Blunt trauma to the thyroid gland is a possibly life- threatening condition known for years. However, only few cases have been reported in the English-language literature, so that no consensus has emerged as to its wo...Blunt trauma to the thyroid gland is a possibly life- threatening condition known for years. However, only few cases have been reported in the English-language literature, so that no consensus has emerged as to its workup or management.展开更多
Full thickness burns of 30% TBSA by napalm was inflicted to rats and the pathologi-cal changes of the thyroid were observed with optical and electron microscopy and with peroxi-dase histoehemistry for 15 days postburn...Full thickness burns of 30% TBSA by napalm was inflicted to rats and the pathologi-cal changes of the thyroid were observed with optical and electron microscopy and with peroxi-dase histoehemistry for 15 days postburn.Dynamic changes of the serum level of T<sub>3</sub> and T<sub>4</sub> wereobserved concomitantly.It was found that the postburn pathological changes of the thyroid couldbe distinguished into 3 phases as follows:The phase of injury inhibition.This lasted from the 2nd to the 24th hour postburn and wascharacterized by marked damage of the follicular epithelium.The phase of structural and functional recovery.This lasted from the 3rd to 6th day post-burn and was characterized by abated damage of the thyroid and a tendency to recover.The phase of active function.This lasted from the 10th to the 15th day postburn.The syn-thesizing and releasing organellae of the thyroid were well-restored.The changes of T<sub>4</sub> were parallel to the pathological changes of the thyroid in all the stages,while T<sub>3</sub> level was continously inhibited because of the low serum level of T<sub>4</sub>,the metabolic dis-turbance of T<sub>4</sub> deiodination,and the inhibition of thyroid secretion in the early postburn stage andthe metabolic disturbance of T<sub>4</sub> deiodination in the middle and late postburn stages.In the earlypostburn stage,the inhibition on thyroid peroxidase was an important factor to inhibit the func-tion of the thyroid.展开更多
文摘Blunt trauma to the thyroid gland is a possibly life- threatening condition known for years. However, only few cases have been reported in the English-language literature, so that no consensus has emerged as to its workup or management.
文摘Full thickness burns of 30% TBSA by napalm was inflicted to rats and the pathologi-cal changes of the thyroid were observed with optical and electron microscopy and with peroxi-dase histoehemistry for 15 days postburn.Dynamic changes of the serum level of T<sub>3</sub> and T<sub>4</sub> wereobserved concomitantly.It was found that the postburn pathological changes of the thyroid couldbe distinguished into 3 phases as follows:The phase of injury inhibition.This lasted from the 2nd to the 24th hour postburn and wascharacterized by marked damage of the follicular epithelium.The phase of structural and functional recovery.This lasted from the 3rd to 6th day post-burn and was characterized by abated damage of the thyroid and a tendency to recover.The phase of active function.This lasted from the 10th to the 15th day postburn.The syn-thesizing and releasing organellae of the thyroid were well-restored.The changes of T<sub>4</sub> were parallel to the pathological changes of the thyroid in all the stages,while T<sub>3</sub> level was continously inhibited because of the low serum level of T<sub>4</sub>,the metabolic dis-turbance of T<sub>4</sub> deiodination,and the inhibition of thyroid secretion in the early postburn stage andthe metabolic disturbance of T<sub>4</sub> deiodination in the middle and late postburn stages.In the earlypostburn stage,the inhibition on thyroid peroxidase was an important factor to inhibit the func-tion of the thyroid.
