Cell membranes actively participate in numerous cellular functions.Inasmuch as bioactivities of cell membranes are known to depend crucially on their lateral organization,much effort has been focused on deciphering th...Cell membranes actively participate in numerous cellular functions.Inasmuch as bioactivities of cell membranes are known to depend crucially on their lateral organization,much effort has been focused on deciphering this organization on different length scales.Within this context,the concept of lipid-dependent membrane domains,the so-called lipid rafts,has been intensively scrutinized over recent years~[1].Using fluorescent correlation spectroscopy(FCS)that has the ability to measure diffusion parameters with great precision,in association with original experimental strategies,we have probed modes of protein and lipid lateral dynamics within the plasma membrane of living cells.These investigations have allowed significant progress展开更多
The relative abilities of several chelating agents to act as antagonists for acute and chronic lead poisoning have been examined in the mouse.The acute LD<sub>50</sub> for lead acetate trihydrate was deter...The relative abilities of several chelating agents to act as antagonists for acute and chronic lead poisoning have been examined in the mouse.The acute LD<sub>50</sub> for lead acetate trihydrate was determined and found to be 135.3 mg Pb/kg for i. p. injection with a 95% confidence interval of 87.1 to 210.3 mg Pb/kg. The relative efficacy of chelating agents to reduce liver,kidney, spleen, bone and brain levels of lead was determined. The spleen levels were found to undergo little differences between the control and treated groups, but the liver, kidney, bone and brain levels showed significant differences in some cases. Of the compounds examind, meso-2, 3-dimercaptosuccinic acid （DMSA）and sodium 2,3-dimercaptopropane-1-sulfonate（DMPS） were as effective as disodium calcium ethylenediaminetetraacetate （Na<sub>2</sub>CaEDT A）. The resuits indicated that DMSA was a promising chelating agent and may be worthy of further investigation in the clinic.展开更多
Based on bounded network-induced time-delay, the networked control system is modeled as a linear time-variant singular system. Using the Lyapunov theory and the linear matrix inequality approach, the criteria for dela...Based on bounded network-induced time-delay, the networked control system is modeled as a linear time-variant singular system. Using the Lyapunov theory and the linear matrix inequality approach, the criteria for delay-independent stability and delay-dependent stability of singular networked control systems are derived and transformed to a feasibility problem of linear matrix inequality formulation, which can be solved by the Matlab LMI toolbox, and the feasible solutions provide the maximum allowable delay bound that makes the system stable. A numerical example is provided, which shows that the analysis method is valid and the stability criteria are feasible.展开更多
基金supported by institutional grants from INSERM and CNRSspecific grants from the Agence Nationale de la Recherche(ANR-08-PCVI-0034ANR-10-BLAN-1509)
文摘Cell membranes actively participate in numerous cellular functions.Inasmuch as bioactivities of cell membranes are known to depend crucially on their lateral organization,much effort has been focused on deciphering this organization on different length scales.Within this context,the concept of lipid-dependent membrane domains,the so-called lipid rafts,has been intensively scrutinized over recent years~[1].Using fluorescent correlation spectroscopy(FCS)that has the ability to measure diffusion parameters with great precision,in association with original experimental strategies,we have probed modes of protein and lipid lateral dynamics within the plasma membrane of living cells.These investigations have allowed significant progress
文摘The relative abilities of several chelating agents to act as antagonists for acute and chronic lead poisoning have been examined in the mouse.The acute LD<sub>50</sub> for lead acetate trihydrate was determined and found to be 135.3 mg Pb/kg for i. p. injection with a 95% confidence interval of 87.1 to 210.3 mg Pb/kg. The relative efficacy of chelating agents to reduce liver,kidney, spleen, bone and brain levels of lead was determined. The spleen levels were found to undergo little differences between the control and treated groups, but the liver, kidney, bone and brain levels showed significant differences in some cases. Of the compounds examind, meso-2, 3-dimercaptosuccinic acid （DMSA）and sodium 2,3-dimercaptopropane-1-sulfonate（DMPS） were as effective as disodium calcium ethylenediaminetetraacetate （Na<sub>2</sub>CaEDT A）. The resuits indicated that DMSA was a promising chelating agent and may be worthy of further investigation in the clinic.
基金the National Natural Science Foundation of China (60574011)the National Natural Science Foundation of Liaoning Province (2050770).
文摘Based on bounded network-induced time-delay, the networked control system is modeled as a linear time-variant singular system. Using the Lyapunov theory and the linear matrix inequality approach, the criteria for delay-independent stability and delay-dependent stability of singular networked control systems are derived and transformed to a feasibility problem of linear matrix inequality formulation, which can be solved by the Matlab LMI toolbox, and the feasible solutions provide the maximum allowable delay bound that makes the system stable. A numerical example is provided, which shows that the analysis method is valid and the stability criteria are feasible.
