The United States Food and Drug Administration's(FDA's)August 2024 determination that an additional phase Ⅱ study will be required to consider the approval of midomafetamine for the treatment of posttraumatic...The United States Food and Drug Administration's(FDA's)August 2024 determination that an additional phase Ⅱ study will be required to consider the approval of midomafetamine for the treatment of posttraumatic stress disorder(PTSD)could delay the potential approval of this promising treatment by several years.展开更多
The Annual Report on Cardiovascular Health and Diseases in China(2022)intricate landscape of cardiovascular health in China.In connection with the previous section,this ninth section of the report offers a comprehensi...The Annual Report on Cardiovascular Health and Diseases in China(2022)intricate landscape of cardiovascular health in China.In connection with the previous section,this ninth section of the report offers a comprehensive analysis of valvular heart disease and cardiomyopathy.Although rheumatic valve disease is still the main cause of valvular heart disease in China,with the aging of the population and the improvement of living standards,the prevalence of degenerative valvular heart disease is on the rise.Because many patients with valvular heart disease have only mild to moderate valve stenosis or insufficiency,and no symptoms,the detection rate in the population is low and late,resulting in many patients been in the severe late stage of disease at visit,increasing the difficulty of treatment and affecting effectiveness and prognosis.Therefore,we should strengthen the examination and screening of valvular heart disease in order to find and prevent it as early as possible.In addition,compared with other diseases,the treatment of valvular heart disease needs more and higher technical support(surgery,intervention,etc).However,not all hospitals can provide relevant technologies.At present,the treatment of valvular heart disease is still mainly concentrated in the provincial hospitals.It is necessary to carry out more professional training so that more doctors and hospitals can participate in the treatment of valvular heart disease.Cardiomyopathy is a group of myocardial diseases with abnormal myocardial structure and/or function,but couldn't be explained by hypertension,coronary atherosclerosis,valvular heart disease and congenital heart disease.It includes hypertrophic cardiomyopathy(HCM),dilated cardiomyopathy(DCM),arrhythmogenic cardiomyopathy(also known as arrhythmogenic right ventricular cardiomyopathy),restrictive cardiomyopathy(RCM)and undifferentiated cardiomyopathy.展开更多
During injection treatments, bottomhole pressure measurements may significantly mismatch modeling results. We devise a computationally effective technique for interpretation of fluid injection in a wellbore interval w...During injection treatments, bottomhole pressure measurements may significantly mismatch modeling results. We devise a computationally effective technique for interpretation of fluid injection in a wellbore interval with multiple geological layers based on the bottomhole pressure measurements. The permeability, porosity and compressibility in each layer are initially setup, while the skin factor and partitioning of injected fluids among the zones during the injection are found as a solution of the problem. The problem takes into account Darcy flow and chemical interactions between the injected acids, diverter fluids and reservoir rock typical in modern matrix acidizing treatments. Using the synchronously recorded injection rate and bottomhole pressure, we evaluate skin factor changes in each layer and actual fluid placement into the reservoir during different pumping jobs: matrix acidizing, water control, sand control, scale squeezes and water flooding. The model is validated by comparison with a simulator used in industry. It gives opportunity to estimate efficiency of a matrix treatment job, role of every injection stage, and control fluid delivery to each layer in real time. The presented interpretation technique significantly improves accuracy of matrix treatments analysis by coupling the hydrodynamic model with records of pressure and injection rate during the treatment.展开更多
A study was conducted to determine the influences of initial planting densities, thinning intensities, exposures and slope sites on physical property （wood density） and mechanical properties such as modulus of elast...A study was conducted to determine the influences of initial planting densities, thinning intensities, exposures and slope sites on physical property （wood density） and mechanical properties such as modulus of elasticity （MOE）, bending strength, impact strength, compression strength along grain and hardness） of Pinus sylvestris var. mongolica plantation in Mao＇ershan Forest Farm, Northeast China. Results show that the different initial planting densities （1.5 m×1.0 m, 1.5 m×2.0 m and 1.5 m×2.5 m） had significant effects on wood density and MOE, and the highest mean wood density and indexes of mechanical properties occurred in the stand with an initial planting density of 1.5 m×1.0 m. The indexes of mechanical properties such as hardness of end, bending strength, MOE and compression strength along grain of wood increased after mild thinning, but decreased after violent thinning. The exposures （sunny slope and shady slope） had a significant effect on MOE, and the highest mean MOE occurred on sunny slope. The slope sites （upper site and lower site） had a significant effect on wood density and main mechanical properties, except hardness. The highest mean wood density and mechanical properties occurred at lower site.展开更多
Dalbergia sissoo Roxb. is one of the promising multipurpose tree species of South Asia. Most of the plantations of D. sissoo from seeds are facing severe threats due to the die-back disease, which ultimately causes de...Dalbergia sissoo Roxb. is one of the promising multipurpose tree species of South Asia. Most of the plantations of D. sissoo from seeds are facing severe threats due to the die-back disease, which ultimately causes death of this potential tree-species within a few months. Vegetative propagation could avoid the die-back disease. Thirty mother trees of different age-groups of D. sissoo were selected for evaluating the rooting behaviour of branch cuttings from D. sissoo as influenced by auxins （IAA or IBA at 100, 200, 500 mg·L^-1）, ages of mother trees （10, 4 and 2 years old） and different environment conditions, i.e., different mediums （soil and sand） or light conditions （in shade and open condition）. The results show that application of IAA and IBA induced more numbers of cuttings （collected from 10-year-old mother trees） to root compared to control. Branch cuttings of D. sissoo collected from 10-year-old mother trees and planted in soil bed in open conditions had 100.0% of cuttings to root in IAA （100 mg·L^-1） and IBA （200 mg·L^-1） treatments. Both rooting medium （Soil and sand） influenced significantly （p〈0.05） on rooting response of branch cuttings. Soil medium was found to achieve maximum no. of branch cuttings to root, compared to sand medium.展开更多
Albizia saman （Jacq.） F. Muell. commonly known as rain tree seeds were treated with five pre-sowing treatments to study the effect of pre-sowing treatments on germination and initial seedling development in the nurs...Albizia saman （Jacq.） F. Muell. commonly known as rain tree seeds were treated with five pre-sowing treatments to study the effect of pre-sowing treatments on germination and initial seedling development in the nursery.The experiment was established in the nursery of the Institute of Forestry and Environmental Sciences.University of Chittagong, Chittagong, Bangladesh. Results revealed that Nail clipping in one side of the seed （at the distal end of the seed） （T4） provides the highest （50%） seed germination. The second highest germination （42%） was obtained for the seeds treated with immersion in cold water for 24 h （T1）. Germination was completely inhibited when the seeds immersed in boiled water for 30 s followed in cold water soaking for 24 h. Other germination parameter and initial morphological growth and biomass production of the seedlings was also higher for the treatments T4and Ti in comparison to the control （Ta）treatment. Pre-sowing treatments of T4 e.g. Nail clipping in one side of the seed （at the distal end of the seed） and T1 （Seeds immersed in cold water for 24 h） may be recommended for maximum germination and initial vigorous seedlings growth of Albizia sarnan in the nursery.展开更多
Schizophrenia is a kind of chronic mental disorder that leads to disability, and it is characterized by the incoor-dination of perception, mind, emotion and behaviour, and the disconnection between mental activi-ties ...Schizophrenia is a kind of chronic mental disorder that leads to disability, and it is characterized by the incoor-dination of perception, mind, emotion and behaviour, and the disconnection between mental activi-ties and reality. It is recurrent and hard to cure. Schizophrenia has caused both agony to patients and their families, and heavy economic burden to their families and society.展开更多
Understanding naturally occurring pine regeneration dynamics in response to thinning and burning treatments is necessary not only to measure the longevity of the restoration or fuels treatment,but also to assess how w...Understanding naturally occurring pine regeneration dynamics in response to thinning and burning treatments is necessary not only to measure the longevity of the restoration or fuels treatment,but also to assess how well regeneration meets forest sustainability guidelines and whether natural regeneration is sufficient for maintaining a sustainable forest structure and composition.A synthesis review was carried out on the effects of mechanical thinning and prescribed burn treatments on natural pine regeneration response in frequent-fire ponderosa pine forests across the western United States.The focus was on site-specific variability in pine regeneration dynamics,temporal trends in regeneration presence and abundance,and response to treatment as described in the current literature using 29 studies that met our evidence-based review protocols.Data showed that the effects of thinning and burning treatments on regeneration depended on time since treatment.Mechanical thinning,prescribed burning,and thinning plus burn treatments all increased seedling density,but there was high variability among sites and studies.There were mixed results in the short-term(<10 years)with both increasing and decreasing regeneration,and a general increase in regeneration 11−20 years post-treatment.Some long-term studies(>20 years)concluded that stands can return to pre-treatment densities in terms of total trees per hectare and forest floor duff levels when there are no maintenance treatments applied.Several studies showed the average ponderosa pine seedling presence,survival and growth found in today’s forests to be at a high density;this combined with missed fire cycles could contribute to future fire risk and reduce the efficacy of maintaining fuel reduction goals.展开更多
Rapid development of anticancer treatments in recent years has greatly improved prognosis of cancer patients.However,with extension of survival time of cancer patients,various short-term and long-term side effects bro...Rapid development of anticancer treatments in recent years has greatly improved prognosis of cancer patients.However,with extension of survival time of cancer patients,various short-term and long-term side effects brought about by anticancer treatments,especially cardiotoxicity,have become increasingly prominent.Nonetheless,at present,there is few diagnostic methods with extremely high sensitivity and specificity to detect and accurately predict whether patients with anticancer treatment will experience cardiovascular complications.Inflammation,fibrosis and oxidative stress are considered to be important mechanisms involved in cardiotoxicity anticancer treatments.The cardiovascular biomarkers having the ability to predict and detect cardiovascular dysfunction earlier than clinical symptoms as well as left ventricular ejection fraction monitored by echocardiography,are of great value to timely treatment adjustment and prognosis evaluation.Cardiac troponin T/I and brain natriuretic peptide/N-terminal prohormone of brain natriuretic peptide have been routinely used in clinical practice to monitor cardiotoxicity,and some new biomarkers such as soluble suppression of tumorigenecity-2,myeloperoxidase,growth differentiation factor-15,galectin-3,endothelin-1,have potential in this area.In the future,larger-scale experimental studies are needed to provide sufficient evidences,and how to detect them quickly and at low cost is also a problem to be dealed with.展开更多
BACKGROUND:Life-sustaining treatments(LSTs)may prolong life but greatly decrease the quality of death.One factor influencing decision-making about withholding and withdrawing these treatments is the attitude of nurses...BACKGROUND:Life-sustaining treatments(LSTs)may prolong life but greatly decrease the quality of death.One factor influencing decision-making about withholding and withdrawing these treatments is the attitude of nurses.This study aimed to evaluate the attitude of critical care nurses towards life-sustaining treatments in South East Iran.METHODS:In this cross-sectional study,"Ethnicity and Attitudes towards Advance Care Directives Questionnaire"was used to investigate the attitude of 104 critical care nurses towards lifesustaining treatments in three hospitals affiliated to Kerman University of Medical Sciences.RESULTS:The findings of this study indicated that although a majority of critical care nurses(77%)did not have personal desire for use of LSTs including CPR and mechanical ventilation,they had moderately negative to neutral attitude towards general use of LSTs(2.95 of 5).CONCLUSIONS:These findings suggest that nurses'attitude towards LSTs can be changed by inclusion of specific courses about death,palliative care and life-sustaining treatments in undergraduate and postgraduate nursing curricula.Educating Muslim nurses about religious aspects of LSTs may also improve their attitudes.展开更多
Seed morphology,germination and seedlings growth of Acacia auriculiformis were studied.The experiment was conducted in the nursery of Forestry and Wood Technology Discipline,Khulna University,Bangladesh.Matured seeds ...Seed morphology,germination and seedlings growth of Acacia auriculiformis were studied.The experiment was conducted in the nursery of Forestry and Wood Technology Discipline,Khulna University,Bangladesh.Matured seeds of the species were collected from healthy trees of road side plantation from different areas of Khulna District,Bangladesh and treated with five pre-sowing treatments（control,immersion in cold water,immersion in hot water,scarification with sand paper and immersion in concentrated H2SO4）.The average length,breadth and thickness were found to be（0.58±0.017） cm,（0.44±0.007） cm and（0.20±0.089） cm,respectively.Germination was conducted in polybags with a mixture of top soil,coconut husk,coarse sand,and fine sand in a ratio of 3：4：1：1.Results reveal that pre-sowing treatments influences the germination rates of seeds that significantly increase the percentage germination compared with those in control（43%） and cold water treatment（52%）.The highest germination success rate was found 83% in hot water treatment followed by 78% in scarification with sand paper,and 75% with immersion in H2SO4.Germination started from 7 to 12 days and completed between 28 and 35 days period in all treatments.ANOVA showed the significant difference（p0.05） among the treatments in seed germination,but no significant difference among treatment with regard to starting day,closing day and total germination period.In case of height and diameter growth,seedlings originated from the seeds with hot water treatment shows significantly higher in wet season（from May to July）.Hot water treatment can be recommended on seed germination of the species in rural Bangladesh.展开更多
The novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the cause of a rapidly spreading illness,coronavirus disease 2019(COVID-19),affecting more than seventeen million people around the world.Diagnos...The novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the cause of a rapidly spreading illness,coronavirus disease 2019(COVID-19),affecting more than seventeen million people around the world.Diagnosis and treatment guidelines for clinicians caring for patients are needed.In the early stage,we have issued"A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV)infected pneumonia(standard version)";now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based guideline.We formed a working group of clinical experts and methodologists.The steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas:chemoprophylaxis,diagnosis,treatments,and discharge management.We searched the literature for direct evidence on the management of COVID-19,and assessed its certainty generated recommendations using the Grading of Recommendations,Assessment,Development and Evaluation(GRADE)approach.Recommendations were either strong or weak,or in the form of ungraded consensus-based statement.Finally,we issued 34 statements.Among them,6 were strong recommendations for,14 were weak recommendations for,3 were weak recommendations against and 11 were ungraded consensus-based statement.They covered topics of chemoprophylaxis(including agents and Traditional Chinese Medicine(TCM)agents),diagnosis(including clinical manifestations,reverse transcription-polymerase chain reaction(RT-PCR),respiratory tract specimens,IgM and IgG antibody tests,chest computed tomography,chest X-ray,and CT features of asymptomatic infections),treatments(including lopinavirritonavir,umifenovir,favipiravir,interferon,remdesivir,combination of antiviral drugs,hydroxychloroquine/chloroquine,interleukin-6 inhibitors,interleukin-1 inhibitors,glucocorticoid,qingfei paidu decoction,lianhua qingwen granules/capsules,convalescent plasma,lung transplantation,invasive or noninvasive ventilation,and extracorporeal membrane oxygenation(ECMO)),and discharge management(including discharge criteria and management plan in patients whose RT-PCR retesting shows SARS-CoV-2 positive after discharge).We also created two figures of these recommendations for the implementation purpose.We hope these recommendations can help support healthcare workers caring for COVID-19 patients.展开更多
Mature seeds of H. salicifolia, collected from five provenances （i.e. Hanuman Chatti, Helang, Lata, Rambara and Janggal Chatti） in west Himalaya, India, were treated with stratification （at 4℃ for 15, 30 and 60 d...Mature seeds of H. salicifolia, collected from five provenances （i.e. Hanuman Chatti, Helang, Lata, Rambara and Janggal Chatti） in west Himalaya, India, were treated with stratification （at 4℃ for 15, 30 and 60 days） and in different concentrations of GA3 （5, 10, 20 mM）, KNO3 （50, 100, 200 mM） and Thiourea （50, 100, 200 mM） solution to determine the variations in seed germination. Results reveal that the germination rates of seeds from different provenances under different pre-sowing treatments are significantly increased compared to those in control （24%-30%）. The seeds treated with Thiourea （100 mM） have highest germination rate （76%-83% for different seed sources）, followed by those （63%-71% for different seed sources） pretreated with stratification （4℃, 30 days）. GA3 treatment significantly shortens the mean germination time （MGT） and improves seed germination percentage. Considering the practical applicability and cost effectiveness, thiourea （100 mM） and stratification （at 4℃） treatments for seed germination are recommended for mass multiplication through seeds of H. saliciifolia in village/forest nurseries of the west Himalaya, India.展开更多
We investigated the morphology and germination of Tamarindus indica seeds in order to discover the ef- fects of variation in seed sources and pre-sowing treatments on germination. The experiment was carried out in the...We investigated the morphology and germination of Tamarindus indica seeds in order to discover the ef- fects of variation in seed sources and pre-sowing treatments on germination. The experiment was carried out in the nursery of the Forestry and Wood Technology Discipline, Khulna University, Bangladesh. Seeds were collected from different but healthy trees from various locations in Bangladesh and subjected to four pre-sowing treatments, i.e., control, immersion in cold water （4℃ for 24 h）, immersion in hot water （80℃ for 10 min） and scarification with sand paper. Seed germination was carried out in poly-bags with a mixture of topsoil and cow dung in the ratio of 3：1. The average length of the fresh seeds was 1.35 ＋ 0.26 cm, their width 1.07 ＋ 0.20 cm and thickness 0.69 ＋ 0.11 cm. The results revealed that pre-sowing treatments affected the germination process of seeds, which significantly increased the germination percentage with the cold water （81.67%） and scarification with sand paper （82.33%） treatments, compared with those in the control （58.33%） and hot water treatment （59.00%）. In all treatments germination started on average within 5 to 7 days after the start of the treatments and were completed from 13 to 19 days later. The greatest success in germination （82.33%） was found in scarification with sand paper, followed with 81.67% in the cold water treatment. The results of analyses of variance （ANOVA） showed significant differences （p 〈 0.05） in germination closing dates, seed germination periods and germination percentages among the treatments but no significant difference among seed sources. However, the effect of the interaction between seed source variation and pre-treatment differed significantly in seed germination closing dates and germination percentages. We recommend cold water treatment （submersion of seed at a temperature of 4℃ for a 24-h period） for seed germination of T. indica in rural Bangladesh.展开更多
Wood plastic composite （WPC） of wood flour （WF）, high density polyethylene （HDPE）, maleic anhydride-grafted polyethylene （MAPE） and lubricant was prepared by extrusion, and then exposed to different temperatur...Wood plastic composite （WPC） of wood flour （WF）, high density polyethylene （HDPE）, maleic anhydride-grafted polyethylene （MAPE） and lubricant was prepared by extrusion, and then exposed to different temperatures to evaluate the effects of freezing and thermal treatment on its dimensional and mechanical properties. At elevated temperatures, WPC expanded rapidly initially, and then contracted slowly until reaching an equilibrium state. Treatment at 52°C and relative humidity of 50% for 16 days improved the mechanical properties of WPC： flexure, tensile strength, and izod unnotched impact strength increased by 8%, 10% and 15%, respectively. Wide-angle X-ray diffraction （XRD） tests showed that the degree of crystalization of HDPE in WPC declined with increasing treatment temperature.展开更多
Solvent rinse treatments using polar methanol(Me OH)and nonpolar n-hexane have been developed for controlling material concentration gradients along the longitudinal direction of non-fullerene acceptor-based bulk hete...Solvent rinse treatments using polar methanol(Me OH)and nonpolar n-hexane have been developed for controlling material concentration gradients along the longitudinal direction of non-fullerene acceptor-based bulk heterojunction(BHJ)films comprised of electron donor polymer,PBDB-T and acceptor,ITIC-m.Before the used solvents(chlorobenzene with 1 vol%DIO)were completely evaporated,ITIC-m rich domains were formed at the top surface of the BHJ films after they were rinsed with Me OH,as evidenced by water contact angle,atomic force microscopy,time-of-flight secondary ion mass spectroscopy,which led to enhanced electron transport in the conventional structure of organic solar cells(OSCs).In contrast,after rinsing with n-hexane,ITIC-m rich domains were formed at the bottom surface of the films,which improved electron transport in the inverted structure OSCs.The enhanced carrier transports increased the PCEs(11.80%and 11.15%)in both conventional and inverted OSCs by 10.29%and 10.35%compared with control devices.The versatile control of material concentration gradients is determined to be feasible owing to the chemical interaction of the used substrates(glass,PEDOT:PSS,and Zn O)and rinsing solvents.展开更多
In this study, 40 Cr Mn Si B steel cylindrical shells were tempered at 350, 500 and 600 ℃ to study the effect of tempering temperature on the dynamic process of expansion and fracture of the metal shell. A midexplosi...In this study, 40 Cr Mn Si B steel cylindrical shells were tempered at 350, 500 and 600 ℃ to study the effect of tempering temperature on the dynamic process of expansion and fracture of the metal shell. A midexplosion recovery experiment for the metal cylinder under internal explosive loading was designed, and the wreckage of the casings at the intermediate phase was obtained. The effects of different tempering temperatures on the macroscopic and microscopic fracture characteristics of 40 Cr Mn Si B steel were studied. The influence of tempering temperatures on the fracture characteristic parameters of the recovered wreckage were measured and analyzed, including the circumferential divide size, the thickness and the number of the circumferential divisions. The results show that as the tempering temperature was increased from 350 to 600 ℃, at first, the degree of fragmentation and the fracture characteristic parameters of the recovered wreckage changed significantly and then became essentially consistent. Scanning electron microscopy analysis revealed flow-like structure characteristics caused by adiabatic shear on different fracture surfaces. At the detonation initiation end of the casing, fracturing was formed by tearing along the crack, which existed a distance from the initiation end and propagated along the axis direction. In contrast, the fracturing near the middle position consists of a plurality of radial shear fracture units. The amount of alloy carbide that was precipitated during the tempering process increased continuously with tempering temperature, leading to an increasing number of spherical carbide particles scattered around the fracture surface.展开更多
A germination experiment of pre-treated seeds of Melia azedarach was conducted in the nursery of Forestry and Wood Technology Discipline,Khulna University,Bangladesh.Matured seeds of Melia azedarach were collected fro...A germination experiment of pre-treated seeds of Melia azedarach was conducted in the nursery of Forestry and Wood Technology Discipline,Khulna University,Bangladesh.Matured seeds of Melia azedarach were collected from healthy trees of National Botanical Garden,Bangladesh and were treated with five pre-sowing treatments（control,immersion in cold water,immersion in hot water,scarification with sand paper,and immersion in concentrated H2SO4） on seed germination.Results revealed that the germination rates of pre-sowing treated seeds were significantly increased compared to those in control,except for cold water treatment.The highest germination success（80%） was found in scarification with sand paper,followed by 74% and 69% in immersion in H2SO4 and hot water treatment,respectively.Germination started on 8-11 days and completed on 20-21 days of the germination period in all cases.Analysis of variance showed the significance difference in germination success among the treatments but no significance difference in germination period among the treatment.Hot water treatment may be recommended on seed germination of the species in rural Bangladesh.展开更多
The microstructure and Ge-V photoluminescent properties of diamond particles treated by microwave oxygen plasma are investigated.The results show that in the first 5 min of microwave plasma treatment,graphite and diso...The microstructure and Ge-V photoluminescent properties of diamond particles treated by microwave oxygen plasma are investigated.The results show that in the first 5 min of microwave plasma treatment,graphite and disordered carbon on the surface of the particles are etched away,so that diamond with regular crystal plane,smaller lattice stress,and better crystal quality is exposed,producing a Ge-V photoluminescence(PL)intensity 4 times stronger and PL peak FWHM(full width at half maximum)value of 6.6 nm smaller than the as-deposited sample.It is observed that the cycles of‘diamond is converted into graphite and disordered carbon,then the graphite and disordered carbon are etched’can occur with the treatment time further increasing.During these cycles,the particle surface alternately appears smooth and rough,corresponding to the strengthening and weakening of Ge-V PL intensity,respectively,while the PL intensity is always stronger than that of the as-deposited sample.The results suggest that not only graphite but also disordered carbon weakens the Ge-V PL intensity.Our study provides a feasible way of enhancing the Ge-V PL properties and effectively controlling the surface morphology of diamond particle.展开更多
In order to investigate the temperature characteristics of wood during microwave(MW) treatments,optical fiber sensors were used to measure wood(Pinus sylvestris L. var. mongolica Litv.) temperatures. The results show ...In order to investigate the temperature characteristics of wood during microwave(MW) treatments,optical fiber sensors were used to measure wood(Pinus sylvestris L. var. mongolica Litv.) temperatures. The results show that the development of internal temperatures in wood basically includes two patterns during the process of MW treatment. The first may be divided into three phases: warming, constant temperature, and a sharply rising phase. The second pattern may be divided into two phases: warming, and constant temperature. The maximum temperature(MT) and rate of temperature increase(RTI)rose as the microwave power increased. The initial wood moisture content decreased while the period of constant temperature fell. Temperatures varied in different positions in the wood. The order of MT and RTI levels were the upper surface, center, bottom surface and the end point.Along the direction of wood thickness, the closer the monitoring point was to the generator, the faster the temperature increased. The MT and RTI of the end point was a minimum value because of the rapid removal of steam.展开更多
文摘The United States Food and Drug Administration's(FDA's)August 2024 determination that an additional phase Ⅱ study will be required to consider the approval of midomafetamine for the treatment of posttraumatic stress disorder(PTSD)could delay the potential approval of this promising treatment by several years.
文摘The Annual Report on Cardiovascular Health and Diseases in China(2022)intricate landscape of cardiovascular health in China.In connection with the previous section,this ninth section of the report offers a comprehensive analysis of valvular heart disease and cardiomyopathy.Although rheumatic valve disease is still the main cause of valvular heart disease in China,with the aging of the population and the improvement of living standards,the prevalence of degenerative valvular heart disease is on the rise.Because many patients with valvular heart disease have only mild to moderate valve stenosis or insufficiency,and no symptoms,the detection rate in the population is low and late,resulting in many patients been in the severe late stage of disease at visit,increasing the difficulty of treatment and affecting effectiveness and prognosis.Therefore,we should strengthen the examination and screening of valvular heart disease in order to find and prevent it as early as possible.In addition,compared with other diseases,the treatment of valvular heart disease needs more and higher technical support(surgery,intervention,etc).However,not all hospitals can provide relevant technologies.At present,the treatment of valvular heart disease is still mainly concentrated in the provincial hospitals.It is necessary to carry out more professional training so that more doctors and hospitals can participate in the treatment of valvular heart disease.Cardiomyopathy is a group of myocardial diseases with abnormal myocardial structure and/or function,but couldn't be explained by hypertension,coronary atherosclerosis,valvular heart disease and congenital heart disease.It includes hypertrophic cardiomyopathy(HCM),dilated cardiomyopathy(DCM),arrhythmogenic cardiomyopathy(also known as arrhythmogenic right ventricular cardiomyopathy),restrictive cardiomyopathy(RCM)and undifferentiated cardiomyopathy.
文摘During injection treatments, bottomhole pressure measurements may significantly mismatch modeling results. We devise a computationally effective technique for interpretation of fluid injection in a wellbore interval with multiple geological layers based on the bottomhole pressure measurements. The permeability, porosity and compressibility in each layer are initially setup, while the skin factor and partitioning of injected fluids among the zones during the injection are found as a solution of the problem. The problem takes into account Darcy flow and chemical interactions between the injected acids, diverter fluids and reservoir rock typical in modern matrix acidizing treatments. Using the synchronously recorded injection rate and bottomhole pressure, we evaluate skin factor changes in each layer and actual fluid placement into the reservoir during different pumping jobs: matrix acidizing, water control, sand control, scale squeezes and water flooding. The model is validated by comparison with a simulator used in industry. It gives opportunity to estimate efficiency of a matrix treatment job, role of every injection stage, and control fluid delivery to each layer in real time. The presented interpretation technique significantly improves accuracy of matrix treatments analysis by coupling the hydrodynamic model with records of pressure and injection rate during the treatment.
基金This study was supported by National Natural Science Foundation of China (30471355) and the Key Technologies R&D Program of Heilongjiang Province (G99B5-3)
文摘A study was conducted to determine the influences of initial planting densities, thinning intensities, exposures and slope sites on physical property （wood density） and mechanical properties such as modulus of elasticity （MOE）, bending strength, impact strength, compression strength along grain and hardness） of Pinus sylvestris var. mongolica plantation in Mao＇ershan Forest Farm, Northeast China. Results show that the different initial planting densities （1.5 m×1.0 m, 1.5 m×2.0 m and 1.5 m×2.5 m） had significant effects on wood density and MOE, and the highest mean wood density and indexes of mechanical properties occurred in the stand with an initial planting density of 1.5 m×1.0 m. The indexes of mechanical properties such as hardness of end, bending strength, MOE and compression strength along grain of wood increased after mild thinning, but decreased after violent thinning. The exposures （sunny slope and shady slope） had a significant effect on MOE, and the highest mean MOE occurred on sunny slope. The slope sites （upper site and lower site） had a significant effect on wood density and main mechanical properties, except hardness. The highest mean wood density and mechanical properties occurred at lower site.
基金supported by Indian Council ofForestry Research and Education (ICFRE), Dehradun, 248 006, Uttarakhand, India
文摘Dalbergia sissoo Roxb. is one of the promising multipurpose tree species of South Asia. Most of the plantations of D. sissoo from seeds are facing severe threats due to the die-back disease, which ultimately causes death of this potential tree-species within a few months. Vegetative propagation could avoid the die-back disease. Thirty mother trees of different age-groups of D. sissoo were selected for evaluating the rooting behaviour of branch cuttings from D. sissoo as influenced by auxins （IAA or IBA at 100, 200, 500 mg·L^-1）, ages of mother trees （10, 4 and 2 years old） and different environment conditions, i.e., different mediums （soil and sand） or light conditions （in shade and open condition）. The results show that application of IAA and IBA induced more numbers of cuttings （collected from 10-year-old mother trees） to root compared to control. Branch cuttings of D. sissoo collected from 10-year-old mother trees and planted in soil bed in open conditions had 100.0% of cuttings to root in IAA （100 mg·L^-1） and IBA （200 mg·L^-1） treatments. Both rooting medium （Soil and sand） influenced significantly （p〈0.05） on rooting response of branch cuttings. Soil medium was found to achieve maximum no. of branch cuttings to root, compared to sand medium.
文摘Albizia saman （Jacq.） F. Muell. commonly known as rain tree seeds were treated with five pre-sowing treatments to study the effect of pre-sowing treatments on germination and initial seedling development in the nursery.The experiment was established in the nursery of the Institute of Forestry and Environmental Sciences.University of Chittagong, Chittagong, Bangladesh. Results revealed that Nail clipping in one side of the seed （at the distal end of the seed） （T4） provides the highest （50%） seed germination. The second highest germination （42%） was obtained for the seeds treated with immersion in cold water for 24 h （T1）. Germination was completely inhibited when the seeds immersed in boiled water for 30 s followed in cold water soaking for 24 h. Other germination parameter and initial morphological growth and biomass production of the seedlings was also higher for the treatments T4and Ti in comparison to the control （Ta）treatment. Pre-sowing treatments of T4 e.g. Nail clipping in one side of the seed （at the distal end of the seed） and T1 （Seeds immersed in cold water for 24 h） may be recommended for maximum germination and initial vigorous seedlings growth of Albizia sarnan in the nursery.
基金National Natural Science Fundation of China(81471358)Shanghai Western Medicine Guidance Project(14411969000)Shanghai Health and Family Planning Commission Project(201540029)
文摘Schizophrenia is a kind of chronic mental disorder that leads to disability, and it is characterized by the incoor-dination of perception, mind, emotion and behaviour, and the disconnection between mental activi-ties and reality. It is recurrent and hard to cure. Schizophrenia has caused both agony to patients and their families, and heavy economic burden to their families and society.
基金Funding came fromwithin the Ecological Restoration Institute。
文摘Understanding naturally occurring pine regeneration dynamics in response to thinning and burning treatments is necessary not only to measure the longevity of the restoration or fuels treatment,but also to assess how well regeneration meets forest sustainability guidelines and whether natural regeneration is sufficient for maintaining a sustainable forest structure and composition.A synthesis review was carried out on the effects of mechanical thinning and prescribed burn treatments on natural pine regeneration response in frequent-fire ponderosa pine forests across the western United States.The focus was on site-specific variability in pine regeneration dynamics,temporal trends in regeneration presence and abundance,and response to treatment as described in the current literature using 29 studies that met our evidence-based review protocols.Data showed that the effects of thinning and burning treatments on regeneration depended on time since treatment.Mechanical thinning,prescribed burning,and thinning plus burn treatments all increased seedling density,but there was high variability among sites and studies.There were mixed results in the short-term(<10 years)with both increasing and decreasing regeneration,and a general increase in regeneration 11−20 years post-treatment.Some long-term studies(>20 years)concluded that stands can return to pre-treatment densities in terms of total trees per hectare and forest floor duff levels when there are no maintenance treatments applied.Several studies showed the average ponderosa pine seedling presence,survival and growth found in today’s forests to be at a high density;this combined with missed fire cycles could contribute to future fire risk and reduce the efficacy of maintaining fuel reduction goals.
文摘Rapid development of anticancer treatments in recent years has greatly improved prognosis of cancer patients.However,with extension of survival time of cancer patients,various short-term and long-term side effects brought about by anticancer treatments,especially cardiotoxicity,have become increasingly prominent.Nonetheless,at present,there is few diagnostic methods with extremely high sensitivity and specificity to detect and accurately predict whether patients with anticancer treatment will experience cardiovascular complications.Inflammation,fibrosis and oxidative stress are considered to be important mechanisms involved in cardiotoxicity anticancer treatments.The cardiovascular biomarkers having the ability to predict and detect cardiovascular dysfunction earlier than clinical symptoms as well as left ventricular ejection fraction monitored by echocardiography,are of great value to timely treatment adjustment and prognosis evaluation.Cardiac troponin T/I and brain natriuretic peptide/N-terminal prohormone of brain natriuretic peptide have been routinely used in clinical practice to monitor cardiotoxicity,and some new biomarkers such as soluble suppression of tumorigenecity-2,myeloperoxidase,growth differentiation factor-15,galectin-3,endothelin-1,have potential in this area.In the future,larger-scale experimental studies are needed to provide sufficient evidences,and how to detect them quickly and at low cost is also a problem to be dealed with.
文摘BACKGROUND:Life-sustaining treatments(LSTs)may prolong life but greatly decrease the quality of death.One factor influencing decision-making about withholding and withdrawing these treatments is the attitude of nurses.This study aimed to evaluate the attitude of critical care nurses towards life-sustaining treatments in South East Iran.METHODS:In this cross-sectional study,"Ethnicity and Attitudes towards Advance Care Directives Questionnaire"was used to investigate the attitude of 104 critical care nurses towards lifesustaining treatments in three hospitals affiliated to Kerman University of Medical Sciences.RESULTS:The findings of this study indicated that although a majority of critical care nurses(77%)did not have personal desire for use of LSTs including CPR and mechanical ventilation,they had moderately negative to neutral attitude towards general use of LSTs(2.95 of 5).CONCLUSIONS:These findings suggest that nurses'attitude towards LSTs can be changed by inclusion of specific courses about death,palliative care and life-sustaining treatments in undergraduate and postgraduate nursing curricula.Educating Muslim nurses about religious aspects of LSTs may also improve their attitudes.
文摘Seed morphology,germination and seedlings growth of Acacia auriculiformis were studied.The experiment was conducted in the nursery of Forestry and Wood Technology Discipline,Khulna University,Bangladesh.Matured seeds of the species were collected from healthy trees of road side plantation from different areas of Khulna District,Bangladesh and treated with five pre-sowing treatments（control,immersion in cold water,immersion in hot water,scarification with sand paper and immersion in concentrated H2SO4）.The average length,breadth and thickness were found to be（0.58±0.017） cm,（0.44±0.007） cm and（0.20±0.089） cm,respectively.Germination was conducted in polybags with a mixture of top soil,coconut husk,coarse sand,and fine sand in a ratio of 3：4：1：1.Results reveal that pre-sowing treatments influences the germination rates of seeds that significantly increase the percentage germination compared with those in control（43%） and cold water treatment（52%）.The highest germination success rate was found 83% in hot water treatment followed by 78% in scarification with sand paper,and 75% with immersion in H2SO4.Germination started from 7 to 12 days and completed between 28 and 35 days period in all treatments.ANOVA showed the significant difference（p0.05） among the treatments in seed germination,but no significant difference among treatment with regard to starting day,closing day and total germination period.In case of height and diameter growth,seedlings originated from the seeds with hot water treatment shows significantly higher in wet season（from May to July）.Hot water treatment can be recommended on seed germination of the species in rural Bangladesh.
基金supported(in part)by the National Key Research and Development Program of China(2020YFC0845500)the Special Project for Emergency of Hubei Province(2020FCA008)the First Level Funding of the Second Medical Leading Talent Project in Hubei Province。
文摘The novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the cause of a rapidly spreading illness,coronavirus disease 2019(COVID-19),affecting more than seventeen million people around the world.Diagnosis and treatment guidelines for clinicians caring for patients are needed.In the early stage,we have issued"A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV)infected pneumonia(standard version)";now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based guideline.We formed a working group of clinical experts and methodologists.The steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas:chemoprophylaxis,diagnosis,treatments,and discharge management.We searched the literature for direct evidence on the management of COVID-19,and assessed its certainty generated recommendations using the Grading of Recommendations,Assessment,Development and Evaluation(GRADE)approach.Recommendations were either strong or weak,or in the form of ungraded consensus-based statement.Finally,we issued 34 statements.Among them,6 were strong recommendations for,14 were weak recommendations for,3 were weak recommendations against and 11 were ungraded consensus-based statement.They covered topics of chemoprophylaxis(including agents and Traditional Chinese Medicine(TCM)agents),diagnosis(including clinical manifestations,reverse transcription-polymerase chain reaction(RT-PCR),respiratory tract specimens,IgM and IgG antibody tests,chest computed tomography,chest X-ray,and CT features of asymptomatic infections),treatments(including lopinavirritonavir,umifenovir,favipiravir,interferon,remdesivir,combination of antiviral drugs,hydroxychloroquine/chloroquine,interleukin-6 inhibitors,interleukin-1 inhibitors,glucocorticoid,qingfei paidu decoction,lianhua qingwen granules/capsules,convalescent plasma,lung transplantation,invasive or noninvasive ventilation,and extracorporeal membrane oxygenation(ECMO)),and discharge management(including discharge criteria and management plan in patients whose RT-PCR retesting shows SARS-CoV-2 positive after discharge).We also created two figures of these recommendations for the implementation purpose.We hope these recommendations can help support healthcare workers caring for COVID-19 patients.
文摘Mature seeds of H. salicifolia, collected from five provenances （i.e. Hanuman Chatti, Helang, Lata, Rambara and Janggal Chatti） in west Himalaya, India, were treated with stratification （at 4℃ for 15, 30 and 60 days） and in different concentrations of GA3 （5, 10, 20 mM）, KNO3 （50, 100, 200 mM） and Thiourea （50, 100, 200 mM） solution to determine the variations in seed germination. Results reveal that the germination rates of seeds from different provenances under different pre-sowing treatments are significantly increased compared to those in control （24%-30%）. The seeds treated with Thiourea （100 mM） have highest germination rate （76%-83% for different seed sources）, followed by those （63%-71% for different seed sources） pretreated with stratification （4℃, 30 days）. GA3 treatment significantly shortens the mean germination time （MGT） and improves seed germination percentage. Considering the practical applicability and cost effectiveness, thiourea （100 mM） and stratification （at 4℃） treatments for seed germination are recommended for mass multiplication through seeds of H. saliciifolia in village/forest nurseries of the west Himalaya, India.
文摘We investigated the morphology and germination of Tamarindus indica seeds in order to discover the ef- fects of variation in seed sources and pre-sowing treatments on germination. The experiment was carried out in the nursery of the Forestry and Wood Technology Discipline, Khulna University, Bangladesh. Seeds were collected from different but healthy trees from various locations in Bangladesh and subjected to four pre-sowing treatments, i.e., control, immersion in cold water （4℃ for 24 h）, immersion in hot water （80℃ for 10 min） and scarification with sand paper. Seed germination was carried out in poly-bags with a mixture of topsoil and cow dung in the ratio of 3：1. The average length of the fresh seeds was 1.35 ＋ 0.26 cm, their width 1.07 ＋ 0.20 cm and thickness 0.69 ＋ 0.11 cm. The results revealed that pre-sowing treatments affected the germination process of seeds, which significantly increased the germination percentage with the cold water （81.67%） and scarification with sand paper （82.33%） treatments, compared with those in the control （58.33%） and hot water treatment （59.00%）. In all treatments germination started on average within 5 to 7 days after the start of the treatments and were completed from 13 to 19 days later. The greatest success in germination （82.33%） was found in scarification with sand paper, followed with 81.67% in the cold water treatment. The results of analyses of variance （ANOVA） showed significant differences （p 〈 0.05） in germination closing dates, seed germination periods and germination percentages among the treatments but no significant difference among seed sources. However, the effect of the interaction between seed source variation and pre-treatment differed significantly in seed germination closing dates and germination percentages. We recommend cold water treatment （submersion of seed at a temperature of 4℃ for a 24-h period） for seed germination of T. indica in rural Bangladesh.
基金support by the Chinese Science and Technology Support Program (Project No. 2012BAD32B04)the Fundamental Research Funds for the Central Universities(DL11BB37)
文摘Wood plastic composite （WPC） of wood flour （WF）, high density polyethylene （HDPE）, maleic anhydride-grafted polyethylene （MAPE） and lubricant was prepared by extrusion, and then exposed to different temperatures to evaluate the effects of freezing and thermal treatment on its dimensional and mechanical properties. At elevated temperatures, WPC expanded rapidly initially, and then contracted slowly until reaching an equilibrium state. Treatment at 52°C and relative humidity of 50% for 16 days improved the mechanical properties of WPC： flexure, tensile strength, and izod unnotched impact strength increased by 8%, 10% and 15%, respectively. Wide-angle X-ray diffraction （XRD） tests showed that the degree of crystalization of HDPE in WPC declined with increasing treatment temperature.
基金supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education,Science and Technology(NRF-2017R1D1A1B03030669)the GIST Research Institute(GRI)APRI grant funded by GIST in 2020。
文摘Solvent rinse treatments using polar methanol(Me OH)and nonpolar n-hexane have been developed for controlling material concentration gradients along the longitudinal direction of non-fullerene acceptor-based bulk heterojunction(BHJ)films comprised of electron donor polymer,PBDB-T and acceptor,ITIC-m.Before the used solvents(chlorobenzene with 1 vol%DIO)were completely evaporated,ITIC-m rich domains were formed at the top surface of the BHJ films after they were rinsed with Me OH,as evidenced by water contact angle,atomic force microscopy,time-of-flight secondary ion mass spectroscopy,which led to enhanced electron transport in the conventional structure of organic solar cells(OSCs).In contrast,after rinsing with n-hexane,ITIC-m rich domains were formed at the bottom surface of the films,which improved electron transport in the inverted structure OSCs.The enhanced carrier transports increased the PCEs(11.80%and 11.15%)in both conventional and inverted OSCs by 10.29%and 10.35%compared with control devices.The versatile control of material concentration gradients is determined to be feasible owing to the chemical interaction of the used substrates(glass,PEDOT:PSS,and Zn O)and rinsing solvents.
基金funded by the National Natural Science Foundation of China (Grant No.11972018)sponsored by the Defense Pre-Research Joint Foundation of Chinese Ordnance Industry (Grant No. 6141B012858)。
文摘In this study, 40 Cr Mn Si B steel cylindrical shells were tempered at 350, 500 and 600 ℃ to study the effect of tempering temperature on the dynamic process of expansion and fracture of the metal shell. A midexplosion recovery experiment for the metal cylinder under internal explosive loading was designed, and the wreckage of the casings at the intermediate phase was obtained. The effects of different tempering temperatures on the macroscopic and microscopic fracture characteristics of 40 Cr Mn Si B steel were studied. The influence of tempering temperatures on the fracture characteristic parameters of the recovered wreckage were measured and analyzed, including the circumferential divide size, the thickness and the number of the circumferential divisions. The results show that as the tempering temperature was increased from 350 to 600 ℃, at first, the degree of fragmentation and the fracture characteristic parameters of the recovered wreckage changed significantly and then became essentially consistent. Scanning electron microscopy analysis revealed flow-like structure characteristics caused by adiabatic shear on different fracture surfaces. At the detonation initiation end of the casing, fracturing was formed by tearing along the crack, which existed a distance from the initiation end and propagated along the axis direction. In contrast, the fracturing near the middle position consists of a plurality of radial shear fracture units. The amount of alloy carbide that was precipitated during the tempering process increased continuously with tempering temperature, leading to an increasing number of spherical carbide particles scattered around the fracture surface.
文摘A germination experiment of pre-treated seeds of Melia azedarach was conducted in the nursery of Forestry and Wood Technology Discipline,Khulna University,Bangladesh.Matured seeds of Melia azedarach were collected from healthy trees of National Botanical Garden,Bangladesh and were treated with five pre-sowing treatments（control,immersion in cold water,immersion in hot water,scarification with sand paper,and immersion in concentrated H2SO4） on seed germination.Results revealed that the germination rates of pre-sowing treated seeds were significantly increased compared to those in control,except for cold water treatment.The highest germination success（80%） was found in scarification with sand paper,followed by 74% and 69% in immersion in H2SO4 and hot water treatment,respectively.Germination started on 8-11 days and completed on 20-21 days of the germination period in all cases.Analysis of variance showed the significance difference in germination success among the treatments but no significance difference in germination period among the treatment.Hot water treatment may be recommended on seed germination of the species in rural Bangladesh.
基金the Key Project of the National Natural Science Foundation of China(Grant No.U1809210)the National Key Research and Development Program of China(Grant No.2016YFE0133200)+3 种基金the Belt and Road Initiative International Cooperation Project from Key Research and Development Program of Zhejiang Province,China(Grant No.2018C04021)the European Union’s Horizon 2020 Research and Innovation Staff Exchange Scheme(Grant No.734578)the Natural Science Foundation of Zhejiang Province,China(Grant No.LY18E020013)the International Science Technology Cooperation Program,China(Grant No.2014DFR51160).
文摘The microstructure and Ge-V photoluminescent properties of diamond particles treated by microwave oxygen plasma are investigated.The results show that in the first 5 min of microwave plasma treatment,graphite and disordered carbon on the surface of the particles are etched away,so that diamond with regular crystal plane,smaller lattice stress,and better crystal quality is exposed,producing a Ge-V photoluminescence(PL)intensity 4 times stronger and PL peak FWHM(full width at half maximum)value of 6.6 nm smaller than the as-deposited sample.It is observed that the cycles of‘diamond is converted into graphite and disordered carbon,then the graphite and disordered carbon are etched’can occur with the treatment time further increasing.During these cycles,the particle surface alternately appears smooth and rough,corresponding to the strengthening and weakening of Ge-V PL intensity,respectively,while the PL intensity is always stronger than that of the as-deposited sample.The results suggest that not only graphite but also disordered carbon weakens the Ge-V PL intensity.Our study provides a feasible way of enhancing the Ge-V PL properties and effectively controlling the surface morphology of diamond particle.
基金financially supported by the National‘‘Twelfth Five-Year’’ Plan for Science&Technology(No.2015BAD14B04)the Special Fund for Forest Scientific Research in the Public Interest of China(No.201404516)
文摘In order to investigate the temperature characteristics of wood during microwave(MW) treatments,optical fiber sensors were used to measure wood(Pinus sylvestris L. var. mongolica Litv.) temperatures. The results show that the development of internal temperatures in wood basically includes two patterns during the process of MW treatment. The first may be divided into three phases: warming, constant temperature, and a sharply rising phase. The second pattern may be divided into two phases: warming, and constant temperature. The maximum temperature(MT) and rate of temperature increase(RTI)rose as the microwave power increased. The initial wood moisture content decreased while the period of constant temperature fell. Temperatures varied in different positions in the wood. The order of MT and RTI levels were the upper surface, center, bottom surface and the end point.Along the direction of wood thickness, the closer the monitoring point was to the generator, the faster the temperature increased. The MT and RTI of the end point was a minimum value because of the rapid removal of steam.
