The bridge between macro and micro scale has been arousing people’s attention for years.As for the vessel wall,the link between material property and microstructural network remains unknown,leaving potential possibil...The bridge between macro and micro scale has been arousing people’s attention for years.As for the vessel wall,the link between material property and microstructural network remains unknown,leaving potential possibility to discover the intrinsic mechanism of biological compound material.The objective of the study is to perform a novel analysis method to investigate how microstructure unit contributes to its mechanical characteristics and what kind of factors relating to macro properties of vessel wall may affect its micro characteristics.In this study,we chose to employ a texture analysis to describe and measure spatial network-like structure and collagen fiber alignment patterns in abdominal aorta,femoral artery and carotid artery of rats,respectively.Several first order texture statistics and second order texture statistics have been selected to be embedded into a feature matrix to characterize significance structural distinction(P<0.01)of the aforementioned types of arteries.Also,aging would also be considered as a chronic factor to affect microstructural network.The featuring matrix was then used for training a SVM classifier to predict the artery’s types,age and mechanical properties based on mechanical tests data.(Accuracy=0.86)This analysis methodreveals the link between micro and macro scale of arterial mechanics and more findings will be uncovered based on the framework in the future.展开更多
Objective All aneurysm coiling procedures were performed with Intravenous(IV) anesthesia in our department. We have reviewed our clinical experiences. Material and Methods Since June 1996 aneurysm coiling was attempte...Objective All aneurysm coiling procedures were performed with Intravenous(IV) anesthesia in our department. We have reviewed our clinical experiences. Material and Methods Since June 1996 aneurysm coiling was attempted with IV anesthesia in 542 procedures. From June 1996 to Feb 2002 only propofol administrated for anesthesia (362 case) after Feb 2002 to June 2004 alfentanil combinded (180 case). Target-controlled infusion (TCI) of alfentanil concentration 0.2 μg/kg/min and propofol at rates were varied up and down depending on systolic blood pressure (Bolus dosage: 6 μg/kg/min Loading dosage: 40-100 μg/kg/min). Systolic and diastolic blood pressure, heart rate, respiratory depression (SpO2<95%), involuntary movement were checked during the operation. Mean infusion rates of alfentanil were 0.1-0.2 μg/kg/min and propofol were 30-70 μg/kg/min. Mean anesthesia time takes 2hours. Conclusions Aneurysm coiling performed using IV anesthesia is a feasible and effective method.展开更多
基金supported by the National Natural Science Foundation of China ( 11732001)
文摘The bridge between macro and micro scale has been arousing people’s attention for years.As for the vessel wall,the link between material property and microstructural network remains unknown,leaving potential possibility to discover the intrinsic mechanism of biological compound material.The objective of the study is to perform a novel analysis method to investigate how microstructure unit contributes to its mechanical characteristics and what kind of factors relating to macro properties of vessel wall may affect its micro characteristics.In this study,we chose to employ a texture analysis to describe and measure spatial network-like structure and collagen fiber alignment patterns in abdominal aorta,femoral artery and carotid artery of rats,respectively.Several first order texture statistics and second order texture statistics have been selected to be embedded into a feature matrix to characterize significance structural distinction(P<0.01)of the aforementioned types of arteries.Also,aging would also be considered as a chronic factor to affect microstructural network.The featuring matrix was then used for training a SVM classifier to predict the artery’s types,age and mechanical properties based on mechanical tests data.(Accuracy=0.86)This analysis methodreveals the link between micro and macro scale of arterial mechanics and more findings will be uncovered based on the framework in the future.
文摘Objective All aneurysm coiling procedures were performed with Intravenous(IV) anesthesia in our department. We have reviewed our clinical experiences. Material and Methods Since June 1996 aneurysm coiling was attempted with IV anesthesia in 542 procedures. From June 1996 to Feb 2002 only propofol administrated for anesthesia (362 case) after Feb 2002 to June 2004 alfentanil combinded (180 case). Target-controlled infusion (TCI) of alfentanil concentration 0.2 μg/kg/min and propofol at rates were varied up and down depending on systolic blood pressure (Bolus dosage: 6 μg/kg/min Loading dosage: 40-100 μg/kg/min). Systolic and diastolic blood pressure, heart rate, respiratory depression (SpO2<95%), involuntary movement were checked during the operation. Mean infusion rates of alfentanil were 0.1-0.2 μg/kg/min and propofol were 30-70 μg/kg/min. Mean anesthesia time takes 2hours. Conclusions Aneurysm coiling performed using IV anesthesia is a feasible and effective method.
