针对大破损彩色纹理图像的修复问题,将TV-L1模型推广到非局部CTV-L1模型。该模型不仅包含非局部算子,同时还引入了CTV(color total variation)规则项,前者可以修复大破损纹理图像,后者充分考虑了彩色图像层与层之间的耦合关系,在处理彩...针对大破损彩色纹理图像的修复问题,将TV-L1模型推广到非局部CTV-L1模型。该模型不仅包含非局部算子,同时还引入了CTV(color total variation)规则项,前者可以修复大破损纹理图像,后者充分考虑了彩色图像层与层之间的耦合关系,在处理彩色图像时可以有效地保持边缘。为提高模型的运算效率,通过引入辅助变量和Lagrange乘子为其设计了相应的增广Lagrangian算法。数值实验结果证实所提出的模型在处理彩色图像时可以有效地保持边缘,同时去除图像中异常的不规则点。该研究可以推广到彩色纹理图像椒盐噪声去除及彩色纹理图像分割中。展开更多
In grey system theory,the studies in the field of grey prediction model are focused on real number sequences,rather than grey number ones.Hereby,a prediction model based on interval grey number sequences is proposed.B...In grey system theory,the studies in the field of grey prediction model are focused on real number sequences,rather than grey number ones.Hereby,a prediction model based on interval grey number sequences is proposed.By mining the geometric features of interval grey number sequences on a two-dimensional surface,all the interval grey numbers are converted into real numbers by means of certain algorithm,and then the prediction model is established based on those real number sequences.The entire process avoids the algebraic operations of grey number,and the prediction problem of interval grey number is usefully solved.Ultimately,through an example＇s program simulation,the validity and practicability of this novel model are verified.展开更多
This paper expresses the efficient outputs of decisionmaking unit（DMU） as the sum of ＂average outputs＂ forecasted by a GM（1,N） model and ＂increased outputs＂ which reflect the difficulty to realize efficient ou...This paper expresses the efficient outputs of decisionmaking unit（DMU） as the sum of ＂average outputs＂ forecasted by a GM（1,N） model and ＂increased outputs＂ which reflect the difficulty to realize efficient outputs.The increased outputs are solved by linear programming using data envelopment analysis efficiency theories,wherein a new sample is introduced whose inputs are equal to the budget in the issue No.n ＋ 1 and outputs are forecasted by the GM（1,N） model.The shortcoming in the existing methods that the forecasted efficient outputs may be less than the possible actual outputs according to developing trends of input-output rate in the periods of pre-n is overcome.The new prediction method provides decision-makers with more decisionmaking information,and the initial conditions are easy to be given.展开更多
Von Willebrand Factor(VWF)is a concatameric glycoprotein that plays a key role in rapid hemostasis and thrombosis.VWF has different functional domains that can bind to various molecules such as collagen,hemostatic fac...Von Willebrand Factor(VWF)is a concatameric glycoprotein that plays a key role in rapid hemostasis and thrombosis.VWF has different functional domains that can bind to various molecules such as collagen,hemostatic factorⅧ,integrin,and platelet glycoprotein lbα(GPlbα)to achieve multiple biological functions.During hemostasis,the A1 domain of VWF binds to GPIbαwhere platelets accumulate in the injured vascular endothelium.Due to forces generated by the hemodynamic gradient flow,the relations of bond-dissociation rates versus forces show that the lifetime of molecular bond has multiple states under the external force.We processed the experimental data of receptor-ligand in a single molecule obtained from optical tweezers by two different methods,including a Dudko-Hummer-Szabo equation,and another method combining force4ime history and force induced bond rupture.Then we used a recently developed physical equation regarding protein unfolding rate to fit our results.The lifetime of the bond between A1 and GPlbαobtained by the above mentioned two methods shows a'three-stage'change upon gradually increasing the external force.When the external force was below 8 pN,the lifetime of the bond deceased as the external force increased,which is a typical expression of a catch bond.The lifetime of the bond started to increase when the external force increased from 8 to 11 pN,and then decrease again when the external force increased to above 11 pN.Kim et al.used different processing methods and proposes a'flex-bond'model:the lifetime of the bond will decrease as the external force increases,then suddenly increase to a peak,and continue to decrease with the increase of force.A recently developed model based on the structural-elastic properties of molecules fits our data well,indicating that the bond formed by Al and GPlbαhas a catch-bond phenomenon in a certain interval of external forces,and a flex bond in other force intervals.In conclusion,A1-GPIbαbond will have a'slip-catch-slip'bond tendency.Our result provides a alternative understanding about the role of Al-GPlbαinteractions in the mechanism of hemostasis.展开更多
Using the latest reported homologous Chemokine receptors （PDB ID： 3ODU, 3OE0 and 3OE6） as templates, twenty models of angiotensin II （Ang II） type 1 （AT1） receptor （known as p30556） were generated by multiple...Using the latest reported homologous Chemokine receptors （PDB ID： 3ODU, 3OE0 and 3OE6） as templates, twenty models of angiotensin II （Ang II） type 1 （AT1） receptor （known as p30556） were generated by multiple templates homology modeling. According to the results of the initial validation of these twenty models, the model 0020 was finally chosen as the best one for further studies. Then, a 2 ns molecular dynamic （MD） simulation for model 0020 was conducted in normal saline （0.9%, w/F） under periodical boundary conditions, which was followed by docking studies of model 0020 with several existing AT1 receptor blockers （ARBs）. The docking results reveal that model 0020 possesses good affinities with these docked ARBs which are in accordance with both the IC50 inhibitor values and their curative effects. The results also show more potent interactions between the model 0020 and its ARBs than those of ever reported results, such as hydrogen bonds, hydrophobic interactions, and especially cation-n interactions and π-π interactions which have never been reported before. This may reveal that the structure of the model 0020 is quite close to its real crystal structure and the model 0020 may have the potential to be used for structure based drug design：展开更多
文摘针对大破损彩色纹理图像的修复问题,将TV-L1模型推广到非局部CTV-L1模型。该模型不仅包含非局部算子,同时还引入了CTV(color total variation)规则项,前者可以修复大破损纹理图像,后者充分考虑了彩色图像层与层之间的耦合关系,在处理彩色图像时可以有效地保持边缘。为提高模型的运算效率,通过引入辅助变量和Lagrange乘子为其设计了相应的增广Lagrangian算法。数值实验结果证实所提出的模型在处理彩色图像时可以有效地保持边缘,同时去除图像中异常的不规则点。该研究可以推广到彩色纹理图像椒盐噪声去除及彩色纹理图像分割中。
基金supported by the National Natural Science Foundation of China(7084001290924022)the Ph.D.Thesis Innovation and Excellent Foundation of Nanjing University of Aeronautics and Astronautics(2010)
文摘In grey system theory,the studies in the field of grey prediction model are focused on real number sequences,rather than grey number ones.Hereby,a prediction model based on interval grey number sequences is proposed.By mining the geometric features of interval grey number sequences on a two-dimensional surface,all the interval grey numbers are converted into real numbers by means of certain algorithm,and then the prediction model is established based on those real number sequences.The entire process avoids the algebraic operations of grey number,and the prediction problem of interval grey number is usefully solved.Ultimately,through an example＇s program simulation,the validity and practicability of this novel model are verified.
基金supported by the Research Start Funds for Introducing High-level Talents of North China University of Water Resources and Electric Power
文摘This paper expresses the efficient outputs of decisionmaking unit（DMU） as the sum of ＂average outputs＂ forecasted by a GM（1,N） model and ＂increased outputs＂ which reflect the difficulty to realize efficient outputs.The increased outputs are solved by linear programming using data envelopment analysis efficiency theories,wherein a new sample is introduced whose inputs are equal to the budget in the issue No.n ＋ 1 and outputs are forecasted by the GM（1,N） model.The shortcoming in the existing methods that the forecasted efficient outputs may be less than the possible actual outputs according to developing trends of input-output rate in the periods of pre-n is overcome.The new prediction method provides decision-makers with more decisionmaking information,and the initial conditions are easy to be given.
基金supported by the National Science Foundation of China ( 11772133, 11372116)the Fundamental Research Funds for the Central Universities ( HUST 0118012051)
文摘Von Willebrand Factor(VWF)is a concatameric glycoprotein that plays a key role in rapid hemostasis and thrombosis.VWF has different functional domains that can bind to various molecules such as collagen,hemostatic factorⅧ,integrin,and platelet glycoprotein lbα(GPlbα)to achieve multiple biological functions.During hemostasis,the A1 domain of VWF binds to GPIbαwhere platelets accumulate in the injured vascular endothelium.Due to forces generated by the hemodynamic gradient flow,the relations of bond-dissociation rates versus forces show that the lifetime of molecular bond has multiple states under the external force.We processed the experimental data of receptor-ligand in a single molecule obtained from optical tweezers by two different methods,including a Dudko-Hummer-Szabo equation,and another method combining force4ime history and force induced bond rupture.Then we used a recently developed physical equation regarding protein unfolding rate to fit our results.The lifetime of the bond between A1 and GPlbαobtained by the above mentioned two methods shows a'three-stage'change upon gradually increasing the external force.When the external force was below 8 pN,the lifetime of the bond deceased as the external force increased,which is a typical expression of a catch bond.The lifetime of the bond started to increase when the external force increased from 8 to 11 pN,and then decrease again when the external force increased to above 11 pN.Kim et al.used different processing methods and proposes a'flex-bond'model:the lifetime of the bond will decrease as the external force increases,then suddenly increase to a peak,and continue to decrease with the increase of force.A recently developed model based on the structural-elastic properties of molecules fits our data well,indicating that the bond formed by Al and GPlbαhas a catch-bond phenomenon in a certain interval of external forces,and a flex bond in other force intervals.In conclusion,A1-GPIbαbond will have a'slip-catch-slip'bond tendency.Our result provides a alternative understanding about the role of Al-GPlbαinteractions in the mechanism of hemostasis.
基金Project(20876180)supported by the National Natural Science Foundation of China
文摘Using the latest reported homologous Chemokine receptors （PDB ID： 3ODU, 3OE0 and 3OE6） as templates, twenty models of angiotensin II （Ang II） type 1 （AT1） receptor （known as p30556） were generated by multiple templates homology modeling. According to the results of the initial validation of these twenty models, the model 0020 was finally chosen as the best one for further studies. Then, a 2 ns molecular dynamic （MD） simulation for model 0020 was conducted in normal saline （0.9%, w/F） under periodical boundary conditions, which was followed by docking studies of model 0020 with several existing AT1 receptor blockers （ARBs）. The docking results reveal that model 0020 possesses good affinities with these docked ARBs which are in accordance with both the IC50 inhibitor values and their curative effects. The results also show more potent interactions between the model 0020 and its ARBs than those of ever reported results, such as hydrogen bonds, hydrophobic interactions, and especially cation-n interactions and π-π interactions which have never been reported before. This may reveal that the structure of the model 0020 is quite close to its real crystal structure and the model 0020 may have the potential to be used for structure based drug design：
