genetic control and environmental conditions,but activity level was more likely to be affected by their environment.We can putatively draw the conclusion that MOR gene has effect on the sham-chewing behavioral traits of sow.展开更多
Methcathinone,a widely abused synthetic cathinone,poses a significant public health risk because of its severe neurotoxicity and high addictive potential.In this study,we used a zebrafish model to investigate the mech...Methcathinone,a widely abused synthetic cathinone,poses a significant public health risk because of its severe neurotoxicity and high addictive potential.In this study,we used a zebrafish model to investigate the mechanisms underlying its neurobehavioural effects.Methcathinone exposure reduced larval survival and induced a range of abnormal behaviours.Most notably,conditioned place preference(CPP)tests demonstrated the potent rewarding properties of methcathinone,as shown by a significant 22.2%increase in time spent in the drug-paired light zone compared with baseline(P<0.01).Transcriptomic analysis of brain tissue revealed systemic disruption of the neuroactive ligand-receptor interaction pathway.Gene set enrichment analysis(GSEA)further revealed significant suppression ofγ-aminobutyric acid(GABA)signalling(NES=-1.64,P<0.05)and glutamate receptor signalling,including ionotropic and AMPA receptor signalling(P<0.05).Quantitative PCR validation confirmed the marked downregulation of key genes involved in these pathways:the mRNA expression of GABAergic receptors(e.g.,gabra 1 and gabra 2),glutamatergic receptors(e.g.,gria 2 and grin2B),and the dopamine transporter slc6a3 decreased by 67.0%to 97.9%(all P<0.01).These results suggest that methcathinone drives reward-seeking behaviour through a synergistic dual-target mechanism;specifically,the concurrent suppression of GABAergic inhibition and slc6a3-mediated reuptake likely facilitates dopaminergic hyperactivity,whereas the downregulation of glutamate receptors reflects a homeostatic response to overstimulation.Our findings provide novel mechanistic insight into the development of methcathinone use disorder in humans.展开更多
目的系统梳理行为理论和模型在药学实践研究中的应用现状,总结其应用特点、作用与价值。方法采用范围综述法,检索Web of Science、PubMed、Embase、Cochrane Library及中国知网、万方数据库、维普中文科技期刊数据库、中国生物医学数据...目的系统梳理行为理论和模型在药学实践研究中的应用现状,总结其应用特点、作用与价值。方法采用范围综述法,检索Web of Science、PubMed、Embase、Cochrane Library及中国知网、万方数据库、维普中文科技期刊数据库、中国生物医学数据库中所有使用行为理论或模型的药学实践相关文章,检索期限为建库至2025年3月31日。由2名研究者独立对纳入的文献数据进行汇总、筛选、归类及分析。结果共检索到文献1669篇,最终纳入110篇。通过文献分析,提取出药学实践中5个高频使用理论模型,依次为计划行为理论(TPB)、跨理论模型(TTM)、行为改变理论(COM-B)、健康信念模型(HBM)、社会认知理论(SCT),国内外药学实践研究常用理论模型及围绕主题存在一定差异。大多数研究采用单一理论模型,国内外最常见的组合分别是TPB与TTM、COM-B与理论领域框架(TDF)。研究多属于英国医学研究委员会(UK MRC)复杂干预研究框架中的前2个阶段。国外研究人员主要为药学人员及卫生管理部门,而我国主要为护理人员,其次为药学人员。结论我国药学实践研究尚处于起步阶段,有必要借鉴国际经验,明确研究问题并选择合适的理论模型,提高药学服务有效性和可持续性的同时提高研究的科学性和实用性,推动国内药学实践研究的发展。展开更多
基金Project(51208176)supported by the National Natural Science Foundation of ChinaProjects(2012M511187,2013T60493)supported by the China Postdoctoral Science FoundationProject(2015B17414)supported by the Fundamental Research Funds for the Central Universities,China
文摘A lightweight aggregate concrete-filled steel tube(LACFST) spatial truss beam was tested under bending load. The performance was studied by the analysis of the beam deflection and strains in its chords and webs. According to the test results, several assumptions were made to deduce the bearing capacity calculation method based on the force balance of the whole section. An optimal dimension relationship for the truss beam chords was proposed and verified by finite element analysis. Results show that the LACFST spatial truss beam failed after excessive deflection. The strain distribution agreed with Bernoulli-Euler theoretical prediction. The truss beam flexural bearing capacity calculation results matched test evidence with only a 3% difference between the two. Finite element analyses with different chord dimensions show that the ultimate bearing capacity increases as the chord dimensions increase when the chords have a diameter smaller than optimal one; otherwise, it remains almost unchanged as the chord dimensions increase.
基金the China National Nature Science Foundation (Grant No. 11872119)China Postdoctoral Science Foundation (Grant Nos. BX20200046, 2020M680394)Pre-research Project of Armament (Grant No. 6142A03202002) for supporting this project
文摘To study the effect of interface behaviour on the mechanical properties and damage evolution of PBX under combined tension-shear loading, the present work establishes the numerical model of a PBX three-phase hybrid system, which introduces a nonlinear plastic damage cohesion model to study the mechanical response and damage process. The parameters in the model were fitted and calibrated.Taking the crack growth rate as the feature, the damage state in each stage was determined, and the damage instability criterion was given. The effects of interfacial tensile strength and shear strength on the damage process of PBX were studied. On this basis, serrated and hemispherical structures interface of PBX has been developed, which affects the damage process and instability during the loading process.The results indicate that damage state response of PBX experiences the process of stable load bearing,unstable propagation, and complete failure. At the critical moment of instability, the overall equivalent effective strain of material reaches 3024 με and instability loading displacement reaches 0.39 mm. The increase of interfacial tensile strength and shear strength significantly inhibits the damage of PBX. The effect of interfacial shear strength on critical instability of PBX is approximately 1.7 times that of the interfacial tensile strength. Further, interface opening along the normal direction is the main damage form at the interface. Serrated and hemispherical rough interfaces can significantly inhibit propagation of cracks, and the load bearing capacity is improved by 22% and 9.7%, respectively. Appropriate improvement of the roughness of the interface structure can effectively improve the mechanical properties. It is significantly important to have a better understanding of deformation, damage and failure mechanisms of PBX and to improve our predictive ability.
基金Projects(41931295,41877258)supported by the National Natural Science Foundation of ChinaProject(2017YFC1501305)supported by the National Key Research and Development Program of China。
文摘Rock bolts have been widely used in slopes as a reinforcement measure.Modelling the shear mechanical behaviours of bolted rock joints is very complicated due to the complex factors that affect the axial force and shear force on the bolts.Rock bolts under shear action exhibit the guide rail effect;that is,the rock mass slides along the rock bolt as if the rock bolt is a rail.The normal stress can inhibit the guide rail effect and reduce the axial force on bolts.However,this factor is not considered by the existing analysis models.Shear tests of bolted joints under different normal stresses were carried out in the laboratory.During the test,the axial force on each point monitored on the bolt was recorded by a strain gauge,and the attenuation trend of the strain was studied.An analytical model that considers the inhibition of the bolt rail effect due to an increase in the normal stress was proposed to predict the shear mechanical behaviour of rock bolted joints.The new model accommodates the bolt shear behaviours in the elastic stage and plastic stage,and the estimated values agree well with the results of the direct shear tests in the laboratory.The validation shows that the proposed model can effectively describe the deformation characteristics of the bolts in the shear tests.
基金Projects(51278216,51478201)supported by the National Natural Science Foundation of China
文摘Geogrid has been extensively used in geotechnical engineering practice due to its effectiveness and economy. Deep insight into the interaction between the backfill soil and the geogrid is of great importance for proper design and construction of geogrid reinforced earth structures. Based on the calibrated model of sand and geogrid, a series of numerical pullout tests are conducted using PFC^(3D) under special considerations of particle angularity and aperture geometry of the geogrid. In this work, interface characteristics regarding the displacement and contact force developed among particles and the deformation and force distribution along the geogrid are all visualized with PFC^(3D) simulations so that new understanding on how geogrid-soil interaction develops under pullout loads can be obtained. Meanwhile, a new variable named fabric anisotropy coefficient is introduced to evaluate the inherent relationship between macroscopic strength and microscopic fabric anisotropy. A correlation analysis is adopted to compare the accuracy between the newly-proposed coefficient and the most commonly used one. Furthermore, additional pullout tests on geogrid with four different joint protrusion heights have been conducted to investigate what extent and how vertical reinforcement elements may result in reinforcement effects from perspectives of bearing resistance contribution, energy dissipation, as well as volumetric response. Numerical results show that both the magnitude and the directional variation of normal contact forces govern the development of macroscopic strength and the reinforcing effects of joint protrusion height can be attributed to the accelerated energy dissipation across the particle assembly and the intensive mobilization of the geogrid.
基金Projects(52075166, 51875197) supported by the National Natural Science Foundation of ChinaProjects(2019RS2064,2019GK5043) supported by the Science and Technology Planning Project of Hunan Province,China。
文摘The effect of T6I6 treatment on the dynamic mechanical and microstructure behaviour of Al-Si-Mg-Cu cast alloy was investigated using split Hopkinson pressure bar(SHPB), transmission electron microscopy(TEM), and highresolution transmission electron microscopy(HRTEM). Besides, the impact resistances of T6I6 and T6 motor shells of new energy vehicles made of Al-Si-Mg-Cu cast alloy were compared using a trolley crash test. The results indicated that the main strengthening-phases of the T6 peak-aged and T6I6 peak-aged alloy were GP zone and β″ precipitates. T6I6treatment can increase the density and size of β″ precipitates in peak-aged alloy and enhance both its tensile strength(σb)and elongation(δ). The dynamic toughness values of T6I6 samples are 50.34 MJ/m^(3) at 2000 s^(-1) and 177.34 MJ/m^(3) at 5000 s^(-1) which are 20% and 12% higher than those of T6 samples, respectively. Compared with a T6 shell, the overall deformation of T6I6 shell is more uniform during the crash test. At an impact momentum of 3.5×10;kg·m/s, the T6I6shell breaks down at 0.38 s which is 0.10 s later than the T6 shell.
基金Projects(51308363,11327801)supported by the National Natural Science Foundation of ChinaProject(2013-1792-9-4)supported by the Scientific Research Foundation for the Returned Overseas Chinese ScholarsProject(YJ201307)supported by the Start-up Research Fund for Introduced Talents of Sichuan University,China
文摘Fatigue is usually the cause for the cracks identified at bridge elements in service. With an increase in the introduction of corrugated steel web girders in recent highway bridge construction, the understanding of the fatigue behaviour of welded details in such structures becomes an important issue for the design. The typical welded details were represented as welded joints assembled by longitudinal corrugated plates. All the experiments were performed under fatigue loading using a servo-control testing machine. The test results from the failure mode observation with the aid of infrared thermo-graph technology show that the failure manner of these welded joints is comparable to that of the corrugated steel web beams reported previously. It is indicated from the stiffness degradation analysis that the welded joints with larger corrugation angle have higher stiffness and greater stiffness degradation in the notable stiffness degradation range. It is shown from the test S-N relations based on the free regression and forced regression analyses that there is a good linear dependence between lg(N) and lg(ΔS). It is also demonstrated that the proposed fracture mechanics analytical model is able to give a prediction slightly lower but on the safe side for the mean stresses at 2 million cycles of the test welded joints.
文摘In the present study a phenomenological constitutive model is developed to describe the flow behaviour of 20MnMoNi55 low carbon reactor pressure vessel (RPV) steel at sub-zero temperature under different strain rates. A set of uniaxial tensile tests is done with the variation of strain rates and temperature ranging from 10^-4s^-1 to 10^-1s^-1 and -80℃ to 140℃ respectively. From the experimental data, family of flow curves at different temperatures and strain rates are generated and fitted exponentially. The strain rate and temperature dependence of the coefficients of the exponential flow curves are extracted from these curves and characterised through a general phenomenological constitutive coupled equation. The coefficients of this coupled equation are optimised using genetic algorithm. Finite element simulation of tensile tests at different strain rates and temperatures are done using this coupled equation in material model of Abaqus FEA software and validated with experimental results. The novelties of proposed model are:(a) it can predict precisely the flow behaviour of tensile tests (b) it is a simple form of equation where fitting parameters are both function of strain rate ratio and temperature ratio,(c) it has ability to characterize flow behaviour with decreasing subzero temperatures and increasing strain rates.
文摘Two experiments were carried out to study the grunting of sows during nursing and the sucking behaviour of piglets. In experimental Ⅰ,six Yorkshire sows and their litters were observed and managed in farrowing crates.In experimental Ⅱ,six Harbin White sows and their litters were selected and housed in farrowing pens.The behaviours and activities of the sows during nursing and the activities of piglets during sucking were recorded with a portable video camera(Panasonic NV-VX22EN) The results showed that the characteristic patterns of grunting by the sows consist of an initial period of rhythmic grunting at a fairly constant rate and followed by a period of more rapid grunting,and then a decline in grunting rate toward the completion of nursing.The pattern of vocalization showed by the mothers bears a reliable synchronization to the sucking behaviour of the piglets.The rate of grunting varied little during jostling for teat and nosing the udder.The beginning of slow sucking usually occurred during or just after the increase in grunt rate.The rapid sucking began 15～25 seconds after the period of most rapid grunting,following the decrease of grunt rate.afterwards the nursing ended.There were individualities found in sows'grunting patterns. It is found that vocalizations attracted the piglets to the sows and synchronized sucking activities of piglets,but the results indicated that the premassaging time and numbers of piglets engaging massaging influenced the grunting pattern and the onset of the milk ejection.As more piglets were involved the massaging,the higher the grunting rate peak,the faster the milk ejection.
文摘Machine gun barrels differ from their rifle counterparts in terms of profile.To support high rates of sustained fire,machine gun barrels are made thicker in order to dissipate more heat and maintain their flexural rigidity and thus accuracy,but on other hand they also contribute in weight addition to weapon.This investigation deals with comparison between a conventional machine gun barrel and an improved innovative design having T-fins,both having same weight and chambered in 5.56×45 NATO ammunition,to compare their structural and harmonic characteristics which were parameterized by factors such as modal spectrum,directional deformation at muzzle ends during a single shot fire and harmonic behaviour at corresponding range of exciting frequencies.The solid models of both the barrels having same weight,were created using Solidworks.The continuous input data functions were generated by MATLAB using the field tested discreet data points.The generated velocity-distance functions were converted into time dependent functions using integration algorithms to calculate transient parameters such as time steps,excitation frequency range,angle of rotation of projectile and its angular velocity.The dynamic condition simulated the varying nature of forces due to eccentricity in projectile and this data was fed to a time step study using ANSYS transient structural work bench followed by modal and harmonic analysis.The results showed a significant reduction in muzzle end deformation which thus proved that the T-finned barrel,although had same weight as that of the conventional one,but had better structural and harmonic characteristics,and hence it would inherit better firing accuracy.
基金Supported by National Natural Sciences Foundation of China(39970533)
文摘Three breeds of sows were observed to investigate the relationship between Single Nucleotide Polymorphisms（SNPs） in Mu Opioid Receptor（MOR）and stereotypic behaviour,such as,sham-chewing,bar biting and standing still in order to better understand the mechanism of stereotypic development of the animals in restrained conditions.MOR exon 2 partial sequences were amplified to analyze single nucleotide polymorphisms by PCR-SSCP.One SNP,a silence mutant was found.A significant difference （P〈0.01）was found in the frequency of genotypes in these 3 breeds where only the BB genotype,which was identical to that published in GenBank,was found in the Duroc breed,while no AA genotype was found in Landrace,3 genotypes AA,BB and AB were found in Yorkshire.The result also indicated that the individuals with AA and AB genotypes tended to be more active in sham-chewing than those with the BB genotype（P〈0.05）.The overall results of this study suggested that sham-chewing of sows may be subjected to both genetic control and environmental conditions,but activity level was more likely to be affected by their environment.We can putatively draw the conclusion that MOR gene has effect on the sham-chewing behavioral traits of sow.
基金Supported by the Natural Science Foundation of Zhejiang Province(No.LTGY23H230001,LGF19H280003)。
文摘Methcathinone,a widely abused synthetic cathinone,poses a significant public health risk because of its severe neurotoxicity and high addictive potential.In this study,we used a zebrafish model to investigate the mechanisms underlying its neurobehavioural effects.Methcathinone exposure reduced larval survival and induced a range of abnormal behaviours.Most notably,conditioned place preference(CPP)tests demonstrated the potent rewarding properties of methcathinone,as shown by a significant 22.2%increase in time spent in the drug-paired light zone compared with baseline(P<0.01).Transcriptomic analysis of brain tissue revealed systemic disruption of the neuroactive ligand-receptor interaction pathway.Gene set enrichment analysis(GSEA)further revealed significant suppression ofγ-aminobutyric acid(GABA)signalling(NES=-1.64,P<0.05)and glutamate receptor signalling,including ionotropic and AMPA receptor signalling(P<0.05).Quantitative PCR validation confirmed the marked downregulation of key genes involved in these pathways:the mRNA expression of GABAergic receptors(e.g.,gabra 1 and gabra 2),glutamatergic receptors(e.g.,gria 2 and grin2B),and the dopamine transporter slc6a3 decreased by 67.0%to 97.9%(all P<0.01).These results suggest that methcathinone drives reward-seeking behaviour through a synergistic dual-target mechanism;specifically,the concurrent suppression of GABAergic inhibition and slc6a3-mediated reuptake likely facilitates dopaminergic hyperactivity,whereas the downregulation of glutamate receptors reflects a homeostatic response to overstimulation.Our findings provide novel mechanistic insight into the development of methcathinone use disorder in humans.
文摘目的系统梳理行为理论和模型在药学实践研究中的应用现状,总结其应用特点、作用与价值。方法采用范围综述法,检索Web of Science、PubMed、Embase、Cochrane Library及中国知网、万方数据库、维普中文科技期刊数据库、中国生物医学数据库中所有使用行为理论或模型的药学实践相关文章,检索期限为建库至2025年3月31日。由2名研究者独立对纳入的文献数据进行汇总、筛选、归类及分析。结果共检索到文献1669篇,最终纳入110篇。通过文献分析,提取出药学实践中5个高频使用理论模型,依次为计划行为理论(TPB)、跨理论模型(TTM)、行为改变理论(COM-B)、健康信念模型(HBM)、社会认知理论(SCT),国内外药学实践研究常用理论模型及围绕主题存在一定差异。大多数研究采用单一理论模型,国内外最常见的组合分别是TPB与TTM、COM-B与理论领域框架(TDF)。研究多属于英国医学研究委员会(UK MRC)复杂干预研究框架中的前2个阶段。国外研究人员主要为药学人员及卫生管理部门,而我国主要为护理人员,其次为药学人员。结论我国药学实践研究尚处于起步阶段,有必要借鉴国际经验,明确研究问题并选择合适的理论模型,提高药学服务有效性和可持续性的同时提高研究的科学性和实用性,推动国内药学实践研究的发展。
